IMMUNITY, ISSN 1074-7613, 06/2011, Volume 34, Issue 6, pp. 932 - 946
The nature of follicular helper CD4(+) T (Tfh) cell differentiation remains controversial, including the minimal signals required for Tfh cell differentiation...
B-CELLS | ACTIVATION | SAP | IN-VIVO | HUMORAL IMMUNITY | CD28 | COMMON VARIABLE IMMUNODEFICIENCY | GERMINAL-CENTERS | IMMUNOLOGY | C-MAF | IL-21
B-CELLS | ACTIVATION | SAP | IN-VIVO | HUMORAL IMMUNITY | CD28 | COMMON VARIABLE IMMUNODEFICIENCY | GERMINAL-CENTERS | IMMUNOLOGY | C-MAF | IL-21
Journal Article
07/2019, ISBN 3030241890, 112
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Immunity, ISSN 1074-7613, 2011, Volume 34, Issue 6, pp. 932 - 946
The nature of follicular helper CD4 T (Tfh) cell differentiation remains controversial, including the minimal signals required for Tfh cell differentiation and...
Inducible T-Cell Co-Stimulator Protein | DNA-Binding Proteins - immunology | T-Lymphocytes, Helper-Inducer - metabolism | Antigens, Differentiation, T-Lymphocyte - immunology | Signal Transduction | Dendritic Cells - immunology | Germinal Center - immunology | Antigens, Differentiation, T-Lymphocyte - metabolism | DNA-Binding Proteins - genetics | Receptors, CXCR5 - immunology | Receptors, Interleukin-2 - immunology | Proteins - immunology | Animals | Proteins - metabolism | Inducible T-Cell Co-Stimulator Ligand | T-Lymphocytes, Helper-Inducer - immunology | Transcription, Genetic | Cell Differentiation | Mice | Proto-Oncogene Proteins c-bcl-6 | Virus diseases | Genetic aspects | Dendritic cells | T cells
Inducible T-Cell Co-Stimulator Protein | DNA-Binding Proteins - immunology | T-Lymphocytes, Helper-Inducer - metabolism | Antigens, Differentiation, T-Lymphocyte - immunology | Signal Transduction | Dendritic Cells - immunology | Germinal Center - immunology | Antigens, Differentiation, T-Lymphocyte - metabolism | DNA-Binding Proteins - genetics | Receptors, CXCR5 - immunology | Receptors, Interleukin-2 - immunology | Proteins - immunology | Animals | Proteins - metabolism | Inducible T-Cell Co-Stimulator Ligand | T-Lymphocytes, Helper-Inducer - immunology | Transcription, Genetic | Cell Differentiation | Mice | Proto-Oncogene Proteins c-bcl-6 | Virus diseases | Genetic aspects | Dendritic cells | T cells
Journal Article
Immunity, ISSN 1074-7613, 2009, Volume 31, Issue 5, pp. 772 - 786
Using a model of lethal oral infection with , we examined the fate of both induced and natural regulatory T (Treg) cells in the face of strong inflammatory...
MOLIMMUNO | CELLIMMUNO | PERORAL INFECTION | TGF-BETA | DENDRITIC CELLS | IFN-GAMMA | C57BL/6 MICE | TOLERANCE | REGULATORY T-CELLS | RESISTANCE | TOXOPLASMA-GONDII | SMALL-INTESTINE | IMMUNOLOGY | Interleukin-2 - metabolism | Toxoplasma | Phenotype | Animals | Cell Proliferation | Toxoplasmosis - immunology | Forkhead Transcription Factors - metabolism | Mice, Inbred C57BL | Mice | T-Lymphocytes, Regulatory - immunology | Genotype & phenotype | Transcription factors | Cysts | Microscopy | Pathogenesis | Homeostasis | Software | Regulation | Immune system
MOLIMMUNO | CELLIMMUNO | PERORAL INFECTION | TGF-BETA | DENDRITIC CELLS | IFN-GAMMA | C57BL/6 MICE | TOLERANCE | REGULATORY T-CELLS | RESISTANCE | TOXOPLASMA-GONDII | SMALL-INTESTINE | IMMUNOLOGY | Interleukin-2 - metabolism | Toxoplasma | Phenotype | Animals | Cell Proliferation | Toxoplasmosis - immunology | Forkhead Transcription Factors - metabolism | Mice, Inbred C57BL | Mice | T-Lymphocytes, Regulatory - immunology | Genotype & phenotype | Transcription factors | Cysts | Microscopy | Pathogenesis | Homeostasis | Software | Regulation | Immune system
Journal Article
Immunity, ISSN 1074-7613, 10/2012, Volume 37, Issue 4, pp. 709 - 720
The strength of interactions between TÂ cell receptors and the peptide-major histocompatibility complex (pMHC) directly modulates TÂ cell fitness, clonal...
BET | TCR | MEMORY | AUTOIMMUNITY | INTEGRIN | CD8 | PROLIFERATION | SELF-ANTIGENS | IMMUNOLOGY | LYMPHOCYTE-RESPONSES | TRANSCRIPTION FACTOR | Phenotype | Animals | T-Lymphocytes - cytology | Lymphocyte Activation | Cell Division | Mice, Inbred C57BL | Cells, Cultured | Ligands | Receptors, Antigen, T-Cell - immunology | T-Lymphocytes - immunology | Cell Differentiation | Mice | Antigens | Universities and colleges | T cells | Integrins | Daughters | Pathology | Peptides | Microscopy | Listeria | Lymphocytes | Cell division | T cell receptors | Diabetes | Immune system | Cell adhesion & migration
BET | TCR | MEMORY | AUTOIMMUNITY | INTEGRIN | CD8 | PROLIFERATION | SELF-ANTIGENS | IMMUNOLOGY | LYMPHOCYTE-RESPONSES | TRANSCRIPTION FACTOR | Phenotype | Animals | T-Lymphocytes - cytology | Lymphocyte Activation | Cell Division | Mice, Inbred C57BL | Cells, Cultured | Ligands | Receptors, Antigen, T-Cell - immunology | T-Lymphocytes - immunology | Cell Differentiation | Mice | Antigens | Universities and colleges | T cells | Integrins | Daughters | Pathology | Peptides | Microscopy | Listeria | Lymphocytes | Cell division | T cell receptors | Diabetes | Immune system | Cell adhesion & migration
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 11/2016, Volume 7, Issue 1, p. 13555
The incidence of type 1 diabetes (T1D) has substantially increased over the past decade, suggesting a role for non-genetic factors such as epigenetic...
METABOLISM | PACKAGE | MULTIDISCIPLINARY SCIENCES | RISK | DIFFERENTIAL VARIABILITY | FIELD DEFECTS | CANCER | EPIGENOME-WIDE ASSOCIATION | T-CELLS | MONOZYGOTIC TWINS | FOXP1 | Type 1 diabetes | Disease genetics | Epigenomics
METABOLISM | PACKAGE | MULTIDISCIPLINARY SCIENCES | RISK | DIFFERENTIAL VARIABILITY | FIELD DEFECTS | CANCER | EPIGENOME-WIDE ASSOCIATION | T-CELLS | MONOZYGOTIC TWINS | FOXP1 | Type 1 diabetes | Disease genetics | Epigenomics
Journal Article
Cancer Journal, ISSN 1528-9117, 07/2010, Volume 16, Issue 4, pp. 336 - 341
Journal Article
Blood, ISSN 0006-4971, 06/2010, Volume 115, Issue 22, pp. 4393 - 4402
CD20 is an important target for the treatment of B-cell malignancies, including non-Hodgkin lymphoma as well as autoimmune disorders. B-cell depletion therapy...
COMPLEMENT | RITUXIMAB | IN-VIVO | LIPID RAFTS | CHRONIC LYMPHOCYTIC-LEUKEMIA | NON-HODGKINS-LYMPHOMA | MONOCLONAL-ANTIBODY | FOLLICULAR LYMPHOMA | C-RECEPTOR POLYMORPHISMS | UMCG Approved | FULLY HUMAN | HEMATOLOGY | Lymphoma, Non-Hodgkin - immunology | Neoplasm Transplantation | Humans | Lymphoma, B-Cell - therapy | Macaca fascicularis | Transplantation, Heterologous | Antibodies, Monoclonal, Humanized | Lymphoma, B-Cell - immunology | Protein Engineering | Female | Antibodies, Monoclonal - immunology | Antigens, CD20 - immunology | Antibodies, Monoclonal, Murine-Derived | Antibody-Dependent Cell Cytotoxicity | Antibodies, Monoclonal - pharmacology | Rituximab | Receptors, IgG - immunology | Mice, SCID | Antibodies, Monoclonal - genetics | Animals | B-Lymphocytes - immunology | Lymphoma, Non-Hodgkin - therapy | Cell Line, Tumor | Immunoglobulin Variable Region - genetics | Mice | In Vitro Techniques | Immunity, Cellular | Immunoglobulin Fc Fragments - genetics | Lymphocyte Depletion - methods | Cytotoxicity, Immunologic | Immunobiology
COMPLEMENT | RITUXIMAB | IN-VIVO | LIPID RAFTS | CHRONIC LYMPHOCYTIC-LEUKEMIA | NON-HODGKINS-LYMPHOMA | MONOCLONAL-ANTIBODY | FOLLICULAR LYMPHOMA | C-RECEPTOR POLYMORPHISMS | UMCG Approved | FULLY HUMAN | HEMATOLOGY | Lymphoma, Non-Hodgkin - immunology | Neoplasm Transplantation | Humans | Lymphoma, B-Cell - therapy | Macaca fascicularis | Transplantation, Heterologous | Antibodies, Monoclonal, Humanized | Lymphoma, B-Cell - immunology | Protein Engineering | Female | Antibodies, Monoclonal - immunology | Antigens, CD20 - immunology | Antibodies, Monoclonal, Murine-Derived | Antibody-Dependent Cell Cytotoxicity | Antibodies, Monoclonal - pharmacology | Rituximab | Receptors, IgG - immunology | Mice, SCID | Antibodies, Monoclonal - genetics | Animals | B-Lymphocytes - immunology | Lymphoma, Non-Hodgkin - therapy | Cell Line, Tumor | Immunoglobulin Variable Region - genetics | Mice | In Vitro Techniques | Immunity, Cellular | Immunoglobulin Fc Fragments - genetics | Lymphocyte Depletion - methods | Cytotoxicity, Immunologic | Immunobiology
Journal Article
Cell, ISSN 0092-8674, 05/2013, Volume 153, Issue 4, pp. 785 - 796
A naive CD4 T cell population specific for a microbial peptide:major histocompatibility complex II ligand (p:MHCII) typically consists of about 100 cells, each...
RESPONSES | TCR | MEDIATED-IMMUNITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | FOLLICULAR HELPER-CELL | LISTERIA-MONOCYTOGENES INFECTION | EXPRESSION | VIRAL-INFECTION | TRANSGENIC MICE | ANTIGEN | CELL BIOLOGY | CD4-Positive T-Lymphocytes - immunology | T-Lymphocyte Subsets - immunology | Animals | Receptors, Antigen, T-Cell - metabolism | T-Lymphocyte Subsets - cytology | Bacterial Infections - immunology | CD4-Positive T-Lymphocytes - cytology | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Histocompatibility Antigens Class II - metabolism | Cell Differentiation | Mice
RESPONSES | TCR | MEDIATED-IMMUNITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | FOLLICULAR HELPER-CELL | LISTERIA-MONOCYTOGENES INFECTION | EXPRESSION | VIRAL-INFECTION | TRANSGENIC MICE | ANTIGEN | CELL BIOLOGY | CD4-Positive T-Lymphocytes - immunology | T-Lymphocyte Subsets - immunology | Animals | Receptors, Antigen, T-Cell - metabolism | T-Lymphocyte Subsets - cytology | Bacterial Infections - immunology | CD4-Positive T-Lymphocytes - cytology | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Histocompatibility Antigens Class II - metabolism | Cell Differentiation | Mice
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2008, Volume 122, Issue 2, pp. 298 - 304
Background On cross-linking of receptor-bound IgE antibodies by allergens, effector cells (basophils and mast cells) involved in type I allergic reactions...
Allergy and Immunology | Allergy | allergen | antibody | Der p 2 | recombinant IgE | diagnosis | basophils | human IgE | effector cell degranulation | basophil activation test | epitope | chimeric IgE | affinity | allergy | HISTAMINE-RELEASE | MITE ALLERGEN | IMMUNOLOGY | CROSS-REACTIVITY | LEUKEMIA-CELLS | IMMUNOASSAY | EXPRESSION | HUMAN BASOPHIL ACTIVATION | ANTI-IGE | EPITOPES | Recombinant Fusion Proteins - immunology | Antibody Specificity | Cell Line | Epitope Mapping | Mast Cells - immunology | Humans | Immunoglobulin E - metabolism | Antibody Affinity | Cell Degranulation - immunology | Recombinant Fusion Proteins - metabolism | Antigens, Dermatophagoides - metabolism | Epitopes - immunology | Antigens, Dermatophagoides - immunology | Animals | Arthropod Proteins | Immunoglobulin E - immunology | Basophils - immunology | Mast Cells - metabolism | Hypersensitivity, Immediate - immunology | Basophils - metabolism | Antigen-antibody reactions | Immunoglobulin E | Allergic reaction | Analysis | Medical research | Patients | Allergies
Allergy and Immunology | Allergy | allergen | antibody | Der p 2 | recombinant IgE | diagnosis | basophils | human IgE | effector cell degranulation | basophil activation test | epitope | chimeric IgE | affinity | allergy | HISTAMINE-RELEASE | MITE ALLERGEN | IMMUNOLOGY | CROSS-REACTIVITY | LEUKEMIA-CELLS | IMMUNOASSAY | EXPRESSION | HUMAN BASOPHIL ACTIVATION | ANTI-IGE | EPITOPES | Recombinant Fusion Proteins - immunology | Antibody Specificity | Cell Line | Epitope Mapping | Mast Cells - immunology | Humans | Immunoglobulin E - metabolism | Antibody Affinity | Cell Degranulation - immunology | Recombinant Fusion Proteins - metabolism | Antigens, Dermatophagoides - metabolism | Epitopes - immunology | Antigens, Dermatophagoides - immunology | Animals | Arthropod Proteins | Immunoglobulin E - immunology | Basophils - immunology | Mast Cells - metabolism | Hypersensitivity, Immediate - immunology | Basophils - metabolism | Antigen-antibody reactions | Immunoglobulin E | Allergic reaction | Analysis | Medical research | Patients | Allergies
Journal Article
Biology of Blood and Marrow Transplantation, ISSN 1083-8791, 03/2019, Volume 25, Issue 3, pp. S439 - S439
Journal Article