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Fish and Shellfish Immunology, ISSN 1050-4648, 07/2019, Volume 90, pp. 80 - 90
Transforming growth factor-β-activating kinase 1 (TAK1) is essential for diverse important biological functions, such as innate immunity, development and cell... 
NF-κB | Innate immunity | TAB1 | TAK1 | Scylla paramamosain
Journal Article
Fish and Shellfish Immunology, ISSN 1050-4648, 06/2019, Volume 89, pp. 736 - 744
TAK1-binding protein 1 (TAB1) forms the protein complex with TAK1 and enhances its kinase activity in human and mammals. To elucidate the role of TAB1 in the... 
IRF7 | Interferon | TAB1 | TAK1 | Black carp
Journal Article
by Wang, L and Zhou, YL and Chen, ZJ and Sun, L and Wu, JH and Li, HH and Liu, F and Wang, F and Yang, CF and Yang, JH and Leng, QB and Zhang, QL and Xu, AJ and Shen, LS and Sun, JQ and Wu, DQ and Fang, CY and Lu, HJ and Yan, DP and Ge, BX
NATURE COMMUNICATIONS, ISSN 2041-1723, 02/2019, Volume 10
Excessive or uncontrolled release of proinflammatory cytokines caused by severe viral infections often results in host tissue injury or even death.... 
CELLS | RECOGNITION | ROLES | MULTIDISCIPLINARY SCIENCES | UBIQUITIN-DEPENDENT KINASE | TAB1 | NF-KAPPA-B | HAND | FOOT
Journal Article
Biochemical Journal, ISSN 0264-6021, 11/2006, Volume 399, Issue 3, pp. 427 - 434
TAB1 [TAK1 (transforining growth factor-beta-activated kinase 1)-binding protein 1] is one of the regulatory subunits of TAK1, a protein kinase that lies at... 
Transforming growth factor-β-activated kinase 1 (TAK1) | X-ray crystallography | Pro-inflammatory cytokine | Transforming growth factor-β-activated kinase 1-binding protein 1 (TAB1) | Protein phosphatase | PHOSPHATASE 2C | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | transforming growth factor-beta-activated kinase 1-binding protein 1 (TAB1) | KINASE KINASE KINASE | protein phosphatase | TAK1 | SIGNALING PATHWAY | transforming growth factor-beta-activated kinase 1 (TAK1) | pro-inflammatory cytokine | TAB1 | P38-ALPHA | AUTOPHOSPHORYLATION | Adaptor Proteins, Signal Transducing - chemistry | Protein Subunits | Nitrophenols - metabolism | Molecular Sequence Data | Substrate Specificity | Crystallography, X-Ray | Structure-Activity Relationship | Phosphoproteins - metabolism | Organophosphorus Compounds - metabolism | Recombinant Fusion Proteins - metabolism | Catalysis | Protein Structure, Tertiary | Amino Acid Sequence | Mutagenesis, Site-Directed | Protein Phosphatase 2C | Models, Molecular | Recombinant Fusion Proteins - chemistry | Protein Folding | Sequence Homology, Amino Acid | Adaptor Proteins, Signal Transducing - physiology | Sequence Alignment | Manganese - metabolism | Phosphoprotein Phosphatases - genetics | Adaptor Proteins, Signal Transducing - genetics | Protein Binding | Calorimetry | Protein Conformation | Phosphoprotein Phosphatases - chemistry | transforming growth factor-β-activated kinase 1-binding protein 1 (TAB1) | NFκB, nuclear factor κB | transforming growth factor-β-activated kinase 1 (TAK1) | GST, glutathione S-transferase | TNF, tumour necrosis factor | IL-1, interleukin-1 | STYX, phosphoSerine, phosphoThreonine or phosphotYrosine interACTion protein | PP2C, protein phosphatase 2C | JNK, c-Jun N-terminal protein kinase | 2, extracellular-signal-regulated kinase 1 | TAK1, transforming growth factor-β-activated kinase 1 | ERK1 | IPTG, isopropyl β-D-thiogalactoside | ITC, isothermal titration microcalorimetry | rmsd, root mean square deviation | LPS, lipopolysaccharide | TAB1, TAK1-binding protein 1 | MAPK, mitogen activated protein kinase | PPM, Mg2+- or Mn2+-dependent protein phosphatase | PTP, protein tyrosine phosphatase
Journal Article
Frontiers in Oncology, 2014, Volume 4
Defects in apoptosis regulation are one main cause of cancer development and may result from overexpression of anti-apoptotic proteins such as Inhibitor of... 
SMAC-mimetic | TAB1 | Tumor Necrosis Factor-alpha | nuclear factor kappa B | BIR domain
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2010, Volume 107, Issue 9, pp. 4188 - 4193
Patients with primary (AL) cardiac amyloidosis suffer from progressive cardiomyopathy with a median survival of less than 8 months and a 5-year survival of <... 
Heart | Oxidative stress | Phosphorylation | Myocardium | Cardiomyopathies | Amyloidosis | Amyloids | Alzheimers disease | Apoptosis | Vehicles | Heart failure | Reactive oxygen species | Amyloid | TAB1 | Cell death | heart failure | ACTIVATED PROTEIN-KINASE | cell death | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | RECEPTOR | MECHANISMS | P38 KINASE | HEART | amyloid | reactive oxygen species | INDEPENDENT ACTIVATION | STRESS
Journal Article
New Phytologist, ISSN 0028-646X, 01/2020, Volume 225, Issue 2, pp. 974 - 984
Summary Shoot branches are formed from the axillary meristem and their formation is a key process in plant development. Although our understanding of the... 
TILLERS ABSENT1 (TAB1) | WOX gene | Oryza sativa (rice) | FLORAL ORGAN NUMBER2 (FON2) | shoot branch | axillary meristem development | stem cell maintenance | tiller
Journal Article
Cancer Research, ISSN 0008-5472, 03/2008, Volume 68, Issue 5, pp. 1462 - 1470
The conversion of transforming growth factor beta (TGF-beta) from a tumor suppressor to a tumor promoter occurs frequently during mammary tumorigenesis, yet... 
APOPTOSIS | SIGNALING PATHWAYS | TGF-BETA | TAK1 | ONCOLOGY | PROTEIN-KINASE | JNK | INFLAMMATION | GENE-EXPRESSION | CELL-PROLIFERATION | TAB1
Journal Article
Journal Article
FASEB Journal, ISSN 0892-6638, 12/2018, Volume 32, Issue 12, pp. 6760 - 6770
Dual-specificity phosphatase (DUSP)14 (also known as MAP-kinase phosphatase 6) inhibits T-cell receptor (TCR) signaling and T-cell-mediated immune responses by... 
MKP6 | TCR signaling | TRAF2 | TAB1 | TAK1 | PROTEIN METHYLATION | SUPPRESSOR | ACTIVATION | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | DEFICIENCY | CELL BIOLOGY | REGULATOR | SPECIFICITY PHOSPHATASE 14 | BIOLOGY | T-CELL DEVELOPMENT | EXPRESSION | Research
Journal Article
by Zhou, YL and Wang, LZ and Gu, WB and Xu, YP and Li, B and Liu, ZP and Dong, WR and Chen, YY and Shu, MA
FISH & SHELLFISH IMMUNOLOGY, ISSN 1050-4648, 07/2019, Volume 90, pp. 80 - 90
Transforming growth factor-beta-activating kinase 1 (TAK1) is essential for diverse important biological functions, such as innate immunity, development and... 
TAK1 MAPKKK | 1ST EVIDENCE | TGF-BETA | Innate immunity | IMMUNOLOGY | IDENTIFICATION | ANTIBACTERIAL DEFENSE | FISHERIES | NF-kappa B | TAK1 | GENE | Scylla paramamosain | MARINE & FRESHWATER BIOLOGY | FUNCTIONAL-ANALYSIS | VETERINARY SCIENCES | TAB1 | ADAPTER PROTEIN | EXPRESSION
Journal Article
Cancer Biology & Therapy, ISSN 1538-4047, 05/2019, Volume 20, Issue 5, pp. 617 - 632
Triple-negative breast cancer (TNBC) has a poor prognosis mainly due to insensitivity or resistance to standard anthracycline- and taxane-based chemotherapy,... 
triple-negative breast cancer | invasion | MDMX | MDM2 | migration | TAB1 | doxorubicin resistance | STEM-CELLS | PROTEIN | METASTASIS | STATISTICS | E-CADHERIN EXPRESSION | P53 PATHWAY | EMT | TO-MESENCHYMAL TRANSITION | ONCOLOGY
Journal Article
Current Science, ISSN 0011-3891, 2017, Volume 113, Issue 11, pp. 2168 - 2174
NF kappa B activation is involved in cell survival and aberration of NF kappa B signalling is found in cancer. I kappa B is an inhibitor that sequesters NF... 
Protein complex | Cell survival | Constitutive activation | Basal activity | Cancer | TAK1 MAPKKK | CELLS | ACTIVATION | cell survival | PROTEIN | MULTIDISCIPLINARY SCIENCES | KINASE | constitutive activation | protein complex | SIGNAL-TRANSDUCTION | PATHWAY | DISEASE | cancer | TAB1
Journal Article
Genes and Development, ISSN 0890-9369, 11/2005, Volume 19, Issue 22, pp. 2668 - 2681
Journal Article
Journal Article
The EMBO Journal, ISSN 0261-4189, 11/2003, Volume 22, Issue 21, pp. 5793 - 5805
TAB1, a subunit of the kinase TAK1, was phosphorylated by SAPK2a/p38α at Ser423, Thr431 and Ser438 in vitro. TAB1 became phosphorylated at all three sites when... 
stress‐activated protein kinase | SB 203580 | TAB1 | p38 | TAK1 | Stress-activated protein kinase | ACTIVATION | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | MAMMALIAN-CELLS | P38 MAP KINASE | CELL BIOLOGY | stress-activated protein kinase | PATHWAY | IN-VIVO | BETA SIGNAL-TRANSDUCTION | SUPPRESSES | P38-ALPHA
Journal Article
Journal Article
FRONTIERS IN IMMUNOLOGY, ISSN 1664-3224, 07/2019, Volume 10, p. 1760
Galectin-3-binding protein (Gal-3BP) is a member of the family of scavenger receptor cysteine-rich (SRCR) domain-containing proteins, which are associated with... 
proinflammatory cytokine | Gal-3BP | PROTEIN | IL-1 | KINASE | SERUM | IMMUNOLOGY | IDENTIFICATION | CANCER | NF-kappa B | TAK1 | TAB1 | lipopolysaccharide | EXPRESSION | GLYCOPROTEIN 90K | TUMOR-ASSOCIATED ANTIGEN | Mitogens | Cysteine | Protein binding | NF-κB
Journal Article
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