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1. Full Text Transcriptional reprogramming of mature CD4 + helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes
by Mucida, Daniel and Husain, Mohammad Mushtaq and Muroi, Sawako and Van Wijk, Femke and Shinnakasu, Ryo and Naoe, Yoshinori and Reis, Bernardo Sgarbi and Huang, Yujun and Lambolez, Florence and Docherty, Michael and Attinger, Antoine and Shui, Jr-Wen and Kim, Gisen and Lena, Christopher J and Sakaguchi, Shinya and Miyamoto, Chizuko and Wang, Peng and Atarashi, Koji and Park, Yunji and Nakayama, Toshinori and Honda, Kenya and Ellmeier, Wilfried and Kronenberg, Mitchell and Taniuchi, Ichiro and Cheroutre, Hilde
Nature Immunology, ISSN 1529-2908, 2013, Volume 14, Issue 3, pp. 281 - 289
TCR alpha beta thymocytes differentiate into either CD8 alpha beta(+) cytotoxic T lymphocytes or CD4(+) helper T cells. This functional dichotomy is controlled... 
LINEAGE COMMITMENT | RESPONSES | INTESTINAL INTRAEPITHELIAL LYMPHOCYTES | CD8 | INTERLEUKIN-15 | DIFFERENTIATION | IMMUNOLOGY | IDENTIFICATION | THYMOCYTES | EXPRESSION | CELIAC-DISEASE | T-Lymphocytes, Cytotoxic - immunology | Citrobacter rodentium - immunology | T-Lymphocytes, Helper-Inducer - metabolism | Thymocytes - metabolism | Mice, Inbred C57BL | Transcription Factors - genetics | Homeodomain Proteins - genetics | Mice, Knockout | Transcription Factors - metabolism | Cell Lineage | Interleukin-7 - genetics | Animals | Histocompatibility Antigens Class II - immunology | T-Lymphocytes, Cytotoxic - metabolism | T-Lymphocytes, Helper-Inducer - immunology | T-Lymphocytes, Helper-Inducer - cytology | Cell Differentiation | Mice | T-Lymphocytes, Cytotoxic - cytology
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2. Full Text Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses
by Nizzoli, Giulia and Nizzoli, Giulia and Krietsch, Jana and Krietsch, Jana and Weick, Anja and Weick, Anja and Steinfelder, Svenja and Steinfelder, Svenja and Facciotti, Federica and Facciotti, Federica and Gruarin, Paola and Gruarin, Paola and Bianco, Annalisa and Bianco, Annalisa and Steckel, Bodo and Steckel, Bodo and Moro, Monica and Moro, Monica and Crosti, Mariacristina and Crosti, Mariacristina and Romagnani, Chiara and Romagnani, Chiara and Stölzel, Katharina and Stölzel, Katharina and Torretta, Sara and Torretta, Sara and Pignataro, Lorenzo and Pignataro, Lorenzo and Scheibenbogen, Carmen and Scheibenbogen, Carmen and Neddermann, Petra and Neddermann, Petra and De Francesco, Raffaele and De Francesco, Raffaele and Abrignani, Sergio and Abrignani, Sergio and Geginat, Jens and Geginat, Jens
Blood, ISSN 0006-4971, 08/2013, Volume 122, Issue 6, pp. 932 - 942
Dendritic cells (DC) have the unique capacities to induce primary T-cell responses. In mice, CD8 alpha+DC are specialized to cross-prime CD8(+) T cells and... 
CD8(+) | ACTIVATION | HELPER | IN-VIVO | MOUSE | PRESENTATION CAPACITY | SUBSETS | ANTIGEN CROSS-PRESENTATION | HEMATOLOGY | INFLAMED LYMPH-NODES | BLOOD | CD8-Positive T-Lymphocytes - cytology | Interferon-alpha - metabolism | Cell Proliferation | Cytokines - metabolism | Cell Separation | Lymphocyte Activation | CD4-Positive T-Lymphocytes - cytology | Humans | Glycoproteins - metabolism | Interferon-gamma - metabolism | Dendritic Cells - secretion | Phenotype | Animals | Antigen Presentation | Antigens, CD1 - metabolism | Immunologic Memory | Dendritic Cells - cytology | Mice | Toll-Like Receptors - metabolism | Interleukin-12 - secretion | T-Lymphocytes, Cytotoxic - cytology
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3. Full Text A Th17‐like developmental process leads to CD8+ Tc17 cells with reduced cytotoxic activity
by Huber, Magdalena and Heink, Sylvia and Grothe, Henrike and Guralnik, Anna and Reinhard, Katharina and Elflein, Karin and Hünig, Thomas and Mittrücker, Hans‐Willi and Brüstle, Anne and Kamradt, Thomas and Lohoff, Michael
European Journal of Immunology, ISSN 0014-2980, 07/2009, Volume 39, Issue 7, pp. 1716 - 1725
Activation of naive CD8+ T cells with antigen in the absence of skewing cytokines triggers their differentiation into effector CTL, which induces death of... 
EAE | Tc17 | CTL | STAT3 | RORγt | TGF-BETA | INTERFERON-REGULATORY FACTOR-4 | ROR gamma t | IMMUNOLOGY | IL-21 | EFFECTOR | ROR-GAMMA | EOMESODERMIN | GENERATION | DIFFERENTIATION | T-H-17 CELLS | T-CELLS | CD8-Positive T-Lymphocytes - cytology | Encephalomyelitis, Autoimmune, Experimental - metabolism | Gene Expression - drug effects | Granzymes - metabolism | Encephalomyelitis, Autoimmune, Experimental - immunology | Immunoblotting | Green Fluorescent Proteins - genetics | Interferon-gamma - metabolism | Receptors, Retinoic Acid - genetics | Cell Differentiation - genetics | Flow Cytometry | Receptors, Thyroid Hormone - genetics | T-Lymphocytes, Helper-Inducer - immunology | T-Lymphocytes, Helper-Inducer - cytology | CD8-Positive T-Lymphocytes - metabolism | Encephalomyelitis, Autoimmune, Experimental - genetics | Interleukins - pharmacology | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Nuclear Receptor Subfamily 1, Group F, Member 3 | T-Lymphocytes, Cytotoxic - immunology | Green Fluorescent Proteins - metabolism | T-Lymphocytes, Helper-Inducer - metabolism | Mice, Inbred C57BL | Receptors, Retinoic Acid - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Receptors, Thyroid Hormone - metabolism | Cell Differentiation - immunology | Interleukin-17 - metabolism | Transforming Growth Factor beta - pharmacology | Animals | Interleukin-6 - pharmacology | T-Lymphocytes, Cytotoxic - metabolism | Cell Differentiation - drug effects | Cell Line, Tumor | Mice | CD8-Positive T-Lymphocytes - immunology | Cytotoxicity, Immunologic - immunology | T-Lymphocytes, Cytotoxic - cytology
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4. Full Text Mesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not activated cytotoxic T lymphocytes or natural killer cells
by Rasmusson, Ida and Ringdén, Olle and Sundberg, Berit and Le Blanc, Katarina
Transplantation, ISSN 0041-1337, 10/2003, Volume 76, Issue 8, pp. 1208 - 1213
Background. Mesenchymal stem cells (MSCs) can reduce the incidence of graft-versus-host disease because of their ability to inhibit T-lymphocyte proliferation.... 
ALLOREACTIVITY | SURGERY | PROLIFERATION | IMMUNOLOGY | TRANSPLANTATION | HEMATOPOIETIC TRANSPLANTS | RECOVERY | IN-VITRO | THERAPY | BONE-MARROW TRANSPLANTATION | GRAFT-VERSUS-LEUKEMIA | HOST-DISEASE | STROMAL CELLS | Cell Division - physiology | Killer Cells, Natural - cytology | Time Factors | Lymphocyte Activation | Humans | Cells, Cultured | Stem Cells - physiology | Mesoderm - cytology | T-Lymphocytes, Cytotoxic - cytology
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5. Full Text NLRC5 Deficiency Selectively Impairs MHC Class I-Dependent Lymphocyte Killing by Cytotoxic T Cells
by Staehli, F and Ludigs, K and Heinz, LX and Seguin-Estevez, Q and Ferrero, I and Braun, M and Schroder, K and Rebsamen, M and Tardivel, A and Mattmann, C and MacDonald, HR and Romero, P and Reith, W and Guarda, G and Tschopp, J
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 04/2012, Volume 188, Issue 8, pp. 3820 - 3828
Nucleotide-binding oligomerization domain-like receptors (NLRs) are intracellular proteins involved in innate-driven inflammatory responses. The function of... 
ANTIVIRAL RESPONSES | TARGETED DISRUPTION | ACTIVATION | CIITA | IMMUNE-RESPONSES | INFLAMMASOME | INNATE | FAMILY-MEMBER NLRC5 | ANTIGEN PRESENTATION | IMMUNOLOGY | NF-KAPPA-B | Cell Nucleus - immunology | Bone Marrow - immunology | Cell Proliferation | Antigen-Presenting Cells - cytology | Humans | NF-kappa B - immunology | Intracellular Signaling Peptides and Proteins - immunology | Killer Cells, Natural - immunology | Cell Differentiation | Intracellular Signaling Peptides and Proteins - genetics | Macrophages - immunology | Adaptive Immunity | T-Lymphocytes, Cytotoxic - immunology | Gene Expression Regulation | Macrophages - cytology | Immunity, Innate | Antigen-Presenting Cells - immunology | Mice, Knockout | Killer Cells, Natural - cytology | Animals | Cell Nucleus - genetics | NF-kappa B - genetics | Cell Line, Tumor | Genes, MHC Class I | Mice | T-Lymphocytes, Cytotoxic - cytology
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6. Full Text The transcription factor Runx3 guards cytotoxic CD8 + effector T cells against deviation towards follicular helper T cell lineage
by Shan, Qiang and Zeng, Zhouhao and Xing, Shaojun and Li, Fengyin and Hartwig, Stacey M and Gullicksrud, Jodi A and Kurup, Samarchith P and Van Braeckel-Budimir, Natalija and Su, Yao and Martin, Matthew D and Varga, Steven M and Taniuchi, Ichiro and Harty, John T and Peng, Weiqun and Badovinac, Vladimir P and Xue, Hai-Hui
Nature Immunology, ISSN 1529-2908, 07/2017, Volume 18, Issue 8, pp. 931 - 939
Activated CD8(+) T cells differentiate into cytotoxic effector (T-EFF) cells that eliminate target cells. How T-EFF cell identity is established and maintained... 
HETEROGENEITY | HOMEOSTASIS | MEMORY B-CELLS | TCF-1 | REPRESSION | RNA-SEQ | UPSTREAM | GENE-EXPRESSION | DIFFERENTIATION | IMMUNOLOGY | VIRAL-INFECTION | Immunohistochemistry | Up-Regulation | Enzyme-Linked Immunosorbent Assay | Hepatocyte Nuclear Factor 1-alpha - genetics | Receptors, CXCR5 - genetics | Epigenesis, Genetic | Gene Expression Regulation | Lymphopoiesis - genetics | Reverse Transcriptase Polymerase Chain Reaction | Proto-Oncogene Proteins c-bcl-6 - genetics | Cell Lineage | Animals | Sequence Analysis, RNA | T-Lymphocytes, Helper-Inducer - cytology | Core Binding Factor Alpha 3 Subunit - genetics | Mice | T-Lymphocytes, Cytotoxic - cytology | Transcription factors | Genetic aspects | T cells | Health aspects | CD8 antigen | Genes | Guards | Effector cells | Cytotoxicity | Cell lineage | Lymphocytes T | Ablation | CXCR5 protein | Lymphocytes | Deviation | Runx3 protein | Bcl-6 protein
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7. Full Text Cytotoxic T Cells Use Mechanical Force to Potentiate Target Cell Killing
by Basu, Roshni and Whitlock, Benjamin M and Husson, Julien and Le Floc’h, Audrey and Jin, Weiyang and Oyler-Yaniv, Alon and Dotiwala, Farokh and Giannone, Gregory and Hivroz, Claire and Biais, Nicolas and Lieberman, Judy and Kam, Lance C and Huse, Morgan
Cell, ISSN 0092-8674, 03/2016, Volume 165, Issue 1, pp. 100 - 110
The immunological synapse formed between a cytotoxic T lymphocyte (CTL) and an infected or transformed target cell is a physically active structure capable of... 
CENTROSOME POLARIZATION | ACTIVATION | ACTIN POLYMERIZATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MEMBRANE TENSION | IMMUNOLOGICAL SYNAPSE | PLASMA-MEMBRANE | GRANULE SECRETION | RETROGRADE FLOW | MYOSIN-II | MECHANOTRANSDUCTION | CELL BIOLOGY | T-Lymphocytes, Cytotoxic - immunology | Immunological Synapses | Biomechanical Phenomena | Animals | Cell Degranulation | Cell Line, Tumor | Mice | Perforin - metabolism | Phosphatidylinositol 3-Kinases - metabolism | T-Lymphocytes, Cytotoxic - cytology | T-Lymphocytes, Cytotoxic - physiology | Medical colleges | T cells | Molecular biology | Proteases | Biomedical engineering | Mechanics | Mechanics of the fluids | Physics
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8. Full Text Positive feedback between PGE2 and COX2 redirects the differentiation of human dendritic cells toward stable myeloid-derived suppressor cells
by Obermajer, Nataša and Muthuswamy, Ravikumar and Lesnock, Jamie and Edwards, Robert P and Kalinski, Pawel
Blood, ISSN 0006-4971, 11/2011, Volume 118, Issue 20, pp. 5498 - 5505
Dendritic cells (DCs) and myeloid-derived suppressor cells (MDSCs) show opposing roles in the immune system. In the present study, we report that the... 
Myeloid Cells - cytology | CD8-Positive T-Lymphocytes - cytology | Immunotherapy - methods | Antigens, CD34 - metabolism | Receptors, Prostaglandin E, EP2 Subtype - metabolism | Dendritic Cells - immunology | Humans | Antigens, CD - metabolism | Lipopolysaccharide Receptors - metabolism | Myeloid Cells - immunology | Ascites - immunology | Female | Sialic Acid Binding Ig-like Lectin 3 | Dendritic Cells - metabolism | Receptors, Prostaglandin E, EP4 Subtype - metabolism | T-Lymphocytes, Cytotoxic - immunology | Dinoprostone - metabolism | Cell Differentiation - immunology | Antigens, Differentiation, Myelomonocytic - metabolism | Cyclooxygenase 2 - metabolism | Myeloid Cells - metabolism | Ovarian Neoplasms - therapy | Dendritic Cells - cytology | Feedback, Physiological - physiology | CD8-Positive T-Lymphocytes - immunology | T-Lymphocytes, Cytotoxic - cytology | Ovarian Neoplasms - immunology | Immunobiology
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9. Full Text IL-21-mediated Foxp3 suppression leads to enhanced generation of antigen-specific CD8+ cytotoxic T lymphocytes
by Li, Yongqing and Yee, Cassian
Blood, ISSN 0006-4971, 01/2008, Volume 111, Issue 1, pp. 229 - 235
Efforts to reproducibly isolate tumor antigen-specific T cells from patients would be facilitated by removing immunoregulatory barriers. Using a human model... 
RECRUITMENT | MELANOMA | AUTOIMMUNITY | TOLERANCE | RECEPTOR | CELL THERAPY | HEMATOLOGY | CANCER | TUMOR-IMMUNITY | IL-21 | CUTTING EDGE | Forkhead Transcription Factors - immunology | CD8-Positive T-Lymphocytes - cytology | T-Lymphocytes, Regulatory - metabolism | Humans | Adoptive Transfer | Interleukins - metabolism | CD28 Antigens - metabolism | Flow Cytometry | Interleukin-2 Receptor alpha Subunit - metabolism | Receptors, CCR7 - metabolism | T-Lymphocytes, Cytotoxic - metabolism | Cell Division - immunology | Forkhead Transcription Factors - metabolism | Interleukins - immunology | T-Lymphocytes, Regulatory - cytology | CD8-Positive T-Lymphocytes - metabolism | Immunologic Memory | In Vitro Techniques | T-Lymphocytes, Cytotoxic - cytology | Immunobiology
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10. Full Text Classification of human natural killer cells based on migration behavior and cytotoxic response
by Vanherberghen, Bruno and Olofsson, Per E and Forslund, Elin and Sternberg-Simon, Michal and Khorshidi, Mohammad Ali and Pacouret, Simon and Guldevall, Karolin and Enqvist, Monika and Malmberg, Karl-Johan and Mehr, Ramit and Önfelt, Björn and Science for Life Laboratory, SciLifeLab and Skolan för teknikvetenskap (SCI) and Centra and Tillämpad fysik and KTH and Cellens fysik
Blood, ISSN 0006-4971, 02/2013, Volume 121, Issue 8, pp. 1326 - 1334
Despite intense scrutiny of the molecular interactions between natural killer (NK) and target cells, few studies have been devoted to dissection of the basic... 
DYNAMICS | COMPLEMENT | HEMATOLOGY | DISTINCT | T-LYMPHOCYTE | T-Lymphocytes, Cytotoxic - immunology | Cell Communication - immunology | Humans | Immunophenotyping | Cell Degranulation - immunology | Time-Lapse Imaging | Killer Cells, Natural - classification | Necrosis - immunology | Cell Movement - immunology | Microchip Analytical Procedures | Killer Cells, Natural - cytology | Lymphocyte Activation - immunology | Apoptosis - immunology | Models, Biological | HEK293 Cells | Killer Cells, Natural - immunology | T-Lymphocytes, Cytotoxic - classification | T-Lymphocytes, Cytotoxic - cytology | Medical and Health Sciences | Hematology | Cell Degranulation | T-Lymphocytes | Medicin och hälsovetenskap | Lymphocyte Activation | Cell Communication | Biological | Klinisk medicin | Natural | Cytotoxic | Necrosis | Clinical Medicine | Hematologi | Killer Cells | Models | Apoptosis | Cell Movement
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11. Full Text Regeneration of Human Tumor Antigen-Specific T Cells from iPSCs Derived from Mature CD8+ T Cells
by Vizcardo, Raul and Masuda, Kyoko and Yamada, Daisuke and Ikawa, Tomokatsu and Shimizu, Kanako and Fujii, Shin-ichiro and Koseki, Haruhiko and Kawamoto, Hiroshi
Cell Stem Cell, ISSN 1934-5909, 01/2013, Volume 12, Issue 1, pp. 31 - 36
Antigen-specific T cells represent a potential therapeutic avenue for a variety of conditions, but current approaches for generating such cells for therapeutic... 
PLURIPOTENT STEM-CELLS | VITRO | PROGENITORS | DEFINED FACTORS | GENERATION | DIFFERENTIATION | INDUCTION | GENOME | CELL & TISSUE ENGINEERING | CELL BIOLOGY | CD8-Positive T-Lymphocytes - cytology | T-Lymphocytes, Cytotoxic - metabolism | MART-1 Antigen - metabolism | Humans | Cells, Cultured | CD8-Positive T-Lymphocytes - metabolism | Induced Pluripotent Stem Cells - cytology | Cell Culture Techniques - methods | T-Lymphocytes, Cytotoxic - cytology | Induced Pluripotent Stem Cells - metabolism
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12. Full Text Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy
by Shalapour, Shabnam and Font-Burgada, Joan and Di Caro, Giuseppe and Zhong, Zhenyu and Sanchez-Lopez, Elsa and Dhar, Debanjan and Willimsky, Gerald and Ammirante, Massimo and Strasner, Amy and Hansel, Donna E and Jamieson, Christina and Kane, Christopher J and Klatte, Tobias and Birner, Peter and Kenner, Lukas and Karin, Michael
Nature, ISSN 0028-0836, 05/2015, Volume 521, Issue 7550, pp. 94 - 98
Cancer-associated genetic alterations induce expression of tumour antigens that can activate CD8(+) cytotoxic T cells (CTLs), but the microenvironment of... 
IMMUNITY | METASTASIS | THERAPY | TRANSGENIC MOUSE | MULTIDISCIPLINARY SCIENCES | MICE | INFILTRATING B-CELLS | RESISTANT PROSTATE-CANCER | GENE-EXPRESSION ANALYSIS | TARGETED DELETION | PROGRESSION | Humans | Organoplatinum Compounds - immunology | Male | Adoptive Transfer | Organoplatinum Compounds - pharmacology | Prostatic Neoplasms - immunology | Plasma Cells - drug effects | T-Lymphocytes, Cytotoxic - drug effects | Organoplatinum Compounds - administration & dosage | I-kappa B Kinase - metabolism | Neoplastic Stem Cells - pathology | Antineoplastic Agents - pharmacology | Prostatic Neoplasms - drug therapy | T-Lymphocytes, Cytotoxic - immunology | Transforming Growth Factor beta - immunology | Prostatic Neoplasms - pathology | Antibodies, Neoplasm - immunology | Signal Transduction | Antineoplastic Agents - immunology | Mice, Inbred C57BL | Cells, Cultured | B7-H1 Antigen - metabolism | Animals | Receptors, Transforming Growth Factor beta - metabolism | Lymphocyte Activation - drug effects | Chemokine CXCL13 - metabolism | Immunoglobulin A - immunology | Mice | Interleukin-10 - immunology | Organoplatinum Compounds - therapeutic use | T-Lymphocytes, Cytotoxic - cytology | Plasma Cells - cytology | Plasma Cells - immunology | Chemotherapy | Immune response | Plasma cells | T cells | Health aspects | Identification and classification | Methods | Cancer | Immunoglobulins | Phosphorylation | Lymphocytes | DNA damage | Metastasis | Cancer therapies | Prostate cancer | Immune system | Tumors | Skin cancer
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