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2014, ISBN 110766182X, Volume 9781107057999, xi, 1535 pages.
This latest Fifth Assessment Report of the Intergovernmental Panel on Climate Change (IPCC) will again form the standard scientific reference for all those... 
Environmental aspects | Greenhouse gas mitigation | Climatic changes | International cooperation | Greenhouse gases | Government policy
Book
2019, ISBN 9781717836793, 222 pages
This book by internationally-acclaimed researcher and speaker Sarah Weise will teach you the new rules for marketing and brand-building for Generation Z.... 
Psychological aspects | Generation Z | Target marketing | Marketing
Book
Circulation research, ISSN 1524-4571, 2018, Volume 122, Issue 3, pp. 489 - 505
The mTOR (mechanistic target of rapamycin) is a master regulator of several crucial cellular processes, including protein synthesis, cellular growth,... 
Heart | Mice | Cardiovascular diseases | Autophagy | Hypertrophy | MAMMALIAN TARGET | CARDIAC & CARDIOVASCULAR SYSTEMS | autophagy | ACTIVATED PROTEIN-KINASE | RAG GTPASES | hypertrophy | MYOCARDIAL-ISCHEMIA | cardiovascular diseases | DIET-INDUCED OBESITY | mice | heart | ISCHEMIA-REPERFUSION INJURY | TERM CALORIC RESTRICTION | CARDIAC-HYPERTROPHY | PERIPHERAL VASCULAR DISEASE | PROMOTES HEART-FAILURE | TUBEROUS SCLEROSIS | HEMATOLOGY | Adaptation, Physiological | Mechanistic Target of Rapamycin Complex 1 - physiology | Mechanistic Target of Rapamycin Complex 2 - physiology | Protein Biosynthesis | Humans | Stress, Mechanical | Hypoxia - metabolism | Organelle Biogenesis | Mammals - physiology | TOR Serine-Threonine Kinases - physiology | Cardiovascular Physiological Phenomena | Signal Transduction | Cell Survival | Heart Diseases - physiopathology | Mechanistic Target of Rapamycin Complex 1 - deficiency | Models, Cardiovascular | Mechanistic Target of Rapamycin Complex 2 - deficiency | Gene Expression Regulation | Cardiomegaly - physiopathology | Lipid Metabolism | Mechanistic Target of Rapamycin Complex 1 - antagonists & inhibitors | Mitochondria - metabolism | Heart Diseases - enzymology | Animals | Energy Metabolism | Heart Diseases - drug therapy | Cell proliferation | Cardiovascular system | Heart failure | Care and treatment | Analysis | Cell metabolism | Physiological aspects | Protein biosynthesis | Rapamycin | Dosage and administration | Research | Cardiopulmonary system | mTOR signaling | mTORC2 | mTORC1 | reperfusion | ischemia
Journal Article
Physics of plasmas, ISSN 1089-7674, 2018, Volume 25, Issue 3, p. 032703
Indirect drive implosion experiments on the National Ignition Facility (NIF) [E. I. Moses et al., Phys. Plasmas 16, 041006 (2009)] have now tested three... 
PHYSICS, FLUIDS & PLASMAS | TARGETS
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 44, pp. 17229 - 17239
Journal Article
ACS Chemical Biology, ISSN 1554-8929, 01/2011, Volume 6, Issue 1, pp. 47 - 60
In the 12 years since the process of RNA interference (RNAi) was first discovered, great progress has been made in understanding its mechanism and exploiting... 
siRNA or miRNA seed sequence | RISC | microRNA (miRNA) | GENOME-WIDE RNAI | BIOCHEMISTRY & MOLECULAR BIOLOGY | INNATE IMMUNE-RESPONSE | Short interfering RNA (siRNA) | FUNCTIONAL DISSECTION | MAMMALIAN-CELLS | DEPENDENT STIMULATION | SMALL INTERFERING RNAS | MESSENGER-RNAS | RNA Interference | RNAI off-target effect | GENE-EXPRESSION | C-ELEGANS | siRNA multiplicity validation | HIV-1 REPLICATION | RNA, Small Interfering - genetics | Gene Expression | Down-Regulation | Genomics | RNA, Messenger - genetics | Untranslated Regions | Validation Studies as Topic | Transcription, Genetic | MicroRNAs - genetics | RNA, Double-Stranded - chemistry | Genetic Techniques - standards | RNA, Small Interfering - metabolism | Short interfering RNA (siRNA): An endogenous or artificial (synthetic) small double strand RNA with perfect pairing of the two strands. One strand (called the guide strand) targets RISC to perfectly complementary mRNAs, resulting in endonucleolytic cleavage of the mRNA by the RISC component Ago2 | siRNA or miRNA seed sequence: The 5′ region of the guide strand of an siRNA or miRNA sequence, extending from nucleotides 2–7 (hexamer) or 2–8 (heptamer) | or mRNA decay | siRNA multiplicity validation: Validation of a gene-phenotype association by showing that the phenotype can be produced by multiple independent siRNAs that target different regions of the same mRNA | MicroRNA (miRNA): A mature endogenous small double strand RNA, often with imperfect pairing of the two strands, originating from processing of a precursor RNA molecule by cellular RNases. miRNAs target RISC complexes to sites that have imperfect sequence complementarity, and that are typically located in the 3′ untranslated region of the mRNA | RISC: The RNA-Induced Silencing Complexes are multi-protein complexes containing an Argonaute protein, a small single strand RNA and additional regulatory proteins | RNA interference: A cellular process that downregulates gene expression at a post-transcriptional step. One strand of a small double strand RNA (siRNA or miRNA) integrates in a protein complex called RISC and targets an mRNA with sequence complementarity for cleavage, translation inhibition and | RNAi off-target effect: Any effect of an RNAi-based treatment that is a consequence of reducing the expression of an unintended target
Journal Article
ACS Chemical Biology, ISSN 1554-8929, 01/2011, Volume 6, Issue 1, pp. 34 - 46
Small-molecule target identification is a vital and daunting task for the chemical biology community as well as for researchers interested in applying the... 
IMMUNOSUPPRESSANT FK506 | CYTOSOLIC BINDING-PROTEIN | CHEMICAL GENETICS | Target identification | NATURAL-PRODUCTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MAMMALIAN PROTEIN | 2D-PAGE | SILAC | FKBP12-RAPAMYCIN COMPLEX | HUMAN GROWTH-HORMONE | Degradomics | LIQUID-CHROMATOGRAPHY | Affinity chromatography | Drug affinity responsive target stability (DARTS) | MudPIT | HYDROGEN-EXCHANGE | COLCHICINE-BINDING | Small Molecule Libraries - chemistry | Chromatography, Affinity | Drug Design | Proteomics | Pharmaceutical Preparations | Proteome - chemistry | Molecular Targeted Therapy - methods | Drug Delivery Systems | Protein Binding - physiology | Drug affinity responsive target stability (DARTS): A method for target identification that relies on drug-induced protease resistance | Reviews | Affinity chromatography: Traditional method of target identification that uses immobilized small molecules to pull down binding proteins from a complex protein mixture | 2D-PAGE: A two-dimensional gel-based method that combines isoelectric focusing and SDS–PAGE to separate proteins by charge and molecular weight | Target identification: Determination of which proteins a particular small molecule binds in the cell | Degradomics: The subfield of proteomics devoted to the study of proteases and their biological substrates | SILAC: Stable isotope labeling of amino acids in cell culture | MudPIT: A gel-free proteomics technique that uses online separation of tryptic peptides by strong cation exchange and reversed-phase HPLC to analyze very complex protein mixtures by mass spectrometry
Journal Article