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Nature Immunology, ISSN 1529-2908, 2013, Volume 14, Issue 3, pp. 281 - 289
Journal Article
European Journal of Immunology, ISSN 0014-2980, 07/2009, Volume 39, Issue 7, pp. 1716 - 1725
Activation of naive CD8+ T cells with antigen in the absence of skewing cytokines triggers their differentiation into effector CTL, which induces death of... 
EAE | Tc17 | CTL | STAT3 | RORγt | TGF-BETA | INTERFERON-REGULATORY FACTOR-4 | ROR gamma t | IMMUNOLOGY | IL-21 | EFFECTOR | ROR-GAMMA | EOMESODERMIN | GENERATION | DIFFERENTIATION | T-H-17 CELLS | T-CELLS | CD8-Positive T-Lymphocytes - cytology | Encephalomyelitis, Autoimmune, Experimental - metabolism | Gene Expression - drug effects | Granzymes - metabolism | Encephalomyelitis, Autoimmune, Experimental - immunology | Immunoblotting | Green Fluorescent Proteins - genetics | Interferon-gamma - metabolism | Receptors, Retinoic Acid - genetics | Cell Differentiation - genetics | Flow Cytometry | Receptors, Thyroid Hormone - genetics | T-Lymphocytes, Helper-Inducer - immunology | T-Lymphocytes, Helper-Inducer - cytology | CD8-Positive T-Lymphocytes - metabolism | Encephalomyelitis, Autoimmune, Experimental - genetics | Interleukins - pharmacology | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Nuclear Receptor Subfamily 1, Group F, Member 3 | T-Lymphocytes, Cytotoxic - immunology | Green Fluorescent Proteins - metabolism | T-Lymphocytes, Helper-Inducer - metabolism | Mice, Inbred C57BL | Receptors, Retinoic Acid - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Receptors, Thyroid Hormone - metabolism | Cell Differentiation - immunology | Interleukin-17 - metabolism | Transforming Growth Factor beta - pharmacology | Animals | Interleukin-6 - pharmacology | T-Lymphocytes, Cytotoxic - metabolism | Cell Differentiation - drug effects | Cell Line, Tumor | Mice | CD8-Positive T-Lymphocytes - immunology | Cytotoxicity, Immunologic - immunology | T-Lymphocytes, Cytotoxic - cytology
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 08/2009, Volume 86, Issue 2, pp. 435 - 443
Lytic CD8+ T cells at the psoriasis plaque’s epidermis secrete IL‐17, IL‐21 and IL‐22 and depends on autocrine TNFalpha production. IL‐17‐producing CD4+ T... 
Tc17 cells | IL‐22 | IL‐21 | IL-22 | IL-21 | VULGARIS LESIONS | AUTOIMMUNE INFLAMMATION | DENDRITIC CELLS | IFN-GAMMA | IMMUNOLOGY | IDENTIFICATION | CELL BIOLOGY | CYCLOSPORINE-A | ACCUMULATION | DIFFERENTIATION | HEMATOLOGY | IL-17 PRODUCTION | TH17 | Tumor Necrosis Factor-alpha - metabolism | T-Lymphocytes, Regulatory - metabolism | Humans | Interferon-gamma - metabolism | T-Lymphocytes, Helper-Inducer - secretion | Interleukins - metabolism | Receptors, Retinoic Acid - genetics | T-Lymphocytes, Regulatory - immunology | Receptors, Thyroid Hormone - genetics | T-Lymphocytes, Helper-Inducer - immunology | Psoriasis - metabolism | CD8-Positive T-Lymphocytes - metabolism | Skin - pathology | Skin - immunology | Nuclear Receptor Subfamily 1, Group F, Member 3 | Psoriasis - immunology | T-Lymphocytes, Cytotoxic - immunology | T-Lymphocytes, Helper-Inducer - metabolism | Cytokines - metabolism | T-Lymphocytes, Regulatory - secretion | Interleukin-17 - secretion | Interferon-gamma - secretion | T-Lymphocytes, Cytotoxic - secretion | Tumor Necrosis Factor-alpha - secretion | Cytokines - secretion | Receptors, Retinoic Acid - metabolism | CD28 Antigens - immunology | Antibodies - pharmacology | Receptors, Thyroid Hormone - metabolism | Interleukin-17 - metabolism | CD8-Positive T-Lymphocytes - secretion | T-Lymphocytes, Cytotoxic - metabolism | Lymphocyte Activation - drug effects | Psoriasis - physiopathology | CD3 Complex - immunology | Skin - physiopathology | CD8-Positive T-Lymphocytes - immunology | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Cell Lineage - immunology | Interleukins - secretion
Journal Article
Cancer Research, ISSN 0008-5472, 02/2011, Volume 71, Issue 4, pp. 1263 - 1271
The tumor microenvironment includes a complex network of immune T-cell subpopulations. In this study, we systematically analyzed the balance between cytotoxic... 
BREAST-CANCER | SURVIVAL | LUNG-CANCER | FOXP3 EXPRESSION | RECRUITMENT | ONCOLOGY | GASTRIC-CANCER | EOSINOPHILS | MACROPHAGES | CARCINOMA | LYMPHOCYTES | Th1 Cells - pathology | Th1 Cells - physiology | Prognosis | Th2 Cells - physiology | Tissue Array Analysis | Colorectal Neoplasms - genetics | Humans | Gene Expression Regulation, Neoplastic | Carcinoma - mortality | Gene Expression Profiling | Th2 Cells - immunology | Th1 Cells - immunology | Colorectal Neoplasms - diagnosis | Lymphocytes, Tumor-Infiltrating - physiology | T-Lymphocytes, Cytotoxic - pathology | Th1 Cells - metabolism | Th17 Cells - metabolism | Forkhead Transcription Factors - metabolism | Microarray Analysis | T-Lymphocytes, Helper-Inducer - immunology | Lymphocytes, Tumor-Infiltrating - metabolism | T-Lymphocytes, Helper-Inducer - pathology | Interleukin-4 - genetics | Th2 Cells - pathology | Th17 Cells - pathology | Colorectal Neoplasms - mortality | T-Lymphocytes, Cytotoxic - immunology | Th17 Cells - physiology | T-Lymphocytes, Helper-Inducer - metabolism | Carcinoma - immunology | Interleukin-4 - metabolism | Carcinoma - diagnosis | Forkhead Transcription Factors - genetics | Th2 Cells - metabolism | T-Lymphocytes, Cytotoxic - physiology | T-Lymphocytes, Helper-Inducer - physiology | Colorectal Neoplasms - immunology | Lymphocytes, Tumor-Infiltrating - pathology | T-Lymphocytes, Cytotoxic - metabolism | Survival Analysis | Th17 Cells - immunology | Carcinoma - genetics | Cohort Studies | Lymphocytes, Tumor-Infiltrating - immunology
Journal Article
Journal Article
Cancer Cell, ISSN 1535-6108, 11/2017, Volume 32, Issue 5, pp. 669 - 683.e5
Cytotoxic T cells infiltrating tumors are thought to utilize HIF transcription factors during adaptation to the hypoxic tumor microenvironment. Deletion... 
hypoxia | HIF transcription factors | VEGF | angiogenesis | immunotherapy | cytotoxic T cells | cytotoxic T cells | BREAST-CANCER | ACCELERATES TUMORIGENESIS | ANGIOGENESIS | ONCOLOGY | HYPOXIA-INDUCIBLE FACTOR-1-ALPHA | EFFECTOR FUNCTION | MOUSE MODEL | REG CELLS | MYELOID CELLS | EXPRESSION | ENDOTHELIAL GROWTH-FACTOR | CELL BIOLOGY
Journal Article
Molecular Immunology, ISSN 0161-5890, 07/2012, Volume 51, Issue 3-4, pp. 263 - 272
► As a strategy to overcome the immunosuppressive effects of tumor programmed death ligand 1 (PD-L1) on adoptively transferred T cells, we sought to convert... 
Programmed death 1 (PD-1) receptor | Costimulation | Adoptive T cell therapy | PROGNOSTIC-FACTORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | COSTIMULATORY MOLECULES | IMMOBILIZED MONOCLONAL-ANTIBODIES | MALIGNANT-MELANOMA | IMMUNOLOGY | POTENTIAL MECHANISM | CD28 COSTIMULATION | IMMUNE EVASION | IN-VIVO | B7 FAMILY | B7-H1 | Recombinant Fusion Proteins - immunology | Leukocytes, Mononuclear - metabolism | Muromonab-CD3 - immunology | Phosphorylation | Granzymes - metabolism | Humans | Cell Growth Processes - physiology | Adoptive Transfer | Extracellular Signal-Regulated MAP Kinases - metabolism | Granzymes - genetics | Extracellular Signal-Regulated MAP Kinases - genetics | Recombinant Fusion Proteins - metabolism | Extracellular Signal-Regulated MAP Kinases - immunology | CD28 Antigens - metabolism | Muromonab-CD3 - metabolism | Muromonab-CD3 - genetics | CD28 Antigens - genetics | Leukocytes, Mononuclear - immunology | CD8-Positive T-Lymphocytes - metabolism | Granzymes - immunology | Cytokines - genetics | Cytokines - immunology | T-Lymphocytes, Cytotoxic - immunology | Cell Line | Cytokines - metabolism | Lymphocyte Activation | Programmed Cell Death 1 Receptor - metabolism | CD28 Antigens - immunology | B7-H1 Antigen - genetics | B7-H1 Antigen - immunology | B7-H1 Antigen - metabolism | Immunosuppression | T-Lymphocytes, Cytotoxic - metabolism | Recombinant Fusion Proteins - genetics | Ligands | Programmed Cell Death 1 Receptor - immunology | CD8-Positive T-Lymphocytes - immunology | Programmed Cell Death 1 Receptor - genetics
Journal Article
Blood, ISSN 0006-4971, 02/2013, Volume 121, Issue 8, pp. 1345 - 1356
Journal Article