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Acta Pharmacologica Sinica, ISSN 1671-4083, 11/2018, Volume 39, Issue 11, pp. 1777 - 1786
Defensins play an essential role in innate immunity. In this study, a novel recombinant beta-defensin that targets the epidermal growth factor receptor (EGFR)... 
mitochondria-mediated apoptosis | human lung carcinoma A549 cells | defensin | recombinant protein | human epidermoid carcinoma A431 cells | EGFR-targeting | human lung carcinoma H460 cells | lidamycin apoprotein | ANALOG | MEMBRANE | RECEPTOR | ANTIMICROBIAL PEPTIDES | CANCER | CHEMISTRY, MULTIDISCIPLINARY | MOLECULES | POTENT ANTITUMOR-ACTIVITY | HUMAN BETA-DEFENSIN-1 | PHARMACOLOGY & PHARMACY | BINDING | INNATE IMMUNITY | ErbB Receptors - metabolism | Apoptosis - drug effects | Humans | Recombinant Fusion Proteins - therapeutic use | Enediynes - metabolism | Antineoplastic Agents - therapeutic use | Enediynes - therapeutic use | Mitochondria - metabolism | Mitochondria - pathology | Recombinant Fusion Proteins - metabolism | beta-Defensins - therapeutic use | Antineoplastic Agents - metabolism | Xenograft Model Antitumor Assays | Aminoglycosides - metabolism | Animals | Carcinoma, Squamous Cell - drug therapy | Mice, Nude | Cell Line, Tumor | Protein Binding | Female | beta-Defensins - metabolism | Apoproteins - therapeutic use | Apoproteins - metabolism | Aminoglycosides - therapeutic use | Cell proliferation | Epidermal growth factor receptors | Toxicity | Xenotransplantation | Body weight | Cytotoxicity | Innate immunity | Lung carcinoma | Immunity | Proteins | Mitochondria | Epidermal growth factor | Defensins | Xenografts | Biocompatibility | Mice | Localization | Fusion protein | Growth factors | Cancer | Apoptosis | Tumors | Recombinant
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2011, Volume 121, Issue 12, pp. 4712 - 4721
Cushing disease is a condition in which the pituitary gland releases excessive adrenocorticotropic hormone (ACTH) as a result of an adenoma arising from the... 
NUCLEAR-LOCALIZATION | MEDICINE, RESEARCH & EXPERIMENTAL | DEPENDENT CUSHINGS-SYNDROME | GEFITINIB INDUCES APOPTOSIS | CYCLE INHIBITOR P27(KIP1) | EPIDERMAL-GROWTH-FACTOR | CORTICOTROPH TUMORS | T-BOX FACTOR | FACTOR RECEPTOR | PROGNOSTIC VALUE | MICE LACKING | ACTH-Secreting Pituitary Adenoma - drug therapy | Neoplasm Transplantation | Humans | Cell Line, Tumor - drug effects | Molecular Targeted Therapy | Pituitary ACTH Hypersecretion - drug therapy | ACTH-Secreting Pituitary Adenoma - complications | Adenoma - enzymology | Adenoma - complications | Dog Diseases - drug therapy | Dog Diseases - etiology | Secretory Rate - drug effects | Adenoma - drug therapy | Corticosterone - blood | Gene Expression Regulation, Neoplastic - drug effects | Pro-Opiomelanocortin - genetics | Adenoma - veterinary | Promoter Regions, Genetic | Pituitary ACTH Hypersecretion - etiology | ACTH-Secreting Pituitary Adenoma - veterinary | Cell Line, Tumor - enzymology | Tumor Burden | Adrenocorticotropic Hormone - secretion | Pituitary ACTH Hypersecretion - blood | Adenoma - blood | Dog Diseases - blood | ACTH-Secreting Pituitary Adenoma - blood | Animals | Mice, Nude | Protein Kinase Inhibitors - therapeutic use | Quinazolines - therapeutic use | Dogs | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Mice | Protein Kinase Inhibitors - pharmacology | ACTH-Secreting Pituitary Adenoma - enzymology | Pituitary ACTH Hypersecretion - veterinary | Quinazolines - pharmacology | Drug Screening Assays, Antitumor | Care and treatment | Pituitary gland tumors | ACTH | Drug targeting | Adenoma | Diagnosis | Research | Properties
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 05/2016, Volume 229, pp. 93 - 105
Journal Article
International Journal of Cancer, ISSN 0020-7136, 03/2002, Volume 98, Issue 3, pp. 398 - 408
Journal Article
Journal Article
Molecular Imaging and Biology, ISSN 1536-1632, 5/2008, Volume 10, Issue 3, pp. 167 - 175
Journal Article
MOLECULAR IMAGING AND BIOLOGY, ISSN 1536-1632, 05/2008, Volume 10, Issue 3, pp. 167 - 175
Journal Article
Oncogene, ISSN 0950-9232, 12/2013, Volume 32, Issue 50, pp. 5593 - 5601
Journal Article