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Bioorganic and Medicinal Chemistry, ISSN 0968-0896, 2016, Volume 24, Issue 18, pp. 4324 - 4338
A novel series of compounds obtained by fusing the acetylcholinesterase (AChE) inhibitor donepezil and the antioxidant melatonin were designed as... 
Melatonin | Biometal chelators | Alzheimer's disease | Antioxidant activity | Donepezil | Cholinesterase | AMYLOID-BETA AGGREGATION | OXIDATIVE STRESS | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | NEUROPROTECTIVE PROPERTIES | CHOLINESTERASE-INHIBITORS | TACRINE-TROLOX HYBRIDS | MULTIFUNCTIONAL AGENTS | ANTIOXIDANT | BIOLOGICAL EVALUATION | DUAL INHIBITORS | PHARMACOLOGICAL EVALUATION | Cholinesterase Inhibitors - toxicity | Humans | Protein Multimerization | Indoles - chemical synthesis | Cholinesterase Inhibitors - chemical synthesis | Zinc - chemistry | Piperidines - pharmacology | Butyrylcholinesterase - metabolism | Indoles - pharmacology | Piperidines - toxicity | Catalytic Domain | Iron - chemistry | Alzheimer Disease - drug therapy | Rats | Electrophorus | Indoles - toxicity | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Chelating Agents - pharmacology | Piperidines - chemical synthesis | Blood-Brain Barrier - metabolism | Antioxidants - toxicity | Melatonin - toxicity | Amyloid beta-Peptides - antagonists & inhibitors | Melatonin - analogs & derivatives | Animals | Chelating Agents - toxicity | Cholinesterase Inhibitors - pharmacology | Peptide Fragments - antagonists & inhibitors | Cell Line, Tumor | Horses | Indans - toxicity | Indans - chemical synthesis | Melatonin - chemical synthesis | Molecular Docking Simulation | Kinetics | Chelating Agents - chemical synthesis | Melatonin - pharmacology | Acetylcholinesterase - metabolism | Indans - pharmacology | Drug therapy | Analysis | Oligomers | Enzyme inhibitors | Surface active agents | Cell death
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 08/2016, Volume 118, pp. 178 - 192
Journal Article
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