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The Journal of experimental medicine, ISSN 1540-9538, 2013, Volume 210, Issue 9, pp. 1695 - 1710
.... Although subject to debate, current models favor a mechanism of activity involving blockade of the inhibitory activity of CTLA-4 on both effector (T eff) and regulatory (T reg... 
EFFECTOR | MEDICINE, RESEARCH & EXPERIMENTAL | CTLA-4 BLOCKADE | LYMPHOCYTE-ASSOCIATED ANTIGEN-4 | CANCER-PATIENTS | IN-VIVO | COMBINATION IMMUNOTHERAPY | MONOCLONAL-ANTIBODY | IMMUNOLOGY | LARGE ESTABLISHED MELANOMA | GAMMA-RIV | ANTITUMOR-ACTIVITY | Fas Ligand Protein - metabolism | Lymph Nodes - pathology | Antibodies, Blocking - pharmacology | Lymphocyte Depletion | Granulocyte-Macrophage Colony-Stimulating Factor - therapeutic use | Receptors, IgG - metabolism | T-Lymphocytes, Regulatory - immunology | Signal Transduction - immunology | Melanoma - prevention & control | Lymph Nodes - drug effects | Cell Membrane - metabolism | Clone Cells | Cell Membrane - drug effects | Tumor Microenvironment - drug effects | Phagocytes - drug effects | Mice, Inbred C57BL | Treatment Outcome | Lymph Nodes - immunology | Lymphocytes, Tumor-Infiltrating - drug effects | Melanoma - pathology | Phagocytes - immunology | TNF-Related Apoptosis-Inducing Ligand - metabolism | Tumor Microenvironment - immunology | T-Lymphocytes, Regulatory - drug effects | Animals | Lymphocytes, Tumor-Infiltrating - pathology | Signal Transduction - drug effects | Melanoma - immunology | CD8-Positive T-Lymphocytes - drug effects | Antibodies, Blocking - therapeutic use | Lymphocyte Count | Mice | CD11b Antigen - metabolism | CD8-Positive T-Lymphocytes - immunology | CTLA-4 Antigen - antagonists & inhibitors | Melanoma - therapy | CD4 Antigens - metabolism | Lymphocytes, Tumor-Infiltrating - immunology
Journal Article
Nature medicine, ISSN 1078-8956, 2018, Volume 24, Issue 7, pp. 1005 - 1014
Interleukin-2 (IL-2) has been shown to suppress immune pathologies by preferentially expanding regulatory T cells (T-regs... 
MEDICINE, RESEARCH & EXPERIMENTAL | SYSTEMIC-LUPUS-ERYTHEMATOSUS | ACTIVATION | ALPHA-RECEPTOR | TOLERANCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMPLEXES | LOW-DOSE INTERLEUKIN-2 | IL-2 | VERSUS-HOST-DISEASE | CELL BIOLOGY | IMMUNOTHERAPY | SELECTIVE STIMULATION | Antibodies - chemistry | Humans | Encephalomyelitis, Autoimmune, Experimental - immunology | Structure-Activity Relationship | Graft vs Host Disease - immunology | STAT5 Transcription Factor - metabolism | Interleukin-2 - immunology | Immunoglobulin Fab Fragments - metabolism | Immunotherapy | Protein Binding - drug effects | Diabetes Mellitus, Type 1 - immunology | Phosphorylation - drug effects | Antibodies - therapeutic use | Encephalomyelitis, Autoimmune, Experimental - drug therapy | Mice, Inbred C57BL | Models, Molecular | Muromegalovirus - drug effects | Diabetes Mellitus, Type 1 - drug therapy | Antibodies - pharmacology | Up-Regulation - drug effects | T-Lymphocytes, Regulatory - drug effects | Animals | Graft vs Host Disease - drug therapy | Signal Transduction - drug effects | CD8-Positive T-Lymphocytes - drug effects | Cell Proliferation - drug effects | Kinetics | CD8-Positive T-Lymphocytes - immunology | Phosphorylation | Usage | Interleukin-2 | Type 1 diabetes | Analysis | Development and progression | T cells | Graft-versus-host reaction | Disease | Immunoregulation | Complications | Diabetes mellitus | Interleukin | Antibodies | Diabetes mellitus (insulin dependent) | Lymphocytes T | Stat5 protein | Experimental allergic encephalomyelitis | Interleukin 2 | Lymphocytes | Xenografts | Remission | Autoimmune diseases | Conformation
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2010, Volume 285, Issue 46, pp. 36158 - 36169
.... One layer of regulation involves regulatory T cells (Tregs) that play an essential role in maintaining peripheral self-tolerance... 
WILD-TYPE | HDL | DENDRITIC CELLS | INFLAMMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ATHEROSCLEROSIS | CHOLESTEROL HOMEOSTASIS | CORONARY-HEART-DISEASE | SUPPRESSION | ENDOTHELIAL FUNCTION | HIGH-DENSITY-LIPOPROTEIN | Lymph Nodes - pathology | Skin - metabolism | Dendritic Cells - immunology | Humans | Male | T-Lymphocytes, Regulatory - immunology | CD11c Antigen - metabolism | Apolipoprotein A-I - genetics | Lymphocyte Activation - immunology | Flow Cytometry | Autoimmunity - immunology | Injections, Subcutaneous | Dendritic Cells - drug effects | Female | Lymph Nodes - drug effects | Dendritic Cells - metabolism | Macrophages - immunology | Skin - pathology | Receptors, LDL - genetics | Cholesterol, HDL - metabolism | Mice, Inbred C57BL | Lymph Nodes - metabolism | Receptors, LDL - metabolism | Apolipoprotein A-I - metabolism | CD3 Complex - metabolism | Diet, Atherogenic | Macrophages - metabolism | T-Lymphocytes, Regulatory - drug effects | Animals | Lymphocyte Activation - drug effects | Lymphocyte Count | Macrophages - drug effects | Apolipoprotein A-I - administration & dosage | Cell Proliferation - drug effects | Mice | Lipids - analysis | Autoimmunity - drug effects | Microscopy, Fluorescence | Skin - drug effects | Autoimmunity | Lipoprotein Metabolism | Cholesterol Metabolism | Regulatory T Cell | Atherosclerosis | Apolipoprotein A-I | Lipids | Apolipoproteins | Lymphocyte | Cholesterol
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 2017, Volume 47, Issue 4, pp. 776 - 788.e5
... with regulatory T cells, were enriched in SIV DNA in blood, lymph nodes (LN), spleen, and gut, and contained replication-competent and infectious virus... 
SIV | animal models | HIV | latent viral reservoir | regulatory T cells | co-inhibitory receptors | CTLA-4 | T follicular helper cells | PD-1 | regulatory T cells | TGF-BETA | REPLICATION | RESERVOIR | REGULATORY CELLS | IMMUNE ACTIVATION | GENE-EXPRESSION | IMMUNODEFICIENCY VIRUS-INFECTION | IMMUNOLOGY | CHRONIC HIV-INFECTION | FOLLICULAR HELPER-CELLS | Humans | Host-Pathogen Interactions - drug effects | Macaca mulatta | Immunologic Memory - drug effects | Host-Pathogen Interactions - immunology | T-Lymphocytes, Helper-Inducer - virology | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | T-Lymphocytes, Helper-Inducer - drug effects | HIV Infections - immunology | Simian Acquired Immunodeficiency Syndrome - virology | HIV-1 - physiology | In Situ Hybridization | T-Lymphocytes, Helper-Inducer - immunology | Lymph Nodes - drug effects | CD4-Positive T-Lymphocytes - virology | Immunologic Memory - immunology | Simian Immunodeficiency Virus - immunology | Anti-Retroviral Agents - therapeutic use | HIV-1 - drug effects | HIV Infections - virology | CTLA-4 Antigen - metabolism | Programmed Cell Death 1 Receptor - metabolism | Lymph Nodes - virology | Lymph Nodes - immunology | CTLA-4 Antigen - immunology | Simian Immunodeficiency Virus - physiology | Microscopy, Confocal | HIV-1 - immunology | T-Lymphocytes, Regulatory - drug effects | Animals | Simian Acquired Immunodeficiency Syndrome - drug therapy | Simian Acquired Immunodeficiency Syndrome - immunology | HIV Infections - drug therapy | Programmed Cell Death 1 Receptor - immunology | Simian Immunodeficiency Virus - drug effects | CD4-Positive T-Lymphocytes - drug effects | T-Lymphocytes, Regulatory - virology | Therapy | PD-1 protein | Memory | Viruses | Infections | Lymphocytes T | Lymph nodes | CTLA-4 protein | Lymphocytes | Antiretroviral agents | Immunotherapy | Human immunodeficiency virus--HIV | Drug therapy | Deoxyribonucleic acid--DNA | Spleen | Antiretroviral drugs | Immunological memory | Memory cells | Immunoregulation | Latent infection | Monkeys & apes | Antiretroviral therapy | CD4 antigen | Lymphocytes B | Replication
Journal Article
Journal Article
Immunity, ISSN 1074-7613, 2010, Volume 33, Issue 6, pp. 942 - 954
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2019, Volume 116, Issue 20, pp. 9999 - 10008
Journal Article
Nature (London), ISSN 1476-4687, 2013, Volume 497, Issue 7448, pp. 258 - 262
Journal Article
The Journal of experimental medicine, ISSN 1540-9538, 2018, Volume 215, Issue 4, pp. 1169 - 1186
The pathophysiology of drug-resistant pediatric epilepsy is unknown. Flow cytometric analysis of inflammatory leukocytes in resected brain tissues from 29 pediatric patients with genetic... 
Inflammation - pathology | Microglia - metabolism |