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1. Full Text Comprehensive phenotyping of regulatory T cells after liver transplantation
by Gronert Álvarez, Anna and Fytili, Paraskevi and Suneetha, Pothakamuri V and Kraft, Anke R. M and Brauner, Christin and Schlue, Jerome and Krech, Till and Lehner, Frank and Meyer‐Heithuis, Christoph and Jaeckel, Elmar and Klempnauer, Juergen and Manns, Michael P and Cornberg, Markus and Wedemeyer, Heiner
Liver Transplantation, ISSN 1527-6465, 03/2015, Volume 21, Issue 3, pp. 381 - 395
Regulatory T cells (Tregs) play an important role in controlling alloreactivity after solid organ transplantation, but they may also impair antiviral immunity.... 
SURGERY | FOXP3(+) CELLS | PERIPHERAL-BLOOD | MECHANISMS | OPERATIONAL TOLERANCE | VERSUS-HOST-DISEASE | TRANSPLANTATION | ACUTE REJECTION | LOW-RISK | C VIRUS-INFECTION | GENE-EXPRESSION | GASTROENTEROLOGY & HEPATOLOGY | HEPATITIS-C | Recurrence | T-Lymphocytes, Regulatory - metabolism | Liver Transplantation - adverse effects | Humans | Middle Aged | Male | Hepatitis C, Chronic - complications | Liver Failure - immunology | Case-Control Studies | T-Lymphocytes, Regulatory - immunology | Liver Failure - virology | Young Adult | Flow Cytometry | Adult | Female | Immunophenotyping - methods | Principal Component Analysis | Biomarkers - metabolism | Treatment Outcome | Phenotype | Adolescent | Hepatitis C, Chronic - immunology | Aged | Graft Rejection - immunology | Liver Failure - surgery | Liver Failure - diagnosis | Original
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2. Full Text HLA-haploidentical transplantation with regulatory and conventional T-cell adoptive immunotherapy prevents acute leukemia relapse
by Martelli, Massimo F and Di Ianni, Mauro and Ruggeri, Loredana and Falzetti, Franca and Carotti, Alessandra and Terenzi, Adelmo and Pierini, Antonio and Massei, Maria Speranza and Amico, Lucia and Urbani, Elena and Del Papa, Beatrice and Zei, Tiziana and Ostini, Roberta Iacucci and Cecchini, Debora and Tognellini, Rita and Reisner, Yair and Aversa, Franco and Falini, Brunangelo and Velardi, Andrea
Blood, ISSN 0006-4971, 07/2014, Volume 124, Issue 4, pp. 638 - 644
Posttransplant relapse is still the major cause of treatment failure in high-risk acute leukemia. Attempts to manipulate alloreactive T cells to spare normal... 
Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology | Prognosis | Follow-Up Studies | Humans | Middle Aged | Male | Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality | Leukemia, Myeloid, Acute - immunology | Lymphocyte Depletion | Neoplasm Recurrence, Local - mortality | Transplantation, Homologous | T-Lymphocytes, Regulatory - immunology | Neoplasm Recurrence, Local - immunology | Young Adult | Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy | Bone Marrow Transplantation | Adult | Female | Leukemia, Myeloid, Acute - therapy | Disease Models, Animal | Immunotherapy, Adoptive | Neoplasm Recurrence, Local - prevention & control | HLA Antigens - immunology | Survival Rate | Remission Induction | Leukemia, Myeloid, Acute - mortality | Animals | Adolescent | Graft vs Leukemia Effect - immunology | Aged | Mice | Transplantation Conditioning | Histocompatibility
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3. Full Text Peripheral biomarkers for individualizing immunosuppression in transplantation - Regulatory T cells
by Schlickeiser, Stephan and Sawitzki, Birgit
Clinica Chimica Acta, ISSN 0009-8981, 09/2012, Volume 413, Issue 17-18, pp. 1406 - 1413
Regulatory T cells have gained much interest in the research community over the last 15 years. Here we give a short overview on the phenotype of Tregs,... 
Rejection | Flow cytometry | Naturally occurring regulatory T cells | Organ transplantation | Foxp3 | TGF-BETA | IMMUNE DEVIATION ACAID | OPERATIONAL TOLERANCE | PLASMACYTOID DENDRITIC CELLS | GROWTH-FACTOR-BETA | ANTI-THYMOCYTE GLOBULIN | KIDNEY-TRANSPLANTATION | TRANSCRIPTION FACTOR FOXP3 | IMMUNOLOGICAL SELF-TOLERANCE | SUPPRESSOR-CELLS | MEDICAL LABORATORY TECHNOLOGY | Organ Transplantation | Immunosuppression | Phenotype | Biomarkers - blood | Humans | T-Lymphocytes, Regulatory - immunology | Antigens | Dendritic cells | Lymphocytes | Analysis | Immunotherapy | Transplantation of organs, tissues, etc | Adenylic acid | Transforming growth factors | T cells
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4. Full Text Clinical Grade Manufacturing of Human Alloantigen‐Reactive Regulatory T Cells for Use in Transplantation
by Putnam, A. L and Safinia, N and Medvec, A and Laszkowska, M and Wray, M and Mintz, M. A and Trotta, E and Szot, G. L and Liu, W and Lares, A and Lee, K and Laing, A and Lechler, R. I and Riley, J. L and Bluestone, J. A and Lombardi, G and Tang, Q
American Journal of Transplantation, ISSN 1600-6135, 11/2013, Volume 13, Issue 11, pp. 3010 - 3020
This study details a good manufacturing practice‐compliant process for short‐term selective expansion of donoralloantigen‐reactive regulatory T cells for... 
regulatory T cells | clinical application | tolerance induction | Cellular therapy | SURGERY | TOLERANCE | TRANSPLANTATION | THERAPY | TREGS | IMMUNOTHERAPY | EXPANSION | CD28 | ANTIGEN-PRESENTING CELLS | Lymphocyte Activation | Graft Rejection - prevention & control | Humans | Cell- and Tissue-Based Therapy | Graft vs Host Disease - immunology | T-Lymphocytes, Regulatory - immunology | Transplantation Tolerance | Animals | Flow Cytometry | Immune Tolerance - immunology | Isoantigens - immunology | Graft vs Host Disease - prevention & control | Skin Transplantation | Mice | Mice, Inbred BALB C | T-Lymphocytes, Regulatory - transplantation | Graft Rejection - immunology | T cells | Immunotherapy | Bone marrow | Manufacturing | Transplants & implants | Good Manufacturing Practice | Alloantigens
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5. Full Text CD4+Foxp3+ regulatory T cell therapy in transplantation
by Tang, Qizhi and Bluestone, Jeffrey A and Kang, Sang-Mo
Journal of Molecular Cell Biology, ISSN 1674-2788, 2/2012, Volume 4, Issue 1, pp. 11 - 21
Regulatory T cells (Tregs) are long-lived cells that suppress immune responses in vivo in a dominant and antigen-specific manner. Therefore, therapeutic... 
regulatory T cells | immune tolerance | cell therapy | transplantation | FOXP3 EXPRESSION | LONG-TERM SURVIVAL | IMMUNE RECONSTITUTION | CALCINEURIN INHIBITOR | RENAL-TRANSPLANTATION | VERSUS-HOST-DISEASE | HOMEOSTATIC PROLIFERATION | CUTTING EDGE | CELL BIOLOGY | IN-VITRO | MIXED CHIMERISM | Forkhead Transcription Factors - immunology | Graft vs Host Disease - therapy | Humans | Autoimmune Diseases - immunology | Organ Transplantation | Graft vs Host Disease - immunology | T-Lymphocytes, Regulatory - immunology | Immunosuppression | Transplantation Tolerance | Animals | Time Factors | Forkhead Transcription Factors - metabolism | Isoantigens - immunology | Autoimmune Diseases - therapy | Transplantation Immunology | Mice | T-Lymphocytes, Regulatory - transplantation | Cell Transplantation - methods | Reviews
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6. Full Text Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation
by Di Ianni, Mauro and Falzetti, Franca and Carotti, Alessandra and Terenzi, Adelmo and Castellino, Flora and Bonifacio, Elisabetta and Del Papa, Beatrice and Zei, Tiziana and Iacucci Ostini, Roberta and Cecchini, Debora and Aloisi, Teresa and Perruccio, Katia and Ruggeri, Loredana and Balucani, Chiara and Pierini, Antonio and Sportoletti, Paolo and Aristei, Cynthia and Falini, Brunangelo and Reisner, Yair and Velardi, Andrea and Aversa, Franco and Martelli, Massimo F
Blood, ISSN 0006-4971, 04/2011, Volume 117, Issue 14, pp. 3921 - 3928
Hastening posttransplantation immune reconstitution is a key challenge in human leukocyte antigen (HLA)-haploidentical hematopoietic stem-cell transplantation... 
ACUTE-LEUKEMIA | BONE-MARROW-TRANSPLANTATION | HIGH-RISK | REGULATORY T-CELLS | BARRIERS | HAPLOTYPE | MEGADOSE | STEM-CELL TRANSPLANTATION | HEMATOLOGY | VERSUS-HOST-DISEASE | ADOPTIVE IMMUNOTHERAPY | Hematologic Neoplasms - therapy | Recurrence | Immune System - physiology | Histocompatibility Testing | Humans | Middle Aged | Male | Transplantation Immunology - physiology | Graft vs Host Disease - immunology | Histocompatibility - immunology | Transplantation, Homologous | T-Lymphocytes, Regulatory - immunology | Young Adult | Hematopoietic Stem Cell Transplantation - adverse effects | Immune System - immunology | Adult | Female | Graft vs Host Disease - prevention & control | T-Lymphocytes, Regulatory - transplantation | Hematologic Neoplasms - immunology | Transplantation Conditioning - methods | T-Lymphocytes, Regulatory - physiology
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7. Full Text Umbilical cord blood-derived T regulatory cells to prevent GVHD: Kinetics, toxicity profile, and clinical effect
by Brunstein, Claudio G and Miller, Jeffrey S and McKenna, David H and Hippen, Keli L and DeFor, Todd E and Sumstad, Darin and Curtsinger, Julie and Verneris, Michael R and MacMillan, Margaret L and Levine, Bruce L and Riley, James L and June, Carl H and Le, Chap and Weisdorf, Daniel J and McGlave, Philip B and Blazar, Bruce R and Wagner, John E
Blood, ISSN 0006-4971, 02/2016, Volume 127, Issue 8, pp. 1044 - 1051
We studied the safety and clinical outcomes of patients treated with umbilical cord blood (UCB)-derived regulatory T cells (Tregs) that expanded in cultures... 
ADULTS | HEMATOLOGY | EXPRESS | TRANSPLANTATION | Graft vs Host Disease - epidemiology | Immunotherapy - methods | Humans | Middle Aged | Kaplan-Meier Estimate | Proportional Hazards Models | Male | Incidence | Young Adult | Cord Blood Stem Cell Transplantation - methods | Disease-Free Survival | Cord Blood Stem Cell Transplantation - adverse effects | Maximum Tolerated Dose | Adolescent | Adult | Female | Graft vs Host Disease - prevention & control | Aged | T-Lymphocytes, Regulatory - transplantation | Kinetics | Transplantation Conditioning - methods | Child | Fetal Blood | Index Medicus | Abridged Index Medicus | Transplantation
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8. Full Text Leukemia inhibitory factor is linked to regulatory transplantation tolerance
by Metcalfe, Su M and Watson, Tracy J and Shurey, Sandra and Adams, Elizabeth and Green, Colin J
Transplantation, ISSN 0041-1337, 03/2005, Volume 79, Issue 6, pp. 726 - 730
Background. The specific regulation of allo-tolerance in vivo occurs within a complex microenvironment and involves co-operation between a small proportion of... 
Tolerance | Signal transduction | Transplantation | SURGERY | VIVO | signal transduction | CONTROLLERS | transplantation | TRANSCRIPTION | DIFFERENTIATION | IMMUNOLOGY | tolerance | T-CELLS | KEY | Spleen - immunology | Cells, Cultured | Spleen - cytology | Interleukin-6 | DNA-Binding Proteins - metabolism | Animals | Proteins - metabolism | Spleen - metabolism | T-Lymphocytes - cytology | T-Lymphocytes - metabolism | T-Lymphocytes - immunology | Trans-Activators - metabolism | Mice | Mice, Inbred BALB C | STAT3 Transcription Factor | Forkhead Transcription Factors | Leukemia Inhibitory Factor | Transplantation Tolerance - immunology
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9. Full Text Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: Safety profile and detection kinetics
by Brunstein, Claudio G and Miller, Jeffrey S and Cao, Qing and McKenna, David H and Hippen, Keli L and Curtsinger, Julie and DeFor, Todd and Levine, Bruce L and June, Carl H and Rubinstein, Pablo and McGlave, Philip B and Blazar, Bruce R and Wagner, John E
Blood, ISSN 0006-4971, 01/2011, Volume 117, Issue 3, pp. 1061 - 1070
Acute graft-versus-host disease (aGVHD) is associated with high risk of morbidity and mortality and is a common complication after double umbilical cord blood... 
RAPAMYCIN | CYCLOSPORINE-A | BONE-MARROW ALLOGRAFTS | TOLERANCE | CLINICAL-TRIALS | GVHD | INHIBITORS | INDUCTION | FOXP3(+) | HEMATOLOGY | VERSUS-HOST-DISEASE | Cell Proliferation | Humans | Middle Aged | Cells, Cultured | Male | Treatment Outcome | Fetal Blood - cytology | Graft vs Host Disease - immunology | Transplantation, Homologous | Leukemia - classification | T-Lymphocytes, Regulatory - immunology | Young Adult | Cord Blood Stem Cell Transplantation - methods | T-Lymphocytes, Regulatory - cytology | Adult | Female | Leukemia - surgery | Aged | T-Lymphocytes, Regulatory - transplantation | Transplantation
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10. Full Text Regulatory T-cell therapy in transplantation: Moving to the clinic
by Tang, Qizhi and Bluestone, Jeffrey A
Cold Spring Harbor Perspectives in Medicine, ISSN 2157-1422, 2013, Volume 3, Issue 11, pp. a015552 - a015552
Regulatory T cells (Tregs) are essential to transplantation tolerance and their therapeutic efficacy is well documented in animal models. Moreover, human Tregs... 
MEDICINE, RESEARCH & EXPERIMENTAL | LIVER-TRANSPLANTATION | DNA METHYLATION | DENDRITIC CELLS | MESSENGER-RNA | INDIRECT ALLOSPECIFICITY | IN-VIVO | CALCINEURIN INHIBITOR | FOXP3 TRANSCRIPTION-FACTOR | EX-VIVO | VERSUS-HOST-DISEASE | Cell- and Tissue-Based Therapy - methods | Immunosuppression - methods | Graft Rejection - prevention & control | Humans | Immunosuppressive Agents - therapeutic use | Clinical Trials as Topic | Cell Separation - methods | Transplantation Tolerance - physiology | Allografts | Animals | Isoantigens - physiology | Transplantation - methods | Mice | T-Lymphocytes, Regulatory - transplantation | Adjuvants, Immunologic - therapeutic use | Disease Models, Animal | 081
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11. Full Text Effect of Ex Vivo–Expanded Recipient Regulatory T Cells on Hematopoietic Chimerism and Kidney Allograft Tolerance Across MHC Barriers in Cynomolgus Macaques
by Duran-Struuck, Raimon and Sondermeijer, Hugo P and Bühler, Leo and Alonso-Guallart, Paula and Zitsman, Jonah and Kato, Yojiro and Wu, Anette and McMurchy, Alicia N and Woodland, David and Griesemer, Adam and Martinez, Mercedes and Boskovic, Svetlan and Kawai, Tatsuo and Cosimi, A Benedict and Wuu, Cheng-Shie and Slate, Andrea and Mapara, Markus Y and Baker, Sam and Tokarz, Rafal and DʼAgati, Vivette and Hammer, Scott and Pereira, Marcus and Lipkin, W Ian and Wekerle, Thomas and Levings, Megan K and Sykes, Megan
Transplantation, ISSN 0041-1337, 02/2017, Volume 101, Issue 2, pp. 274 - 283
BACKGROUNDInfusion of recipient regulatory T (Treg) cells promotes durable mixed hematopoietic chimerism and allograft tolerance in mice receiving allogeneic... 
SURGERY | WHOLE-BODY IRRADIATION | BONE-MARROW-TRANSPLANTATION | MONOCLONAL-ANTIBODY | PERIPHERAL-BLOOD | INDUCTION | IMMUNOLOGY | ANTIBODY MAB INJECTIONS | TRANSPLANTATION | MIXED-CHIMERISM | RENAL-ALLOGRAFT | THYMIC IRRADIATION | MONKEYS | T-Lymphocytes, Regulatory - metabolism | Cell Proliferation | Transplantation Chimera - immunology | Graft Rejection - metabolism | Macaca fascicularis | Male | Cytomegalovirus Infections - immunology | Kidney Transplantation - methods | T-Lymphocytes, Regulatory - immunology | Transplantation Tolerance | Allografts | Time Factors | Bone Marrow Transplantation | Models, Animal | Transplantation Conditioning - adverse effects | Transplantation Conditioning - methods | Histocompatibility Antigens - metabolism | Biomarkers - metabolism | Histocompatibility Antigens - immunology | Antiviral Agents - therapeutic use | Graft Rejection - prevention & control | Cells, Cultured | Graft Survival | Animals | Cytomegalovirus Infections - drug therapy | T-Lymphocytes, Regulatory - transplantation | Graft Rejection - immunology | Histocompatibility | Kidney Transplantation - adverse effects | Index Medicus
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