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1. Full Text Tryptophan Catabolism by Indoleamine 2,3-Dioxygenase 1 Alters the Balance of TH17 to Regulatory T Cells in HIV Disease
by David Favre and Jeff Mold and Peter W. Hunt and Bittoo Kanwar and P’ng Loke and Lillian Seu and Jason D. Barbour and Margaret M. Lowe and Anura Jayawardene and Francesca Aweeka and Yong Huang and Daniel C. Douek and Jason M. Brenchley and Jeffrey N. Martin and Frederick M. Hecht and Steven G. Deeks and Joseph M. McCune
Science Translational Medicine, ISSN 1946-6234, 05/2010, Volume 2, Issue 32, pp. 32ra36 - ra36
Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | T-Lymphocytes, Regulatory - metabolism | Up-Regulation | Prospective Studies | Colon, Sigmoid - immunology | Dendritic Cells - immunology | Humans | Interleukin-17 - immunology | HIV Infections - enzymology | Lipopolysaccharides - immunology | Rectum - virology | Tryptophan - metabolism | Viral Load | T-Lymphocytes, Helper-Inducer - virology | T-Lymphocytes, Regulatory - immunology | Lymph Nodes - enzymology | HIV Infections - immunology | CD4-CD8 Ratio | Colon, Sigmoid - virology | Time Factors | T-Lymphocytes, Helper-Inducer - immunology | Colon, Sigmoid - enzymology | Kynurenine - metabolism | Dendritic Cells - virology | Inflammation Mediators - immunology | T-Lymphocytes, Helper-Inducer - metabolism | HIV Seropositivity | HIV Infections - virology | Cells, Cultured | Inflammation - virology | CD4 Lymphocyte Count | Inflammation - immunology | Lymph Nodes - virology | 3-Hydroxyanthranilic Acid - metabolism | Lymph Nodes - immunology | Rectum - immunology | Disease Progression | Rectum - enzymology | Biopsy | Dendritic Cells - enzymology | Interferon-gamma - immunology | HIV Infections - drug therapy | Inflammation - enzymology | T-Lymphocytes, Regulatory - virology | Index Medicus
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2. Full Text T Regulatory and Primed Uncommitted CD4 T Cells Express CD73, Which Suppresses Effector CD4 T Cells by Converting 5'-Adenosine Monophosphate to Adenosine
by Kobie, James J and Shah, Pranav R and Yang, Li and Rebhahn, Jonathan A and Fowell, Deborah J and Mosmann, Tim R
The Journal of immunology (1950), ISSN 0022-1767, 11/2006, Volume 177, Issue 10, pp. 6780 - 6786
Life Sciences & Biomedicine | Immunology | Science & Technology | T-Lymphocyte Subsets - immunology | Th1 Cells - pathology | Stem Cells - immunology | Cell Proliferation | Coculture Techniques | Th2 Cells - immunology | CD4-Positive T-Lymphocytes - enzymology | CD4-Positive T-Lymphocytes - pathology | Th1 Cells - immunology | T-Lymphocytes, Regulatory - pathology | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | Stem Cells - enzymology | Inflammation Mediators - metabolism | Female | Growth Inhibitors - biosynthesis | Inflammation Mediators - physiology | Th2 Cells - pathology | 5'-Nucleotidase - biosynthesis | Adenosine Monophosphate - metabolism | Mice, Inbred C57BL | Cells, Cultured | Animals | T-Lymphocyte Subsets - pathology | T-Lymphocyte Subsets - enzymology | Adenosine - physiology | 5'-Nucleotidase - physiology | Hybridomas | Adenosine - metabolism | Growth Inhibitors - physiology | Stem Cells - pathology | Th1 Cells - enzymology | Mice | Cytokines - antagonists & inhibitors | Th2 Cells - enzymology | Cytokines - biosynthesis | T-Lymphocytes, Regulatory - enzymology | Index Medicus | Abridged Index Medicus
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3. Full Text CD69(+)CD4(+)CD25(-) T Cells, a New Subset of Regulatory T Cells, Suppress T Cell Proliferation through Membrane-Bound TGF-beta 1
by Han, Yanmei and Guo, Qiuli and Zhang, Minggang and Chen, Zhubo and Cao, Xuetao
The Journal of immunology (1950), ISSN 0022-1767, 01/2009, Volume 182, Issue 1, pp. 111 - 120
Life Sciences & Biomedicine | Immunology | Science & Technology | T-Lymphocyte Subsets - immunology | Carcinoma, Lewis Lung - enzymology | Antigens, CD - biosynthesis | Coculture Techniques | Carcinoma, Lewis Lung - immunology | Lung Neoplasms - pathology | Extracellular Signal-Regulated MAP Kinases - metabolism | Enzyme Activation - immunology | T-Lymphocytes, Regulatory - pathology | T-Lymphocytes, Regulatory - immunology | Melanoma, Experimental - immunology | Membrane Proteins - physiology | Antigens, Differentiation, T-Lymphocyte - physiology | Membrane Proteins - metabolism | Melanoma, Experimental - enzymology | Lung Neoplasms - enzymology | Lectins, C-Type | Mice, Inbred C57BL | Melanoma, Experimental - pathology | Mice, Transgenic | Protein Binding - immunology | Transforming Growth Factor beta1 - physiology | Disease Progression | Lung Neoplasms - immunology | Animals | T-Lymphocyte Subsets - pathology | Interleukin-2 Receptor alpha Subunit - metabolism | T-Lymphocyte Subsets - enzymology | Carcinoma, Lewis Lung - pathology | Cell Line, Tumor | Growth Inhibitors - physiology | Antigens, CD - physiology | Mice | Mice, Inbred BALB C | Antigens, Differentiation, T-Lymphocyte - biosynthesis | CD4 Antigens - biosynthesis | T-Lymphocytes, Regulatory - enzymology | Index Medicus | Abridged Index Medicus
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4. Full Text Phosphoinositide 3‐kinase δ is a regulatory T‐cell target in cancer immunotherapy
by Lim, Ee Lyn and Okkenhaug, Klaus
Immunology, ISSN 0019-2805, 07/2019, Volume 157, Issue 3, pp. 210 - 218
regulatory T cell | signal transduction | T cell | tumour immunology | Life Sciences & Biomedicine | Immunology | Science & Technology | Tumor Escape | Humans | Neoplasms - enzymology | Tumor Microenvironment | Antineoplastic Agents - therapeutic use | Lymphocytes, Tumor-Infiltrating - drug effects | Protein Kinase Inhibitors - adverse effects | Molecular Targeted Therapy | Lymphocytes, Tumor-Infiltrating - enzymology | Immunotherapy - adverse effects | Neoplasms - drug therapy | T-Lymphocytes, Regulatory - immunology | Phenotype | T-Lymphocytes, Regulatory - drug effects | Animals | Signal Transduction - drug effects | Antineoplastic Agents - adverse effects | Neoplasms - immunology | Protein Kinase Inhibitors - therapeutic use | Class Ib Phosphatidylinositol 3-Kinase - metabolism | Neoplasms - pathology | Class Ib Phosphatidylinositol 3-Kinase - immunology | T-Lymphocytes, Regulatory - enzymology | Lymphocytes, Tumor-Infiltrating - immunology | Immune response | Lymphocytes T | Kinases | CD28 antigen | Cell surface | 1-Phosphatidylinositol 3-kinase | Metastases | Signal transduction | Signaling | Receptors | Immune checkpoint | Immunotherapy | Infiltration | Cancer | Tumors | Immune system | Index Medicus | Where are we now? | Review | Review Series | Tregs in Cancer
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5. Full Text Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer
by Ali, Khaled and Soond, Dalya R and Piñeiro, Roberto and Hagemann, Thorsten and Pearce, Wayne and Lim, Ee Lyn and Bouabe, Hicham and Scudamore, Cheryl L and Hancox, Timothy and Maecker, Heather and Friedman, Lori and Turner, Martin and Okkenhaug, Klaus and Vanhaesebroeck, Bart
Nature (London), ISSN 0028-0836, 2014, Volume 510, Issue 7505, pp. 407 - 411
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Enzyme Inhibitors - pharmacology | Neoplasms - enzymology | Phosphatidylinositol 3-Kinases - metabolism | Enzyme Activation - drug effects | T-Lymphocytes, Regulatory - immunology | T-Lymphocytes, Regulatory - drug effects | Animals | Immune Tolerance - immunology | Neoplasms - immunology | Antineoplastic Agents - pharmacology | Mice | T-Lymphocytes, Regulatory - enzymology | Immune Tolerance - drug effects | Index Medicus
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6. Full Text Protein kinase CK2 enables regulatory T cells to suppress excessive TH2 responses in vivo
by Ulges, Alexander and Klein, Matthias and Reuter, Sebastian and Gerlitzki, Bastian and Hoffmann, Markus and Grebe, Nadine and Staudt, Valérie and Stergiou, Natascha and Bohn, Toszka and Brühl, Till-Julius and Muth, Sabine and Yurugi, Hajime and Rajalingam, Krishnaraj and Bellinghausen, Iris and Tuettenberg, Andrea and Hahn, Susanne and Reißig, Sonja and Haben, Irma and Zipp, Frauke and Waisman, Ari and Probst, Hans-Christian and Beilhack, Andreas and Buchou, Thierry and Filhol-Cochet, Odile and Boldyreff, Brigitte and Breloer, Minka and Jonuleit, Helmut and Schild, Hansjörg and Schmitt, Edgar and Bopp, Tobias
Nature immunology, ISSN 1529-2908, 02/2015, Volume 16, Issue 3, pp. 267 - 275
Forkhead Transcription Factors - immunology | Cell Growth Processes - immunology | Dendritic Cells - immunology | Humans | Hypersensitivity - immunology | Male | Th2 Cells - immunology | CD4-Positive T-Lymphocytes - enzymology | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | Leukocytes, Mononuclear - immunology | Cell Line | Casein Kinase II - immunology | Mice, Inbred C57BL | Mice, Transgenic | Receptors, Cell Surface - immunology | Cell Differentiation - immunology | Interferon Regulatory Factors - immunology | Animals | Dendritic Cells - enzymology | Mice | Mice, Inbred BALB C | Th2 Cells - enzymology | T-Lymphocytes, Regulatory - enzymology | Hypersensitivity - blood | Index Medicus
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7. Full Text Human Th17 cells express high levels of enzymatically active dipeptidylpeptidase IV (CD26)
by Bengsch, Bertram and Seigel, Bianca and Flecken, Tobias and Wolanski, Julia and Blum, Hubert E and Thimme, Robert
The Journal of immunology (1950), ISSN 0022-1767, 06/2012, Volume 188, Issue 11, pp. 5438 - 5447
Life Sciences & Biomedicine | Immunology | Science & Technology | Dipeptidyl Peptidase 4 - metabolism | Hepatitis, Viral, Human - immunology | Humans | Inflammatory Bowel Diseases - immunology | Dipeptidyl Peptidase 4 - blood | Th2 Cells - immunology | CD4-Positive T-Lymphocytes - enzymology | Th1 Cells - immunology | Hepatitis, Autoimmune - pathology | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | Hepatitis, Viral, Human - enzymology | Inflammatory Bowel Diseases - enzymology | Inflammatory Bowel Diseases - pathology | Inflammation Mediators - metabolism | Th17 Cells - enzymology | Dipeptidyl Peptidase 4 - biosynthesis | Cells, Cultured | Inflammation Mediators - blood | Hepatitis, Autoimmune - immunology | Interleukin-17 - biosynthesis | Hepatitis, Viral, Human - pathology | Up-Regulation - immunology | Th17 Cells - immunology | Th1 Cells - enzymology | Th2 Cells - enzymology | Hepatitis, Autoimmune - enzymology | T-Lymphocytes, Regulatory - enzymology | Index Medicus | Abridged Index Medicus
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8. Full Text Differential PI3Kδ signaling in CD4+ T-cell subsets enables selective targeting of t regulatory cells to enhance cancer immunotherapy
by Ahmad, Shamim and Abu-Eid, Rasha and Shrimali, Rajeev and Webb, Mason and Verma, Vivek and Doroodchi, Atbin and Berrong, Zuzana and Samara, Raed and Rodriguez, Paulo C and Mkrtichyan, Mikayel and Khleif, Samir N
Cancer research (Chicago, Ill.), ISSN 0008-5472, 04/2017, Volume 77, Issue 8, pp. 1892 - 1904
Life Sciences & Biomedicine | Oncology | Science & Technology | T-Lymphocyte Subsets - immunology | Immunotherapy - methods | Cancer Vaccines - pharmacology | Neoplasms, Experimental - enzymology | CD4-Positive T-Lymphocytes - enzymology | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Phosphatidylinositol 3-Kinases - immunology | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | Signal Transduction - immunology | Neoplasms, Experimental - immunology | Female | Quinazolinones - pharmacology | Isoenzymes | Lymphocyte Activation | Purines - pharmacology | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Neoplasms, Experimental - therapy | Mice, Knockout | Drug Synergism | Phosphatidylinositol 3-Kinases - genetics | Cancer Vaccines - immunology | Animals | Mice | CD8-Positive T-Lymphocytes - immunology | T-Lymphocytes, Regulatory - enzymology | Cell proliferation | Animal models | Cell survival | Immunoregulation | CD8 antigen | Lung cancer | Lymphocytes T | T cell receptors | Vaccines | 1-Phosphatidylinositol 3-kinase | CD4 antigen | Anticancer properties | T-cell receptor | Signaling | Inhibitors | Lymphocytes | Immunotherapy | Isoforms | Antitumor activity | Cancer | Index Medicus
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9. Full Text High expression of the ectonucleotidase CD39 on T cells from the inflamed site identifies two distinct populations, one regulatory and one memory T cell population
by Moncrieffe, Halima and Nistala, Kiran and Kamhieh, Yasmine and Evans, Jamie and Eddaoudi, Ayad and Eaton, Simon and Wedderburn, Lucy R
The Journal of immunology (1950), ISSN 0022-1767, 07/2010, Volume 185, Issue 1, pp. 134 - 143
Life Sciences & Biomedicine | Immunology | Science & Technology | T-Lymphocyte Subsets - immunology | Inflammation - pathology | Antigens, CD - biosynthesis | Humans | Male | CD4-Positive T-Lymphocytes - enzymology | CD4-Positive T-Lymphocytes - pathology | T-Lymphocytes, Regulatory - pathology | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | Apyrase - biosynthesis | Inflammation Mediators - metabolism | Arthritis, Juvenile - enzymology | Female | Autoimmune Diseases - pathology | Child | Inflammation Mediators - physiology | Autoimmune Diseases - enzymology | Autoimmune Diseases - immunology | Immunophenotyping | Inflammation - immunology | T-Lymphocyte Subsets - pathology | Arthritis, Juvenile - immunology | T-Lymphocyte Subsets - enzymology | Adolescent | Immunologic Memory | Gene Expression Regulation, Enzymologic - immunology | Inflammation - enzymology | Arthritis, Juvenile - pathology | T-Lymphocytes, Regulatory - enzymology | Index Medicus | Abridged Index Medicus
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10. Full Text T Regulatory Cells Maintain Intestinal Homeostasis by Suppressing γδ T Cells
by Park, Sung-Gyoo and Mathur, Ramkumar and Long, Meixiao and Hosh, Namiko and Hao, Liming and Hayden, Matthew S and Ghosh, Sankar
Immunity (Cambridge, Mass.), ISSN 1074-7613, 2010, Volume 33, Issue 5, pp. 791 - 803
T-Lymphocyte Subsets - immunology | Interleukin-17 - immunology | Protein-Serine-Threonine Kinases - genetics | Homeostasis - immunology | Immune Tolerance | Receptors, Antigen, T-Cell, gamma-delta - immunology | Adoptive Transfer | Intestines - immunology | CD8 Antigens - immunology | T-Lymphocytes, Regulatory - immunology | Colitis - etiology | Lymphocyte Activation - immunology | Animals | Colitis - enzymology | T-Lymphocyte Subsets - enzymology | Mice | Colitis - immunology | T-Lymphocytes, Regulatory - enzymology | Intestines - enzymology | Index Medicus
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