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Journal of Leukocyte Biology, ISSN 0741-5400, 03/2019, Volume 105, Issue 3, pp. 531 - 538
Chronic lymphocytic leukemia (CLL) can be defined as a clonal expansion of B cells with stereotypic BCRs. Somatic hypermutation of the BCR heavy chains (IGVH)... 
splenocytes | Eμ‐TCL1 mouse model | B cell receptor | VDJ rearrangement | Eμ-TCL1 mouse model | SURVIVAL | ACTIVATION | CLL | CELL-DEVELOPMENT | MOUSE | IMMUNOLOGY | CELL BIOLOGY | E mu-TCL1 mouse model | RITUXIMAB | CALCINEURIN | MUTATIONS | HEMATOLOGY | NF-KAPPA-B | TRANSCRIPTION FACTOR
Journal Article
PLOS ONE, ISSN 1932-6203, 10/2018, Volume 13, Issue 10
T Cell Leukemia/Lymphoma 1 A is expressed during B-cell differentiation and, when over-expressed, acts as an oncogene in mouse (Tcl1a) and human (TCL1A) B-cell... 
PROTEIN-KINASE-C | STEM-CELLS | JUN | MULTIDISCIPLINARY SCIENCES | CHRONIC LYMPHOCYTIC-LEUKEMIA | TCL1 EXPRESSION | SELF-RENEWAL | AKT | DIFFERENTIATION | PROTOONCOGENE TCL1 | TRANSGENIC MICE
Journal Article
Current Cancer Drug Targets, ISSN 1568-0096, 12/2014, Volume 14, Issue 8, pp. 700 - 712
Cell survival in chronic lymphocytic leukemia (CLL) largely depends on B-cell receptor-induced AKT activation. Gain-of-function genomic lesions of... 
mTOR | Inhibitor response | CLL | AKT | TCL1 | PI3K | B-CELL RECEPTOR | KINASE-ACTIVITY | DRUG DISCOVERY | MOUSE | inhibitor response | PROTOONCOGENE TCL1 | CANCER | ONCOLOGY | LYMPHOMA | RAPAMYCIN INHIBITOR | STROMAL CELLS | EXPRESSION
Journal Article
BLOOD, ISSN 0006-4971, 08/2019, Volume 134, Issue 6, pp. 534 - 547
Targeted therapy is revolutionizing the treatment of cancers, but resistance evolves against these therapies and derogates their success. The... 
17P DELETION | TCL1 | IDELALISIB | INTEGRIN | KINASE | GENE-EXPRESSION | IBRUTINIB | OPEN-LABEL | HEMATOLOGY | FACTOR-I RECEPTOR | CANCER
Journal Article
BLOOD, ISSN 0006-4971, 08/2019, Volume 134, Issue 5, pp. 432 - 444
Chronic lymphocytic leukemia (CLL) occurs in 2 major forms: aggressive and indolent. Low miR-29b expression in aggressive CLL is associated with poor... 
TCL1 | SP1 | DNMT3A | MICRORNA-29B | DOWN-REGULATION | CHRONIC LYMPHOCYTIC-LEUKEMIA | ROR1 | ACUTE MYELOID-LEUKEMIA | HEMATOLOGY | PHASE-I | HYPOMETHYLATION
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 09/2019, Volume 859, p. 172494
To better define the biological impact of immunosuppression on peripheral blood mononuclear cells (PBMC), we employed RNASeq analysis to compare the whole... 
Renal transplantation | Tacrolimus | Everolimus | RNASeq | Transcriptome | APOPTOSIS | IMMUNITY | COMPLEMENT | ACTIVATION | COACTIVATOR | CALCINEURIN INHIBITORS | PROTOONCOGENE TCL1 | ANTIBODY-MEDIATED REJECTION | CANCER-RISK | PHARMACOLOGY & PHARMACY | EXPRESSION
Journal Article
Journal Article
Journal Article
Molecular Cancer, ISSN 1476-4598, 06/2015, Volume 14, Issue 1, p. 114
Journal Article