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Expert Opinion on Investigational Drugs, ISSN 1354-3784, 08/2019, Volume 28, Issue 8, pp. 659 - 666
Introduction: Pruritus is a common symptom associated with several potential underlying causes, including both dermatologic and systemic diseases; it can also... 
serlopitant | receptor | neurokinin 1 receptor | psoriasis | prurigo nodularis | Chronic nodular prurigo | chronic pruritus | DORSAL-HORN NEURONS | DIAGNOSIS | NK1 receptor | GUIDELINES | APREPITANT | CLINICAL CHARACTERISTICS | TACHYKININ RECEPTORS | PHARMACOLOGY & PHARMACY | QUALITY-OF-LIFE | SUBSTANCE-P | ITCH-ASSOCIATED RESPONSE | EPIDEMIOLOGY
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 07/2018, Volume 366, Issue 1, pp. 136 - 144
Tachykinin neurokinin 2 (NK2) receptor agonists may have potential to alleviate clinical conditions associated with bladder and gastrointestinal underactivity... 
ANTAGONIST | TACHYKININS | PHARMACOLOGY & PHARMACY | COLON | MECHANISMS | BLADDER | SUBSTANCE-P | NEUROKININ-A
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 10/2016, Volume 118, pp. 88 - 95
Journal Article
Neuroscience Letters, ISSN 0304-3940, 10/2019, Volume 711, p. 134456
The affinity, potency, efficacy, and selectivity of the NK2 receptor agonist GR64349 ([Lys ,Gly ,-R-γ-lactam-Leu ]NKA(3–10)) at human recombinant NK2 and NK1... 
NK1 receptor | Tachykinin NK2 receptor | GR64349 | PATHWAYS | CONTRACTION | ANALOGS | COLON | BLADDER | SUBSTANCE-P | NEUROSCIENCES
Journal Article
Biological research, ISSN 0716-9760, 01/2018, Volume 51, Issue 1, pp. 14 - 8
Journal Article
Naunyn-Schmiedeberg's Archives of Pharmacology, ISSN 0028-1298, 3/2018, Volume 391, Issue 3, pp. 299 - 308
Journal Article
EUROPEAN JOURNAL OF PHARMACOLOGY, ISSN 0014-2999, 11/2016, Volume 791, pp. 274 - 283
Increasing number of genetic and cancer biology studies indicated a prominent role for tachykinin NK1 receptor (Will) in cancer cell growth and survival.... 
Aprepitant | TARGET | ANTAGONIST APREPITANT | NK-1 RECEPTOR | NEUROKININ-1 RECEPTOR | P53 | Tachykinin NK1 receptor | MELANOMA | Acute lymphoblastic leukemia | alm-6 cells | ANTITUMOR ACTION | GROWTH | PHARMACOLOGY & PHARMACY | P53 N | NF-KAPPA-B | EXPRESSION
Journal Article
Journal Article
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 11/2016, Volume 791, pp. 274 - 283
Increasing number of genetic and cancer biology studies indicated a prominent role for tachykinin NK receptor (NK R) in cancer cell growth and survival.... 
Aprepitant | Tachykinin NK1 receptor | Acute lymphoblastic leukemia | Nalm-6 cells | P53
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 06/2012, Volume 684, Issue 1-3, pp. 64 - 70
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 12/2018, Volume 115, Issue 52, pp. 13264 - 13269
The NK1 tachykinin G-protein-coupled receptor (GPCR) binds substance P, the first neuropeptide to be discovered in mammals. Through activation of NK1R,... 
ANTAGONIST | drug design | PERFORMANCE | MULTIDISCIPLINARY SCIENCES | ALGORITHM | ATOMIC CHARGES | NEUROKININ-1 RECEPTOR | FREE-ENERGIES | tachykinin receptor | IDENTIFICATION | GPCR | substance P | SUBSTANCE-P | BINDING-SITES | ligand recognition | AGONIST | Biological Sciences
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2018, Volume 115, Issue 52
The NK1 tachykinin G-protein–coupled receptor (GPCR) binds substance P, the first neuropeptide to be discovered in mammals. Through activation of NK1R,... 
drug design | GPCR | substance P | tachykinin receptor | 60 APPLIED LIFE SCIENCES | ligand recognition
Journal Article
Journal Article