X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
tbk1 (226) 226
index medicus (188) 188
humans (116) 116
animals (98) 98
activation (96) 96
phosphorylation (77) 77
protein-serine-threonine kinases - metabolism (76) 76
immunology (65) 65
interferon (61) 61
mice (60) 60
cell biology (59) 59
nf-kappa-b (59) 59
biochemistry & molecular biology (57) 57
innate immunity (56) 56
protein-serine-threonine kinases - genetics (49) 49
signal transduction (49) 49
autophagy (38) 38
ikk-epsilon (36) 36
inflammation (33) 33
cell line (31) 31
biological response modifiers (30) 30
hek293 cells (30) 30
proteins (30) 30
article (28) 28
irf3 (27) 27
optineurin (27) 27
rig-i (27) 27
interferon regulatory factor-3 - metabolism (26) 26
kinases (26) 26
protein binding (26) 26
recognition (26) 26
mutation (25) 25
protein (25) 25
cancer (24) 24
expression (24) 24
neurosciences (24) 24
female (23) 23
immunity, innate (23) 23
male (23) 23
binding kinase 1 (22) 22
analysis (21) 21
gene expression (21) 21
viruses (21) 21
amyotrophic lateral sclerosis (20) 20
genetic aspects (20) 20
health aspects (20) 20
mice, inbred c57bl (20) 20
amino acid sequence (19) 19
amyotrophic-lateral-sclerosis (19) 19
immune response (18) 18
research (18) 18
rna (18) 18
sting (18) 18
toll-like receptors (18) 18
ubiquitin (18) 18
binding (17) 17
fisheries (17) 17
protein-serine-threonine kinases - antagonists & inhibitors (17) 17
research article (17) 17
identification (16) 16
ikkε (16) 16
induction (16) 16
macrophages (16) 16
mutations (16) 16
oncology (16) 16
tank (16) 16
amyotrophic lateral sclerosis - genetics (15) 15
antiviral response (15) 15
cytokines (15) 15
frontotemporal dementia (15) 15
gene (15) 15
i-kappa b kinase - metabolism (15) 15
multidisciplinary sciences (15) 15
nf-kappa b (15) 15
nf-κb (15) 15
pathway (15) 15
signaling pathway (15) 15
tank-binding kinase 1 (15) 15
veterinary sciences (15) 15
virology (15) 15
biology (14) 14
dendritic cells (14) 14
gene-expression (14) 14
immunity (14) 14
marine & freshwater biology (14) 14
pharmacology & pharmacy (14) 14
receptors (14) 14
transcription factors (14) 14
ubiquitination (14) 14
virus diseases (14) 14
aged (13) 13
als (13) 13
biophysics (13) 13
cells, cultured (13) 13
dementia (13) 13
dna (13) 13
genes (13) 13
interferon regulatory factor-3 - genetics (13) 13
pattern-recognition receptors (13) 13
protein-serine-threonine kinases - immunology (13) 13
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2018, Volume 61, Issue 2, pp. 583 - 598
Proteolysis targeting chimeras (PROTACs) are bifunctional molecules that recruit an E3 ligase to a target protein to facilitate ubiquitination and subsequent... 
SMALL-MOLECULE PROTACS | COMPLEX | CHEMISTRY, MEDICINAL | TBK1 | THERAPY | PROTEIN-DEGRADATION | CLINICAL CANDIDATES | STRATEGY | INHIBITORS | CANCER | E3 UBIQUITIN LIGASE
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2011, Volume 286, Issue 41, pp. 35663 - 35674
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 02/2014, Volume 111, Issue 5, pp. E601 - E610
Journal Article
Expert Opinion on Therapeutic Targets, ISSN 1472-8222, 05/2019, Volume 23, Issue 5, pp. 437 - 446
Introduction: TANK-binding kinase 1 (TBK1) is vital for the induction of antiviral innate immune responses. Both RNA and DNA viral infection induces TBK1... 
antiviral drugs | TBK1 | TBK1 regulation | innate immune response | virus | viral diseases | DOUBLE-STRANDED-RNA | CYCLIC GMP-AMP | IFN-BETA PRODUCTION | I-INTERFERON | RIG-I | CYTOSOLIC DNA | NEGATIVE REGULATOR | INTERFERON ANTIVIRAL RESPONSE | PHARMACOLOGY & PHARMACY | NF-KAPPA-B | INNATE IMMUNITY
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 12/2019, Volume 116, Issue 49, pp. 24517 - 24526
Exonic DNA sequence variants in the Tbk1 gene associate with both sporadic and familial amyotrophic lateral sclerosis (ALS). Here, we examine functional... 
STRUCTURAL INSIGHTS | ACTIVATION | PHOSPHORYLATION | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | ALS | dimerization | AMYOTROPHIC-LATERAL-SCLEROSIS | AUTOPHAGY | OPTINEURIN | PROTEOSTASIS | kinase | TBK1 | mutations | GENE-EXPRESSION
Journal Article
Hepatology, ISSN 0270-9139, 10/2018, Volume 68, Issue 4, pp. 1331 - 1346
Obesity commonly leads to hepatic steatosis, which often provokes lipotoxic injuries to hepatocytes that cause nonalcoholic steatohepatitis (NASH). NASH, in... 
OXIDATIVE STRESS | OBESITY | ACTIVATION | TBK1 | P62/SQSTM1 | FATTY LIVER | NONALCOHOLIC STEATOHEPATITIS | MECHANISMS | AUTOPHAGY | GASTROENTEROLOGY & HEPATOLOGY | P62 | Index Medicus
Journal Article
ARTHRITIS & RHEUMATOLOGY, ISSN 2326-5191, 07/2017, Volume 69, Issue 7, pp. 1495 - 1501
Objective. Gain-of-function mutations in TMEM173, encoding the stimulator of interferon (IFN) genes (STING) protein, underlie a novel type I interferonopathy... 
IMMUNITY | TBK1 | IKK-EPSILON | TREX1 | DISEASE | MUTATIONS | RHEUMATOLOGY | VASCULOPATHY | RUXOLITINIB
Journal Article
Journal Article
Journal of Biosciences, ISSN 0250-5991, 12/2018, Volume 43, Issue 5, pp. 947 - 957
Classical swine fever (CSF) is a contagious disease with a high mortality rate and is caused by classical swine fever virus (CSFV). CSFV non-structural protein... 
TBK1 | interactive cellular protein | NS4B | CSFV | ORF4 PROTEIN | RNA REPLICATION | N-PRO | ANTIVIRAL RESPONSE | HEAVY-CHAIN | NS5A PROTEIN | SIGNALING PATHWAY | E2-INTERACTING PROTEIN | ENDOTHELIAL-CELLS | BIOLOGY | Macrophages, Alveolar - virology | Classical Swine Fever Virus - genetics | Immunoprecipitation | Gene Library | Signal Transduction | Saccharomyces cerevisiae - genetics | Molecular Sequence Annotation | Gene Expression Regulation | Protein-Serine-Threonine Kinases - genetics | Viral Nonstructural Proteins - genetics | Plasmids - metabolism | Host-Pathogen Interactions | Saccharomyces cerevisiae - metabolism | Two-Hybrid System Techniques | Animals | Swine | Plasmids - chemistry | Protein Binding | Viral Nonstructural Proteins - metabolism | Classical Swine Fever Virus - metabolism | Macrophages, Alveolar - metabolism | Gene Ontology | Protein-Serine-Threonine Kinases - metabolism | Viral proteins | Causes of | Physiological aspects | Hog cholera | Genetic aspects | Cellular signal transduction | Research | Yeasts | Yeast | Pathogenesis | Oxidoreductase | Viruses | Catalytic activity | Macrophages | Proteins | Signal transduction | Glutathione transferase | cDNA | Catalysis | Localization | Alveoli | Glutathione | Binding | Pathogens | Metabolism | Fever | Biological activity | Pathogenicity | DNA | Hybrid systems | Transduction | Livestock | Oxidoreductases
Journal Article
International Immunopharmacology, ISSN 1567-5769, 08/2019, Volume 73, pp. 482 - 490
Journal Article