X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (29625) 29625
Book Review (12731) 12731
Publication (4335) 4335
Book Chapter (496) 496
Conference Proceeding (175) 175
Book / eBook (70) 70
Dissertation (16) 16
Newspaper Article (16) 16
Magazine Article (11) 11
Government Document (6) 6
Reference (6) 6
Web Resource (4) 4
Data Set (3) 3
Trade Publication Article (2) 2
Presentation (1) 1
Streaming Video (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (23496) 23496
humans (18686) 18686
animals (11637) 11637
molecular targeted therapy (9467) 9467
oncology (8576) 8576
cancer (6784) 6784
targeted therapy (5730) 5730
mutation (5405) 5405
mice (5286) 5286
female (4940) 4940
antineoplastic agents - therapeutic use (3781) 3781
male (3764) 3764
biochemistry & molecular biology (3622) 3622
cell biology (3514) 3514
care and treatment (3472) 3472
targeted disruption (3452) 3452
health aspects (3417) 3417
research (3141) 3141
chemotherapy (3101) 3101
pharmacology & pharmacy (3093) 3093
genetic aspects (3063) 3063
article (3006) 3006
proteins (2792) 2792
expression (2677) 2677
analysis (2602) 2602
antineoplastic agents - pharmacology (2472) 2472
tumors (2411) 2411
gene expression (2398) 2398
signal transduction (2378) 2378
molecular targeted therapy - methods (2335) 2335
cell line, tumor (2093) 2093
review (2055) 2055
apoptosis (2030) 2030
neoplasms - drug therapy (2012) 2012
metastasis (1988) 1988
signal transduction - drug effects (1881) 1881
development and progression (1853) 1853
genetics & heredity (1765) 1765
genes (1689) 1689
prognosis (1684) 1684
mutations (1651) 1651
medicine, research & experimental (1642) 1642
medicine & public health (1639) 1639
kinases (1630) 1630
immunotherapy (1624) 1624
middle aged (1610) 1610
treatment outcome (1558) 1558
protein kinase inhibitors - therapeutic use (1555) 1555
in-vivo (1533) 1533
physiological aspects (1498) 1498
gene (1431) 1431
cancer therapies (1427) 1427
genomics (1404) 1404
adult (1390) 1390
cells (1386) 1386
aged (1385) 1385
drug therapy (1364) 1364
hematology (1364) 1364
lung cancer (1345) 1345
therapy (1343) 1343
breast cancer (1328) 1328
breast-cancer (1309) 1309
hematology, oncology and palliative medicine (1308) 1308
neoplasms - genetics (1278) 1278
targeted therapies (1276) 1276
biotechnology & applied microbiology (1275) 1275
mice, knockout (1261) 1261
phenotype (1228) 1228
multidisciplinary sciences (1221) 1221
growth-factor receptor (1203) 1203
gene-expression (1202) 1202
lung neoplasms - drug therapy (1188) 1188
melanoma (1164) 1164
open-label (1163) 1163
clinical trials as topic (1153) 1153
medicine (1153) 1153
cell lung-cancer (1141) 1141
biology (1116) 1116
disease models, animal (1111) 1111
protein kinase inhibitors - pharmacology (1104) 1104
resistance (1082) 1082
drug design (1076) 1076
clinical trials (1074) 1074
antineoplastic combined chemotherapy protocols - therapeutic use (1068) 1068
immunology (1068) 1068
neoplasms - metabolism (1066) 1066
activation (1059) 1059
phase-ii trial (1052) 1052
biomarkers (1048) 1048
neurosciences (1045) 1045
genetics (1040) 1040
gene expression regulation, neoplastic (1007) 1007
neoplasms - pathology (1004) 1004
medical research (999) 999
pathology (981) 981
lung neoplasms - genetics (969) 969
genomes (962) 962
stem cells (962) 962
research article (952) 952
survival (951) 951
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Gerstein Science - Stacks (13) 13
Online Resources - Online (2) 2
Sunnybrook Health Sciences Centre - Sunnybrook Stacks (2) 2
Collection Dvlpm't (Acquisitions) - Closed Orders (1) 1
Collection Dvlpm't (Acquisitions) - Vendor file (1) 1
Gerstein Science - Missing (1) 1
Lakeridge Health Sciences - Oshawa (1) 1
St. Michael's College (John M. Kelly) - 2nd Floor (1) 1
St. Michael's Hospital - Stacks (1) 1
UofT at Mississauga - Stacks (1) 1
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (29121) 29121
French (294) 294
German (266) 266
Japanese (168) 168
Chinese (55) 55
Russian (38) 38
Korean (25) 25
Polish (21) 21
Hungarian (17) 17
Spanish (17) 17
Czech (13) 13
Italian (4) 4
Turkish (4) 4
Portuguese (3) 3
Swedish (2) 2
Hebrew (1) 1
Slovak (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


2016, ISBN 0128044691, ix, 180 pages
Nonsense Mutation Correction in Human Diseases: An Approach for Targeted Medicine provides an introduction on genetic diseases, discusses the prevalence of... 
Genetic Diseases, Inborn | Mutation (Biology) | Genetic disorders | Nonsense mutation | Biology, life sciences
Book
Journal of Clinical Investigation, ISSN 0021-9738, 07/2014, Volume 124, Issue 7, pp. 3003 - 3015
The majority of non-small cell lung cancer (NSCLC) patients harbor EGFR-activating mutations that can be therapeutically targeted by EGFR tyrosine kinase... 
CELL LUNG-CANCER | TYROSINE KINASE INHIBITORS | BREAST-CANCER | TARGETED THERAPY | MEDICINE, RESEARCH & EXPERIMENTAL | FACTOR-RECEPTOR GENE | DIFFERENTIAL IMMUNOHISTOCHEMICAL DETECTION | ACQUIRED-RESISTANCE | E-CADHERIN | MESENCHYMAL TRANSITION | GEFITINIB RESISTANCE | Erlotinib Hydrochloride | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | Homeodomain Proteins - metabolism | Humans | Lung Neoplasms - metabolism | MicroRNAs - metabolism | Neoplasm Proteins - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Epithelial-Mesenchymal Transition | src-Family Kinases - metabolism | Antineoplastic Agents - pharmacology | Neoplasm Proteins - genetics | Lung Neoplasms - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Intercellular Signaling Peptides and Proteins - genetics | GPI-Linked Proteins - metabolism | Transcription Factors - metabolism | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Genes, erbB-1 | Animals | Mice, Nude | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Mice | MicroRNAs - genetics | Protein Kinase Inhibitors - pharmacology | Carcinoma, Non-Small-Cell Lung - drug therapy | Mutation | Quinazolines - pharmacology | GPI-Linked Proteins - genetics | Zinc Finger E-box-Binding Homeobox 1 | Care and treatment | Gene mutations | Genetic aspects | Properties | Drug resistance | Lung cancer, Non-small cell | Growth factors | Identification and classification | Proteins | Studies | Medical research | Lung cancer | Mortality | Cell cycle | Kinases | Cancer therapies | Tumors | Index Medicus | Abridged Index Medicus
Journal Article
Nature, ISSN 0028-0836, 09/2010, Volume 467, Issue 7315, pp. 596 - 599
B-RAF is the most frequently mutated protein kinase in human cancers. The finding that oncogenic mutations in BRAF are common in melanoma, followed by the... 
ACTIVATION | PATHWAY | MULTIDISCIPLINARY SCIENCES | MUTATION | KERATOACANTHOMAS | SENSITIVITY | SENESCENCE | SORAFENIB | HUMAN CANCER | PROGRESSION | BRAF(V600E) | Humans | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Macaca fascicularis | Melanoma - enzymology | Substrate Specificity | Positron-Emission Tomography | Extracellular Signal-Regulated MAP Kinases - metabolism | Indoles - administration & dosage | Neoplasm Metastasis | Melanoma - genetics | Phosphorylation - drug effects | Mutant Proteins - antagonists & inhibitors | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins B-raf - chemistry | Sulfonamides - chemistry | Mutant Proteins - genetics | Models, Molecular | Rats | Mutant Proteins - metabolism | Melanoma - pathology | Mutation - genetics | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | Indoles - adverse effects | MAP Kinase Signaling System - drug effects | Sulfonamides - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Mutant Proteins - chemistry | Alleles | Dogs | Sulfonamides - adverse effects | Indoles - therapeutic use | Indoles - chemistry | Sulfonamides - administration & dosage | Control | Gene mutations | Melanoma | Development and progression | Genetic aspects | Research | Health aspects | Protein kinases | Cancer | Proteins | Mutation | Kinases | Rodents | Index Medicus | targeted therapy | melanoma | BRAF | PLX4032 | biomarker | oncogene
Journal Article
Lung Cancer, ISSN 0169-5002, 2014, Volume 85, Issue 1, pp. 19 - 24
Abstract Aim Non-small cell lung cancer (NSCLC)-patients with an epidermal growth factor receptor ( EGFR )-mutation have median progression-free survival (PFS)... 
Hematology, Oncology and Palliative Medicine | Pulmonary/Respiratory | EGFR mutation | T790M-mutation | NSCLC | Targeted therapy | Rebiopsy | TKI-resistance | TRANSFORMATION | NONSMALL CELL | GEFITINIB | MECHANISM | ADENOCARCINOMA | ACQUIRED-RESISTANCE | DRUG-RESISTANCE | CELL LUNG-CANCER | TYROSINE KINASE INHIBITORS | ONCOLOGY | RESPIRATORY SYSTEM | KRAS | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | Lung Neoplasms - mortality | Humans | Middle Aged | Drug Resistance, Neoplasm | Male | Antineoplastic Agents - therapeutic use | Carcinoma, Non-Small-Cell Lung - diagnosis | Mutation, Missense | Molecular Targeted Therapy | Incidence | Aged, 80 and over | Adult | Female | Adenocarcinoma - genetics | Antineoplastic Agents - pharmacology | Retrospective Studies | Lung Neoplasms - genetics | Lung - pathology | Carcinoma, Non-Small-Cell Lung - genetics | Kaplan-Meier Estimate | Adenocarcinoma - drug therapy | Carcinoma, Non-Small-Cell Lung - mortality | Adenocarcinoma - diagnosis | Biopsy | Protein Kinase Inhibitors - therapeutic use | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Aged | Protein Kinase Inhibitors - pharmacology | Carcinoma, Non-Small-Cell Lung - drug therapy | Lung Neoplasms - diagnosis | Adenocarcinoma - mortality | Lung cancer, Non-small cell | Genetic aspects | Index Medicus
Journal Article
2016, ISBN 0128044691
Nonsense Mutation Correction in Human Diseases: An Approach for Targeted Medicine provides an introduction on genetic diseases, discusses the prevalence of... 
Nonsense Mediated mRNA Decay | Genetic disorders | Targeted Gene Repair | Codon, Nonsense | Mutation (Biology)
Web Resource
Journal of Clinical Investigation, ISSN 0021-9738, 06/2016, Volume 126, Issue 6, pp. 2334 - 2340
Journal Article
The Lancet Oncology, ISSN 1470-2045, 05/2018, Volume 19, Issue 5, pp. 603 - 615
Journal Article