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NATURE GENETICS, ISSN 1061-4036, 09/2015, Volume 47, Issue 9, pp. 1020 - 1020
TCF3-HLF-positive acute lymphoblastic leukemia (ALL) is currently incurable. Using an integrated approach, we uncovered distinct mutation, gene expression and... 
PROGENITOR CELLS | CHROMOSOMAL TRANSLOCATIONS | SET ENRICHMENT ANALYSIS | RAS PATHWAY | GENETICS & HEREDITY | GENE-EXPRESSION | B-CELL DIFFERENTIATION | SEQUENCING DATA | CHAIN REARRANGEMENT | TRANSCRIPTION FACTOR | HEMATOPOIETIC STEM | Sequence Deletion | Oncogene Proteins, Fusion - metabolism | Coculture Techniques | Genomics | Humans | Drug Resistance, Neoplasm | Male | Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality | Antineoplastic Agents - therapeutic use | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | DNA Mutational Analysis | Inhibitory Concentration 50 | Female | Antineoplastic Agents - pharmacology | Immunoglobulin Light Chains, Surrogate - genetics | Gene Expression | Genetic Association Studies | Kaplan-Meier Estimate | PAX5 Transcription Factor - genetics | Mice, SCID | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Xenograft Model Antitumor Assays | Animals | Oncogene Proteins, Fusion - genetics | Mice, Inbred NOD | Mutation | Cohort Studies | Gene mutations | Genetic aspects | Acute lymphocytic leukemia | Research | Identification and classification | Health aspects | Risk factors | Bone marrow | Genes | Leukemia | cytarabine | integrative | leukemic stem cell | drug activity profiling | panobinostat | mTOR inhibitor | genomics | glucocorticoids | bortezomib | ABT-199 | dexamethasone | HSP90 | TCF3-PBX1 | vincristine | BH3-mimetics | leukemia xenograft model | next generation sequencing | TCF3-HLF | venetoclax | anthracycline | acute lymphoblastic leukemia | AUY922 | BCL2 | drug resistance | prednisone
Journal Article
Cancer Letters, ISSN 0304-3835, 2016, Volume 386, pp. 131 - 140
Abstract Poly (ADP-ribose) polymerase (PARP) is an indispensable component of the DNA repair machinery. PARP inhibitors are used as cutting-edge treatments for... 
Hematology, Oncology and Palliative Medicine | Homologous recombination repair | TCF3-HLF | Acute lymphoblastic leukemia | PARP inhibitor | POLY(ADP-RIBOSE) POLYMERASE | ADVANCED SOLID TUMORS | ACUTE-LYMPHOBLASTIC-LEUKEMIA | DNA-DAMAGE RESPONSE | ONCOGENIC TRANSCRIPTION FACTORS | ONCOLOGY | E2A-HLF FUSION PROTEINS | MYELOID-LEUKEMIA | HOMOLOGOUS RECOMBINATION | B-LINEAGE LEUKEMIA | PHASE-I | Oncogene Proteins, Fusion - metabolism | Leukemia - pathology | Humans | Drug Resistance, Neoplasm | RNA, Messenger - metabolism | DNA Breaks, Double-Stranded | Dose-Response Relationship, Drug | Transfection | Time Factors | U937 Cells | BRCA1 Protein - metabolism | Female | Leukemia - genetics | Recombinational DNA Repair | Jurkat Cells | Leukemia - enzymology | RNA, Messenger - genetics | Leukemia - drug therapy | Gene Expression Regulation, Leukemic | Nerve Tissue Proteins - genetics | Piperazines - pharmacology | Nerve Tissue Proteins - metabolism | Xenograft Model Antitumor Assays | BRCA1 Protein - genetics | Cell Lineage | Phthalazines - pharmacology | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Poly(ADP-ribose) Polymerases - metabolism | Oncogene Proteins, Fusion - genetics | K562 Cells | Medical colleges | Developmental biology | Analysis | Leukemia | B cells | Sugars | Monosaccharides | Immunoglobulins | Hematology | Cytotoxicity | Breast cancer | DNA repair | Proteins | Rodents | Medical prognosis | Fibroblasts | Lymphomas | Mutation | Deoxyribonucleic acid--DNA | Tumors | Apoptosis
Journal Article
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