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Molecular Cell, ISSN 1097-2765, 10/2017, Volume 68, Issue 1, pp. 118 - 129.e5
Journal Article
Molecular Cell, ISSN 1097-2765, 10/2017, Volume 68, Issue 1, pp. 130 - 143.e5
Journal Article
Science, ISSN 0036-8075, 12/2006, Volume 314, Issue 5805, pp. 1565 - 1568
Journal Article
Molecular Cell, ISSN 1097-2765, 07/2004, Volume 15, Issue 1, pp. 95 - 105
The expression of polyglutamine-expanded mutant proteins in Huntington's disease and other neurodegenerative disorders is associated with the formation of... 
NEURONAL INTRANUCLEAR INCLUSIONS | YEAST | EXPANDED POLYGLUTAMINE | SCA1 MICE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISEASE | BODY FORMATION | HUNTINGTIN | EXPRESSION | BINDING | AGGREGATION | CELL BIOLOGY | Molecular Chaperones - metabolism | Exons | Neurodegenerative Diseases - etiology | Peptides - genetics | TATA-Box Binding Protein - metabolism | Nerve Tissue Proteins - toxicity | Cell Nucleus - metabolism | Peptides - metabolism | TATA-Box Binding Protein - genetics | Trans-Activators - genetics | Nuclear Proteins - genetics | CREB-Binding Protein | Molecular Chaperones - genetics | HSP70 Heat-Shock Proteins - genetics | Neurodegenerative Diseases - genetics | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Neurodegenerative Diseases - metabolism | Transcription Factors - genetics | Mutation - genetics | Nerve Tissue Proteins - genetics | Nuclear Proteins - toxicity | Protein Folding | HSP70 Heat-Shock Proteins - metabolism | Macromolecular Substances | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Animals | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Trinucleotide Repeat Expansion - genetics | Protein Conformation | Trans-Activators - metabolism | Mice | TATA-Box Binding Protein - antagonists & inhibitors | Trans-Activators - antagonists & inhibitors | Saccharomyces cerevisiae | Oligomers | Nervous system diseases | DNA binding proteins
Journal Article
Journal Article
Science, ISSN 0036-8075, 2/2008, Volume 319, Issue 5866, pp. 1092 - 1096
Mammalian telomeres are protected by a six-protein complex: shelterin. Shelterin contains two closely related proteins (TRF1 and TRF2), which recruit various... 
Proteins | Telomeres | Colors | Atomic interactions | Amino acids | Reports | Grants | Electrostatics | Binding sites | Crystal structure | COMPLEX | DNA | INTERACTS | MULTIDISCIPLINARY SCIENCES | POLYMERASE | APOLLO | TIN2 | Humans | Molecular Sequence Data | Telomeric Repeat Binding Protein 1 - metabolism | Crystallography, X-Ray | TATA Box Binding Protein-Like Proteins - metabolism | Telomeric Repeat Binding Protein 1 - chemistry | Telomere-Binding Proteins - genetics | Inhibitor of Apoptosis Proteins - chemistry | TATA Box Binding Protein-Like Proteins - genetics | Tumor Suppressor Proteins - chemistry | TATA Box Binding Protein-Like Proteins - chemistry | Inhibitor of Apoptosis Proteins - metabolism | Nuclear Proteins - genetics | Telomere-Binding Proteins - metabolism | Dimerization | Protein Structure, Tertiary | Amino Acid Sequence | Tumor Suppressor Proteins - metabolism | Protein Structure, Secondary | Telomeric Repeat Binding Protein 2 | Models, Molecular | Mutant Proteins - metabolism | Nuclear Proteins - metabolism | Nuclear Proteins - chemistry | Amino Acid Motifs | Hydrogen Bonding | Mutant Proteins - chemistry | Hydrophobic and Hydrophilic Interactions | Protein Binding | Protein Conformation | Telomere-Binding Proteins - chemistry | Cellular proteins | Evaluation | Thyrotropin releasing factor | Influence | Properties | Protein binding | Protons | Biochemistry
Journal Article
Molecular Cell, ISSN 1097-2765, 08/2017, Volume 67, Issue 4, pp. 594 - 607.e4
Pervasive transcription initiates from cryptic promoters and is observed in eukaryotes ranging from yeast to mammals. The Set2-Rpd3 regulatory system prevents... 
Sir3 | pervasive transcription | polycomb | Ino80 | promoter | Mot1 | NC2 | silencing | heterochromatin | RNA-POLYMERASE-II | TATA-BINDING PROTEIN | SET2 METHYLATION | ANTISENSE TRANSCRIPTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | NUCLEOSOME-FREE REGIONS | HISTONE EXCHANGE | CHROMATIN REMODELERS | CELL-DIFFERENTIATION | SILENT CHROMATIN | READTHROUGH TRANSCRIPTION | CELL BIOLOGY | TATA-Binding Protein Associated Factors - metabolism | Saccharomyces cerevisiae - genetics | Phosphoproteins - metabolism | Silent Information Regulator Proteins, Saccharomyces cerevisiae - genetics | TATA-Box Binding Protein - metabolism | Transfection | Heterochromatin - metabolism | RNA Interference | TATA-Box Binding Protein - genetics | Transcription, Genetic | Euchromatin - genetics | Binding Sites | Repressor Proteins - metabolism | Gene Expression Regulation, Fungal | Cell Line | Promoter Regions, Genetic | Silent Information Regulator Proteins, Saccharomyces cerevisiae - metabolism | Gene Silencing | Adenosine Triphosphatases - metabolism | Repressor Proteins - genetics | Embryonic Stem Cells - enzymology | Genotype | Phosphoproteins - genetics | Saccharomyces cerevisiae Proteins - genetics | Transcription Factors - genetics | TATA-Binding Protein Associated Factors - genetics | Euchromatin - metabolism | Transcription Factors - metabolism | Phenotype | Heterochromatin - genetics | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Saccharomyces cerevisiae - enzymology | Adenosine Triphosphatases - genetics | Medical colleges | Control systems | Chromatin | Genetic transcription | Embryonic stem cells | Protein binding | Anopheles | Promoter | Heterochromatin | Pervasive Transcription | Polycomb | Silencing
Journal Article
Molecular Cell, ISSN 1097-2765, 11/2016, Volume 64, Issue 4, pp. 815 - 825
The five-subunit yeast Paf1 complex (Paf1C) regulates all stages of transcription and is critical for the monoubiquitylation of histone H2B (H2Bub), a... 
transcription elongation | Bre1 | Rad6 | Paf1 complex | H2B ubiquitylation | Rtf1 | histone modifications | chromatin | RNA Polymerase II | RNA-POLYMERASE-II | RECRUITMENT | STRUCTURAL BASIS | HUMAN-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | H3K4 METHYLATION | GENE-EXPRESSION | TUMOR-SUPPRESSOR | CRYPTIC TRANSCRIPTION | SACCHAROMYCES-CEREVISIAE | TRANSCRIPTIONAL ELONGATION | CELL BIOLOGY | Formaldehyde - chemistry | Histones - chemistry | Saccharomyces cerevisiae - genetics | Crystallography, X-Ray | RNA Polymerase II - metabolism | Ubiquitin-Conjugating Enzymes - chemistry | TATA-Box Binding Protein - metabolism | Saccharomyces cerevisiae - metabolism | Ubiquitination | TATA-Box Binding Protein - genetics | Transcription, Genetic | Protein Interaction Domains and Motifs | Transcriptional Elongation Factors - genetics | TATA-Box Binding Protein - chemistry | Nuclear Proteins - genetics | Binding Sites | Gene Expression Regulation, Fungal | Recombinant Proteins - metabolism | Protein Conformation, alpha-Helical | Cross-Linking Reagents - chemistry | Chromosomal Proteins, Non-Histone - metabolism | Models, Molecular | Recombinant Proteins - chemistry | Nuclear Proteins - metabolism | Ubiquitin-Conjugating Enzymes - genetics | Recombinant Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | Amino Acid Motifs | Chromosomal Proteins, Non-Histone - genetics | Transcriptional Elongation Factors - metabolism | Histones - genetics | Ubiquitin-Conjugating Enzymes - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | RNA Polymerase II - genetics | Histones - metabolism | Saccharomyces cerevisiae Proteins - chemistry | Ubiquitin | Medical colleges | Crosslinked polymers | Chromatin | Developmental biology | Analysis | Crystals | Structure | RNA | Genetic transcription | BASIC BIOLOGICAL SCIENCES
Journal Article
Molecular Cell, ISSN 1097-2765, 09/2015, Volume 59, Issue 5, pp. 755 - 767
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 1782, Volume 289, Issue 21, pp. 14981 - 14995
Transcription by RNA polymerase II (Pol II) in eukaryotes requires the Mediator complex, and often involves chromatin remodeling and histone eviction at active... 
TRANSCRIPTIONAL ACTIVATION | COMPLEX | DISASSEMBLY RATHER | CHROMATIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | SWI/SNF | PHO5 PROMOTER | CHAPERONE ASF1 | SRB MEDIATOR | SACCHAROMYCES-CEREVISIAE | Chromatin - metabolism | Basic-Leucine Zipper Transcription Factors - metabolism | Mediator Complex - metabolism | Saccharomyces cerevisiae - genetics | Transcriptional Activation | RNA Polymerase II - metabolism | Promoter Regions, Genetic - genetics | TATA-Box Binding Protein - metabolism | DNA-Binding Proteins - metabolism | Saccharomyces cerevisiae - metabolism | Chromatin Immunoprecipitation | TATA-Box Binding Protein - genetics | Transcription Initiation, Genetic | Nuclear Proteins - genetics | Chromosomal Proteins, Non-Histone - metabolism | Chromatin Assembly and Disassembly | Nucleosomes - metabolism | Mediator Complex - genetics | Nuclear Proteins - metabolism | Nucleosomes - genetics | Basic-Leucine Zipper Transcription Factors - genetics | Saccharomyces cerevisiae Proteins - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Chromosomal Proteins, Non-Histone - genetics | Transcription Factors - metabolism | Blotting, Northern | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | RNA Polymerase II - genetics | Histones - metabolism | Mutation | Chromatin - genetics | Gene Regulation | Gene Transcription | Transcription Coactivators | Chromatin Remodeling | Transcription | Swi | Yeast Genetics | Snf Complex | Nucleosome | Mediator | Chromatin Immunoprecipitation (ChiP) | Saccharomyces Cerevisiae
Journal Article
The FEBS Journal, ISSN 1742-464X, 02/2017, Volume 284, Issue 4, pp. 615 - 633
In Schizosaccharomyces pombe , ribosomal protein gene ( RPG ) promoters contain a TATA box analog, the HomolD box, which is bound by the Rrn7 protein. Despite... 
Schizosaccharomyces pombe | ribosomal protein | RNA | general transcription factor | HomolD | polymerase | RNA polymerase II | FISSION YEAST | DEPENDENT TRANSCRIPTION | HUMAN COACTIVATOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING-PROTEIN | CORE PROMOTERS | IN-VITRO | BASAL TRANSCRIPTION | TATA-LESS PROMOTERS | TRANSCRIPTION FACTOR | MEDIATOR COMPLEX | Transcription Factor TFIIB - metabolism | Mediator Complex - metabolism | Transcription Factor TFIIB - genetics | RNA Polymerase II - metabolism | Ribosomal Proteins - metabolism | TATA-Box Binding Protein - metabolism | Schizosaccharomyces - genetics | Pol1 Transcription Initiation Complex Proteins - genetics | TATA-Box Binding Protein - genetics | Pol1 Transcription Initiation Complex Proteins - metabolism | Cloning, Molecular | Escherichia coli - metabolism | Transcription, Genetic | Binding Sites | Transcription Factor TFIIA - metabolism | Gene Expression Regulation, Fungal | Recombinant Proteins - metabolism | Promoter Regions, Genetic | Gene Expression | Ribosomal Proteins - genetics | Mediator Complex - genetics | Recombinant Proteins - genetics | Fungal Proteins - genetics | Schizosaccharomyces - metabolism | Transcription Factors, TFII - genetics | Escherichia coli - genetics | TATA Box | Protein Binding | Transcription Factor TFIIA - genetics | Transcription Factors, TFII - metabolism | RNA Polymerase II - genetics | Fungal Proteins - metabolism | Genetic research | Genetic transcription | DNA binding proteins | Genes | Protein binding | Proteins | Yeast | RNA polymerase | Gene expression
Journal Article