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CORNEA, ISSN 0277-3740, 10/2017, Volume 36, Issue 10, pp. E25 - E27
Journal Article
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ISSN 0146-0404, 09/2018, Volume 59, Issue 11, pp. 4748 - 4754
PURPOSE. To assess the occurrence and diagnostic performance of nine single-nucleotide variants (SNVs) in the TCF4, SLC4A11, LOXHD1 , and AGBL1 genes and the... 
ENDOTHELIAL DYSTROPHY | corneal dystrophy | TRINUCLEOTIDE REPEAT EXPANSION | Fuchs dystrophy | LOCUS | MISSENSE MUTATIONS | TCF4 GENE | POLYMORPHISMS | OPHTHALMOLOGY | microsatellite expansion | TCF4 | LINKAGE | molecular markers | ASSOCIATION | EXPRESSION | RNA FOCI
Journal Article
CANCER SCIENCE, ISSN 1349-7006, 01/2018, Volume 109, pp. 636 - 636
Conference Proceeding
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 10/2019, Volume 135, pp. 90 - 96
Increased nuclear β-catenin interacting with T-cell factor 4 (TCF4) affects the expression of target genes including in ischemic heart disease, which is... 
β-Catenin | Na+ channel | TCF4 | Inhibitor | NaV1.5 | Index Medicus
Journal Article
Heart Rhythm, ISSN 1547-5271, 05/2019
BACKGROUNDβ-Catenin/T-cell factor 4 (TCF4) signaling is enhanced in ischemic heart disease in which ventricular tachycardia (VT)/ventricular fibrillation... 
Index Medicus
Journal Article
Journal of Experimental and Clinical Cancer Research, ISSN 1756-9966, 01/2019, Volume 38, Issue 1, pp. 38 - 38
Early invasion and metastasis are responsible for the dismal prognosis of pancreatic ductal adenocarcinoma (PDAC), and epithelial-to-mesenchymal transition... 
SPRY2 | FOXO3a | β-Catenin/TCF4 pathway | Epithelial-to-mesenchymal transition | Pancreatic ductal adenocarcinoma | beta-Catenin/TCF4 pathway | TRANSCRIPTION | DOWN-REGULATION | PHENOTYPE | EMT | INACTIVATION | MALIGNANCY | SPROUTY-2 | ONCOLOGY | CANCER METASTASIS | GROWTH | EXPRESSION | Carcinoma, Pancreatic Ductal - secondary | Cell Proliferation | Pancreatic Neoplasms - metabolism | Prognosis | Follow-Up Studies | Humans | Middle Aged | Carcinoma, Pancreatic Ductal - metabolism | Gene Expression Regulation, Neoplastic | Male | Intracellular Signaling Peptides and Proteins - metabolism | Carcinoma, Pancreatic Ductal - genetics | Forkhead Box Protein O3 - genetics | Neoplasm Metastasis | Transcription Factor 4 - metabolism | Epithelial-Mesenchymal Transition | Biomarkers, Tumor - metabolism | Female | Forkhead Box Protein O3 - antagonists & inhibitors | Membrane Proteins - metabolism | Tumor Cells, Cultured | Intracellular Signaling Peptides and Proteins - genetics | Signal Transduction | Membrane Proteins - genetics | Neoplasm Invasiveness | Pancreatic Neoplasms - pathology | Transcription Factor 4 - genetics | Pancreatic Neoplasms - genetics | Survival Rate | beta Catenin - metabolism | Forkhead Box Protein O3 - metabolism | beta Catenin - genetics | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Biomarkers, Tumor - genetics | Mice | Mice, Inbred BALB C | Apoptosis | Cell Movement | Transcription factors | Homeostasis | Breast cancer | Metastasis | Kinases | Stomach cancer | Ovarian cancer | Cell adhesion & migration | Proteins | Liver cancer | Cell growth | Pancreatic cancer | Medical prognosis | Cell cycle | Tumorigenesis | Tumors | Index Medicus
Journal Article
Molecular Medicine Reports, ISSN 1791-2997, 04/2018, Volume 17, Issue 4, pp. 6023 - 6027
Journal Article
Bone, ISSN 8756-3282, 06/2019, Volume 123, pp. 129 - 136
MicroRNAs (miRNAs, miRs) are frequently dysregulated in osteoarthritis (OA), but the role of specific miRNAs in OA remains unclear. In this study, we found... 
Extracellular matrix | TCF4 | miR-93-5p | Osteoarthritis | Apoptosis | ACTIVATION | ENDOCRINOLOGY & METABOLISM | ALPHA | SUPPRESSES | EXPRESSION
Journal Article
Investigative Ophthalmology and Visual Science, ISSN 0146-0404, 09/2018, Volume 59, Issue 11, pp. 4748 - 4754
To assess the occurrence and diagnostic performance of nine single-nucleotide variants (SNVs) in the TCF4, SLC4A11, LOXHD1, and AGBL1 genes and the CTG18.1... 
Molecular markers | Tcf4 | Microsatellite expansion | Corneal dystrophy | Fuchs dystrophy | Index Medicus
Journal Article
Journal of Biomolecular Structure and Dynamics, ISSN 0739-1102, 03/2019, Volume 37, Issue 4, pp. 877 - 891
By virtue of their regulatory role in the biological process, certain protein-protein complexes form potential targets for designing and discovery of drugs.... 
β-catenin/Tcf4 complex | binding free energy calculations | Sesamin | colon cancer | molecular dynamics simulation | STRUCTURAL INSIGHTS | CELLS | DOMAIN | DOCKING | BIOCHEMISTRY & MOLECULAR BIOLOGY | DRUG DISCOVERY | beta-catenin/Tcf4 complex | QUERCETIN | BIOPHYSICS | GROWTH | LIGNANS | SIMULATIONS | INHIBITOR
Journal Article
European Journal of Neuroscience, ISSN 0953-816X, 07/2013, Volume 38, Issue 1, pp. 2153 - 2165
Journal Article
International Journal of Oncology, ISSN 1019-6439, 02/2012, Volume 40, Issue 2, pp. 519 - 526
Transcription factor 7 like 2 (TCF7L2, also known as TCF4) is a Wnt signaling pathway transcription factor involved in regulation of numerous Wnt targeted... 
β-catenin/TCF4 signaling | miRNA | Transcription initiation site | miR-21 | DOWN-REGULATION | MICRORNAS | BETA-CATENIN | EGFR PATHWAY | CELL GROWTH | ONCOLOGY | SIGNALING PATHWAY | COLORECTAL-CANCER | SUPPRESSES | beta-catenin/TCF4 signaling | BINDING-SITES | EXPRESSION | transcription initiation site
Journal Article
by McRae, Jeremy F and Clayton, Stephen and Fitzgerald, Tomas W and Kaplanis, Joanna and Prigmore, Elena and Rajan, Diana and Sifrim, Alejandro and Aitken, Stuart and Akawi, Nadia and Alvi, Mohsan and Ambridge, Kirsty and Barrett, Daniel M and Bayzetinova, Tanya and Jones, Philip and Jones, Wendy D and King, Daniel and Krishnappa, Netravathi and Mason, Laura E and Singh, Tarjinder and Tivey, Adrian R and Ahmed, Munaza and Anjum, Uruj and Archer, Hayley and Armstrong, Ruth and Awada, Jana and Balasubramanian, Meena and Banka, Siddharth and Baralle, Diana and Barnicoat, Angela and Batstone, Paul and Baty, David and Bennett, Chris and Berg, Jonathan and Bernhard, Birgitta and Bevan, A. Paul and Bitner-Glindzicz, Maria and Blair, Edward and Blyth, Moira and Bohanna, David and Bourdon, Louise and Bourn, David and Bradley, Lisa and Brady, Angela and Brent, Simon and Brewer, Carole and Brunstrom, Kate and Bunyan, David J and Burn, John and Canham, Natalie and Castle, Bruce and Chandler, Kate and Chatzimichali, Elena and Cilliers, Deirdre and Clarke, Angus and Clasper, Susan and Clayton-Smith, Jill and Clowes, Virginia and Coates, Andrea and Cole, Trevor and Colgiu, Irina and Collins, Amanda and Collinson, Morag N and Connell, Fiona and Cooper, Nicola and Cox, Helen and Cresswell, Lara and Cross, Gareth and Crow, Yanick and D'Alessandro, Mariella and Dabir, Tabib and Davidson, Rosemarie and Davies, Sally and De Vries, Dylan and Dean, John and Deshpande, Charu and Devlin, Gemma and Dixit, Abhijit and Dobbie, Angus and Donaldson, Alan and Donnai, Dian and Donnelly, Deirdre and Donnelly, Carina and Douglas, Angela and Douzgou, Sofia and Duncan, Alexis and Eason, Jacqueline and Ellard, Sian and Ellis, Ian and Elmslie, Frances and Evans, Karenza and Everest, Sarah and Fendick, Tina and Fisher, Richard and Flinter, Frances and Foulds, Nicola and Fry, Andrew and Fryer, Alan and Gardiner, Carol and Gaunt, Lorraine and Ghali, Neeti and ... and Deciphering Developmental Disorders Study
Nature, ISSN 0028-0836, 02/2017, Volume 542, Issue 7642, pp. 433 - 438
The genomes of individuals with severe, undiagnosed developmental disorders are enriched in damaging de novo mutations (DNMs) in developmentally important... 
INTELLECTUAL DISABILITY | METAANALYSIS | VARIANTS | GENETICS | HEART-DEFECTS | MULTIDISCIPLINARY SCIENCES | GENES | SEQUENCE | FRAMEWORK | DISCOVERY | GENOME | Prevalence | Humans | Middle Aged | Parents | Male | Mi-2 Nucleosome Remodeling and Deacetylase Complex - genetics | Developmental Disabilities - genetics | Casein Kinase II - genetics | Autoantigens - genetics | Young Adult | ras GTPase-Activating Proteins - genetics | Adult | Female | Child | CDC2 Protein Kinase - genetics | Histone-Lysine N-Methyltransferase - genetics | Repressor Proteins - genetics | Sex Characteristics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mutation - genetics | Nerve Tissue Proteins - genetics | Sequence Analysis, DNA | Homeodomain Proteins - genetics | DEAD-box RNA Helicases - genetics | Exome - genetics | Phenotype | Myeloid-Lymphoid Leukemia Protein - genetics | Adolescent | Heredity - genetics | Protein Phosphatase 2C - genetics | Cohort Studies | Child development deviations | Genetic aspects | Genetic disorders | Developmental disabilities | Distribution | Genes | Families & family life | Births | Genomes | Mutation | Causality | Estimates | Age | Index Medicus | TRIO | MYT1L | EHMT1 | HNRNPU | SUV420H1 | COL4A3BP | SYNGAP1 | PPP2R1A | POGZ | EP300 | KCNH1 | SCN1A | MEF2C | CDKL5 | CSNK2A1 | DYRK1A | CASK | ALG13 | FOXP1 | KAT6B | TBL1XR1 | KAT6A | SCN8A | KCNQ2 | EEF1A2 | KCNQ3 | ADNP | PhenIcons | SET | KMT2A | ANKRD11 | STXBP1 | FOXG1 | ZC4H2 | ITPR1 | De novo mutation | Seizures | ZBTB18 | CREBBP | SMAD4 | PDHA1 | IQSEC2 | AUTS2 | BCL11A | BRAF | SMARCA2 | GRIN2B | MED13L | GNAO1 | CNOT3 | TCF4 | SCN2A | CDK13 | GABRB3 | SETD5 | KDM5B | Developmental Disease | DDX3X | CHD8 | PTEN | CHD4 | TCF20 | CTCF | CHD2 | WDR45 | SLC6A1 | MECP2 | CHAMP1 | KIF1A | Average Faces | MSL3 | PPP2R5D | SMC1A | ARID1B | DNM1 | CNKSR2 | PACS1 | WAC | ZMYND11 | AHDC1 | NFIX | SATB2 | HDAC8 | PPM1D | GNAI1 | PURA | PUF60 | NSD1 | Intellectual Disability | SLC35A2 | DYNC1H1 | NAA10 | USP9X | PTPN11 | GATAD2B | ASXL1 | KANSL1 | ASXL3 | CTNNB1 | QRICH1
Journal Article