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MARINE DRUGS, ISSN 1660-3397, 02/2019, Volume 17, Issue 2
The G protein-coupled receptor (GPCR) family of proteins comprises signaling proteins that mediate cellular responses to various hormones and... 
MOLECULAR-DYNAMICS | CHEMISTRY, MEDICINAL | Parkinson's disease | STIMULATION | dopamine agonist | DISCOVERY | MULTIPLE | PHLOROTANNINS | ALGA EISENIA-BICYCLIS | PATHWAY | TRANSACTIVATION | eckol | ECKLONIA CAVA | GPCR-targeting | BROWN ALGA
Journal Article
CHEMICO-BIOLOGICAL INTERACTIONS, ISSN 0009-2797, 09/2019, Volume 310, p. 108757
Fucoxanthin and fucosterol are archetypal lipid components of edible brown algae that provide several health benefits. Lately, their protective role in A... 
APOPTOSIS | Parkinson's disease | EISENIA-BICYCLIS | DOCKING | BIOCHEMISTRY & MOLECULAR BIOLOGY | INJURY | Fucoxanthin | IN-VITRO | INHIBITION | Fucosterol | Dopamine agonist | ALGAE | PHARMACOLOGY & PHARMACY | TOXICOLOGY | GPCR-targeting
Journal Article
PSYCHOPHARMACOLOGY, ISSN 0033-3158, 05/2003, Volume 167, Issue 2, pp. 167 - 173
Rationale: In the absence of agonists and antagonists evidencing appropriate selectivities, individual and interactive properties of D-1 and D-3 dopamine... 
behavioural topography | D-1 dopamine receptor | PSYCHIATRY | MOUSE | gene targeting | LOCOMOTOR-ACTIVITY | D-1/D-3 double knockout | KNOCK-OUT | NEUROSCIENCES | D2 RECEPTORS | D-3 dopamine receptor | ethological assessment | DEFICIENT | LINE | PHARMACOLOGY & PHARMACY | BRAIN-FUNCTION | TARGETED GENE DELETION | D-1-LIKE
Journal Article
Neuroscience, ISSN 0306-4522, 1999, Volume 91, Issue 3, pp. 911 - 924
Within the D-2-class of dopamine receptors, the D-2 and D-3 subtypes share the highest degree of similarity in their primary structure. However, the extent to... 
gene targeting | homologous recombination | dopamine metabolism | dopamine D 3 receptors | dopamine D 2 receptors | locomotion | CELLS | TYROSINE-HYDROXYLASE | PHOSPHORYLATION | HYPERACTIVITY | NEUROSCIENCES | dopamine D-2 receptors | D2 RECEPTORS | MESSENGER-RNA | dopamine D-3 receptors | H-3 7-OH-DPAT | GENE-EXPRESSION | RAT-BRAIN
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 09/2017, Volume 138, pp. 438 - 457
Journal Article
MedChemComm, ISSN 2040-2503, 12/2011, Volume 2, Issue 12, pp. 1194 - 1200
A series of 15 heterocyclic butyrophenone analogues was synthesized as potential multi-target ligands. The compounds were assayed for their in vitro human D-2... 
SEROTONIN 5-HT1A | CHEMISTRY, MEDICINAL | PHARMACOLOGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | DRUGS | SCHIZOPHRENIA | TARGETING DOPAMINE D-3 | 5-HT2A RECEPTORS | AGENTS | ANTAGONISTS | DERIVATIVES | DISCOVERY
Journal Article
Neuroscience, ISSN 0306-4522, 2000, Volume 97, Issue 3, pp. 495 - 504
The present study used mice deficient for dopamine D-2 and D-3 receptors to test whether the expression of these two members of the D-2 class of receptors is... 
calbindin | gene targeting | acetylcholinesterase | striatum | D 2-like dopamine receptors | tyrosine hydroxylase | RAT | BASAL GANGLIA | ISLANDS | D-2-like dopamine receptors | NEUROSCIENCES | D2 RECEPTORS | MONKEY | MUTANT MICE | MUTATION | NEURONS | CALCIUM CURRENTS | BRAIN
Journal Article
Neuron, ISSN 0896-6273, 2003, Volume 38, Issue 2, pp. 291 - 303
Journal Article
Pharmacology and Therapeutics, ISSN 0163-7258, 2001, Volume 91, Issue 1, pp. 63 - 83
In the past few years, a number of laboratories have used gene targeting via homologous recombination to generate mice deficient for key molecules involved in... 
Striatum | Heteroligomers | Gene targeting | Dopamine | Immediate early genes | Dopamine receptors | BASAL GANGLIA | gene targeting | DEFICIENT MICE | heteroligomers | D-3 RECEPTORS | D2 RECEPTORS | MUTANT MICE | dopamine receptors | striatum | C-FOS RESPONSES | immediate early genes | WILD-TYPE MICE | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | INSITU HYBRIDIZATION | SUBSTANCE-P | dopamine
Journal Article
Journal Article
04/2000, Volume 6, Issue 2, 12
Dopamine receptors are targets for drugs with antipsychotic potency, and they are also the primary target in the treatment of Parkinson’s disease. Molecular... 
Gene targeting | Oligomeric assembly | Homologous recombination | Dopamine receptors | oligomeric assembly | PALMITOYLATION | gene targeting | DEFICIENT MICE | AUTORECEPTOR FUNCTION | D-2 RECEPTORS | NEUROSCIENCES | CLINICAL NEUROLOGY | D2 RECEPTORS | MUTANT MICE | LACKING | dopamine receptors | homologous recombination | MESSENGER-RNA | EXPRESSION
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