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Journal Article
INTERNATIONAL IMMUNOLOGY, ISSN 0953-8178, 04/2016, Volume 28, Issue 4, pp. 163 - 171
CD4(+) T cells are crucial for directing appropriate immune responses during host defense and for the pathogenesis of inflammatory diseases. In addition to the... 
T-cell plasticity | SYSTEMIC-LUPUS-ERYTHEMATOSUS | TH2 CELLS | TGF-BETA | T(h)1/T(h)2 paradigm | PATHOGENIC T(H)17 CELLS | AIRWAY INFLAMMATION | IMMUNOLOGY | epigenetics | AUTOIMMUNE ENCEPHALOMYELITIS | LINEAGE COMMITMENT | memory T(h)2 cells | pathogenic T(h)2 (T(path)2) cells | GENE-EXPRESSION | TYPE-2 IMMUNITY | TRANSCRIPTION FACTOR
Journal Article
BLOOD, ISSN 0006-4971, 08/2014, Volume 124, Issue 7, pp. 1070 - 1080
With the notable exception of B-cell malignancies, the efficacy of chimeric antigen receptor (CAR) T cells has been limited, and CAR T cells have not been... 
EFFECTOR | ANTI-CTLA-4 THERAPY | DISTINCT | CD28 | CANCER-IMMUNOTHERAPY | ANTITUMOR IMMUNITY | MELANOMA PATIENTS | HEMATOLOGY | LINEAGE | CD8(+) T-CELLS | TH17 CELLS
Journal Article
SCIENCE, ISSN 0036-8075, 10/2017, Volume 358, Issue 6361, pp. 359 - 359
Intestinal colonization by bacteria of oral origin has been correlated with several negative health outcomes, including inflammatory bowel disease. However, a... 
CROHNS-DISEASE | DIET | ENTEROBACTER-AEROGENES | GUT MICROBIOME | MULTIDISCIPLINARY SCIENCES | DIVERSITY | INFECTION | KLEBSIELLA-PNEUMONIAE
Journal Article
NATURE MEDICINE, ISSN 1078-8956, 07/2007, Volume 13, Issue 7, pp. 843 - 850
CD4(+) T cells have a crucial role in mediating protection against a variety of pathogens through production of specific cytokines. However, substantial... 
MYCOBACTERIUM-TUBERCULOSIS | MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNE-RESPONSE | BIOCHEMISTRY & MOLECULAR BIOLOGY | NECROSIS-FACTOR-ALPHA | CD8(+) T-CELLS | CELL BIOLOGY | INTERFERON-GAMMA | MEMORY CD4(+) | IN-VIVO | NITRIC-OXIDE | INFECTION | FLOW-CYTOMETRY
Journal Article
Nature Immunology, ISSN 1529-2908, 08/2015, Volume 16, Issue 8, pp. 801 - 801
Journal Article
NATURE IMMUNOLOGY, ISSN 1529-2908, 02/2015, Volume 16, Issue 2, pp. 178 - 178
The interplay between effector T cells and regulatory T cells (T-reg cells) is crucial for adaptive immunity, but how T-reg cells control diverse effector... 
HOMEOSTASIS | ACTIVATION | STABILITY | IN-VIVO | IL-2 | DIFFERENTIATION | IMMUNOLOGY | FOLLICULAR HELPER | FOXP3 | MTOR | PLASTICITY
Journal Article
NATURE MEDICINE, ISSN 1078-8956, 06/2009, Volume 15, Issue 6, pp. 633 - U141
Two distinct helper T (T-H) subsets, T(H)1 and T(H)17, mediate tissue damage and inflammation in animal models of various immune diseases such as multiple... 
MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | DENDRITIC CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | E-2 | AUTOIMMUNE ENCEPHALOMYELITIS | BOWEL-DISEASE | CELL BIOLOGY | CROHN-DISEASE | MULTIPLE-SCLEROSIS | T-CELLS | GENOME-WIDE ASSOCIATION | TH17 CELLS
Journal Article
SCIENCE TRANSLATIONAL MEDICINE, ISSN 1946-6234, 02/2013, Volume 5, Issue 173
The relevance of regulatory B cells in the maintenance of tolerance in healthy individuals or in patients with immune disorders remains understudied. In... 
RHEUMATOID-ARTHRITIS | MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNITY | SYSTEMIC-LUPUS-ERYTHEMATOSUS | SUPPRESSIVE FUNCTION | MICE | TNF-ALPHA | TRANSCRIPTION FACTOR | EXPRESSION | FOXP3 | DISEASE-ACTIVITY | CELL BIOLOGY
Journal Article
Nature, ISSN 0028-0836, 07/2011, Volume 475, Issue 7354, pp. 65 - 72
The biogenic amine histamine is an important pharmacological mediator involved in pathophysiological processes such as allergies and inflammations. Histamine... 
H1 RECEPTOR | PROTEIN-COUPLED RECEPTOR | STRUCTURE-BASED DISCOVERY | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | BINDING-SITE | ANTAGONISTS | SITE-DIRECTED MUTAGENESIS | MUTATIONAL ANALYSIS | A(2A) ADENOSINE RECEPTOR | AGONIST
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2011, Volume 286, Issue 45, pp. 39318 - 39327
Journal Article
SCIENCE TRANSLATIONAL MEDICINE, ISSN 1946-6234, 11/2011, Volume 3, Issue 111
Immune surveillance by T helper type 1 (T(H)1) cells is not only critical for the host response to tumors and infection, but also contributes to autoimmunity... 
MEDICINE, RESEARCH & EXPERIMENTAL | RESPONSES | ACTIVATION | INTERFERON-GAMMA | PROGRAMMED DEATH-1 | PATHWAY | INTERLEUKIN-12 | VERSUS-HOST-DISEASE | EXPRESSION | TH17 CELLS | PLASTICITY | CELL BIOLOGY
Journal Article
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, ISSN 0091-6749, 11/2015, Volume 136, Issue 5, pp. 1277 - 1287
Background: Alopecia areata (AA) is a common T cell-mediated disorder with limited therapeutics. A molecular profile of cytokine pathways in AA tissues is... 
TO-SEVERE PSORIASIS | DENDRITIC CELLS | T cell | COMBINATION THERAPY | SUSCEPTIBILITY LOCI | atopic dermatitis | hair keratin | IMMUNOLOGY | IL-23 | T(H)1 | Alopecia areata | T(H)2 | SEVERE ATOPIC-DERMATITIS | COMORBIDITY PROFILES | IN-VITRO | ALLERGY | HAIR-FOLLICLES | SKIN | TH17 CELLS
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 137, Issue 6, pp. 1764 - 1771.e4
Journal Article
NATURE IMMUNOLOGY, ISSN 1529-2908, 11/2010, Volume 11, Issue 11, pp. 1047 - U103
Naive CD4(+) T cells differentiate into diverse effector and regulatory lineages to orchestrate immunity and tolerance. Here we found that the differentiation... 
LINEAGE COMMITMENT | FOXP3 EXPRESSION | TGF-BETA | ROR-GAMMA-T | ARYL-HYDROCARBON RECEPTOR | RETINOIC-ACID | AKT-MTOR | INDUCTION | IMMUNOLOGY | LYMPHOCYTE EGRESS | TRANSGENIC MICE
Journal Article
NATURE IMMUNOLOGY, ISSN 1529-2908, 12/2004, Volume 5, Issue 12, pp. 1260 - 1265
Naive T cells are stimulated by antigen-presenting dendritic cells (DCs) in secondary lymphoid organs, but whether other types of cell participate in T cell... 
IMMUNE-RESPONSE | NATURAL-KILLER-CELLS | LEISHMANIA-MAJOR | HUMAN DENDRITIC CELLS | INTERFERON-GAMMA | CHEMOKINE RECEPTOR CXCR3 | CENTRAL MEMORY | CD4(+) T-CELLS | IMMUNOLOGY | HIGH ENDOTHELIAL VENULES |