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1. Full Text Regulation of the mitochondrial tricarboxylic acid cycle
by Nunes-Nesi, Adriano and Araújo, Wagner L and Obata, Toshihiro and Fernie, Alisdair R
Current Opinion in Plant Biology, ISSN 1369-5266, 06/2013, Volume 16, Issue 3, pp. 335 - 343
► The functional roles of the constituent enzymes of the plant TCA cycle are largely clarified. ► By contrast, the regulation of the flux through this vital... 
PHOTOSYNTHETIC PERFORMANCE | MOLECULAR CHARACTERIZATION | ARABIDOPSIS LEAVES | SUCCINATE-DEHYDROGENASE | TCA CYCLE | RESPIRATORY METABOLISM | PLANT-MITOCHONDRIA | ACONITASE ACTIVITY | DEPENDENT ISOCITRATE DEHYDROGENASE | NITROGEN ASSIMILATION | PLANT SCIENCES | Mitochondria - genetics | Transcriptome | Citric Acid Cycle - physiology | Mitochondria - metabolism | Kinetics | Proteomics - methods | Enzymes - metabolism | Gene expression | Enzymes
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2. Full Text The pyruvate-tricarboxylic acid cycle node: A focal point of virulence control in the enteric pathogen Yersinia pseudotuberculosis
by Bücker, René and Heroven, Ann Kathrin and Becker, Judith and Dersch, Petra and Wittmann, Christoph
Journal of Biological Chemistry, ISSN 0021-9258, 10/2014, Volume 289, Issue 43, pp. 30114 - 30132
Background:Yersinia pseudotuberculosis is a human pathogen and the ancestor of Y. pestis. Results: The pyruvate-tricarboxylic acid cycle node in the carbon... 
Gene Expression | Bacterial Metabolism | Yersinia | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | Pyruvate | CHROMOSOMAL GENES | Metabolic Flux Analysis | Systems Biology | GLUCOSEPHOSPHATE STRESS | LYSINE PRODUCTION | BACILLUS-SUBTILIS | Tricarboxylic Acid Cycle (TCA Cycle) (Krebs Cycle) | Bacterial Pathogenesis | SECRETION SYSTEM | PESTIS | Bacteria | EXPRESSION | CORYNEBACTERIUM-GLUTAMICUM | Virulence - drug effects | Molecular Weight | Escherichia coli - drug effects | Adaptation, Physiological - drug effects | Yersinia pseudotuberculosis - growth & development | Biomass | Gene Regulatory Networks | Virulence - genetics | Adaptation, Physiological - genetics | Escherichia coli - metabolism | Female | Stress, Physiological - drug effects | Iron - pharmacology | Pyruvates - metabolism | Stress, Physiological - genetics | Bacterial Proteins - genetics | Citric Acid Cycle - drug effects | Glucose - pharmacology | Transcriptome - drug effects | Transcriptome - genetics | Mutation - genetics | Yersinia pseudotuberculosis - genetics | Gene Expression Regulation, Bacterial - drug effects | Citric Acid Cycle - genetics | Animals | Yersinia pseudotuberculosis - metabolism | Yersinia pseudotuberculosis Infections - microbiology | Bacterial Proteins - metabolism | Mice | Mice, Inbred BALB C | Yersinia pseudotuberculosis Infections - pathology | Yersinia pseudotuberculosis - pathogenicity | Microbiology
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3. Full Text Increased lysine production by flux coupling of the tricarboxylic acid cycle and the lysine biosynthetic pathway—Metabolic engineering of the availability of succinyl-CoA in Corynebacterium glutamicum
by Kind, Stefanie and Becker, Judith and Wittmann, Christoph
Metabolic Engineering, ISSN 1096-7176, 01/2013, Volume 15, Issue 1, pp. 184 - 195
In this study, we demonstrate increased lysine production by flux coupling using the industrial work horse bacterium , which was mediated by the targeted... 
Systems metabolic engineering | Lysine | TCA cycle | Escherichia coli | Glyoxylate shunt | 13C metabolic flux | Succinyl-CoA synthetase | Succinylase pathway | C metabolic flux | QUANTIFICATION | SPLIT PATHWAY | IDENTIFICATION | STRAIN IMPROVEMENT | FRUCTOSE | GENE | C-13 metabolic flux | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | IN-VIVO | GROWTH | ACETATE METABOLISM | EXPRESSION | Metabolic Engineering - methods | Lysine - biosynthesis | Biological Availability | Citric Acid Cycle - physiology | Lysine - isolation & purification | Acyl Coenzyme A - metabolism | Corynebacterium glutamicum - physiology | Horses | Ligases | Analysis
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4. Full Text APC/C-CDH1-Regulated IDH3 beta Coordinates with the Cell Cycle to Promote Cell Proliferation
by Wu, QN and Zhang, WM and Xue, LY and Wang, Y and Fu, M and Ma, LY and Song, YM and Zhan, QM
CANCER RESEARCH, ISSN 0008-5472, 07/2019, Volume 79, Issue 13, pp. 3281 - 3293
Metabolic activities are often accompanied by cell-cycle progression, yet known connections between these two processes remain limited. Here, we identified the... 
PROTEIN | TCA CYCLE | ONCOLOGY | PATHWAY | GLUCOSE | ADAPTATION | IDH | CANCER | EXPRESSION | PROGRESSION | GLUTAMINE-METABOLISM
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5. Full Text Beyond the Calvin cycle: Autotrophic carbon fixation in the ocean
by Hügler, Michael and Sievert, Stefan M
Annual Review of Marine Science, ISSN 1941-1405, 2011, Volume 3, Issue 1, pp. 261 - 289
Organisms capable of autotrophic metabolism assimilate inorganic carbon into organic carbon. They form an integral part of ecosystems by making an otherwise... 
marine microbiology | oxygen deficiency zones | hydrothermal vents | reductive TCA cycle | mesopelagic | bathypelagic | subseafloor | COENZYME-A REDUCTASE | SEA HYDROTHERMAL VENTS | GEOCHEMISTRY & GEOPHYSICS | DE-FUCA RIDGE | COMPLETE GENOME SEQUENCE | MID-ATLANTIC RIDGE | OCEANOGRAPHY | TRICARBOXYLIC-ACID CYCLE | ANAEROBIC AMMONIUM OXIDATION | ATP-CITRATE LYASE | SULFATE-REDUCING BACTERIA | UPPER TEMPERATURE LIMIT | Carbon Cycle - physiology | Archaea - metabolism | Bacteria - metabolism | Oceans and Seas | Autotrophic Processes - physiology | Photosynthesis - physiology | Environmental aspects | Research | Oceanographic research | Carbon fixation | Autotrophs
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6. Full Text TCA cycle‐independent acetate metabolism via the glyoxylate cycle in Saccharomyces cerevisiae
by Lee, Yong Joo and Jang, Jin Won and Kim, Kyung Jin and Maeng, Pil Jae
Yeast, ISSN 0749-503X, 02/2011, Volume 28, Issue 2, pp. 153 - 166
In Saccharomyces cerevisiae, the accepted theory is that due to TCA cycle dysfunction, the Δcit1 mutant lacking the mitochondrial enzyme citrate synthase... 
acetate | citrate synthase | glyoxylate cycle | TCA cycle | yeast | Yeast | Acetate | Citrate synthase | Glyoxylate cycle | CARNITINE ACETYLTRANSFERASES | MALATE-DEHYDROGENASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MICROBIOLOGY | YEAST GENES | RAT-LIVER MITOCHONDRIA | STRUCTURAL GENE | DEPENDENT ISOCITRATE DEHYDROGENASE | SUCCINATE-DEHYDROGENASE | CLONING | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PEROXISOMAL CITRATE SYNTHASE | MYCOLOGY | NUCLEOTIDE-SEQUENCE | Saccharomyces cerevisiae - metabolism | Metabolic Networks and Pathways - genetics | Energy Metabolism | Glyoxylates - metabolism | Saccharomyces cerevisiae - genetics | Acetates - metabolism | Gene Deletion | Saccharomyces cerevisiae Proteins - metabolism | Saccharomyces cerevisiae Proteins - genetics | Culture Media - chemistry | Saccharomyces cerevisiae - growth & development
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7. Full Text Using metabolic charge production in the tricarboxylic acid cycle (QTCA) to evaluate the extracellular-electron-transfer performances of Shewanella spp
by Li, Shiue-Lin and Yen, Jui-Hung and Kano, Kenji and Liu, Chien-Liang and Liu, Shiu-Mei and Cheng, Sheng-Shung and Chen, Hsun-Yi
Bioelectrochemistry, ISSN 1567-5394, 12/2018, Volume 124, pp. 119 - 126
Using an electrochemical cell equipped with carbon felt electrodes (poised at +0.63 V vs. SHE), the current production capabilities of two strains—NTOU1 and... 
Substrate-level phosphorylation | Shewanella sp. KR-12 | Shewanella decolorationis NTOU1 | Extracellular electron transfer | Mass-balance calculation | QTCA | ELECTROCHEMISTRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | OUTER-MEMBRANE CYTOCHROMES | TRANSPORT | Shewanella sp KR-12 | BIOPHYSICS | REDUCTION | MANGANESE | RESPIRATION | BIOELECTROCHEMICAL SYSTEMS | BIOLOGY | ONEIDENSIS STRAIN MR-1 | BACTERIAL NANOWIRES | Q(TCA) | MICROBIAL FUEL-CELLS | PUTREFACIENS MR-1 | Electrochemistry | Lactates | Marine biology | Electron transport
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8. Full Text Dysfunctional TCA‐Cycle Metabolism in Glutamate Dehydrogenase Deficient Astrocytes
by Nissen, Jakob D and Pajęcka, Kamilla and Stridh, Malin H and Skytt, Dorte M and Waagepetersen, Helle S
Glia, ISSN 0894-1491, 12/2015, Volume 63, Issue 12, pp. 2313 - 2326
Astrocytes take up glutamate in the synaptic area subsequent to glutamatergic transmission by the aid of high affinity glutamate transporters. Glutamate is... 
truncated TCA cycle | glucose | metabolism | aspartate aminotransferase | Aspartate aminotransferase | Glucose | Metabolism | Truncated TCA cycle | MITOCHONDRIAL | ULTRASTRUCTURAL-LOCALIZATION | PRIMARY CULTURES | NEUROSCIENCES | IN-VITRO | L-LEUCINE | PYRUVATE-CARBOXYLASE | ASPARTATE-AMINOTRANSFERASE | AMINO-ACIDS | ENZYMES | COMPARTMENTATION | Carbon Dioxide - metabolism | Lactic Acid - metabolism | Cells, Cultured | Astrocytes - enzymology | Glutamate Dehydrogenase - genetics | Cerebral Cortex - metabolism | Aspartate Aminotransferases - metabolism | Gene Knockdown Techniques | Isoleucine - metabolism | Tricarboxylic Acids - metabolism | Animals | Glutamate Dehydrogenase - deficiency | Glucose - metabolism | Aspartic Acid - metabolism | Citric Acid Cycle - physiology | Glutamic Acid - metabolism | Mice | RNA, Small Interfering - metabolism | Physiological aspects | Glucose metabolism | Amino acids | Glutamate | Dextrose | Dehydrogenases | Insulin | Rodents
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9. Full Text Glutamate– oxaloacetate transaminase activity promotes palmitate lipotoxicity in rat hepatocytes by enhancing anaplerosis and citric acid cycle flux
by Egnatchik, Robert A and Leamy, Alexandra K and Sacco, Sarah A and Cheah, Yi Ern and Shiota, Masakazu and Young, Jamey D
Journal of Biological Chemistry, ISSN 0021-9258, 2019, Volume 294, Issue 9, pp. 3081 - 3090
Hepatocyte lipotoxicity is characterized by aberrant mitochondrial metabolism, which predisposes cells to oxidative stress and apoptosis. Previously, we... 
RESPIRATORY-CHAIN | OXIDATIVE STRESS | ACTIVATION | hepatocyte | metabolic flux analysis | GLUTAMINASE | TCA cycle | BIOCHEMISTRY & MOLECULAR BIOLOGY | fatty acid | NONALCOHOLIC STEATOHEPATITIS | glutamine | Krebs cycle | fatty liver disease | tricarboxylic acid cycle | METABOLISM | anaplerosis | INSULIN-RESISTANCE | lipotoxicity | LIVER | 1 PROTECTS
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10. Full Text Krebs Cycle Metabolon: Structural Evidence of Substrate Channeling Revealed by Cross‐Linking and Mass Spectrometry
by Wu, Fei and Minteer, Shelley
Angewandte Chemie International Edition, ISSN 1433-7851, 02/2015, Volume 54, Issue 6, pp. 1851 - 1854
It has been hypothesized that the high metabolic flux in the mitochondria is due to the self‐assembly of enzyme supercomplexes (called metabolons) that channel... 
protein–protein interactions | substrate channeling | mass spectrometry | metabolon | Krebs cycle | Substrate channeling | Mass spectrometry | Protein-protein interactions | Metabolon | OXALOACETATE | CITRATE SYNTHASE | CHEMISTRY, MULTIDISCIPLINARY | protein-protein interactions | ORGANIZATION | TCA CYCLE | ENZYMES | MITOCHONDRIAL MALATE-DEHYDROGENASE | FUSION PROTEIN | Cross-Linking Reagents - chemistry | Mass Spectrometry - methods | Molecular Dynamics Simulation | Citric Acid Cycle | Enzymes | Mitochondrial DNA | Analysis | Proteins | Scientific imaging | Self assembly | Channeling | Crosslinking | Electrostatics | Channels
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11. Full Text Citric Acid Cycle and Role of its Intermediates in Metabolism
by Akram, Muhammad
Cell Biochemistry and Biophysics, ISSN 1085-9195, 4/2014, Volume 68, Issue 3, pp. 475 - 478
The citric acid cycle is the final common oxidative pathway for carbohydrates, fats and amino acids. It is the most important metabolic pathway for the energy... 
Life Sciences | Biochemistry, general | Energetics of TCA cycle | Biotechnology | Amphibolic role of TCA cycle | TCA cycle | Biophysics and Biological Physics | Regulation of TCA cycle | Pharmacology/Toxicology | Cell Biology | OXIDATION | BIOPHYSICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CITRATE | DEHYDROGENASE | CELL BIOLOGY | Biosynthetic Pathways | Acetyl Coenzyme A - metabolism | Citric Acid Cycle - drug effects | Physiological aspects | Citric acid
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12. Full Text 'Candidatus Liberibacter asiaticus' and Its Vector, Diaphorina citri, Augment the Tricarboxylic Acid Cycle of Their Host via the gamma-Aminobutyric Acid Shunt and Polyamines Pathway
by Nehela, Y and Killiny, N
MOLECULAR PLANT-MICROBE INTERACTIONS, ISSN 0894-0282, 04/2019, Volume 32, Issue 4, pp. 413 - 427
Huanglongbing (HLB), a destructive citrus disease, is associated with 'Candidatus Liberibacter asiaticus', which is transmitted by the Asian citrus psyllid... 
GREENING DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SYNEPHRINE | LEAVES | PLANT SCIENCES | GABA SHUNT | METABOLOMIC DIFFERENTIATION | SWEET ORANGE | TCA CYCLE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | AMINO-ACIDS | GENE-EXPRESSION | PCR
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13. Full Text Pyruvate cycle increases aminoglycoside efficacy and provides respiratory energy in bacteria
by Su, Yu-bin and Peng, Bo and Li, Hui and Cheng, Zhi-xue and Zhang, Tian-tuo and Zhu, Jia-xin and Li, Dan and Li, Min-yi and Ye, Jin-zhou and Du, Chao-chao and Zhang, Song and Zhao, Xian-liang and Yang, Man-jun and Peng, Xuan-Xian
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2018, Volume 115, Issue 7, pp. E1578 - E1587
The emergence and ongoing spread of multidrug-resistant bacteria puts humans and other species at risk for potentially lethal infections. Thus, novel... 
Energy metabolism | Metabolites | TCA cycle | Antibiotic resistance | P cycle | MYCOBACTERIUM-TUBERCULOSIS | MECHANISM | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | METABOLIC PATHWAYS | ANTIBIOTIC-RESISTANCE | metabolites | PHOSPHOENOLPYRUVATE CARBOXYKINASE | antibiotic resistance | KREBS CYCLE | EDWARDSIELLA-TARDA | GLUCOSE | energy metabolism | CORYNEBACTERIUM-GLUTAMICUM | Biological Sciences | PNAS Plus
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14. Full Text Respiratory metabolism: glycolysis, the TCA cycle and mitochondrial electron transport
by Fernie, Alisdair R and Carrari, Fernando and Sweetlove, Lee J
Current Opinion in Plant Biology, ISSN 1369-5266, 2004, Volume 7, Issue 3, pp. 254 - 261
The respiratory pathways of glycolysis, the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain are ubiquitous throughout nature.... 
Aconitase1 | TCA | tricarboxylic acid | UCP | reactive oxygen species | ROS | NADH dehydrogenase | AOX | NDA | Aco1 | alternative oxidase | uncoupling protein | ARABIDOPSIS-THALIANA | OXIDATIVE STRESS | UNCOUPLING PROTEIN | FUNCTIONAL RECONSTITUTION | ISOCITRATE DEHYDROGENASE | NAD(P)H DEHYDROGENASES | POTATO MITOCHONDRIA | ANTISENSE REPRESSION | PLANT-MITOCHONDRIA | INNER SURFACE | PLANT SCIENCES | Glycolysis - physiology | Plants - metabolism | Biological Transport | Cell Respiration | Citric Acid Cycle - physiology | Mitochondria - metabolism | Electron Transport - physiology | Plant Physiological Phenomena
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