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humans (34) 34
tandem diabody (34) 34
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Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2010, Volume 285, Issue 27, pp. 20844 - 20849
Journal Article
The FEBS Journal, ISSN 1742-464X, 01/2010, Volume 277, Issue 2, pp. 477 - 487
We previously reported the use of a humanized bi‐specific diabody that targets epidermal growth factor receptor and CD3 (hEx3‐Db) for cancer immunotherapy.... 
small therapeutic antibody | Fc fusion format | preparation method | bi‐specific diabody | tag‐free protein | Preparation method | Tag-free protein | Small therapeutic antibody | Bi-specific diabody | RECOMBINANT BISPECIFIC ANTIBODIES | SINGLE-CHAIN DIABODY | bi-specific diabody | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | IGG | ANTIGEN-BINDING | TUMOR-CELLS | FV FRAGMENT | CANCER-THERAPY | tag-free protein | TANDEM DIABODY | CONSTRUCTION | Rhinovirus - enzymology | Cricetulus | Protein Engineering - methods | Recombinant Fusion Proteins - pharmacology | Humans | Antibodies, Bispecific - biosynthesis | Antibodies, Bispecific - genetics | Neoplasms - therapy | Immunotherapy | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | CHO Cells | Recombinant Fusion Proteins - biosynthesis | Cricetinae | Gene Expression | Antibodies, Bispecific - pharmacology | Immunoglobulin Fc Fragments - chemistry | Recombinant Fusion Proteins - chemistry | Animals | Chromatography, Affinity | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | Antibodies, Bispecific - chemistry | Peptide Hydrolases | Immunoglobulin Fc Fragments - genetics | Rhinovirus - genetics | Viral antibodies | Prevention | Epidermal growth factor | Antibodies | Papain | Universities and colleges | Health aspects | Chromatography | Cancer | Oncology | Biochemistry | Immunology | Proteases | Research methodology
Journal Article
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 1999, Volume 293, Issue 1, pp. 41 - 56
Journal Article
PROTEIN ENGINEERING DESIGN & SELECTION, ISSN 1741-0126, 08/2010, Volume 23, Issue 8, pp. 667 - 677
Thrombopoietin receptor agonist humanized VB22B single-chain diabody (hVB22B (scFv)(2)) was found to be expressed as a mixture of two conformational isomers, a... 
conformational isomer | isomerization | DOMAIN INTERACTIONS | STABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | BISPECIFIC TANDEM DIABODY | ANTIBODY FRAGMENTS | CELL-DEATH | antibody engineering | THERAPY | RECOMBINANT | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | single-chain diabody | BINDING | RESIDUES | V-H-V-L interface
Journal Article
Journal Article
The Journal of Immunology, ISSN 0022-1767, 07/2002, Volume 169, Issue 1, pp. 137 - 144
To target NK cells against non-Hodgkin's lymphoma, we constructed a bispecific diabody (BsDb) with reactivity against both human CD19 and FcgammaRIII (CD16).... 
CYTOTOXIC T-CELLS | B-CELL LYMPHOMA | NATURAL-KILLER-CELLS | TANDEM DIABODY | IMMUNE-RESPONSES | SINGLE-CHAIN ANTIBODY | RECOMBINANT ANTIBODIES | MONOCLONAL-ANTIBODY | LOCOREGIONAL TREATMENT | IMMUNOLOGY | CD28 COSTIMULATION | Lymphoma, Non-Hodgkin - immunology | Injections, Intravenous | Antineoplastic Agents - chemical synthesis | Humans | Antibodies, Bispecific - biosynthesis | Antibody Specificity - genetics | Antigens, CD19 - genetics | Antineoplastic Agents - administration & dosage | Antibodies, Bispecific - genetics | Lymphoma, Non-Hodgkin - pathology | Receptors, IgG - metabolism | Receptors, IgG - genetics | CD3 Complex - genetics | Recombinant Proteins - chemical synthesis | Burkitt Lymphoma - immunology | Antibodies, Bispecific - administration & dosage | Killer Cells, Natural - immunology | Antineoplastic Agents - pharmacology | Tumor Cells, Cultured | Antigens, CD19 - immunology | Burkitt Lymphoma - therapy | Cell Line | Cytotoxicity, Immunologic - genetics | Drug Screening Assays, Antitumor - methods | Binding Sites, Antibody - genetics | Antibodies, Bispecific - pharmacology | Jurkat Cells | Recombinant Proteins - genetics | Receptors, IgG - immunology | Recombinant Proteins - pharmacology | Mice, SCID | Recombinant Proteins - administration & dosage | Drug Synergism | Animals | Lymphoma, Non-Hodgkin - therapy | Biosensing Techniques | CD3 Complex - immunology | Antigens, CD19 - metabolism | Mice
Journal Article
Future Oncology, ISSN 1479-6694, 06/2012, Volume 8, Issue 6, pp. 687 - 695
Tandem diabodies (TandAbs (R)) are tetravalent bispecific molecules comprised of antibody variable domains with two binding sites for each antigen.... 
CD30 | antibody | bispecific | TandAb | CD19 | Hodgkins lymphoma | non-Hodgkins lymphoma | diabody | BISPECIFIC ANTIBODIES | FC-GAMMA-RIIIA | ANTI-TARGET CELL | THERAPY | TANDEM DIABODY | ONCOLOGY | non-Hodgkin's lymphoma | TandAb (R) | LYMPHOMA | GENERATION | ACCESSORY CELLS | BINDING | T-CELLS | Hodgkin's lymphoma
Journal Article
Frontiers in Oncology, ISSN 2234-943X, 05/2017, Volume 7, Issue MAY, p. 100
To harness the cytotoxic capacity of immune cells for the treatment of solid tumors, we developed tetravalent, bispecific tandem diabody (TandAb) antibodies... 
CD3 | Tandem diabody | Immunotherapy | EGFRvIII | Affinity maturation | T cells | Glioblastoma multiforme | Bispecific antibodies | glioblastoma multiforme | tandem diabody | bispecific antibodies
Journal Article