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by Jones, David T. W and Jäger, Natalie and Kool, Marcel and Zichner, Thomas and Hutter, Barbara and Sultan, Marc and Cho, Yoon-Jae and Pugh, Trevor J and Hovestadt, Volker and Stütz, Aian M and Rausch, Tobias and Warnatz, Hans-Jörg and Ryzhova, Marina and Bender, Sebastian and Sturm, Dominik and Pleier, Sabrina and Cin, Huriye and Pfaff, Elke and Sieber, Laura and Wittmann, Anea and Remke, Marc and Witt, Henik and Hutter, Sonja and Tzaridis, Theophilos and Weischenfeldt, Joachim and Raeder, Benjamin and Avci, Meryem and Amstislavskiy, Vyacheslav and Zapatka, Marc and Weber, Ursula D and Wang, Qi and Lasitschka, Bärbel and Bartholomae, Cynthia C and Schmidt, Manfred and von Kalle, Christof and Ast, Volker and Lawerenz, Chris and Eils, Jürgen and Kabbe, Rolf and Benes, Vladimir and van Sluis, Peter and Koster, Jan and Volckmann, Richard and Shih, David and Betts, Matthew J and Russell, Robert B and Coco, Simona and Tonini, Gian Paolo and Schüller, Ulrich and Hans, Volkmar and Graf, Norbert and Kim, Yoo-Jin and Monoranu, Camelia and Roggendorf, Wolfgang and Unterberg, Aneas and Herold-Mende, Christel and Milde, Till and Kulozik, Aneas E and von Deimling, Aneas and Witt, Olaf and Maass, Eberhard and Rössler, Jochen and Ebinger, Martin and Schuhmann, Martin U and Frühwald, Michael C and Hasselblatt, Martin and Jabado, Nada and Rutkowski, Stefan and von Bueren, Ané O and Williamson, Dan and Clifford, Steven C and McCabe, Martin G and Collins, V. Peter and Wolf, Stephan and Wiemann, Stefan and Lehrach, Hans and Brors, Benedikt and Scheurlen, Wolfram and Felsberg, Jörg and Reifenberger, Guido and Northcott, Paul A and Taylor, Michael D and Meyerson, Matthew and Pomeroy, Scott L and Yaspo, Marie-Laure and Korbel, Jan O and Korshunov, Aney and Eils, Roland and Pfister, Stefan M and Lichter, Peter
Nature, ISSN 0028-0836, 2012, Volume 488, Issue 7409, pp. 100 - 105
Medulloblastoma is an aggressively growing tumour, arising in the cerebellum or medulla/brain stem. It is the most common malignant brain tumour in children,... 
ACTIVATION | PATHWAY | LANDSCAPE | MULTIDISCIPLINARY SCIENCES | GENES | TETRAPLOID TUMOR-CELLS | TBR1 | MUTATIONS | SUBGROUPS | CANCER | Chromatin - metabolism | Cerebellar Neoplasms - diagnosis | Genomics | Humans | Hedgehog Proteins - metabolism | Wnt Proteins - metabolism | Histone Demethylases - genetics | Aging - genetics | Medulloblastoma - pathology | Cerebellar Neoplasms - pathology | Patched Receptors | Cerebellar Neoplasms - classification | Medulloblastoma - genetics | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Child | DNA Helicases - genetics | Amino Acid Sequence | Polyploidy | Signal Transduction | Chromosomes, Human - genetics | Medulloblastoma - diagnosis | Mutation Rate | Cerebellar Neoplasms - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mutation - genetics | T-Box Domain Proteins - genetics | Genome, Human - genetics | beta Catenin - genetics | DEAD-box RNA Helicases - genetics | Phosphoprotein Phosphatases - genetics | Sequence Analysis, RNA | Cell Transformation, Neoplastic | Oncogene Proteins, Fusion - genetics | High-Throughput Nucleotide Sequencing | Methylation | Medulloblastoma - classification | Patched-1 Receptor | Receptors, Cell Surface - genetics | Medulloblastoma | Physiological aspects | Development and progression | Genetic aspects | Research | Metastasis | Cancer | Index Medicus
Journal Article
Science, ISSN 0036-8075, 12/2012, Volume 338, Issue 6114, pp. 1619 - 1622
Journal Article
Journal Article
Circulation, ISSN 0009-7322, 10/2014, Volume 130, Issue 15, pp. 1225 - 1235
BACKGROUND—Atrial fibrillation (AF) affects >30 million individuals worldwide and is associated with an increased risk of stroke, heart failure, and death. AF... 
Atrial fibrillation | Genetics | Zebrafish | Gene expression | Single nucleotide | Epidemiology | Polymorphism | CARDIAC & CARDIOVASCULAR SYSTEMS | RISK-FACTORS | METAANALYSIS | VARIANTS | polymorphism | LOCI | epidemiology | atrial fibrillation | PR INTERVAL | genetics | single nucleotide | PERIPHERAL VASCULAR DISEASE | PRAVASTATIN | zebrafish | HEART-RATE | ISCHEMIC-STROKE | gene expression | ONSET | GENOME-WIDE ASSOCIATION | T-Box Domain Proteins - physiology | Humans | Middle Aged | Male | Genetic Loci - physiology | Atrial Fibrillation - physiopathology | Ubiquitin-Protein Ligases - physiology | Gene Knockdown Techniques | Repressor Proteins - physiology | Muscle Proteins | Connexin 43 - physiology | Female | Nuclear Proteins - genetics | Connexin 43 - genetics | Transcription Factors - physiology | Europe | Japan | Repressor Proteins - genetics | Atrial Fibrillation - ethnology | Genotype | Chromosome Mapping | Transcription Factors - genetics | Atrial Fibrillation - genetics | T-Box Domain Proteins - genetics | Homeodomain Proteins - genetics | Zebrafish Proteins - physiology | Animals | Genetic Predisposition to Disease - ethnology | Aged | Nuclear Proteins - physiology | Zebrafish Proteins - genetics | Homeodomain Proteins - physiology | Quantitative Trait Loci | Ubiquitin-Protein Ligases - genetics | Stroke (Disease) | Care and treatment | Usage | Analysis | Genetic transcription | Diagnosis | Nucleotides | Risk factors | Index Medicus | Abridged Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 08/2011, Volume 71, Issue 15, pp. 5296 - 5306
The switch of tumor cells from an epithelial to a mesenchymal-like phenotype [designated as epithelial-to-mesenchymal transition (EMT)] is known to induce... 
BREAST-CARCINOMA | STEM-CELLS | IN-VITRO | ONCOLOGY | SERUM INTERLEUKIN-8 | PROSTATE-CANCER | METASTATIC PHENOTYPE | MALIGNANT-MELANOMA | TUMOR-GROWTH | EXPRESSION | PROGRESSION | Receptors, Interleukin-8 - genetics | T-Box Domain Proteins - physiology | Breast Neoplasms - secretion | Fibronectins - biosynthesis | Carcinoma - secretion | T-Box Domain Proteins - antagonists & inhibitors | Epithelial-Mesenchymal Transition - physiology | Humans | Neoplasm Proteins - physiology | T-Box Domain Proteins - biosynthesis | Culture Media, Conditioned - pharmacology | Culture Media, Serum-Free | Interleukin-8 - physiology | Neoplasm Proteins - antagonists & inhibitors | Bystander Effect | Tumor Microenvironment - physiology | Recombinant Fusion Proteins - antagonists & inhibitors | Cell Line, Tumor - pathology | Receptors, Interleukin-8 - biosynthesis | Cell Line, Tumor - secretion | Gene Expression Regulation, Neoplastic - drug effects | Intercellular Signaling Peptides and Proteins - secretion | Carcinoma - pathology | Neoplasm Proteins - genetics | Pancreatic Neoplasms - secretion | Promoter Regions, Genetic | Chemokines - secretion | Neoplasm Invasiveness | Neoplasm Proteins - biosynthesis | Pancreatic Neoplasms - pathology | RNA, Small Interfering - pharmacology | Cytokines - secretion | Fetal Proteins - physiology | Fetal Proteins - antagonists & inhibitors | Fetal Proteins - biosynthesis | T-Box Domain Proteins - genetics | Breast Neoplasms - pathology | Fetal Proteins - genetics | Fibronectins - genetics | Cell Movement | Index Medicus | Brachyury | tumor microenvironment | IL-8 | metastasis | EMT
Journal Article
Immunity, ISSN 1074-7613, 04/2015, Volume 42, Issue 4, pp. 613 - 626
Epigenetic regulation of lineage-specific genes is important for the differentiation and function of T cells. Ten-eleven translocation (Tet) proteins catalyze... 
METHYLATION | INTERLEUKIN-27 | TRANSCRIPTION | DISEASE | POPULATIONS | PATTERNS | GENERATION | DIFFERENTIATION | SPECIFICATION | IMMUNOLOGY | PLASTICITY | Cytosine - analogs & derivatives | 5-Methylcytosine - analogs & derivatives | E1A-Associated p300 Protein - immunology | Humans | E1A-Associated p300 Protein - genetics | T-Box Domain Proteins - immunology | Th1 Cells - immunology | DNA Methylation | Cytosine - metabolism | Proto-Oncogene Proteins - immunology | Th17 Cells - cytology | Cell Differentiation | STAT4 Transcription Factor - immunology | Cytokines - immunology | Cytosine - immunology | DNA-Binding Proteins - immunology | Th17 Cells - enzymology | DNA - immunology | Gene Expression Regulation | Mice, Transgenic | Proto-Oncogene Proteins - genetics | DNA - metabolism | DNA-Binding Proteins - genetics | T-Box Domain Proteins - genetics | Animals | Epigenesis, Genetic - immunology | Th17 Cells - immunology | STAT4 Transcription Factor - genetics | Th1 Cells - enzymology | Mice | Th1 Cells - cytology | Genome | Cytokines - biosynthesis | Proteins | Epigenetic inheritance | Cytokines | Genes | Genomics | DNA | Genetic research | Genomes | Ophthalmology | T cells | Gene expression | Cell differentiation | Transcription factors | Lymphocytes | Rodents | DNA methylation | Epigenetics | Genetic testing | Experiments | Binding sites | Deoxyribonucleic acid--DNA | Index Medicus
Journal Article
Development (Cambridge), ISSN 0950-1991, 03/2014, Volume 141, Issue 6, pp. 1381 - 1391
How signaling gradients supply positional information in a field of moving cells is an unsolved question in patterning and morphogenesis. Here, we ask how a... 
Signal gradient | Wnt signaling | Embryonic elongation | Fgf signaling | Segmentation clock | Time-lapse microscopy | WAVE-FRONT ACTIVITY | SIGNALING PATHWAYS | MOUSE EMBRYOS | NOTCH | DEVELOPMENTAL BIOLOGY | BOUNDARY FORMATION | GENE-EXPRESSION | BODY FORMATION | PRESOMITIC MESODERM | VERTEBRATE SEGMENTATION | T-Box Domain Proteins - physiology | Fibroblast Growth Factors - genetics | Wnt Signaling Pathway - physiology | Zebrafish - embryology | Intercellular Signaling Peptides and Proteins - physiology | Somites - embryology | Wnt Proteins - genetics | Gene Expression Regulation, Developmental | Fibroblast Growth Factors - physiology | Somites - metabolism | Basic Helix-Loop-Helix Transcription Factors - physiology | Basic Helix-Loop-Helix Transcription Factors - genetics | Animals, Genetically Modified | Zebrafish Proteins - antagonists & inhibitors | Intercellular Signaling Peptides and Proteins - genetics | Heat-Shock Response - physiology | T-Box Domain Proteins - genetics | Zebrafish - genetics | Zebrafish Proteins - physiology | Body Patterning - physiology | Heat-Shock Response - genetics | Animals | Wnt Signaling Pathway - genetics | Models, Biological | Zebrafish - metabolism | Wnt Proteins - physiology | Zebrafish Proteins - genetics | Wnt Proteins - antagonists & inhibitors | Body Patterning - genetics | Index Medicus | Life Sciences | Genetics
Journal Article
Nature Neuroscience, ISSN 1097-6256, 05/2010, Volume 13, Issue 5, pp. 551 - 558
Brain structure and size require precise division of neural stem cells (NSCs), which self-renew and generate intermediate neural progenitors (INPs) and... 
HUMAN-CHROMOSOMES | PROTEIN | LIS1 EXPRESSION | LISSENCEPHALY GENE | SECKEL-SYNDROME | NASHI | SPINDLE ORIENTATION | NEUROGENESIS | NEUROSCIENCES | MESSENGER-RNA LOCALIZATION | CEREBRAL CORTICAL SIZE | Brain - embryology | Microcephaly - genetics | Embryo, Mammalian | Homeodomain Proteins - metabolism | Humans | Apoptosis - genetics | Green Fluorescent Proteins - genetics | RNA, Messenger - metabolism | Neurogenesis - genetics | DNA Mutational Analysis | Organ Size - genetics | Repressor Proteins - metabolism | Animals, Newborn | Oligonucleotide Array Sequence Analysis - methods | Repressor Proteins - genetics | Genotype | Mice, Transgenic | In Situ Nick-End Labeling - methods | Mutation - genetics | T-Box Domain Proteins - metabolism | Eye Proteins - metabolism | Brain - pathology | Mice | HeLa Cells | Paired Box Transcription Factors - genetics | Neurons - pathology | Age Factors | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Gene Expression Regulation, Developmental - genetics | Brain - growth & development | Cell Differentiation - genetics | 1-Alkyl-2-acetylglycerophosphocholine Esterase - genetics | Transfection | Microcephaly - pathology | Microcephaly - physiopathology | Bromodeoxyuridine - metabolism | Eye Proteins - genetics | Nuclear Proteins - genetics | RNA Interference - physiology | Cell Division - genetics | Mice, Inbred C57BL | Gene Expression Profiling - methods | Nuclear Proteins - metabolism | PAX6 Transcription Factor | Nerve Tissue Proteins - genetics | T-Box Domain Proteins - genetics | Homeodomain Proteins - genetics | Nerve Tissue Proteins - metabolism | 1-Alkyl-2-acetylglycerophosphocholine Esterase - metabolism | Animals | Stem Cells - physiology | Paired Box Transcription Factors - metabolism | Animal experimentation | Axons | Usage | Brain research | Cell division | Physiological aspects | Causes of | Research | Microcephaly | Mental retardation | Risk factors | Index Medicus
Journal Article
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 11/2008, Volume 205, Issue 12, pp. 2763 - 2779
Progressive loss of T cell functionality is a hallmark of chronic infection with human immunodeficiency virus 1 (HIV-1). We have identified a novel population... 
MEDICINE, RESEARCH & EXPERIMENTAL | SKEWED MATURATION | ACTIVATION | MULTIPLE-SCLEROSIS | IMMUNODEFICIENCY-VIRUS-INFECTION | IMPAIRED FUNCTION | CD4(+) | IMMUNOLOGY | CHRONIC VIRAL-INFECTION | DISEASE PROGRESSION | LYMPHOCYTES | ANTIGEN | GATA3 Transcription Factor - genetics | T-Lymphocyte Subsets - immunology | Antigens, CD - immunology | HIV-1 - pathogenicity | T-Lymphocyte Subsets - cytology | GATA3 Transcription Factor - immunology | Humans | STAT5 Transcription Factor - immunology | T-Box Domain Proteins - immunology | Antigens, CD - genetics | Extracellular Signal-Regulated MAP Kinases - genetics | Extracellular Signal-Regulated MAP Kinases - immunology | HIV Infections - immunology | STAT5 Transcription Factor - genetics | Signal Transduction - immunology | HIV Infections - pathology | Apoptosis Regulatory Proteins - genetics | Apoptosis Regulatory Proteins - immunology | Membrane Proteins - genetics | p38 Mitogen-Activated Protein Kinases - genetics | Membrane Proteins - immunology | p38 Mitogen-Activated Protein Kinases - immunology | Hepatitis A Virus Cellular Receptor 2 | T-Box Domain Proteins - genetics | Disease Progression | Antiretroviral Therapy, Highly Active | HIV-1 - immunology | Phenotype | Animals | T-Lymphocytes - cytology | HIV Infections - drug therapy | Programmed Cell Death 1 Receptor | T-Lymphocytes - immunology | HIV Infections - physiopathology | HLA Antigens | Index Medicus
Journal Article