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Immunity, ISSN 1074-7613, 04/2015, Volume 42, Issue 4, pp. 613 - 626
Epigenetic regulation of lineage-specific genes is important for the differentiation and function of T cells. Ten-eleven translocation (Tet) proteins catalyze... 
METHYLATION | INTERLEUKIN-27 | TRANSCRIPTION | DISEASE | POPULATIONS | PATTERNS | GENERATION | DIFFERENTIATION | SPECIFICATION | IMMUNOLOGY | PLASTICITY | Cytosine - analogs & derivatives | 5-Methylcytosine - analogs & derivatives | E1A-Associated p300 Protein - immunology | Humans | E1A-Associated p300 Protein - genetics | T-Box Domain Proteins - immunology | Th1 Cells - immunology | DNA Methylation | Cytosine - metabolism | Proto-Oncogene Proteins - immunology | Th17 Cells - cytology | Cell Differentiation | STAT4 Transcription Factor - immunology | Cytokines - immunology | Cytosine - immunology | DNA-Binding Proteins - immunology | Th17 Cells - enzymology | DNA - immunology | Gene Expression Regulation | Mice, Transgenic | Proto-Oncogene Proteins - genetics | DNA - metabolism | DNA-Binding Proteins - genetics | T-Box Domain Proteins - genetics | Animals | Epigenesis, Genetic - immunology | Th17 Cells - immunology | STAT4 Transcription Factor - genetics | Th1 Cells - enzymology | Mice | Th1 Cells - cytology | Genome | Cytokines - biosynthesis | Proteins | Epigenetic inheritance | Cytokines | Genes | Genomics | DNA | Genetic research | Genomes | Ophthalmology | T cells | Gene expression | Cell differentiation | Transcription factors | Lymphocytes | Rodents | DNA methylation | Epigenetics | Genetic testing | Experiments | Binding sites | Deoxyribonucleic acid--DNA | Index Medicus
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 11/2008, Volume 205, Issue 12, pp. 2763 - 2779
Progressive loss of T cell functionality is a hallmark of chronic infection with human immunodeficiency virus 1 (HIV-1). We have identified a novel population... 
MEDICINE, RESEARCH & EXPERIMENTAL | SKEWED MATURATION | ACTIVATION | MULTIPLE-SCLEROSIS | IMMUNODEFICIENCY-VIRUS-INFECTION | IMPAIRED FUNCTION | CD4(+) | IMMUNOLOGY | CHRONIC VIRAL-INFECTION | DISEASE PROGRESSION | LYMPHOCYTES | ANTIGEN | GATA3 Transcription Factor - genetics | T-Lymphocyte Subsets - immunology | Antigens, CD - immunology | HIV-1 - pathogenicity | T-Lymphocyte Subsets - cytology | GATA3 Transcription Factor - immunology | Humans | STAT5 Transcription Factor - immunology | T-Box Domain Proteins - immunology | Antigens, CD - genetics | Extracellular Signal-Regulated MAP Kinases - genetics | Extracellular Signal-Regulated MAP Kinases - immunology | HIV Infections - immunology | STAT5 Transcription Factor - genetics | Signal Transduction - immunology | HIV Infections - pathology | Apoptosis Regulatory Proteins - genetics | Apoptosis Regulatory Proteins - immunology | Membrane Proteins - genetics | p38 Mitogen-Activated Protein Kinases - genetics | Membrane Proteins - immunology | p38 Mitogen-Activated Protein Kinases - immunology | Hepatitis A Virus Cellular Receptor 2 | T-Box Domain Proteins - genetics | Disease Progression | Antiretroviral Therapy, Highly Active | HIV-1 - immunology | Phenotype | Animals | T-Lymphocytes - cytology | HIV Infections - drug therapy | Programmed Cell Death 1 Receptor | T-Lymphocytes - immunology | HIV Infections - physiopathology | HLA Antigens | Index Medicus
Journal Article
Nature Immunology, ISSN 1529-2908, 2013, Volume 14, Issue 11, pp. 1190 - 1198
Although intergenic long noncoding RNAs (lincRNAs) have been linked to gene regulation in various tissues, little is known about lincRNA transcriptomes in the... 
STEM-CELLS | INTERFERON | INTEGRATIVE ANNOTATION | GENE-EXPRESSION | POPULATIONS | IMMUNOLOGY | GENOME-WIDE IDENTIFICATION | TRANSCRIPTION FACTOR | SEQ | CUTTING EDGE | REVEALS | GATA3 Transcription Factor - genetics | GATA3 Transcription Factor - immunology | STAT4 Transcription Factor - metabolism | STAT6 Transcription Factor - genetics | T-Box Domain Proteins - immunology | Th2 Cells - immunology | Transcriptome - immunology | Genetic Loci | Th1 Cells - immunology | RNA, Long Noncoding - immunology | Th1 Cells - metabolism | Th17 Cells - metabolism | Precursor Cells, T-Lymphoid - metabolism | Precursor Cells, T-Lymphoid - cytology | Th17 Cells - cytology | Cell Differentiation | GATA3 Transcription Factor - metabolism | STAT4 Transcription Factor - immunology | Signal Transduction | Gene Expression Regulation - immunology | Mice, Inbred C57BL | Molecular Sequence Annotation | Th2 Cells - cytology | RNA, Long Noncoding - genetics | STAT6 Transcription Factor - metabolism | STAT6 Transcription Factor - immunology | T-Box Domain Proteins - genetics | Th2 Cells - metabolism | T-Box Domain Proteins - metabolism | Animals | Protein Binding | Th17 Cells - immunology | STAT4 Transcription Factor - genetics | Mice | Th1 Cells - cytology | Precursor Cells, T-Lymphoid - immunology | Cell Movement | Physiological aspects | Genetic aspects | Research | Cell differentiation | Gene expression | T cells | Index Medicus | Cell migration
Journal Article
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 2015, Volume 212, Issue 12, pp. 2041 - 2056
The transcription factor T-bet is critical for cytotoxic T lymphocyte (CTL) differentiation, but it is unclear how it operates in a graded manner in the... 
EFFECTOR | MEDICINE, RESEARCH & EXPERIMENTAL | PROTECTIVE IMMUNITY | STEM-CELLS | SELECTIVE EXPRESSION | MEMORY | GENE | IN-VIVO | SUBSETS | GENERATION | IMMUNOLOGY | CUTTING EDGE | Lymphocytic choriomeningitis virus - immunology | Oligonucleotide Array Sequence Analysis | Homeodomain Proteins - immunology | T-Box Domain Proteins - immunology | Transcriptome - immunology | Lymphocytic Choriomeningitis - immunology | Zinc Finger E-box Binding Homeobox 2 | Host-Pathogen Interactions - immunology | Cell Differentiation - genetics | Flow Cytometry | Repressor Proteins - deficiency | CD8-Positive T-Lymphocytes - metabolism | Lymphocytic choriomeningitis virus - physiology | Receptors, Immunologic - immunology | Lymphocytic Choriomeningitis - genetics | T-Lymphocytes, Cytotoxic - immunology | Lymphocytic Choriomeningitis - virology | Mice, Inbred C57BL | Repressor Proteins - genetics | Mice, Transgenic | Transcriptome - genetics | Protein Binding - immunology | Reverse Transcriptase Polymerase Chain Reaction | T-Box Domain Proteins - genetics | Homeodomain Proteins - genetics | T-Box Domain Proteins - metabolism | Mice, Knockout | Cell Differentiation - immunology | Animals | T-Lymphocytes, Cytotoxic - metabolism | Repressor Proteins - immunology | CD8-Positive T-Lymphocytes - immunology | Receptors, Immunologic - metabolism | Cluster Analysis | Index Medicus
Journal Article
Immunity, ISSN 1074-7613, 09/2012, Volume 37, Issue 3, pp. 511 - 523
Interferon-γ (IFN-γ) promotes a population of T-bet CXCR3 regulatory T (Treg) cells that limit T helper 1 (Th1) cell-mediated pathology. Our studies... 
BET | RESPONSES | TOXOPLASMA-GONDII INFECTION | DENDRITIC CELLS | IFN-GAMMA | IN-VIVO | REGULATORY T-CELLS | IL-27 | IMMUNOLOGY | EXPRESSION | VIRAL-INFECTION | Forkhead Transcription Factors - immunology | Toxoplasma - immunology | T-Lymphocytes, Regulatory - metabolism | Oligonucleotide Array Sequence Analysis | Interleukin-17 - immunology | Male | Gene Expression Profiling | T-Box Domain Proteins - immunology | Interleukin-17 - pharmacology | T-Lymphocytes, Regulatory - immunology | Salmonella Infections, Animal - immunology | STAT1 Transcription Factor - metabolism | Flow Cytometry | Toxoplasmosis, Animal - parasitology | Forkhead Transcription Factors - metabolism | Mice, Inbred CBA | Female | Interferon-gamma - genetics | Receptors, CXCR3 - metabolism | Salmonella Infections, Animal - pathology | Salmonella typhimurium - immunology | Mice, Inbred C57BL | Cells, Cultured | Interleukin-17 - genetics | Mice, Transgenic | Forkhead Transcription Factors - genetics | STAT1 Transcription Factor - genetics | T-Box Domain Proteins - genetics | STAT1 Transcription Factor - immunology | T-Box Domain Proteins - metabolism | Mice, Knockout | Cell Differentiation - immunology | T-Lymphocytes, Regulatory - drug effects | Animals | Cell Differentiation - drug effects | Interferon-gamma - immunology | Receptors, CXCR3 - genetics | Receptors, CXCR3 - immunology | Salmonella Infections, Animal - microbiology | Toxoplasmosis, Animal - immunology | Mice | Interferon-gamma - pharmacology | Toxoplasmosis, Animal - pathology | Index Medicus
Journal Article
Immunity, ISSN 1074-7613, 12/2012, Volume 37, Issue 6, pp. 1061 - 1075
Interleukin-22 (IL-22) is central to host protection against bacterial infections at barrier sites. Both innate lymphoid cells (ILCs) and T cells produce... 
INDUCER-LIKE CELLS | MUCOSAL IMMUNITY | INTERLEUKIN 22 | T(H)17 DIFFERENTIATION | INNATE LYMPHOID-CELLS | INTESTINAL PATHOLOGY | IMMUNOLOGY | CHRONIC VIRAL-INFECTION | CITROBACTER-RODENTIUM | POTENTIAL ROLE | T-CELLS | Enterobacteriaceae Infections - prevention & control | T-Box Domain Proteins - immunology | Interleukins - metabolism | Enterobacteriaceae Infections - immunology | Interleukin-23 - metabolism | Interleukins - physiology | Th17 Cells - metabolism | T-Lymphocytes, Helper-Inducer - immunology | Inflammation Mediators - metabolism | Interleukin-6 - metabolism | Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics | Inflammation Mediators - immunology | Nuclear Receptor Subfamily 1, Group F, Member 3 - immunology | Citrobacter rodentium - immunology | T-Lymphocytes, Helper-Inducer - metabolism | Enterobacteriaceae Infections - mortality | Gene Expression Regulation | Receptors, Aryl Hydrocarbon - genetics | T-Box Domain Proteins - genetics | Interleukin-23 - immunology | Mice, Knockout | Animals | Mucous Membrane - immunology | Interleukin-6 - immunology | Th17 Cells - immunology | Mice | Receptors, Aryl Hydrocarbon - immunology | Mucous Membrane - microbiology | Bacteria | Bacterial infections | Interleukins | T cells | Transforming growth factors | Studies | Inflammatory bowel disease | Transcription factors | Rodents | Cloning | Gene expression | Immune system | Index Medicus
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 2015, Volume 212, Issue 12, pp. 2015 - 2025
Journal Article