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Journal of receptor and signal transduction research, ISSN 1079-9893, 1995
Journal
Journal of clinical oncology, ISSN 0732-183X, 05/2015, Volume 33, Issue 15, pp. 1688 - 1696
Journal Article
Neuro-signals, ISSN 1424-862X, 2002
Journal
PloS one, ISSN 1932-6203, 07/2017, Volume 12, Issue 7, p. e0179431
Cytokines are potent immune modulating agents but are not ideal medicines in their natural form due to their short half-life and pleiotropic systemic effects.... 
LIGAND-BINDING | ALPHA-RECEPTOR | MULTIDISCIPLINARY SCIENCES | LONG-TERM SAFETY | COMPLEXES | REGULATORY T-CELLS | MODULATION THERAPIES | IL-2 | CYTOKINE | HIGH-DOSE INTERLEUKIN-2 | RENAL-CELL CARCINOMA | Neoplasms - metabolism | T-Lymphocytes, Regulatory - metabolism | Immunotherapy - methods | Interleukin-2 Receptor beta Subunit - metabolism | Interleukin Receptor Common gamma Subunit - metabolism | Transplantation, Homologous | T-Lymphocytes, Regulatory - immunology | STAT5 Transcription Factor - metabolism | Neoplasms - therapy | Interleukin Receptor Common gamma Subunit - agonists | CD8-Positive T-Lymphocytes - metabolism | Female | Interleukin-2 - analogs & derivatives | Phosphorylation - drug effects | Polyethylene Glycols - pharmacology | Models, Theoretical | Tumor Microenvironment - drug effects | Interleukin-2 - pharmacokinetics | Interleukin-2 Receptor beta Subunit - agonists | Mice, Inbred C57BL | Polyethylene Glycols - pharmacokinetics | Receptors, Interleukin-2 - metabolism | Mice, Inbred C3H | Tumor Microenvironment - immunology | T-Lymphocytes, Regulatory - drug effects | Algorithms | Animals | Interleukin-2 Receptor alpha Subunit - agonists | Interleukin-2 Receptor alpha Subunit - metabolism | Prodrugs - pharmacokinetics | Neoplasms - immunology | CD8-Positive T-Lymphocytes - drug effects | Cell Line, Tumor | Drug Liberation | Interleukin-2 - pharmacology | Mice, Inbred BALB C | Kinetics | CD8-Positive T-Lymphocytes - immunology | Prodrugs - pharmacology | Receptors, Interleukin-2 - agonists | Physiological aspects | Care and treatment | Interleukin-2 | Immunotherapy | Patient outcomes | Cancer | Polyethylenes | Conjugates | CD8 antigen | Interleukin | Lymphocytes T | Anticancer properties | Proteins | Biological effects | Cell activation | Immunology | Interleukin 2 | Lymphocytes | Polyethylene glycol | Modelling | Drug dosages | Immune system | Interleukin 2 receptors | Pharmacodynamics | Cytokines | Immunoregulation | Melanoma | Pharmacology | Affinity | Ligands | Mutation | Pharmacokinetics | In vitro methods and tests | Tumors
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 2018, Volume 48, Issue 4, pp. 745 - 759.e6
.... We showed that active transforming growth factor β (TGF-β) signaling was present in naive T cells, and T cell receptor (TCR... 
signaling | T cell activation | receptor I downregulation | autoimmunity | NF-kB | TCR signaling | T cell quiescence | TGF-β | CARD11 | IL-6 | GROWTH-FACTOR-BETA | TARGETED DISRUPTION | HOMEOSTASIS | AUTOIMMUNITY | IMMUNOSUPPRESSION | TRANSCRIPTION FACTOR FOXP3 | MECHANISMS | MICE | DIFFERENTIATION | IMMUNOLOGY | NF-KAPPA-B | Cell Proliferation | Humans | Transforming Growth Factor beta1 - metabolism | Colitis - pathology | NF-kappa B - metabolism | CARD Signaling Adaptor Proteins - genetics | CD4-Positive T-Lymphocytes - immunology | Receptor, Transforming Growth Factor-beta Type I - metabolism | Signal Transduction - immunology | CARD Signaling Adaptor Proteins - metabolism | Lymphocyte Activation - immunology | Autoimmunity - immunology | HEK293 Cells | Lupus Erythematosus, Systemic - immunology | Receptors, Antigen, T-Cell - immunology | Colitis - immunology | Transforming Growth Factor beta1 - biosynthesis | Disease Models, Animal | Cell Line | Receptor, Transforming Growth Factor-beta Type I - biosynthesis | Mice, Inbred C57BL | Guanylate Cyclase - metabolism | Mice, Knockout | Animals | Down-Regulation - immunology | Interleukin-6 - immunology | Guanylate Cyclase - genetics | Mice | Mice, Inbred BALB C | Cell proliferation | NF-κB protein | Antigens | Transcription factors | Statistical analysis | Research & development--R&D | Transforming growth factor | Interleukin | Caspase | Autoantigens | Activation | Lymphocytes T | T cell receptors | Experiments | Interleukin 6 | Proteins | T-cell receptor | Mitigation | Studies | Signaling | Cell activation | Lymphocytes
Journal Article
PloS one, ISSN 1932-6203, 2018, Volume 13, Issue 6, p. e0198347
Gastric cancer is a malignancy that has a high mortality rate. Although progress has been made in the treatment of gastric cancer, many patients experience cancer recurrence and metastasis. Folate receptor 1 (FOLR1... 
FARLETUZUMAB | ACTIVATION | DOMAIN | MULTIDISCIPLINARY SCIENCES | ANTIBODY | ALPHA | PROLIFERATION | MODEL | ADOPTIVE IMMUNOTHERAPY | COLON-CARCINOMA | LYMPHOCYTES | Recombinant Fusion Proteins - immunology | Immunotherapy, Adoptive - methods | Cell Proliferation | Folate Receptor 1 - immunology | Cell Survival | Jurkat Cells | Humans | Stomach Neoplasms - therapy | T-Lymphocytes - transplantation | Stomach Neoplasms - immunology | Xenograft Model Antitumor Assays | Animals | Receptors, Chimeric Antigen - immunology | K562 Cells | Cell Line, Tumor | Receptors, Antigen, T-Cell - immunology | T-Lymphocytes - immunology | Mice | Cancer patients | Usage | Care and treatment | Antigen receptors, T cell | Receptors | Prognosis | Immunotherapy | Patient outcomes | Research | T cells | Health aspects | Stomach cancer | Clinical trials | Cytotoxicity | Lymphocytes T | Malignancy | Kinases | CD28 antigen | Cancer therapies | Cell surface | Folic acid | Metastases | Ovarian cancer | Proteins | Cell activation | Cell growth | Epidermal growth factor | Lymphocytes | Vitamin B | Natural killer cells | Gastric cancer | Antigens | Cytokines | Research & development--R&D | T cell receptors | Patients | Signaling | Chemotherapy | Major histocompatibility complex | Cell death | Pharmacy | Laboratory animals | Cancer | Tumors | Research & development | R&D
Journal Article
The Journal of experimental medicine, ISSN 1540-9538, 2013, Volume 210, Issue 9, pp. 1685 - 1693
Fc γ receptor (FcγR) coengagement can facilitate antibody-mediated receptor activation in target cells... 
MEDICINE, RESEARCH & EXPERIMENTAL | RESPONSES | MELANOMA | ANTI-GITR MAB | REGULATORY T-CELLS | COSTIMULATION | IGG1 | CANCER-IMMUNOTHERAPY | IMMUNOLOGY | BLOCKADE | BINDING | TUMOR-IMMUNITY | Brief Definitive Report
Journal Article
International immunopharmacology, ISSN 1567-5769, 2013, Volume 17, Issue 3, pp. 638 - 650
.... Neutrophils express a large number of cell surface receptors for the recognition of pathogen invasion and the inflammatory environment... 
Signaling | Receptors | Inflammation | Kinases | Neutrophils | ACTIVATED PROTEIN-KINASE | COLONY-STIMULATING FACTOR | LEUKOCYTE ADHESION DEFICIENCY | IMMUNOLOGY | SRC-FAMILY KINASES | FORMYL PEPTIDE RECEPTORS | HIGH-AFFINITY RECEPTOR | NOD-LIKE RECEPTORS | BETA-GAMMA-SUBUNIT | TOLL-LIKE RECEPTORS | PHARMACOLOGY & PHARMACY | NF-KAPPA-B | Signal Transduction - immunology | Animals | Receptors, Cell Surface - immunology | Humans | Neutrophils - immunology | Selectins - immunology | Mycoses | Lectins | Fc receptors | Integrins | FcR, Fc-receptor | GPI, glycosylphosphatidylinositol anchor | CLEC, C-type lectin | OSCAR, osteoclast-associated receptor | PKB, protein kinase B | DAG, diacyl-glycerol | Tyk2, tyrosine protein kinase 2 | VCAM-1, vascular cell adhesion molecule 1 | ICAM-1, intercellular adhesion molecule 1 | FADD, Fas-associated protein with death domain | IκB, inhibitor of NF-κB | GM-CSF, granulocyte | MyD88, myeloid differentiation protein 88 | TNF, tumor necrosis factor | LTβ, lymphotoxin β | TRADD, TNFR1-associated death domain protein | Abl, Abelson leukemia proto-oncogene | SLP-76, SH2 domain-containing leukocyte protein of 76 kDa | CALDAG-GEFI, calcium and DAG-regulated guanine nucleotide exchange factor I | IL, interleukin | Src, Rous sarcoma virus proto-oncogene | IRF, IFN regulatory factor | RIG, retinoic acid-inducible gene | PLC, phospholipase C | TCR, T-cell receptor | IKK, IκB kinase | ITAM, immunoreceptor tyrosine-based activation motif | CARD, caspase activation and recruitment domain | IP3, inositol-tris-phosphate | CHO, Chinese hamster ovary cells | MKK, MAP kinase kinase | fMLP, formly-Met-Leu-Phe | TRAF, TNF receptor-associated factor | MIP, macrophage inflammatory protein | Rac, Ras-related C3 botulinum toxin substrate | monocyte colony-stimulating factor | PIP3, phosphatidylinositol-3-phosphate | VLA-4, very late antigen 4 (α4β1 integrin) | PAF, platelet activating factor | STAT, signal transducer and activator of transcription | TAK, TGFβ-activated kinase 1 | Mac-1, macrophage antigen 1 (αMβ2 integrin) | FcRγ, Fc-receptor γ-chain | Asc, apoptosis-associated speck-like protein containing a CARD | cIAP, cellular inhibitor of apoptosis | BCR, B-cell receptor | Fgr, Gardner–Rasheed feline sarcoma proto-oncogene | VASP, vasodilator-stimulated phosphoprotein | Hck, hematopoietic cell kinase | TGFβ, transforming growth factor β | Rap, Ras-related protein | SHP-1, SH2 domain-containing protein tyrosine phosphatase 1 | Syk, spleen tyrosine kinase | GPCR, G protein-coupled receptor | G-CSF, granulocyte colony-stimulating factor | TREM, triggering receptor expressed on myeloid cells | DISC, death-inducing signaling complex | MDL-1, myeloid DAP12-associating lectin 1 | C3G, Crk SH3 domain-binding guanine nucleotide exchange factor (RapGEF1) | NF-κB, nuclear factor κB | ERM, ezrin-radixin-moesin | Epac1, exchange protein activated by cyclic AMP 1 | LTB4, leukotriene B4 | Mcl, macrophage C-type lectin | SAP130, Sin3A-associated protein of 130 kDa | SH2, Src-homology 2 domain | MAP kinase, mitogen-activated protein kinase | PSGL-1, P-selectin glycoprotein ligand | PI3K, phoshoinositide-3-kinase | ADAP, adhesion and degranulation promoting adapter protein (Fyb, SLAP-130) | NLRP3, NOD-like receptor family, pyrin domain containing 3 | MDA5, melanoma differentiation-associated protein 5 | TLR, Toll-like receptor | GRK, GPCR kinase | LAD, leukocyte adhesion deficiency | MAPKAP-kinase, MAP kinase-associated protein kinase | ZAP-70, ζ-chain-associated protein of 70 kDa | TRAIL, TNF-related apoptosis-inducing ligand | JNK, c-Jun N-terminal kinase | LFA-1, lymphocyte function-associated receptor 1 (αLβ2 integrin) | ROS, reactive oxygen species | RIP3, receptor-interacting serine-threonine protein kinase 3 | DAP12, DNAX activating protein 12 | IFN, interferon | PIR, paired immunoglobulin-like receptor | PKC, protein kinase C | PAK, p21-activated kinase | ESL-1, E-selectin ligand 1 | GAP, GTPase activating protein | ERK, extracellular signal-regulated kinase | SOCS, suppressor of cytokine signaling | JAK, Janus kinase | RANK, receptor activator of NF-κB | IRAK, IL-1 receptor-associated kinase | NOD, nucleotide-binding oligomerization domain containing protein | CEACAM3, carcinoembryonic antigen-related cell adhesion molecule 3 (CD66b)
Journal Article
BMC cancer, ISSN 1471-2407, 2017, Volume 17, Issue 1, pp. 551 - 17
Journal Article