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Angewandte Chemie International Edition, ISSN 1433-7851, 01/2014, Volume 53, Issue 4, pp. 999 - 1002
Phen‐DC3 is a highly promising compound that specifically targets G‐quadruplexes, with potent biological effects observed in vivo. We used NMR spectroscopy to... 
bisquinolinium ligands | π interactions | NMR spectroscopy | drug design | G‐quadruplex DNA | G-quadruplex DNA | π interactions | TELOMERIC G-QUADRUPLEX | RNA | RECOGNITION | SMALL-MOLECULE | STABILIZATION | TELOMESTATIN | TRANSLATION | CHEMISTRY, MULTIDISCIPLINARY | interactions | LIGANDS | DNA | EFFICIENT | Purines | Nuclear magnetic resonance spectroscopy | Nuclear magnetic resonance--NMR
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 01/2013, Volume 41, Issue 1, pp. D1115 - D1123
The G-quadruplex ligands database (G4LDB, http://www.g4ldb.org) provides a unique collection of reported G-quadruplex ligands to streamline ligand/drug... 
TELOMERASE INHIBITOR | IN-VITRO | RNA G-QUADRUPLEXES | SMALL-MOLECULE | DNA | TELOMESTATIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMPLEXES | TARGETS | PROMOTER | HUMAN TUMOR-CELLS | Ligands | Molecular Docking Simulation | G-Quadruplexes - drug effects | Internet | Databases, Chemical | Drug Design
Journal Article
Nucleic acids research, ISSN 1362-4962, 2019, Volume 47, Issue 20, pp. 10744 - 10753
G-quadruplex (GQ) stabilizing small molecule (SM) ligands have been used to stabilize human telomeric GQ (hGQ) to inhibit telomerase activity, or non-telomeric... 
TELOMERASE INHIBITOR | BLM | ASSAY | SYNDROME GENE-PRODUCT | RECQ HELICASES | MECHANISM | SINGLE-MOLECULE | DNA | TELOMESTATIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | G-Quadruplexes | Ligands | Telomere - metabolism | RecQ Helicases - metabolism | Humans | Molecular Biology
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 02/2007, Volume 129, Issue 7, pp. 1856 - 1857
Journal Article
BioEssays, ISSN 1521-1878, 2007, Volume 29, Issue 2, pp. 155 - 165
Journal Article
Nucleic acids research, ISSN 1362-4962, 2014, Volume 42, Issue 9, pp. 5447 - 5455
Specific guanine-rich regions in human genome can form higher-order DNA structures called G-quadruplexes, which regulate many relevant biological processes.... 
METADYNAMICS | BINDERS | MOLECULAR-DYNAMICS | IN-VITRO | PROTEIN | TELOMERASE | TELOMESTATIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | FORCE-FIELD | FREE-ENERGY | NUCLEIC-ACIDS | Benzopyrans - chemistry | Thermodynamics | DNA - chemistry | Humans | Benzothiazoles - chemistry | G-Quadruplexes | Ligands | Molecular Docking Simulation | Binding Sites | Molecular Dynamics Simulation | Computational Biology
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 08/2007, Volume 129, Issue 33, pp. 10220 - 10228
Journal Article
Current Topics in Medicinal Chemistry, ISSN 1568-0266, 2008, Volume 8, Issue 15, pp. 1405 - 1415
Guanine-rich sequences of DNA can form quadruply-stranded structures. It has been shown that folding single-stranded telomeric DNA into a quadruplex structure... 
Quadruplex DNA | Telomerase inhibition | Oncogene regulation | Small molecule | CATIONIC PORPHYRINS | small molecule | CHEMISTRY, MEDICINAL | RECOGNITION | TELOMESTATIN | oncogene regulation | telomerase inhibition | CANCER-THERAPY | EXPANDED PORPHYRIN | SELECTIVE INTERACTIONS | INTRAMOLECULAR G-QUADRUPLEX | POTENT TELOMERASE INHIBITOR | BINDING | DERIVATIVES
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 4766 - 11
The G-quadruplex (G4) structures of nucleic acids are considered to play an intrinsic role in gene expression. To this end, the development of new G4 ligands... 
RNA | HUMAN-CELLS | DNA | TELOMESTATIN | MULTIDISCIPLINARY SCIENCES | LIGHT-UP PROBE | FLUORESCENT-PROBES | TELOMERASE INHIBITION | PARALLEL G-QUADRUPLEXES | BINDING | DERIVATIVES | Optical properties | High-throughput screening | Cytotoxicity | Ligands | Affinity | Gene expression | Probes | Sugar
Journal Article
Chinese Journal of Chemistry, ISSN 1001-604X, 07/2014, Volume 32, Issue 7, pp. 557 - 557
The cover picture shows the design and synthesis of polyoxazole‐based macrocycles containing a phosphonate group in the macrocyclic ring periphery. Such novel... 
Telomestatin | telomerase | macrocyclic compound | phosphonate | oxazole
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 11/2008, Volume 130, Issue 47, pp. 15950 - 15956
Journal Article