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JOURNAL OF PHYSIOLOGY-LONDON, ISSN 0022-3751, 02/2018, Volume 596, Issue 3, pp. 359 - 360
Journal Article
Frontiers in Physiology, ISSN 1664-042X, 2013, Volume 4, pp. 198 - 198
TASK-2 (K2P5.1) is a two-pore domain K(+) channel belonging to the TALK subgroup of the K2P family of proteins. TASK-2 has been shown to be activated by extra-... 
Central chemoception | Cell volume regulation | Bicarbonate reabsorption | K2P channels | TASK-2 channel | Chondrocytes
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 10391 - 9
The establishment of relative size of organs and structures is paramount for attaining final form and function of an organism. Importantly, variation in the... 
ISOMETRIC GROWTH | TARGET | DEFECTS | HUMAN MYOBLAST DIFFERENTIATION | REGENERATION | MULTIDISCIPLINARY SCIENCES | CALCIUM | CHANNELS | MECHANISMS | TASK-2 | CAUDAL FIN | Calcineurin | Calcineurin inhibitors | Fins | Epistasis | C-Terminus | Potassium channels | Allometry | Potassium
Journal Article
Journal Article
Pflugers Archiv European Journal of Physiology, ISSN 0031-6768, 10/2014, Volume 467, Issue 5, pp. 1043 - 1053
TASK-2 (K(2P)5) was one of the earliest members of the K-2P two-pore, four transmembrane domain K+ channels to be identified. TASK-2 gating is controlled by... 
Basolateral membrane | TASK-2 gating | Proximal tubules | ACID-BASE REGULATION | PHYSIOLOGY | ESSENTIAL COMPONENT | CRYSTAL-STRUCTURE | 2-PORE DOMAIN | EXTRACELLULAR HISTIDINE | RENAL PROXIMAL TUBULES | DOMAIN POTASSIUM CHANNELS | VOLUME REGULATION | ASCITES TUMOR-CELLS | REGULATED ANION CHANNEL
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 2016, Volume 68, Issue 17, pp. 1881 - 1894
Abstract Background Antiarrhythmic drugs are widely used to treat patients with atrial fibrillation (AF), but the mechanisms conveying their variable... 
Cardiovascular | Internal Medicine | drug targets | antiarrhythmic drugs | atrial fibrillation | electrophysiology | personalized medicine | rhythm control | POST-REPOLARIZATION REFRACTORINESS | FIBRILLATION | POSTREPOLARIZATION REFRACTORINESS | CARDIAC & CARDIOVASCULAR SYSTEMS | MECHANISMS | EXPERIMENTAL-MODEL | PLEXUS ABLATION | RANOLAZINE | TASK-1 | DRONEDARONE | K+ CHANNEL | Transcription Factors - physiology | Atrial Fibrillation - drug therapy | Anti-Arrhythmia Agents - pharmacology | Humans | Middle Aged | Gene Expression Regulation | Male | Transcription Factors - genetics | Atrial Fibrillation - physiopathology | Membrane Potentials - physiology | Homeodomain Proteins - genetics | Animals | Voltage-Gated Sodium Channel Blockers - therapeutic use | Adult | Female | Aged | Mice | Electrophysiological Phenomena | Heart Atria - physiopathology | Homeodomain Proteins - physiology | Flecainide - therapeutic use | Heart | Medical colleges | Hospitals | Atrial fibrillation | Anti-arrhythmia drugs | Cardiology | Gene expression | Pharmaceutical industry | Electric properties | Cardiac arrhythmia | Transcription factors | Sodium | Velocity | Rodents | Deoxyribonucleic acid--DNA | Index Medicus | Abridged Index Medicus | LAA, left atrial appendage | PITX2, paired like homeodomain-2 | APD, action potential duration | ERP, effective refractory period | LA, left atrium | TASK-2, TWIK-related acid-sensitive K+ channel | RMP, resting membrane potential | HEK, human embryonic kidney | Na, sodium | SNP, single nucleotide polymorphism | PRR, post-repolarization refractoriness | mRNA, messenger ribonucleic acid | Original Investigation | AAD, antiarrhythmic drug
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 11/2017, Volume 37, Issue 48, pp. 11744 - 11757
Journal Article
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, ISSN 0031-6768, 12/2013, Volume 465, Issue 12, pp. 1715 - 1726
TASK-2 (K(2P)5.1) is a background K+ channel opened by extra- or intracellular alkalinisation that plays a role in renal bicarbonate handling, central... 
ACTIVATED K+ CHANNEL | PHYSIOLOGY | TYROSINE PHOSPHORYLATION | Background conductance | 2-PORE DOMAIN | Patch-clamp | IMMATURE B-CELLS | RECEPTOR STIMULATION | VOLUME REGULATION | ASCITES TUMOR-CELLS | Cell volume regulation | COUPLED RECEPTORS | TASK-2 | BETA-GAMMA-SUBUNITS | FUNCTIONAL-CHARACTERISTICS | G protein
Journal Article
CELLS, ISSN 2073-4409, 12/2018, Volume 7, Issue 12, p. 276
Vesicle fusion is a fundamental cell biological process similar from yeasts to humans. For secretory vesicles, swelling is considered a step required for the... 
HETEROTRIMERIC G-PROTEIN | ACTIVATION | CHLORIDE CHANNELS | MEMBRANE | FUNCTIONAL INVOLVEMENT | swelling | Gi protein | CELL BIOLOGY | Aquaporin-2 | PANCREATIC ZYMOGEN GRANULES | K+-CHANNEL | PH | exocytosis | TASK-2 | SECRETORY GRANULES
Journal Article
FRONTIERS IN PHYSIOLOGY, ISSN 1664-042X, 2013, Volume 4
TASK-2 (K(2p)5.1) is a two-pore domain K+ channel belonging to the TALK subgroup of the K2p family of proteins. TASK-2 has been shown to be activated by extra-... 
PHYSIOLOGY | chondrocytes | CRYSTAL-STRUCTURE | 2-PORE DOMAIN | K-2p channels | IMMATURE B-CELLS | G-PROTEIN | cell volume regulation | DOMAIN POTASSIUM CHANNELS | central chemoception | VOLUME REGULATION | TASK-2 channel | ASCITES TUMOR-CELLS | RENAL TUBULAR-ACIDOSIS | EXTRACELLULAR PH | bicarbonate reabsorption | UP-REGULATION
Journal Article
FRONTIERS IN PHYSIOLOGY, ISSN 1664-042X, 10/2015, Volume 6
The alkaline pH activated, two pore domain K+ channel K(2P)5.1 (also known as TASK2/KCNK5) plays an important role in maintaining the resting membrane... 
cytokine production | PHYSIOLOGY | POTASSIUM CHANNELS | Ca2+ influx | MODULATORS | ULCERATIVE-COLITIS | CURRENTS | inflammatory bowel disease | background K+ channel | K(2P)5.1 | VOLUME REGULATION | GENES | TASK-2 | CD4(+) T cell | UP-REGULATION | EXPRESSION | LYMPHOCYTES
Journal Article
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1422-0067, 08/2015, Volume 16, Issue 8, pp. 16880 - 16896
Lymphocytes express potassium channels that regulate physiological cell functions, such as activation, proliferation and migration. Expression levels of... 
K(2P)5 | KCNK5 | multiple sclerosis | BIOCHEMISTRY & MOLECULAR BIOLOGY | EAE | CHEMISTRY, MULTIDISCIPLINARY | ion channels | DOMAIN POTASSIUM CHANNELS | B-CELLS | 1 | TASK2 | MULTIPLE-SCLEROSIS | VOLUME REGULATION | potassium channels | autoimmune neuroinflammation | PH | TASK-2 | K2P channels | K+ CHANNEL | UP-REGULATION | T-LYMPHOCYTES
Journal Article
Journal Article