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biochemistry & molecular biology (87) 87
index medicus (71) 71
tcep (53) 53
humans (45) 45
animals (33) 33
amino acid sequence (30) 30
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tcep, trisphosphine (26) 26
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protein folding (9) 9
tev, tobacco etch virus (9) 9
activation (8) 8
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disulfide (8) 8
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sequence homology, amino acid (8) 8
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peptides - chemistry (7) 7
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Tetrahedron Letters, ISSN 0040-4039, 08/2017, Volume 58, Issue 32, pp. 3101 - 3106
Iminoboronates are stable and formed fast. Their B N bonds could be reverted by some endogenous biological molecules. The reversible characteristic attracts... 
Reversible reaction | Efficient disconnection | Iminoboronates | TCEP | CHEMISTRY, ORGANIC | FUNCTIONALIZATION | NUCLEOPHILES | SACCHARIDE-ACCELERATED HYDROLYSIS | BORONIC ACID IMINES | NEUTRAL PH | CHEMISTRY | LEADS | OXIME
Journal Article
Journal of Pharmaceutical and Biomedical Analysis, ISSN 0731-7085, 09/2019, Volume 174, pp. 518 - 524
Identification and localization of modifications in peptides containing multiple disulfide bonds is challenging due to inefficient fragmentation in mass... 
Tris(2-carboxyethyl)phosphine (TCEP) | Liquid chromatography | Peptides | Dithiothreitol (DTT) | Mass spectrometry | Disulfide bond reduction | REAGENT | CHEMISTRY, ANALYTICAL | PHARMACOLOGY & PHARMACY | PROTEINS | MASS-SPECTROMETRY
Journal Article
Molecular Biology Reports, ISSN 0301-4851, 2/2019, Volume 46, Issue 1, pp. 639 - 645
Rapid and on-site DNA-based molecular detection has become increasingly important for sensitive, specific, and timely detection and treatment of various... 
Life Sciences | TBA | cPCR | Molecular diagnostics | On-site | Animal Biochemistry | Animal Anatomy / Morphology / Histology | TCEP | STORAGE | REDUCTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TYPHIMURIUM | DITHIOTHREITOL | IDENTIFICATION | PCR | Polymerase chain reaction | Reducing agents | Phosphine | Convection | Freeze-drying | Drying
Journal Article
BioTechniques, ISSN 0736-6205, 12/2013, Volume 55, Issue 6, pp. 292 - 294
Trivalent phosphines have been used for disulfide reduction for many years (1, 2). Tris[2-carboxyethyl]phosphine (TCEP) has the added advantages of water... 
peptide/protein reduction | antimicrobial peptide | immobilized TCEP | Tris[2-carboxyethyl]phosphine | TCEP | Immobilized TCEP | Peptide/protein reduction | Antimicrobial peptide | Cations - chemistry | Osmolar Concentration | Phosphines - chemistry | Sepharose - chemistry | Cysteine - chemistry | Buffers | Research Design
Journal Article
Bioconjugate Chemistry, ISSN 1043-1802, 10/2016, Volume 27, Issue 10, pp. 2260 - 2265
Journal Article
Journal Article
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2012, Volume 448, Issue 2, pp. 213 - 220
To investigate the range of autoinhibitory mechanisms used by TKDs (tyrosine kinase domains) from the insulin receptor family of RTKs (receptor tyrosine... 
X-ray crystallography | Insulin receptor kinase | Autoinhibition | Receptor tyrosine kinase (RTK) | Receptor tyrosine kinase-like orphan receptor 2 (Ror2) | Tropomyosin receptor kinase A (TrkA) | ALK | ACTIVATION | CRYSTAL-STRUCTURE | TYROSINE KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CATALYTIC DOMAIN | autoinhibition | receptor tyrosine kinase-like orphan receptor 2 (Ror2) | CANCER | ANAPLASTIC LYMPHOMA KINASE | insulin receptor kinase | receptor tyrosine kinase (RTK) | MUTATIONS | INHIBITOR | tropomyosin receptor kinase A (TrkA) | EGF RECEPTOR | Neoplasms - metabolism | Humans | Receptor, trkA - antagonists & inhibitors | Crystallography, X-Ray | Antigens, CD - genetics | Antigens, CD - metabolism | Neoplasms - genetics | Receptor, Insulin - genetics | Protein Structure, Quaternary | Antigens, CD - chemistry | Recombinant Proteins - metabolism | Amino Acid Sequence | Catalytic Domain | Recombinant Proteins - antagonists & inhibitors | Receptor Tyrosine Kinase-like Orphan Receptors - metabolism | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Receptor, Insulin - antagonists & inhibitors | Amino Acid Motifs | Receptor Tyrosine Kinase-like Orphan Receptors - antagonists & inhibitors | Receptor Tyrosine Kinase-like Orphan Receptors - chemistry | Receptor, trkA - metabolism | Receptor, Insulin - chemistry | Receptor, trkA - chemistry | Receptor, trkA - genetics | Receptor Tyrosine Kinase-like Orphan Receptors - genetics | Receptor, Insulin - metabolism | Mutation | Enzyme Activation - genetics | In Vitro Techniques | ALK, anaplastic lymphoma kinase | FGFR, fibroblast growth factor receptor | Trk, tropomyosin receptor kinase | C-lobe, C-terminal lobe | EGFR, epidermal growth factor receptor | TKD, tyrosine kinase domain | DTT, dithiothreitol | NSCLC, non-small-cell lung cancer | TCEP, tris-(2-carboxyethyl)phosphine | COSMIC, Catalogue Of Somatic Mutations In Cancer | Ni-NTA, Ni2+-nitrilotriacetate | N-lobe, N-terminal lobe | RTK, receptor tyrosine kinase | CDK, cyclin-dependent kinase | IGF1R, insulin-like growth factor 1 receptor | MuSK, muscle-specific kinase | IRK, insulin receptor kinase | Ror, receptor tyrosine kinase-like orphan receptor
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 06/2014, Volume 426, Issue 13, pp. 2457 - 2470
The discoidin domain receptors (DDRs), DDR1 and DDR2, form a unique subfamily of receptor tyrosine kinases that are activated by the binding of triple-helical... 
crystallography | gleevec | drug design | phosphorylation | oncology | FIBROSIS | ACTIVATION | TYROSINE KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-SURVIVAL | IDENTIFICATION | CANCER | DISCOVERY | INVASION | IMATINIB | STI-571 INHIBITION | Proto-Oncogene Proteins c-abl - antagonists & inhibitors | Humans | Molecular Sequence Data | Pyridazines - pharmacology | Discoidin Domain Receptors | Protein Kinase Inhibitors - chemistry | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Receptors, Collagen - genetics | Benzamides - pharmacology | Binding Sites | Receptors, Collagen - chemistry | Protein Structure, Tertiary | Amino Acid Sequence | Proto-Oncogene Proteins c-abl - genetics | Protein Structure, Secondary | Receptors, Mitogen - antagonists & inhibitors | Proto-Oncogene Proteins c-abl - chemistry | Models, Molecular | Imidazoles - pharmacology | Discoidin Domain Receptor 1 | Pyrimidines - pharmacology | Receptors, Mitogen - chemistry | Imatinib Mesylate | Piperazines - pharmacology | Receptors, Collagen - antagonists & inhibitors | Sequence Homology, Amino Acid | Receptor Protein-Tyrosine Kinases - genetics | Protein Kinase Inhibitors - pharmacology | Receptor Protein-Tyrosine Kinases - chemistry | Receptors, Mitogen - genetics | Memory (Computers) | Collagen | Atherosclerosis | Crystals | Development and progression | Drug resistance | Structure | Phosphotransferases | CML, chronic myeloid leukemia | KID, kinase insert domain | A-loop, activation loop | ITC, isothermal titration calorimetry | TCEP, tris(2-carboxyethyl)phosphine | DDR, discoidin domain receptor | TKI, tyrosine kinase inhibitor | RTKs, receptor tyrosine kinases | TrkB, tropomyosin-related kinase B | IGF1R, insulin-like growth factor 1 receptor
Journal Article