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tca, taurocholic acid (9) 9
animals (8) 8
index medicus (8) 8
cdca, chenodeoxycholic acid (7) 7
udca, ursodeoxycholic acid (7) 7
dca, deoxycholic acid (6) 6
humans (6) 6
male (6) 6
ca, cholic acid (5) 5
fxr, farnesoid x receptor (5) 5
liver (5) 5
liver - metabolism (5) 5
mice (5) 5
pharmacology & pharmacy (5) 5
alt, alanine aminotransferase (4) 4
bile acids (4) 4
biochemistry & molecular biology (4) 4
farnesoid x receptor (4) 4
hepatocytes - metabolism (4) 4
mice, inbred c57bl (4) 4
rats (4) 4
alp, alkaline phosphatase (3) 3
bile acids and salts - metabolism (3) 3
bsep, bile salt export pump (3) 3
cbdl, common bile duct ligation (3) 3
disease (3) 3
gut microbiota (3) 3
h&e, hematoxylin and eosin (3) 3
hepatocytes - drug effects (3) 3
mice, knockout (3) 3
review (3) 3
taurocholic acid (3) 3
tca (3) 3
therapeutics. pharmacology (3) 3
time factors (3) 3
tudca, tauroursodeoxycholic acid (3) 3
19, fibroblast growth factor 15 (2) 2
activated receptor (2) 2
adipose-tissue (2) 2
ae2, anion exchanger 2 (2) 2
autoantigens - genetics (2) 2
autoantigens - metabolism (2) 2
ba, bile acid (2) 2
bas, bile acids (2) 2
bile acids and salts - pharmacology (2) 2
bile-acids (2) 2
biophysics (2) 2
ccl4, carbon tetrachloride (2) 2
cell biology (2) 2
cells, cultured (2) 2
chaperone (2) 2
chemical and drug induced liver injury - metabolism (2) 2
chemical and drug induced liver injury - pathology (2) 2
chemical and drug induced liver injury - prevention & control (2) 2
cholesterol (2) 2
cholesterol - metabolism (2) 2
cholic acid (2) 2
common bile duct ligation (2) 2
ddc, 3,5-diethoxycarbonyl-1,4-dihydrocollidine (2) 2
deoxycholic acid (2) 2
endocrinology & metabolism (2) 2
female (2) 2
fgf, fibroblast growth factor (2) 2
fgf15 (2) 2
functional expression (2) 2
fxr (2) 2
fxre, fxr response element (2) 2
gastroenterology & hepatology (2) 2
gastroenterology and hepatology (2) 2
gca, glycocholic acid (2) 2
gcdca, glycochenodeoxycholic acid (2) 2
hdca, hyodeoxycholic acid (2) 2
hepatocytes - pathology (2) 2
high-fat diet (2) 2
identification (2) 2
ifm, immunofluorescence microscopy (2) 2
ihc, immunohistochemistry (2) 2
internal medicine (2) 2
intestinal microbiota (2) 2
k, keratin (2) 2
keratin aggregates (2) 2
keratin-18 - metabolism (2) 2
keratin-8 - genetics (2) 2
keratin-8 - metabolism (2) 2
lca, lithocholic acid (2) 2
liver - injuries (2) 2
liver - pathology (2) 2
low density lipoproteins (2) 2
lxr, liver x receptor (2) 2
mapk, mitogen-activated protein kinase (2) 2
mdbs, mallory-denk bodies (2) 2
membrane transport proteins - metabolism (2) 2
metabolism (2) 2
methylamines - pharmacology (2) 2
mice, transgenic (2) 2
molecular chaperones - genetics (2) 2
molecular chaperones - metabolism (2) 2
oa, okadaic acid (2) 2
original (2) 2
original article (2) 2
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Gastroenterology, ISSN 0016-5085, 2011, Volume 140, Issue 3, pp. 998 - 1008.e4
Journal Article
Journal of Pharmaceutical and Biomedical Analysis, ISSN 0731-7085, 02/2017, Volume 135, pp. 167 - 175
Si-miao-yong-an decoction (SMYAD), a traditional Chinese medicine formula, significantly reduced plasma TC, LDL-c levels and increased HDL-c level in... 
Bile acids | Hyperlipidemia | LC–MS/MS | Si-miao-yong-an decoction | cholic acid | taurocholic acid | low-density lipoprotein cholesterol | ALT | glutamic oxalacetic transaminase | total cholesterol | GCDCA | high-density lipoprotein cholesterol | SMYAD | CDCA | AST | GCA | LDL-c | glycocholic acid | traditional Chinese medicine | TCDCA | total triglyceride | HDL-c | glyco chenodeoxycholic acid | glutamic pyruvic transaminase | taurochenodeoxycholic acid | TCA | chenodeoxycholic acid | TCM | CHEMISTRY, ANALYTICAL | BIOLOGICAL-FLUIDS | MASS-SPECTROMETRY | HIGH-DENSITY-LIPOPROTEIN | PERFORMANCE LIQUID-CHROMATOGRAPHY | LC-MS/MS | GLUCOSE-METABOLISM | CHLOROGENIC ACID | SULFATE METABOLITES | GENE-EXPRESSION | TRADITIONAL CHINESE MEDICINE | PHARMACOLOGY & PHARMACY | SOLID-PHASE EXTRACTION | Bile Acids and Salts - blood | Administration, Oral | Anticholesteremic Agents - blood | Cholesterol - blood | Liver - metabolism | Rats | Bile Acids and Salts - metabolism | Male | Plasma - drug effects | Random Allocation | Cholesterol - metabolism | Drugs, Chinese Herbal - metabolism | Rats, Sprague-Dawley | Plasma - metabolism | Animals | Anticholesteremic Agents - metabolism | Liver - drug effects | Anticholesteremic Agents - administration & dosage | Metabolic Networks and Pathways - physiology | Bile Acids and Salts - analysis | Drugs, Chinese Herbal - administration & dosage | Metabolic Networks and Pathways - drug effects | Chromatography, Liquid - methods | Tandem Mass Spectrometry - methods | Cholesterol | Methods | Taurine | Analysis and chemistry | Low density lipoproteins | Liver | Physiological aspects | Glycine | Blood | Deoxycholic acid
Journal Article
Molecular Metabolism, ISSN 2212-8778, 04/2019, Volume 22, pp. 96 - 109
The gut microbiota is an important influencing factor of metabolic health. Although dietary interventions with probiotics, prebiotics, and synbiotics can be... 
Gut microbiota | Obesity | Dietary intervention | High-fat diet | Synbiotics | PHYSIOLOGY | HIGH-FAT-DIET | PROBIOTICS | OLIGOFRUCTOSE | GENOME SEQUENCE | OVERWEIGHT | PREBIOTICS | ENDOCRINOLOGY & METABOLISM | SP-NOV | INTERVENTION | BILE-ACIDS | Index Medicus
Journal Article
Molecular Aspects of Medicine, ISSN 0098-2997, 06/2014, Volume 37, Issue 100, pp. 57 - 76
Hepatobiliary bile salt (BS) transporters are critical determinants of BS homeostasis controlling intracellular concentrations of BSs and their enterohepatic... 
Nuclear receptors | ATB-binding cassette transporters | Cholestasis | ORGANIC-SOLUTE-TRANSPORTER | MEDICINE, RESEARCH & EXPERIMENTAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | VITAMIN-D-RECEPTOR | NA+/TAUROCHOLATE-COTRANSPORTING POLYPEPTIDE | ORPHAN NUCLEAR RECEPTOR | EXPORT PUMP BSEP | CONSTITUTIVE ANDROSTANE RECEPTOR | PRIMARY BILIARY-CIRRHOSIS | ALPHA-OST-BETA | FARNESOID-X-RECEPTOR | FAMILIAL INTRAHEPATIC CHOLESTASIS | Cholestasis - genetics | Transcriptional Activation - genetics | Cholestasis - therapy | Humans | Gene Expression Regulation | Bile Acids and Salts - metabolism | Symporters - metabolism | Organic Anion Transporters, Sodium-Dependent - genetics | Cholestasis - pathology | ATP-Binding Cassette Transporters - genetics | Biological Transport | ATP Binding Cassette Subfamily B Member 11 | Membrane Transport Proteins - genetics | Symporters - genetics | ATP-Binding Cassette Transporters - metabolism | Membrane Transport Proteins - metabolism | Organic Anion Transporters, Sodium-Dependent - metabolism | Genetic aspects | Genetic transcription | MAF, musculo-aponeurotic fibrosacroma | TNF-α, tumor necrosis factor alpha | NDRG2, NMYC downstrean-regulated gene 2 | RARα (NR1B1), retinoic acid receptor | IL-6, interleukin 6 | ABC, ATP-binding cassette | DCA, deoxycholic acid | GGT, gamma-glutamyl transpeptidase | CARM1, co-activator-associated arginine methyltransferase 1 | SRC2, steroid receptor co-activator 2 | TCDCA, taurochenodeoxycholic acid | MRP2 (ABCC2), multidrug resistance-associated protein 2 | SREBP1, sterol regulatory element-binding protein 1 | ASBT (SLC10A2), apical sodium-dependent bile acid transporter | CA, cholic acid | UDCA, ursodeoxycholic acid | FGF15, fibroblast growth factor 19 | MARE, MAF recognition element | TβMCA, β-tauromuricholic acid | VDR (NR1I1), vitamin D receptor | CBDL, common bile duct ligation | STAT-5, signal transducer and activator of transcription 5 | MCL-1, myeloid cell leukemia factor 1 | PPARγ (NR1C3), peroxisome proliferator-activated receptor gamma | FXRE, FXR response element | LXR (NR1H3), liver X receptor | CtBP, C-terminal binding protein | OSTβ (SLC51A | SHP (NR0B2), short heterodimer partner | PL, phospholipid | BCRP (ABCG2), breast cancer resistance protein | TUDCA, tauroursodeoxycholic acid | OATP, organic anion transporting polypeptide | TCA, taurocholic acid | NTCP (SLC10A1), Na+-taurocholate cotransporting polypeptide solute carrier family 10 member 1 | PSC, primary sclerosing cholangitis | LRH1 (NR5A2), liver receptor homologue 1 | LPS, lipopolysaccharide | MRP3 (ABCC3), multidrug resistance-associated protein 3 | SLC51B), organic solute transporter alpha | TGR5, G protein coupled bile acid receptor | MDR2 (ABCB4), multidrug resistance protein 2 | FXR, farnesoid X receptor (NR1H4) | IR-1, inverse repeat 1 | OCA, obeticholic acid | MRP4 (ABCC4), multidrug resistance-associated protein 4 | AE2 (SLC4A2), anion exchanger 2 | NF-κB, nuclear factor kappa-B | CCl4, carbone tetrachloride | AMPK, AMP-activated protein kinase | ALP, alkaline phosphatase | PPARα (NR1C1), peroxisome proliferator-activated receptor alpha | Review | DILI, drug-induced liver injury | JNK, c-Jun N-terminal kinase | GR (NR3C1), glucocorticoid receptor | BS, bile salt | IL-1β, interleukin-1 beta | cAMP, cyclic adenosine monophosphate | PGC-1α, peroxisome proliferator-activated receptor gamma coactivator-1 alpha | RXRα (NR2B1), retinoid X receptor | VPAC-1, vasoactive intestinal polypeptide activated receptor | ASCOM, activating signal cointegrator-2-containing complex | ICP, intrahepatic cholestasis of pregnancy | GCA, glycocholic acid | MDR1 (ABCB1), multidrug resistance protein 1 | NRF2, nuclear factor erythroid 2-related factor 2 | beta | ALT, alanine aminotransferase | LCA, litocholic acid | BRIC2, benign recurrent intrahepatic cholestasis type 2 | OSTα | CDCA, chenodeoxycholic acid | PBC, primary biliary cirrhosis | HNF1α, hepatocyte nuclear factor 1 alpha | GRE, glucocorticoid response element | TαMCA, α-tauromuricholic acid | FGF19 | PFIC2, progressive familial intrahepatic cholestasis type 2 | PXR (NR1I2), pregnane X receptor | BSEP (ABCB11), bile salt export pump | TPN, total parenteral nutrition | HNF4α, hepatocyte nuclear factor 4 alpha
Journal Article
Journal Article
Acta Pharmaceutica Sinica B, ISSN 2211-3835, 2015, Volume 5, Issue 2, pp. 123 - 128
Journal Article
Acta Pharmaceutica Sinica B, ISSN 2211-3835, 2019, Volume 9, Issue 4, pp. 702 - 710
Since metabolic process differs between humans and mice, studies were performed in hamsters, which are generally considered to be a more appropriate animal... 
Gut microbiota | FXR | TβMCA | CYP7B1 | Metabolic disorders | CHOLESTEROL | INTESTINAL MICROBIOTA | T beta MCA | INDIVIDUALS | FARNESOID X RECEPTOR | INSULIN-RESISTANCE | LIVER | PHARMACOLOGY & PHARMACY | ANIMAL-MODEL | MICE | ALTERS | AXIS | BAs, bile acids | CAPE, caffeic acid phenethyl ester | ApoB, apolipoprotein B | CYP8B1, cytochrome P450 family 8 subfamily B member 1 | DCA, deoxycholic acid | PBA | T2D, type 2 diabetes | NAFLD, non-alcoholic fatty liver disease | CYP27A1, cytochrome P450 family 27 subfamily A member 1 | 19, fibroblast growth factor 15 | H&E, hematoxylin and eosin | GCDCA, glycochenodeoxycholic acid | SBA, primary bile acids to secondary bile acids | CETP, cholesterol ester transfer protein | TG, triglycerides | ITT, insulin tolerance test | CA, cholic acid | GCA, glycocholic acid | UDCA, ursodeoxycholic acid | UPLC–MS | LCA, lithocholic acid | sWAT, subcutaneous white adipose tissue | HFD, high fat diet | GTT, glucose tolerance test | NASH, non-alcoholic steatohepatitis | FXR, farnesoid X receptor | CDCA, chenodeoxycholic acid | eWAT, epididymal white adipose tissue | ALT, alanine amino-transferase | AUC, area under curve | AST, aspartate transaminase | BSH, bile acid hydrolase | CYP7A1, cytochrome P450 family 7 subfamily A member 1 | FGF15 | TCA, taurocholic acid | MS, ultra performance liquid chromatography–tandem mass spectrometry | VLDL, very low-density lipoprotein | TβMCA, tauro-β-muricholic acid | CYP7B1, cytochrome P450 family 7 subfamily B member 1 | Original article | TC, total cholesterol
Journal Article
Acta Pharmaceutica Sinica B, ISSN 2211-3835, 2015, Volume 5, Issue 2, pp. 158 - 167
Alcoholic liver disease (ALD) is one of the major causes of liver morbidity and mortality worldwide. Chronic alcohol consumption leads to development of liver... 
Farnesoid X receptor | Bile acids | Autophagy | FoxO3 | Alcoholic liver disease | TRANSCRIPTION FACTORS | OXIDATIVE STRESS | LIPID-METABOLISM | ETHANOL-INDUCED AUTOPHAGY | ACTIVATED RECEPTOR | NUCLEAR RECEPTOR | PERSISTENT ACTIVATION | URSODEOXYCHOLIC ACID | PHARMACOLOGY & PHARMACY | BACTERIAL OVERGROWTH | HEPATIC STEATOSIS | DR1, direct repeat 1 | IR-1, inverted repeat-1 | CRTC2, CREB regulated transcription coactivator 2 | LC3, light chain 3 | DCA, deoxycholic acid | NTCP, sodium taurocholate cotransporting polypeptide | TFEB, transcription factor EB | SREBP1, sterol regulatory element-binding protein 1 | TUDCA, tauro-ursodeoxycholic acid | CA, cholic acid | FoxO3a, forkhead box-containing protein class O3a | FGFR4, fibroblast growth factor receptor 4 | UDCA, ursodeoxycholic acid | ADH, alcohol dehydrogenase | GGT, gamma-glutamyltranspeptidase | MRP4, multidrug resistance protein 4 | 6ECDCA, 6α-ethyl-chenodeoxycholic acid | ALD, alcoholic liver disease | CREBH, cAMP response element-binding protein, hepatocyte specific | PE, phosphatidylethanolamine | SQSTM, sequestome-1 | BAAT, bile acid CoA:amino acid N-acyltransferase | AKT, protein kinase B | KO, knockout | TCA, taurocholic acid | LXR, liver X receptor | CB1R, cannabinoid receptor type 1 | RXRα, retinoid X receptor-alpha | Review | ASBT, apical sodium dependent bile acid transporter | LRH-1, liver receptor homolog 1 | 19, fibroblast growth factor 15 | BSEP, bile salt export pump | SHP, small heterodimer partner | AF, activation function | PPARα, peroxisome proliferator-activated receptor alpha | ROS, reactive oxygen species | Sirt1, sirtuin 1 | TLR4, toll-like receptor 4 | CYP, cytochrome P450 | ALT, alanine aminotransferase | Atg, autophagy-related | OSTα | FXR, farnesoid X receptor | BACS, bile acid CoA synthetase | CDCA, chenodeoxycholic acid | CREB, cAMP response element-binding protein | WT, wild type | β, organic solute transporter α | NAD+, nicotinamide adenine dinucleotide | FGF15 | WAY, WAY-362450 | HCC, hepatocellular carcinoma
Journal Article
FEBS Letters, ISSN 0014-5793, 2004, Volume 566, Issue 1, pp. 173 - 177
The farnesoid X receptor (FXR) is a nuclear receptor activated by bile acids (BAs). In response to ligand‐binding, FXR regulates many genes involved in BA,... 
Farnesoid X receptor | Small interfering RNA | VLDL receptor | Microarray analysis | PFIC, progressive familial intrahepatic cholestasis |