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taurine/alpha-ketoglutarate dioxygenase (158) 158
biochemistry & molecular biology (61) 61
index medicus (60) 60
chemistry, multidisciplinary (57) 57
escherichia-coli (49) 49
chemistry, inorganic & nuclear (48) 48
enzymes (41) 41
oxygen activation (41) 41
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iron - chemistry (37) 37
alpha-ketoglutarate (35) 35
crystal-structure (35) 35
iron (35) 35
chemical properties (32) 32
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analysis (29) 29
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hydroxylation (29) 29
spin fe complex (29) 29
nonheme iron enzymes (26) 26
2-his-1-carboxylate facial triad (25) 25
oxygen - chemistry (25) 25
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mixed function oxygenases - chemistry (18) 18
nonheme iron proteins - chemistry (18) 18
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oxidation (15) 15
oxygen (15) 15
protein conformation (15) 15
activation (14) 14
ketoglutaric acids - chemistry (14) 14
mixed function oxygenases - metabolism (14) 14
structure (14) 14
c-h hydroxylation (13) 13
density functional calculations (13) 13
density-functional theory (13) 13
ferrous active-site (13) 13
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intermediate (13) 13
proteins (13) 13
4-hydroxyphenylpyruvate dioxygenase (12) 12
biosynthesis (12) 12
dioxygenases - chemistry (12) 12
heme (12) 12
isopenicillin-n-synthase (12) 12
oxygenases - chemistry (12) 12
protein binding (12) 12
spectroscopic characterization (12) 12
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dioxygenase (11) 11
oxidative demethylation (11) 11
oxygenase (11) 11
animals (10) 10
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clavaminate synthase (10) 10
hydrogen-atom abstraction (10) 10
ketoglutaric acids - metabolism (10) 10
molecular conformation (10) 10
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density functional theory (9) 9
density functionals (9) 9
dioxygenases - metabolism (9) 9
fe-iv=o (9) 9
fe-iv=o complex (9) 9
high-valent iron (9) 9
hydrogen bonding (9) 9
iron-oxo complexes (9) 9
nonheme iron proteins - metabolism (9) 9
oxidases (9) 9
spin fe intermediate (9) 9
alkane hydroxylation (8) 8
coupled electron-transfer (8) 8
cysteine dioxygenase (8) 8
deacetoxycephalosporin-c-synthase (8) 8
enzym (8) 8
heme - chemistry (8) 8
methane monooxygenase (8) 8
nonheme iron (8) 8
amino acid sequence (7) 7
bacterial proteins - chemistry (7) 7
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Archives of Biochemistry and Biophysics, ISSN 0003-9861, 2005, Volume 433, Issue 1, pp. 117 - 128
4-Hydroxyphenylpyruvate dioxygenase (HPPD) is an Fe(II)-dependent, non-heme oxygenase that catalyzes the conversion of 4-hydroxyphenylpyruvate to... 
Oxygenase | Dioxygenase | 4-Hydroxyphenylpyruvate | Molecular Oxygen | Ferrous | Inhibitor | Activation | Iron | Non-heme | Review | Alpha-keto acid | non-heme | oxygenase | FERROUS ACTIVE-SITE | PHENYLALANINE-HYDROXYLASE | 4-hydroxyphenylpyruvate | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | dioxygenase | ALPHA-KETOGLUTARATE | P-HYDROXYPHENYLPYRUVATE DIOXYGENASE | TAURINE/ALPHA-KETOGLUTARATE DIOXYGENASE | ISOPENICILLIN N-SYNTHASE | BIOPHYSICS | inhibitor | review | TYROSINEMIA TYPE-I | alpha-keto acid | iron | PROLYL HYDROXYLASE REACTION | activation | molecular oxygen | ferrous | 4-Hydroxyphenylpyruvate Dioxygenase - antagonists & inhibitors | Models, Structural | Humans | Substrate Specificity | Holoenzymes - chemistry | 4-Hydroxyphenylpyruvate Dioxygenase - isolation & purification | Homogentisic Acid - metabolism | Holoenzymes - metabolism | Enzyme Inhibitors - chemistry | Homogentisic Acid - chemistry | Oxygen - chemistry | Spectrum Analysis, Raman | Ferrous Compounds - chemistry | Molecular Structure | Catalysis | 4-Hydroxyphenylpyruvate Dioxygenase - chemistry | Binding Sites | Protein Structure, Tertiary | 4-Hydroxyphenylpyruvate Dioxygenase - metabolism | Enzyme Inhibitors - metabolism | Hydroxylation | Oxidation-Reduction | Enzyme Inhibitors - pharmacology | Models, Molecular | Tyrosine - metabolism | Pseudomonas fluorescens - enzymology | Ferrous Compounds - metabolism | Protein Binding | Streptomyces - enzymology | Enzyme Activation | Kinetics
Journal Article
Coordination Chemistry Reviews, ISSN 0010-8545, 01/2013, Volume 257, Issue 2, pp. 541 - 563
► The Cupin fold provides metal binding motif plasticity. ► The 2-His binding motif offers a platform for halogenations. ► The 3-His binding motif affects the... 
Metal binding motif | Dioxygenase | Structure–function relationships | Facial triad | Enzyme catalysis | Dioxygen activation | Structure-function relationships | RING-CLEAVING DIOXYGENASES | MOUSE CYSTEINE DIOXYGENASE | TAURINE/ALPHA-KETOGLUTARATE DIOXYGENASE | METHIONINE SALVAGE PATHWAY | CHEMISTRY, INORGANIC & NUCLEAR | PSEUDOMONAS-PAUCIMOBILIS TMY1009 | NONHEME IRON ENZYMES | 2-HIS-1-CARBOXYLATE FACIAL TRIAD | ELECTRON-PARAMAGNETIC-RESONANCE | CYANOBACTERIUM LYNGBYA-MAJUSCULA | CONTAINING QUERCETIN 2,3-DIOXYGENASE | Enzymes | Taurine | Flavonoids | Cysteine | Peptides | Flavones | Bioflavonoids | Collateralized debt obligations | TauD, taurine hydroxylase | acac, acetylacetone (2,4-pentanedione) | BsQDO, quercetin 2,3-dioxygenase from Bacillus subtilis | 2OH-1,3-Ph2PD, 2-hydroxy-1,3-diphenylpropanedione | CS2, clavaminate synthase | 6-Ph2TPA, N,N-bis[(6-phenyl-2-pyridyl)methyl]-N-[(2-pyridyl)-methyl]amine | QDO, quercetin 2,3-dioxygenase | MNHEs, mononuclear non-heme-Fe(II) dependent enzymes | EPR, electron paramagnetic resonance | XAS, X-ray absorption spectroscopy | Review | Dke1, diketone dioxygenase | ADO, cysteamine dioxygenase | GDO, gentisate 1,2-dioxygenase | fla, flavonolate | SDO, salicylate 1,2-dioxygenase | HNDO, hydroxy-2-naphthoate dioxygenase | CDO, cysteine dioxygenase | HADO, 3-hydroxyanthranilate 3,4-dioxygenase | HGDO, homogentisate 1,2-dioxygenase | NRP, nonribosomal peptide | EXAFS, extended X-ray absorption fine structure spectroscopy | α-KG, α-ketoglutarate | DFT, density functional theory | CarOs, carotenoid oxygenases | MCD, magnetic circular dichroism | AO, apocarotenoid 15,15′-oxygenase | ARD, aci-reductone dioxygenase | PDB, protein data bank | CGDO, 5-chloro-gentisate 1,2-dioxygenase | OTf-, trifluormethanesulfonate | 1,3-bis(2-pyridylimino)isoindoline, ind | CD, circular dichroism
Journal Article
JOURNAL OF PHYSICAL CHEMISTRY B, ISSN 1520-6106, 09/2019, Volume 123, Issue 37, pp. 7785 - 7793
2-Oxoglutarate (20G)-dependent dioxygenases catalyze C-H activation while performing a wide range of chemical transformations. In contrast to their heme... 
HEME | CRYSTAL-STRUCTURE | ENZYMES | CHEMISTRY, PHYSICAL | ALPHA-KETOGLUTARATE | DIRECT ELECTROCHEMISTRY | TAURINE/ALPHA-KETOGLUTARATE DIOXYGENASE | INFRARED-SPECTROSCOPY | BINDING | ELECTRON-TRANSFER REACTIONS | COPPER PROTEIN
Journal Article
BIOCHEMISTRY, ISSN 0006-2960, 10/2019, Volume 58, Issue 41, pp. 4218 - 4223
Iron(II)- and 2-(oxo)-glutarate-dependent (Fe/2OG) oxygenases catalyze a diverse array of oxidation reactions via a common iron(IV)-oxo (ferryl) intermediate.... 
OXYGEN ACTIVATION | COMPLEX | PSEUDOMONAS-PUTIDA | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | REACTIVITY | DEPENDENT DIOXYGENASE | INTERMEDIATE | HALOGENASE | TAURINE/ALPHA-KETOGLUTARATE DIOXYGENASE | PROTEINS
Journal Article
Physical Chemistry Chemical Physics, ISSN 1463-9076, 2017, Volume 19, Issue 30, pp. 20188 - 20197
Herein, we use in-protein quantum mechanical/molecular mechanical (QM/MM) calculations to elucidate the mechanism of dioxygen activation, oxygen atom exchange... 
DEPENDENT DIOXYGENASES | NONHEME IRON ENZYMES | SPECTROSCOPIC EVIDENCE | 2-HIS-1-CARBOXYLATE FACIAL TRIAD | PHYSICS, ATOMIC, MOLECULAR & CHEMICAL | CHEMISTRY, PHYSICAL | ALPHA-KETOGLUTARATE | MECHANICS/MOLECULAR MECHANICS | CRYSTAL-STRUCTURES | TAURINE/ALPHA-KETOGLUTARATE DIOXYGENASE | DNA-REPAIR | SPIN FE(IV) COMPLEX
Journal Article
Physical chemistry chemical physics : PCCP, ISSN 1463-9076, 08/2017, Volume 19, Issue 30, pp. 20188 - 20197
Herein, we use in-protein quantum mechanical/molecular mechanical (QM/MM) calculations to elucidate the mechanism of dioxygen activation, oxygen atom exchange... 
Catalytic Domain | Dioxygenases - metabolism | Dioxygenases - chemistry | Oxidation-Reduction | Spectroscopy, Mossbauer | Iron - chemistry | Molecular Conformation | Models, Molecular | Substrate Specificity | Isomerism | Oxygen - metabolism | Thermodynamics | Quantum Theory | Oxygen - chemistry
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 03/2010, Volume 107, Issue 9, pp. 3982 - 3987
Journal Article
BIOCHEMISTRY, ISSN 0006-2960, 12/2013, Volume 52, Issue 51, pp. 9104 - 9119
Cysteine dioxygenase (CDO) is a non-heme iron enzyme that catalyzes the O-2-dependent oxidation of L-cysteine (L-Cys) to produce cysteinesulfinic acid (CSA).... 
ACTIVATION | ELECTRON-PARAMAGNETIC-RESONANCE | ACTIVE-SITE | SELF-HYDROXYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | SUPEROXIDE REDUCTASE | INTERMEDIATE | BASIS-SETS | IRON | TAURINE/ALPHA-KETOGLUTARATE DIOXYGENASE | BOND
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2015, Volume 290, Issue 34, pp. 20702 - 20711
Mononuclear non-hemeFe(II)-and 2-oxoglutarate (2OG)-dependent oxygenases comprise a large family of enzymes that utilize an Fe(IV)-oxo intermediate to initiate... 
CARBAPENEM BIOSYNTHESIS | FACIAL TRIAD | SPECTROSCOPIC EVIDENCE | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALPHA-KETOGLUTARATE | ALIPHATIC HALOGENASE | TAURINE/ALPHA-KETOGLUTARATE DIOXYGENASE | HYOSCYAMINE 6-BETA-HYDROXYLASE |