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1. Full Text Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells
by Moro, K and Yamada, T and Tanabe, M and Takeuchi, T and Ikawa, T and Kawamoto, H and Furusawa, J and Ohtani, M and Fujii, H and Koyasu, S
NATURE, ISSN 0028-0836, 01/2010, Volume 463, Issue 7280, pp. 540 - U160
Innate immune responses are important in combating various microbes during the early phases of infection. Natural killer (NK) cells are innate lymphocytes... 
NATURAL-KILLER-CELLS | ROR-GAMMA-T | EXPULSION | MULTIDISCIPLINARY SCIENCES | GENERATION | DIFFERENTIATION | IL-33 | EXPRESSION | MICE LACKING | INDUCER CELLS | LYMPHOCYTES | B-Lymphocytes - cytology | Cell Proliferation | Membrane Proteins - genetics | Humans | Mice, Inbred C57BL | Antigens, Ly - genetics | Gene Expression Regulation | Adipose Tissue - cytology | Membrane Proteins - immunology | Th2 Cells - immunology | Adipose Tissue - immunology | Proto-Oncogene Proteins c-kit - immunology | Nematoda - physiology | Animals | B-Lymphocytes - immunology | Lymphocytes - immunology | Antigens, Ly - immunology | Mesentery - immunology | Antigens, Ly - metabolism | Proto-Oncogene Proteins c-kit - genetics | Mice | Nematode Infections - immunology | Cytokines - immunology
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2. Full Text Pediatric severe asthma is characterized by eosinophilia and remodeling without T(H)2 cytokines
by Bossley, CJ and Fleming, L and Gupta, A and Regamey, N and Frith, J and Oates, T and Tsartsali, L and Lloyd, CM and Bush, A and Saglani, S
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, ISSN 0091-6749, 04/2012, Volume 129, Issue 4, pp. 974 - U469
Background: The pathology of pediatric severe therapy-resistant asthma (STRA) is little understood. Objectives: We hypothesized that STRA in children is... 
remodeling | RESPONSIVENESS | mediators | MEPOLIZUMAB | NONATOPIC CHILDREN | IMMUNOLOGY | FLOW LIMITATION | DIFFICULT ASTHMA | Pediatric asthma | SMOOTH-MUSCLE | ALLERGY | severe therapy-resistant asthma | eosinophilia | NEUTROPHILIC AIRWAY INFLAMMATION | CHRONIC COUGH | CELL | BASEMENT-MEMBRANE | Inflammation - pathology | Steroids - administration & dosage | Humans | Child, Preschool | Interleukin-13 - immunology | Male | Th2 Cells - immunology | Th2 Cells - drug effects | Bronchoalveolar Lavage Fluid - microbiology | Eosinophilia - pathology | Inflammation - drug therapy | Asthma - immunology | Female | Steroids - pharmacology | Child | Cytokines - immunology | Anti-Asthmatic Agents - pharmacology | Asthma - drug therapy | Interleukin-5 - immunology | Sputum - chemistry | Eosinophilia - immunology | Adolescent | Airway Remodeling - drug effects | Anti-Asthmatic Agents - administration & dosage | Bronchoalveolar Lavage Fluid - chemistry | Asthma - pathology
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3. Full Text T(H)2 Cytokines from Malignant Cells Suppress T(H)1 Responses and Enforce a Global T(H)2 Bias in Leukemic Cutaneous T-cell Lymphoma
by Guenova, E and Watanabe, R and Teague, JE and Desimone, JA and Jiang, Y and Dowlatshahi, M and Schlapbach, C and Schaekel, K and Rook, AH and Tawa, M and Fisher, DC and Kupper, TS and Clark, RA
CLINICAL CANCER RESEARCH, ISSN 1078-0432, 07/2013, Volume 19, Issue 14, pp. 3755 - 3763
Purpose: In leukemic cutaneous T-cell lymphoma (L-CTCL), malignant T cells accumulate in the blood and give rise to widespread skin inflammation. Patients have... 
SURVIVAL | PATTERN | ONCOLOGY | EXPRESS | IMMUNOPATHOGENESIS | SUBSETS | MYCOSIS-FUNGOIDES | PROLIFERATION | SEZARY-SYNDROME | EORTC CLASSIFICATION | BLOOD
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4. Full Text T(H)2 cytokines increase kallikrein 7 expression and function in patients with atopic dermatitis
by Morizane, S and Yamasaki, K and Kajita, A and Ikeda, K and Zhan, MS and Aoyama, Y and Gallo, RL and Iwatsuki, K
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, ISSN 0091-6749, 07/2012, Volume 130, Issue 1, pp. 259 - 261
ALLERGY | IMMUNOLOGY
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5. Full Text Differential Influence on Regulatory B Cells by T(H)2 Cytokines Affects Protection in Allergic Airway Disease
by Taitano, SH and van der Vlugt, LEPM and Shea, MM and Yang, J and Lukacs, NW and Lundy, SK
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 10/2018, Volume 201, Issue 7, pp. 1865 - 1874
The role of regulatory B cells (Bregs) in modulating immune responses and maintaining tolerance are well established. However, how cytokines present during... 
B-1 CELLS | MURINE MODEL | FAS LIGAND | DENDRITIC CELLS | IL-5 | VH GENE | DEFICIENT MICE | IMMUNOLOGY | PRONE MICE | T-CELLS | LYMPHOCYTES
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6. Full Text Vitamin D insufficiency, T(H)2 cytokines, and allergy markers in Puerto Rican children with asthma
by Han, YY and Forno, E and Boutaoui, N and Canino, G and Celedon, JC
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, ISSN 1081-1206, 10/2018, Volume 121, Issue 4, pp. 497 - 497
ALLERGY | IMMUNOLOGY
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7. Full Text Effects of IL-10 and T(h)2 cytokines on human M phi phenotype and response to CSF1R inhibitor
by Pradel, LP and Franke, A and Ries, CH
JOURNAL OF LEUKOCYTE BIOLOGY, ISSN 0741-5400, 03/2018, Volume 103, Issue 3, pp. 545 - 558
Tumor-associated M phi s display a plastic phenotype that is regulated by the local tumor milieu. Gene expression analysis and functional characterization of M... 
RG7155 | emactuzumab | ACTIVATION | MONOCYTES | INTERLEUKIN-13 | tumor-associated M phi | IMMUNOLOGY | CANCER | CELL BIOLOGY | cancer immunotherapy | GENE-EXPRESSION | TUMOR-ASSOCIATED MACROPHAGES | IL-4 and-13 | gene expression profiling | HEMATOLOGY | NF-KAPPA-B | POLARIZATION | PROGRESSION | REVEALS
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8. Full Text Chenodeoxycholic acid attenuates ovalbumin-induced airway inflammation in murine model of asthma by inhibiting the T(H)2 cytokines
by Shaik, FB and Panati, K and Narasimha, VR and Narala, VR
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ISSN 0006-291X, 08/2015, Volume 463, Issue 4, pp. 600 - 605
Asthma is a complex highly prevalent airway disease that is a major public health problem for which current treatment options are inadequate. Recently,... 
Farnesoid X receptor | FIBROSIS | BILE-ACID | CELLS | LUNG | Nuclear receptor | BIOCHEMISTRY & MOLECULAR BIOLOGY | T(H)2 cytokines | FACTOR-KAPPA-B | FXR LIGANDS | BIOPHYSICS | Airway inflammation | URSODEOXYCHOLIC ACID | FARNESOID-X-RECEPTOR | EXPRESSION | Bronchitis - chemically induced | Asthma - physiopathology | Asthma - prevention & control | Bronchitis - prevention & control | DNA Primers | Th2 Cells - drug effects | Th2 Cells - metabolism | Animals | Ovalbumin - administration & dosage | Base Sequence | Bronchitis - metabolism | Chenodeoxycholic Acid - pharmacology | Female | Mice | Mice, Inbred BALB C | Cytokines - antagonists & inhibitors | Disease Models, Animal
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9. Full Text Type 3 muscarinic receptors contribute to intestinal mucosal homeostasis and clearance of Nippostrongylus brasiliensis through induction of T(H)2 cytokines
by McLean, LP and Smith, A and Cheung, LM and Urban, JF and Sun, R and Grinchuk, V and Desai, N and Zhao, AP and Raufman, JP and Shea-Donohue, T
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, ISSN 0193-1857, 07/2016, Volume 311, Issue 1, pp. G130 - G141
Despite increased appreciation for the role of nicotinic receptors in the modulation of and response to inflammation, the contribution of muscarinic receptors... 
VAGUS NERVE | PHYSIOLOGY | host defense | BARRIER FUNCTION | T(H)2 cytokines | NICOTINIC ACETYLCHOLINE-RECEPTORS | Nippostrongylus brasiliensis | muscarinic receptor | mucosal homeostasis | SMOOTH-MUSCLE | IN-VITRO | M-2 | INFECTION | MICE | GASTROENTEROLOGY & HEPATOLOGY | MACROPHAGE POLARIZATION | T-CELLS
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10. Full Text Modulation of chicken macrophage effector function by T(H)1/T(H)2 cytokines
by He, HQ and Genovese, KJ and Kogut, MH
CYTOKINE, ISSN 1043-4666, 03/2011, Volume 53, Issue 3, pp. 363 - 369
Regulation of macrophage activity by T(H)1/2 cytokines is important to maintain the balance of immunity to provide adequate protective immunity while avoiding... 
Salmonella | NITRIC-OXIDE SYNTHASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | Cytokine | Oxidative burst | Chicken macrophage | MAREKS-DISEASE | IMMUNOLOGY | AVIAN MACROPHAGE | CELL BIOLOGY | IFN-GAMMA-PRODUCTION | IN-VITRO | EIMERIA-TENELLA | INTERFERON-GAMMA | Nitric oxide | IMMUNE-RESPONSES | BURSAL DISEASE VIRUS | ACTIVATED MACROPHAGES | Cell Line | Phagocytosis - drug effects | Poly I-C - pharmacology | Th2 Cells - metabolism | Respiratory Burst - drug effects | Dose-Response Relationship, Drug | Host-Pathogen Interactions | Th1 Cells - metabolism | Interleukin-4 - pharmacology | Macrophages - metabolism | Animals | Teichoic Acids - pharmacology | Chickens | Lipopolysaccharides - pharmacology | Macrophages - drug effects | Interleukin-18 - pharmacology | Nitric Oxide - metabolism | Oligodeoxyribonucleotides - pharmacology | Peptidoglycan - pharmacology | Interleukin-10 - pharmacology | Interferon-gamma - pharmacology | Macrophages - microbiology | Salmonella enteritidis - physiology
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11. Full Text Chenodeoxycholic acid attenuates ovalbumin-induced airway inflammation in murine model of asthma by inhibiting the T H 2 cytokines
by Shaik, Firdose Begum and Panati, Kalpana and Narasimha, Vydyanath R and Narala, Venkata Ramireddy
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 07/2015, Volume 463, Issue 4, pp. 600 - 605
Asthma is a complex highly prevalent airway disease that is a major public health problem for which current treatment options are inadequate. Recently,... 
Farnesoid X receptor | Nuclear receptor | Airway inflammation | T H 2 cytokines
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12. Full Text T(H)2 cytokines and allergic challenge induce YM1 expression in macrophages by a STAT6-dependent mechanism
by Welch, JS and Escoubet-Lozach, L and Sykes, DB and Liddiard, K and Greaves, DR and Glass, CK
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 11/2002, Volume 277, Issue 45, pp. 42821 - 42829
The diverse functions of macrophages as participants in innate and acquired immune responses are regulated by the specific milieu of environmental factors,... 
SIGNAL-TRANSDUCTION | PERITONEAL-CAVITY | INTERFERON-GAMMA | EOSINOPHIL INFILTRATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | AIRWAY HYPERRESPONSIVENESS | MICE | GROWTH-FACTOR | CELL-LINES | HUMAN MONOCYTES
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13. Full Text A circulating T(H)2 cytokines profile predicts survival in patients with resectable pancreatic adenocarcinoma
by Piro, G and Simionato, F and Carbone, C and Frizziero, M and Malleo, G and Zanini, S and Casolino, R and Santoro, R and Mina, MM and Zecchetto, C and Merz, V and Scarpa, A and Bassi, C and Tortora, G and Melisi, D
ONCOIMMUNOLOGY, ISSN 2162-402X, 2017, Volume 6, Issue 9
Surgery is the only potentially curative option for patients with pancreatic ductal adenocarcinoma (PDAC), but metastatic relapse remains common. We... 
pancreatic adenocarcinoma | RECRUITMENT | circulating cytokine profile | IMMUNE CONTEXTURE | MACROPHAGE | T(H)2 cytokines | IMMUNOLOGY | CANCER | GEMCITABINE | STRATEGIES | IL4 | ONCOLOGY | INFLAMMATION | REGULATORY T-CELLS | prognostic biomarker | HUMAN TUMORS | PROGRESSION
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14. Full Text Proinflammatory effects of T(H)2 cytokines in a murine model of chronic small intestinal inflammation
by Bamias, G and Martin, C and Mishina, M and Ross, WG and Rivera-Nieves, J and Marini, M and Cominelli, F
GASTROENTEROLOGY, ISSN 0016-5085, 03/2005, Volume 128, Issue 3, pp. 654 - 666
Background & Aims: Strict T(H)1 polarization is believed to underlie the pathogenesis of intestinal inflammation in Crohn's disease. In the present study we... 
RESPONSES | ILEITIS | CROHNS-DISEASE | INTERFERON-GAMMA | COLITIS | IN-VIVO | MICE | IL-13 | GASTROENTEROLOGY & HEPATOLOGY | T-CELLS | BOWEL-DISEASE
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15. Full Text Lung dendritic cells induce T(H)17 cells that produce T(H)2 cytokines, express GATA-3, and promote airway inflammation
by Raymond, M and Van, VQ and Wakahara, K and Rubio, M and Sarfati, M
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, ISSN 0091-6749, 07/2011, Volume 128, Issue 1, pp. 192 - U313
Background: Dendritic cells (DCs) are crucial to shape the adaptive immune response. Extensive in vitro manipulation reprograms T(H)2 and T(H)17 cell lines... 
airway inflammation | MIGRATION | ACTIVATION | IMMUNOLOGY | HYPERRESPONSIVENESS | T(H)2 | dendritic cells | INTERLEUKIN-17 | ALLERGY | IMMUNE-RESPONSES | T(H)17 | GENERATION | signal regulatory protein alpha | DIFFERENTIATION | MEMORY T-CELLS | TH17 CELLS | TH2 | T-Lymphocyte Subsets - immunology | Coculture Techniques | Dendritic Cells - immunology | GATA3 Transcription Factor - immunology | GATA3 Transcription Factor - biosynthesis | Th2 Cells - immunology | Lung - cytology | Lymphocyte Activation - immunology | Flow Cytometry | Th17 Cells - metabolism | Pneumonia - immunology | Female | Th17 Cells - cytology | Cytokines - immunology | Cell Separation | Th2 Cells - cytology | Th2 Cells - metabolism | Cell Differentiation - immunology | Cell Lineage | Animals | T-Lymphocyte Subsets - metabolism | Th17 Cells - immunology | Mice | Mice, Inbred BALB C | Pneumonia - metabolism | Cytokines - biosynthesis | Lung - immunology
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16. Full Text Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-gamma but not T(H)2 cytokines
by Kane, LP and Andres, PG and Howland, KC and Abbas, AK and Weiss, A
NATURE IMMUNOLOGY, ISSN 1529-2908, 01/2001, Volume 2, Issue 1, pp. 37 - 44
A region of the interleukin-2 (IL-2) promoter known as the RE/AP element is activated in concert by signals that originate from the T cell antigen receptor and... 
RESPONSE ELEMENT | ACCESSORY MOLECULE CD28 | PROTEIN-KINASE-B | PHOSPHATIDYLINOSITOL 3-KINASE | T-CELL ACTIVATION | INTERLEUKIN-2 GENE-EXPRESSION | ANTIGEN RECEPTOR COMPLEX | C-REL | IMMUNOLOGY | NF-KAPPA-B | PHOSPHOINOSITIDE 3-KINASE
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17. Full Text Roles of T(H)1 and T(H)2 cytokines in a murine model of allergic dermatitis
by Spergel, Jonathan M and Mizoguchi, Emiko and Oettgen, Hans and Bhan, Atul K and Geha, Raif S
Journal of Clinical Investigation, ISSN 0021-9738, 1999, Volume 103, Issue 8, pp. 1103 - 1111
Skin lesions in atopic dermatitis (AD) are characterized by hypertrophy of the dermis and epidermis, infiltration by T cells and eosinophils, and expression of... 
LUNG DAMAGE | MEDICINE, RESEARCH & EXPERIMENTAL | ATOPIC-DERMATITIS | INTERFERON-GAMMA | IFN-GAMMA | EOSINOPHILIC INFLAMMATION | BRONCHIAL HYPERREACTIVITY | KNOCKOUT MICE | AIRWAYS HYPERREACTIVITY | EXPRESSION | T-CELLS
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18. Full Text A circulating T H 2 cytokines profile predicts survival in patients with resectable pancreatic adenocarcinoma
by Piro, Geny and Simionato, Francesca and Carbone, Carmine and Frizziero, Melissa and Malleo, Giuseppe and Zanini, Silvia and Casolino, Raffaella and Santoro, Raffaela and Mina, Maria Mihaela and Zecchetto, Camilla and Merz, Valeria and Scarpa, Aldo and Bassi, Claudio and Tortora, Giampaolo and Melisi, Davide
Oncoimmunology, ISSN 2162-4011, 2017, Volume 6, Issue 9, p. e1322242
Surgery is the only potentially curative option for patients with pancreatic ductal adenocarcinoma (PDAC), but metastatic relapse remains common. We... 
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19. Full Text The other side of the coin: The protective role of the T(H)2 cytokines
by Finkelman, FD and Urban, JF
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, ISSN 0091-6749, 05/2001, Volume 107, Issue 5, pp. 772 - 780
Although T(H)2 cytokine involvement in allergy makes these cytokines attractive therapeutic targets, they protect against ectoparasites and gastrointestinal... 
T-CELL SUBSETS | worm | PARASITE TRICHURIS-MURIS | IgE | SCHISTOSOMA-MANSONI | IL-4 | mast cell | allergy | IL-5 | NECROSIS-FACTOR-ALPHA | IL-3 | IL-13 | IMMUNOLOGY | NIPPOSTRONGYLUS-BRASILIENSIS | IL-9 | MAST-CELL | INTERLEUKIN-5 TRANSGENIC MICE | W-WV MICE | VIRUS TYPE-I | TRICHINELLA-SPIRALIS INFECTION | eosinophil
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20. Full Text Vitamin D insufficiency, T H 2 cytokines, and allergy markers in Puerto Rican children with asthma
by Han, Yueh-Ying and Forno, Erick and Boutaoui, Nadia and Canino, Glorisa and Celedón, Juan C
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 10/2018, Volume 121, Issue 4, p. 497
Asthma - diagnosis | Biomarkers - metabolism | United States - epidemiology | Cytokines - metabolism | Humans | Hispanic Americans | Male | Th2 Cells - immunology | Vitamin D Deficiency - diagnosis | Vitamin D Deficiency - epidemiology | Adolescent | Hypersensitivity - diagnosis | Female | Vitamin D - metabolism | Hypersensitivity - epidemiology | Child | Asthma - epidemiology
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