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1. Full Text CD4+ T‐cell subsets in transplantation
by Liu, Zhongmin and Fan, Huimin and Jiang, Shuiping
Immunological Reviews, ISSN 0105-2896, 03/2013, Volume 252, Issue 1, pp. 183 - 191
Summary The identification of T‐helper 9 (Th9), Th17, Th22 cells as distinct subsets of CD4+ T cells has extended the Th1/Th2 paradigm in the adaptive... 
regulatory T cells | follicular T‐helper cells | transplantation rejection | Th22 | Th9 | transplantation tolerance | Th1 | Th17 | Th2 | Transplantation rejection | Transplantation tolerance | Regulatory T cells | Follicular T-helper cells | TGF-BETA | HELPER-CELLS | IMMUNOLOGY | ORGAN-TRANSPLANTATION | RENAL-ALLOGRAFT REJECTION | LUNG TRANSPLANTATION | follicular T-helper cells | IN-VIVO | OBLITERATIVE BRONCHIOLITIS | DISPARATE SKIN-GRAFTS | AUTOIMMUNE-DISEASE | TH17 CELLS | Forkhead Transcription Factors - immunology | CD4 Antigens - immunology | Gene Expression | Humans | Th1-Th2 Balance | Organ Transplantation | Th2 Cells - cytology | Th2 Cells - immunology | Forkhead Transcription Factors - genetics | Th1 Cells - immunology | T-Lymphocytes, Regulatory - immunology | Transplantation Tolerance | T-Lymphocytes, Regulatory - cytology | Th17 Cells - immunology | Th17 Cells - cytology | Cell Differentiation | Th1 Cells - cytology | Graft Rejection - immunology | Cytokines - genetics | Graft Rejection - pathology | CD4 Antigens - genetics | Cytokines - immunology | T cells | Cells | Animal models | Reviews | Immunoregulation | Helper cells | Foxp3 protein | Lymphocytes T | Immunological tolerance | Interleukin 17 | CD4 antigen | Graft rejection
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2. Full Text Specific lymphocyte subsets predict response to adoptive cell therapy using expanded autologous tumor-infiltrating lymphocytes in metastatic melanoma patients
by Radvanyi, Laszlo G and Bernatchez, Chantale and Zhang, Minying and Fox, Patricia S and Miller, Priscilla and Chacon, Jessica and Wu, Richard and Lizee, Gregory and Mahoney, Sandy and Alvarado, Gladys and Glass, Michelle and Johnson, Valen E and McMannis, John D and Shpall, Elizabeth and Prieto, Victor and Papadopoulos, Nicholas and Kim, Kevin and Homsi, Jade and Bedikian, Agop and Hwu, Wen-Jen and Patel, Sapna and Ross, Merrick I and Lee, Jeffrey E and Gershenwald, Jeffrey E and Lucci, Anthony and Royal, Richard and Cormier, Janice N and Davies, Michael A and Mansaray, Rahmatu and Fulbright, Orenthial J and Toth, Christopher and Ramachandran, Renjith and Wardell, Seth and Gonzalez, Audrey and Hwu, Patrick
Clinical Cancer Research, ISSN 1078-0432, 12/2012, Volume 18, Issue 24, pp. 6758 - 6770
Purpose: Adoptive cell therapy (ACT) using autologous tumor-infiltrating lymphocytes (TIL) is a promising treatment for metastatic melanoma unresponsive to... 
EFFECTOR | ACTIVATION | INHIBITION | MEMORY | ONCOLOGY | PERSISTENCE | COSTIMULATION | DIFFERENTIATION | EXPRESSION | CD8(+) T-CELLS | TELOMERE LENGTH | Humans | Middle Aged | Interleukin-2 - therapeutic use | Male | Transplantation, Autologous | T-Lymphocytes, Cytotoxic - transplantation | Skin Neoplasms - mortality | Female | Telomere - metabolism | Skin Neoplasms - pathology | Immunotherapy, Adoptive | Skin Neoplasms - immunology | Skin Neoplasms - therapy | Cells, Cultured | Treatment Outcome | Combined Modality Therapy | Remission Induction | Melanoma - secondary | Disease-Free Survival | Melanoma - immunology | Survival Analysis | Melanoma - therapy | Lymphocyte Subsets - transplantation | Melanoma - mortality | Tumor Burden - immunology | melanoma | tumor-infiltrating lymphocytes | adoptive cell therapy
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3. Full Text Human effector CD8+ T cells derived from naive rather than memory subsets possess superior traits for adoptive immunotherapy
by Hinrichs, Christian S and Borman, Zachary A and Gattinoni, Luca and Yu, Zhiya and Burns, William R and Huang, Jianping and Klebanoff, Christopher A and Johnson, Laura A and Kerkar, Sid P and Yang, Shicheng and Muranski, Pawel and Palmer, Douglas C and Scott, Christopher D and Morgan, Richard A and Robbins, Paul F and Rosenberg, Steven A and Restifo, Nicholas P
Blood, ISSN 0006-4971, 01/2011, Volume 117, Issue 3, pp. 808 - 814
Cluster of differentiation (CD)8(+) T cells exist as naive, central memory, and effector memory subsets, and any of these populations can be genetically... 
THERAPY | ENGINEERED LYMPHOCYTES | CORD BLOOD | TUMOR-REGRESSION | CHIMERIC ANTIGEN RECEPTOR | ANTITUMOR IMMUNITY | DIFFERENTIATION | HEMATOLOGY | TRANSCRIPTION FACTOR | CANCER | TELOMERE LENGTH | T-Lymphocyte Subsets - immunology | Gene Expression | Immunotherapy, Adoptive - methods | Cell Proliferation | Transduction, Genetic | Cytokines - metabolism | CD8-Positive T-Lymphocytes - transplantation | Cell Survival | Humans | Cells, Cultured | T-Lymphocyte Subsets - transplantation | Genetic Vectors - genetics | Cell Differentiation - immunology | Flow Cytometry | Retroviridae - genetics | T-Lymphocyte Subsets - metabolism | Tumor Necrosis Factor Receptor Superfamily, Member 7 - metabolism | CD8-Positive T-Lymphocytes - metabolism | Cell Line, Tumor | CD8-Positive T-Lymphocytes - immunology | Immunologic Memory - immunology | Telomere - genetics | Gene Therapy
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4. Full Text CD19 CAR-T cells of defined CD4+:CD8+ composition in adult B cell ALL patients
by Turtle, Cameron J and Hanafi, Laïla-Aïcha and Berger, Carolina and Gooley, Theodore A and Cherian, Sindhu and Hudecek, Michael and Sommermeyer, Daniel and Melville, Katherine and Pender, Barbara and Budiarto, Tanya M and Robinson, Emily and Steevens, Natalia N and Chaney, Colette and Soma, Lorinda and Chen, Xueyan and Yeung, Cecilia and Wood, Brent and Li, Daniel and Cao, Jianhong and Heimfeld, Shelly and Jensen, Michael C and Riddell, Stanley R and Maloney, David G
Journal of Clinical Investigation, ISSN 0021-9738, 06/2016, Volume 126, Issue 6, pp. 2123 - 2138
BACKGROUND. T cells that have been modified to express a CD19-specific chimeric antigen receptor (CAR) have antitumor activity in B cell malignancies; however,... 
SUSTAINED REMISSIONS | MEDICINE, RESEARCH & EXPERIMENTAL | MALIGNANCY | MEMORY | PERSISTENCE | SUBSET | LYMPHOCYTES | Immunotherapy, Adoptive - adverse effects | T-Lymphocyte Subsets - immunology | Immunotherapy, Adoptive - methods | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - pathology | Humans | Middle Aged | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - therapy | T-Lymphocyte Subsets - transplantation | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - immunology | Young Adult | Disease-Free Survival | CD4-CD8 Ratio | Adult | Receptors, Antigen, T-Cell - immunology | Aged | Lymphocyte Depletion - methods | Tumor Burden - immunology | Index Medicus | Abridged Index Medicus
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5. Full Text Role of memory T cell subsets for adoptive immunotherapy
by Busch, Dirk H and Fräßle, Simon P and Sommermeyer, Daniel and Buchholz, Veit R and Riddell, Stanley R
Seminars in Immunology, ISSN 1044-5323, 2016, Volume 28, Issue 1, pp. 28 - 34
Highlights • Differentiation status of transferred T cells is a crucial parameter for effective adoptive immunotherapy. • A distinct subset of weakly... 
Allergy and Immunology | Clinical cell processing and purification | T cell engineering | Memory stem cells | T cell subsets | Adoptive T cell therapy | STEM-CELLS | VIRUS | IMMUNOLOGY | EFFECTOR | PROTECTIVE IMMUNITY | NONLYMPHOID TISSUE | FLOW-CYTOMETRY | DIFFERENTIATION | EXPRESSION | FATES | LYMPHOCYTES | Adult Stem Cells - physiology | T-Lymphocyte Subsets - immunology | Immunotherapy, Adoptive - methods | Infection - therapy | Cell Separation | Cell Survival | Infection - immunology | Humans | T-Lymphocyte Subsets - transplantation | T-Lymphocytes - transplantation | Neoplasms - therapy | Animals | Neoplasms - immunology | Immunologic Memory | T-Lymphocytes - immunology | Cell Differentiation | Microbiology | T cells | Immunotherapy | Stem cells | Oncology, Experimental | Genetically modified organisms | Transplantation | Genetic engineering | Research | Cell differentiation | Cancer
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6. Full Text Follicular CXCR5-expressing CD8+ T cells curtail chronic viral infection
by He, Ran and Hou, Shiyue and Liu, Cheng and Zhang, Anli and Bai, Qiang and Han, Miao and Yang, Yu and Wei, Gang and Shen, Ting and Yang, Xinxin and Xu, Lifan and Chen, Xiangyu and Hao, Yaxing and Wang, Pengcheng and Zhu, Chuhong and Ou, Juanjuan and Liang, Houjie and Ni, Ting and Zhang, Xiaoyan and Zhou, Xinyuan and Deng, Kai and Chen, Yaokai and Luo, Yadong and Xu, Jianqing and Qi, Hai and Wu, Yuzhang and Ye, Lilin
Nature, ISSN 0028-0836, 2016, Volume 537, Issue 7620, pp. 412 - 416
During chronic viral infection, virus-specific CD8(+) T cells become exhausted, exhibit poor effector function and lose memory potential(1-4). However,... 
HIV-1 | VIRUS | REPLICATION | FOLLICLES | MULTIDISCIPLINARY SCIENCES | IN-VIVO | TRANSCRIPTION | DIFFERENTIATION | BLOCKADE | EXHAUSTION | SELF-TOLERANCE | Lymphocytic choriomeningitis virus - immunology | T-Lymphocyte Subsets - immunology | CD8-Positive T-Lymphocytes - cytology | T-Lymphocyte Subsets - cytology | CD8-Positive T-Lymphocytes - transplantation | Germinal Center - immunology | Humans | Male | Adoptive Transfer | Lymphocytic Choriomeningitis - immunology | HIV Infections - immunology | Basic Helix-Loop-Helix Transcription Factors - metabolism | CD8-Positive T-Lymphocytes - metabolism | Female | Cell Differentiation | Germinal Center - cytology | Lymphocytic Choriomeningitis - virology | Receptors, CXCR5 - metabolism | Signal Transduction | HIV Infections - virology | Receptors, CXCR5 - deficiency | Virus Replication - immunology | T-Lymphocyte Subsets - transplantation | Inhibitor of Differentiation Protein 2 - metabolism | Viral Load - immunology | Lymphocytic choriomeningitis virus - growth & development | Animals | B-Lymphocytes - immunology | T-Lymphocyte Subsets - metabolism | Mice | CD8-Positive T-Lymphocytes - immunology | Chronic Disease | Virus diseases | Physiological aspects | T cells | Health aspects | Membrane proteins
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7. Full Text IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors
by Cieri, Nicoletta and Camisa, Barbara and Cocchiarella, Fabienne and Forcato, Mattia and Oliveira, Giacomo and Provasi, Elena and Bondanza, Attilio and Bordignon, Claudio and Peccatori, Jacopo and Ciceri, Fabio and Lupo-Stanghellini, Maria Teresa and Mavilio, Fulvio and Mondino, Anna and Bicciato, Silvio and Recchia, Alessandra and Bonini, Chiara
Blood, ISSN 0006-4971, 01/2013, Volume 121, Issue 4, pp. 573 - 584
Long-living memory stem T cells (T-SCM) with the ability to self-renew and the plasticity to differentiate into potent effectors could be valuable weapons in... 
EFFECTOR | THERAPY | PLASMA-LEVELS | ACUTE GVHD | RECEPTOR EXPRESSION | SUBSETS | SUPERIOR ANTITUMOR IMMUNITY | DIFFERENTIATION | HEMATOLOGY | VERSUS-HOST-DISEASE | LYMPHOCYTES | Cell Proliferation | Leukocyte Common Antigens - metabolism | T-Lymphocyte Subsets - cytology | Humans | Gene Expression Profiling | fas Receptor - metabolism | L-Selectin - metabolism | Interleukin-7 - genetics | Precursor Cells, T-Lymphoid - metabolism | Female | Precursor Cells, T-Lymphoid - cytology | Cell Differentiation | Interleukin-7 - metabolism | Cell Survival | Immunophenotyping | Mice, SCID | T-Lymphocyte Subsets - transplantation | Animals | Interleukin-15 - genetics | Precursor Cells, T-Lymphoid - transplantation | T-Lymphocyte Subsets - metabolism | Interleukin-15 - metabolism | Immunologic Memory | Mice, Inbred NOD | Mice | Cluster Analysis
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8. Full Text Th1, Th17, and Th9 Effector Cells Induce Experimental Autoimmune Encephalomyelitis with Different Pathological Phenotypes
by Jager, Anneli and Dardalhon, Valerie and Sobel, Raymond A and Bettelli, Estelle and Kuchroo, Vijay K
The Journal of Immunology, ISSN 0022-1767, 12/2009, Volume 183, Issue 11, pp. 7169 - 7177
Experimental autoimmune encephalomyelitis (EAE) is a model of human multiple sclerosis induced by autoreactive Th cells that mediate tissue inflammation and... 
TGF-BETA | T(H)17 CELLS | MULTIPLE-SCLEROSIS | INFLAMMATION | EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS | REGULATORY T-CELLS | EAE | CENTRAL-NERVOUS-SYSTEM | MICE | IMMUNOLOGY | EXPRESSION | T-Lymphocyte Subsets - immunology | Encephalomyelitis, Autoimmune, Experimental - pathology | Enzyme-Linked Immunosorbent Assay | T-Lymphocyte Subsets - cytology | Mice, Inbred C57BL | Interleukin-17 - immunology | Encephalomyelitis, Autoimmune, Experimental - immunology | Myelin-Oligodendrocyte Glycoprotein | Th2 Cells - cytology | Th2 Cells - immunology | Adoptive Transfer | T-Lymphocyte Subsets - transplantation | Th1 Cells - immunology | Th1 Cells - transplantation | Cell Differentiation - immunology | Myelin-Associated Glycoprotein - immunology | Phenotype | Animals | Myelin Proteins | Mice | Th1 Cells - cytology | Interleukin-9 - immunology | Th2 Cells - transplantation
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9. Full Text Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning
by Pegram, Hollie J and Lee, James C and Hayman, Erik G and Imperato, Gavin H and Tedder, Thomas F and Sadelain, Michel and Brentjens, Renier J
Blood, ISSN 0006-4971, 05/2012, Volume 119, Issue 18, pp. 4133 - 4141
Adoptive cell therapy with tumor-targeted T cells is a promising approach to cancer therapy. Enhanced clinical outcome using this approach requires... 
RECOMBINANT HUMAN INTERLEUKIN-12 | B-CELL | PERSISTENCE | NEUROBLASTOMA | CHIMERIC ANTIGEN RECEPTOR | ANTITUMOR-ACTIVITY | HEMATOLOGY | PHASE-I | CANCER | ADOPTIVE IMMUNOTHERAPY | ESTABLISHED TUMORS | T-Lymphocyte Subsets - immunology | Thymus Neoplasms - therapy | B7-1 Antigen - genetics | Interleukin-12 - genetics | Humans | Antigens, CD19 - genetics | Cyclophosphamide - therapeutic use | T-Lymphocytes, Regulatory - immunology | Interleukin-12 - blood | Thymus Neoplasms - immunology | Thymoma - therapy | Thymoma - drug therapy | Interleukin-12 - secretion | Antigens, CD19 - immunology | Immunotherapy, Adoptive | Thymoma - immunology | Mice, Inbred C57BL | Mice, Transgenic | Combined Modality Therapy | Thymus Neoplasms - drug therapy | T-Lymphocyte Subsets - transplantation | Transplantation, Isogeneic | Mice, Knockout | Antineoplastic Agents, Alkylating - therapeutic use | B-Lymphocytes - drug effects | T-Lymphocytes, Regulatory - drug effects | Animals | Recombinant Fusion Proteins - genetics | T-Cell Antigen Receptor Specificity | Mice | T-Lymphocyte Subsets - secretion | Transplantation Conditioning | Interferon-gamma - blood | Cytotoxicity, Immunologic | Gene Therapy | Immunobiology
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10. Full Text Novel agents may positively impact chemotherapy and transplantation in subsets of diffuse large B-cell lymphoma
by Dahi, Parastoo B and Moskowitz, Craig H and Giralt, Sergio A and Lazarus, Hillard M
Expert Review of Hematology, ISSN 1747-4086, 06/2019, Volume 12, Issue 6, pp. 407 - 418
Introduction: Molecular and biologic heterogeneity in diffuse large B-cell lymphoma (DLBCL) has resulted in a broad range of clinical outcomes. While standard... 
checkpoint blockade | CAR T cell | Autologous transplant | transplant | allogeneic transplant | diffuse large B-cell lymphoma | novel agents | large cell lymphoma | lymphoma immunotherapy | RITUXIMAB PLUS CYCLOPHOSPHAMIDE | BONE-MARROW-TRANSPLANTATION | DETUDES DES LYMPHOMES | PHASE-II | CYTOTOXIC T-LYMPHOCYTES | CHOP-LIKE CHEMOTHERAPY | DOUBLE-HIT LYMPHOMA | NON-HODGKINS-LYMPHOMA | HIGH-DOSE CHEMOTHERAPY | HEMATOLOGY | ELDERLY-PATIENTS
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11. Full Text TH17 Cells Mediate Steroid-Resistant Airway Inflammation and Airway Hyperresponsiveness in Mice
by McKinley, Laura and Alcorn, John F and Peterson, Alanna and DuPont, Rachel B and Kapadia, Shernaaz and Logar, Alison and Henry, Adam and Irvin, Charles G and Piganelli, Jon D and Ray, Anuradha and Kolls, Jay K
The Journal of Immunology, ISSN 0022-1767, 09/2008, Volume 181, Issue 6, pp. 4089 - 4097
Steroid-resistant asthma comprises an important source of morbidity in patient populations. T(H)17 cells represent a distinct population of CD4(+) Th cells... 
T-Lymphocyte Subsets - immunology | Bronchial Hyperreactivity - immunology | Male | Receptors, Interleukin-17 - genetics | Th2 Cells - immunology | Receptors, Interleukin-17 - deficiency | Dexamethasone - pharmacology | Receptors, Interleukin-17 - physiology | Clone Cells | Disease Models, Animal | Lung - pathology | Cells, Cultured | Mice, Transgenic | Bronchial Hyperreactivity - prevention & control | Mice, SCID | T-Lymphocyte Subsets - transplantation | Th2 Cells - metabolism | Mice, Knockout | Interleukin-17 - metabolism | Bronchial Hyperreactivity - pathology | Animals | T-Lymphocyte Subsets - metabolism | Drug Resistance - immunology | Chemokines - metabolism | Mice | Mice, Inbred BALB C | Chemotaxis, Leukocyte - immunology | Th2 Cells - transplantation | Lung - immunology
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