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1. Full Text Concomitant WT1 mutations predict poor prognosis in acute myeloid leukemia patients with double mutant CEBPA
by Tien, Feng-Ming and Hou, Hsin-An and Tang, Jih-Luh and Kuo, Yuan-Yeh and Chen, Chien-Yuan and Tsai, Cheng-Hong and Yao, Ming and Lin, Chien-Ting and Li, Chi-Cheng and Huang, Shang-Yi and Ko, Bor-Sheng and Hsu, Szu-Chun and Wu, Shang-Ju and Liu, Jia-Hau and Chou, Sheng-Chieh and Tsay, Woei and Tseng, Mei-Hsuan and Liu, Ming-Chih and Liu, Chia-Wen and Lin, Liang-In and Chou, Wen-Chien and Tien, Hwei-Fang
Haematologica, ISSN 0390-6078, 10/2018, Volume 103, Issue 11, pp. e510 - e513
GENE | TET2 | HEMATOLOGY | Online Only
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2. Full Text TET2 mutations and clonal dynamics
by Kishtagari, Ashwin and Jha, Babal K and Maciejewski, Jaroslaw P
Oncotarget, ISSN 1949-2553, 03/2019, Volume 10, Issue 21, pp. 2010 - 2011
Clonal hierarchy | TET2 | Mutations
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3. Full Text Residents'corner, July-August 2018 What's new this month?
by Cunha, N and Hernandez-Aragues, I and Fattouh, K and Frings, V and Stembridge, N and Kuonen, F
EUROPEAN JOURNAL OF DERMATOLOGY, ISSN 1167-1122, 07/2018, Volume 28, Issue 4, pp. 565 - 566
MANAGEMENT | TET2 | DERMATOLOGY
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4. Full Text Efects of TET2 mutations on DNA methylation in chronic myelomonocytic leukemia
by Yamazaki, Jumpei and Taby, Rodolphe and Vasanthakumar, Aparna and Macrae, Trisha and Ostler, Kelly R and Shen, Lanlan and Kantarjian, Hagop M and Estecio, Marcos R and Jelinek, Jaroslav and Godley, Lucy A and Issa, Jean-Pierre
Epigenetics, ISSN 1559-2294, 2012, Volume 7, Issue 2, pp. 201 - 207
Promoter | DNA methylation | TET2 | Mutation | CMML
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5. Full Text The catalytic activity of TET2 is essential for its myeloid malignancy-suppressive function in hematopoietic stem/progenitor cells
by Zhao, Z and Chen, S and Zhu, X and Pan, F and Li, R and Zhou, Y and Yuan, W and Ni, H and Yang, F.-C and Xu, M
Leukemia, ISSN 0887-6924, 08/2016, Volume 30, Issue 8, pp. 1784 - 1788
STEM-CELLS | MAMMALIAN DNA | 5-METHYLCYTOSINE | ONCOLOGY | LEADS | MICE | MUTATIONS | HEMATOLOGY | 5-CARBOXYLCYTOSINE | Care and treatment | Gene mutations | Growth | Stem cells | Tumor suppressor genes | Development and progression | Genetic aspects | Properties | Health aspects | Myelodysplastic syndromes | Index Medicus | progenitor cells | myeloid malignancies | TET2 mutations | TET2 catalytic activity | hematopoietic stem | Tet2 knock-out
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6. Full Text Treatment with 5-azacytidine induces a sustained response in patients with angioimmunoblastic T-cell lymphoma
by Lemonnier, François and Lemonnier, François and Dupuis, Jehan and Dupuis, Jehan and Sujobert, Pierre and Sujobert, Pierre and Tournillhac, Olivier and Cheminant, Morgane and Cheminant, Morgane and Sarkozy, Clémentine and Sarkozy, Clémentine and Pelletier, Laura and Pelletier, Laura and Marçais, Ambroise and Marçais, Ambroise and Robe, Cyrielle and Robe, Cyrielle and Fataccioli, Virginie and Fataccioli, Virginie and Haioun, Corinne and Haioun, Corinne and Hermine, Olivier and Hermine, Olivier and Gaulard, Philippe and Gaulard, Philippe and Delarue, Richard and Delarue, Richard
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue 21, pp. 2305 - 2309
HYPOMETHYLATING AGENTS | PHASE-II | HEMATOLOGY | TET2 MUTATIONS | Life Sciences | Cancer
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7. Full Text IDH2(R172) mutations define a unique subgroup of patients with angioimmunoblastic T-cell lymphoma
by Wang, C and McKeithan, TW and Gong, Q and Zhang, WW and Bouska, A and Rosenwald, A and Gascoyne, RD and Wu, XW and Wang, JH and Muhammad, Z and Jiang, B and Rohr, J and Cannon, A and Steidl, C and Fu, K and Li, YP and Hung, S and Weisenburger, DD and Greiner, TC and Smith, L and Ott, G and Rogan, EG and Staudt, LM and Vose, J and Iqbal, J and Chan, WC
BLOOD, ISSN 0006-4971, 10/2015, Volume 126, Issue 15, pp. 1741 - 1752
Angioimmunoblastic T-cell lymphoma (AITL) is a common subtype of peripheral T-cell lymphoma (PTCL) with a poor prognosis. We performed targeted resequencing on... 
IDH2 MUTATIONS | FREQUENT | LANDSCAPE | TET2 | UTX | ACUTE MYELOID-LEUKEMIA | HEMATOLOGY | ONCOMETABOLITE 2-HYDROXYGLUTARATE | RHOA | FOLLICULAR HELPER-CELLS
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8. Full Text Mutational Cooperativity Linked to Combinatorial Epigenetic Gain of Function in Acute Myeloid Leukemia
by Shih, Alan H and Jiang, Yanwen and Meydan, Cem and Shank, Kaitlyn and Pandey, Suveg and Barreyro, Laura and Antony-Debre, Ileana and Viale, Agnes and Socci, Nicholas and Sun, Yongming and Robertson, Alexander and Cavatore, Magali and de Stanchina, Elisa and Hricik, Todd and Rapaport, Franck and Woods, Brittany and Wei, Chen and Hatlen, Megan and Baljevic, Muhamed and Nimer, Stephen D and Tallman, Martin and Paietta, Elisabeth and Cimmino, Luisa and Aifantis, Iannis and Steidl, Ulrich and Mason, Chris and Melnick, Ari and Levine, Ross L
Cancer Cell, ISSN 1535-6108, 04/2015, Volume 27, Issue 4, pp. 502 - 515
Specific combinations of acute myeloid leukemia (AML) disease alleles, including and mutations, confer distinct biologic features and adverse outcome. We... 
TRANSFORMATION | STEM-CELLS | PROGENITOR | 5-METHYLCYTOSINE | ONCOLOGY | TET2 MUTATIONS | FLT3 | CLONAL HEMATOPOIESIS | DNA | MALIGNANCIES | DIFFERENTIATION | CELL BIOLOGY | Proto-Oncogene Proteins - metabolism | Doxorubicin - therapeutic use | Cytarabine - therapeutic use | Epigenesis, Genetic | Gene Expression Regulation, Neoplastic | Gene Silencing | Proto-Oncogene Proteins - genetics | Antineoplastic Agents - therapeutic use | DNA-Binding Proteins - genetics | fms-Like Tyrosine Kinase 3 - metabolism | Haploinsufficiency | DNA-Binding Proteins - metabolism | fms-Like Tyrosine Kinase 3 - genetics | Cell Differentiation - genetics | DNA Methylation | Mutation | GATA2 Transcription Factor - genetics | Leukemia, Myeloid, Acute - genetics | Epigenetic inheritance | Chemotherapy | Gene mutations | Lubrication and lubricants | Stem cells | Methylation | Gene expression | Cancer | Index Medicus | AML | Epigenetics | TET2
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9. Full Text The TET2/E-cadherin/β-catenin regulatory loop confers growth and invasion in hepatocellular carcinoma cells
by Yang, Guohua and Zeng, Xiang and Wang, Mengchuan and Wu, Aiguo
Experimental Cell Research, ISSN 0014-4827, 02/2018, Volume 363, Issue 2, pp. 218 - 226
The poor outcome of hepatocellular carcinoma (HCC) is mainly due to the development of fast growth, invasion and metastasis. The role of TET2 has been... 
TET2 | β-catenin | Hepatocellular carcinoma | E-cadherin | beta-catenin | TO-MESENCHYMAL TRANSITION | 5-METHYLCYTOSINE | ONCOLOGY | TET2 MUTATIONS | DNA | PROTEINS | CANCER | CELL BIOLOGY | Index Medicus
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10. Full Text IDH1 and IDH2 mutation studies in 1473 patients with chronic-, fibrotic- or blast-phase essential thrombocythemia, polycythemia vera or myelofibrosis
by Tefferi, A and Lasho, T.L and Abdel-Wahab, O and Guglielmelli, P and Patel, J and Caramazza, D and Pieri, L and Finke, C.M and Kilpivaara, O and Wadleigh, M and Mai, M and McClure, R.F and Gilliland, D.G and Levine, R.L and Pardanani, A and Vannucchi, A.M
Leukemia, ISSN 0887-6924, 2010, Volume 24, Issue 7, pp. 1302 - 1309
In a multi-institutional collaborative project, 1473 patients with myeloproliferative neoplasms (MPN) were screened for isocitrate dehydrogenase 1 (IDH1)/IDH2... 
MPL | TET2 | JAK2 | myeloproliferative | PROGNOSTIC SCORING SYSTEM | MYELOPROLIFERATIVE NEOPLASMS | ISOCITRATE-DEHYDROGENASE 1 | INTERNATIONAL WORKING GROUP | JAK2 46/1 HAPLOTYPE | CONFERS SUSCEPTIBILITY | ACTIVATING MUTATION | ONCOLOGY | TET2 MUTATIONS | LEUKEMIA | HEMATOLOGY | MYELOID METAPLASIA | Prognosis | Humans | Middle Aged | Janus Kinase 2 - genetics | Isocitrate Dehydrogenase - genetics | Male | Polycythemia Vera - genetics | Mutation - genetics | Thrombocythemia, Essential - genetics | Young Adult | Receptors, Thrombopoietin - genetics | Primary Myelofibrosis - genetics | Adolescent | Polymerase Chain Reaction | Aged, 80 and over | Adult | Female | Aged | Blast Crisis | Cohort Studies | Gene mutations | Development and progression | Genetic aspects | Research | Health aspects | Isocitrate dehydrogenase | Methods | Myeloproliferative disorders | Risk factors | Index Medicus | Original
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11. Full Text DNA methylation processes in atherosclerotic plaque
by Aavik, Einari and Babu, Mohan and Ylä-Herttuala, Seppo
Atherosclerosis, ISSN 0021-9150, 02/2019, Volume 281, pp. 168 - 179
Underlying mechanisms of cardiovascular diseases (CVD) have been investigated for over 100 years and novel molecular level mechanisms in the pathophysiology... 
DNA methylation | TET2 | Cardiovascular disease | DNMT1 | Atherosclerosis | DNMT3A
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12. Full Text Vpr Targets TET2 for Degradation by CRL4VprBP E3 Ligase to Sustain IL-6 Expression and Enhance HIV-1 Replication
by Lv, Lei and Wang, Qi and Xu, Yanping and Tsao, Li-Chung and Nakagawa, Tadashi and Guo, Haitao and Su, Lishan and Xiong, Yue
Molecular Cell, ISSN 1097-2765, 06/2018, Volume 70, Issue 5, pp. 961 - 970.e5
HIV-1 expresses several accessory proteins to counteract host anti-viral restriction factors to facilitate viral replication and disease progression. One such... 
HIV-1 | TET2 | Vpr | inflammation | VprBP | IL-6 | Index Medicus
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13. Full Text Molecular analysis of patients with polycythemia vera or essential thrombocythemia receiving pegylated interferon alpha-2a
by Quintas-Cardama, A and Abdel-Wahab, O and Manshouri, T and Kilpivaara, O and Cortes, J and Roupie, AL and Zhang, SJ and Harris, D and Estrov, Z and Kantarjian, H and Levine, RL and Verstovsek, S
BLOOD, ISSN 0006-4971, 08/2013, Volume 122, Issue 6, pp. 893 - 901
Pegylated interferon alpha-2a (PEG-IFN-alpha-2a) has previously been shown to induce hematologic and molecular responses in patients with polycythemia vera... 
MYELOFIBROSIS | HEMATOPOIETIC STEM-CELLS | MUTATION | TYROSINE KINASE JAK2 | TET2 | MYELOPROLIFERATIVE NEOPLASMS | DISORDERS | MYELOID MALIGNANCIES | DIFFERENTIATION | HEMATOLOGY | CHRONIC MYELOMONOCYTIC LEUKEMIA
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14. Full Text Transcriptome-wide distribution and function of RNA hydroxymethylcytosine
by Delatte, Benjamin and Wang, Fei and Ngoc, Long Vo and Collignon, Evelyne and Bonvin, Elise and Deplus, Rachel and Calonne, Emilie and Hassabi, Bouchra and Putmans, Pascale and Awe, Stephan and Wetzel, Collin and Kreher, Judith and Soin, Romuald and Creppe, Catherine and Limbach, Patrick A and Gueydan, Cyril and Kruys, Véronique and Brehm, Alexander and Minakhina, Svetlana and Defrance, Matthieu and Steward, Ruth and Fuks, François
Science, ISSN 0036-8075, 01/2016, Volume 351, Issue 6270, pp. 282 - 285
Hydroxymethylcytosine, well described in DNA, occurs also in RNA. Here, we show that hydroxymethylcytosine preferentially marks polyadenylated RNAs and is... 
CELLS | METHYLATION | 5-METHYLCYTOSINE | DNA | MULTIDISCIPLINARY SCIENCES | TET2 | 5-HYDROXYMETHYLCYTOSINE | DROSOPHILA | REVEALS | RNA sequencing | Physiological aspects | Genetic aspects | Cytosine | Drosophila | Methods | Studies | Biomarkers | Biochemistry | Ribonucleic acid--RNA | Deoxyribonucleic acid--DNA
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15. Full Text One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering
by Wang, Haoyi and Yang, Hui and Shivalila, Chikdu S and Dawlaty, Meelad M and Cheng, Albert W and Zhang, Feng and Jaenisch, Rudolf
Cell, ISSN 0092-8674, 05/2013, Volume 153, Issue 4, pp. 910 - 918
Mice carrying mutations in multiple genes are traditionally generated by sequential recombination in embryonic stem cells and/or time-consuming intercrossing... 
CELLS | BACTERIA | ENDONUCLEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TET2 | EMBRYO MICROINJECTION | SYSTEMS | POSTNATAL-DEVELOPMENT | CAS9 | ZINC-FINGER NUCLEASES | KNOCKOUT RATS | CELL BIOLOGY | Embryonic Stem Cells - metabolism | Gene Targeting - methods | Mice - genetics | Animals | RNA, Guide - genetics | Base Sequence | Mice, Inbred C57BL | Molecular Sequence Data | Female | Male | Mice, Inbred DBA | RNA | Gene mutations | Genes | Genomics | Genetic research | Genetic aspects | Embryonic stem cells | Mice | Index Medicus
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16. Full Text CARDIOVASCULAR DISEASE Hematopoietic stem cells gone rogue Somatic mutations in hematopoietic stem cells aggravate cardiovascular disease
by Zhu, YFPP and Hedrick, CC and Gaddis, DE
SCIENCE, ISSN 0036-8075, 02/2017, Volume 355, Issue 6327, pp. 798 - 799
DNA METHYLATION | MULTIDISCIPLINARY SCIENCES | TET2 | ATHEROSCLEROSIS | 5-CARBOXYLCYTOSINE
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17. Full Text Loss of TET2 has dual roles in murine myeloproliferative neoplasms: Disease sustainer and disease accelerator
by Kameda, Takuro and Shide, Kotaro and Yamaji, Takumi and Kamiunten, Ayako and Sekine, Masaaki and Taniguchi, Yasuhiro and Hidaka, Tomonori and Kubuki, Yoko and Shimoda, Haruko and Marutsuka, Kousuke and Sashida, Goro and Aoyama, Kazumasa and Yoshimitsu, Makoto and Harada, Taku and Abe, Hiroo and Miike, Tadashi and Iwakiri, Hisayoshi and Tahara, Yoshihiro and Sueta, Mitsue and Yamamoto, Shojiro and Hasuike, Satoru and Nagata, Kenji and Iwama, Atsushi and Kitanaka, Akira and Shimoda, Kazuya
Blood, ISSN 0006-4971, 08/2015, Volume 125, Issue 2, pp. 304 - 315
Acquired mutations of JAK2 and TET2 are frequent in myeloproliferative neoplasms (MPNs). We examined the individual and cooperative effects of these mutations... 
POLYCYTHEMIA-VERA | ACTIVATING MUTATION | HEMATOPOIETIC STEM-CELLS | TYROSINE KINASE JAK2 | SELF-RENEWAL | MICE | ESSENTIAL THROMBOCYTHEMIA | HEMATOLOGY | JAK2(V617F) EXPRESSION | JAK2V617F | SOMATIC MUTATIONS | Animals | Flow Cytometry | Oligonucleotide Array Sequence Analysis | Mice, Inbred C57BL | Janus Kinase 2 - genetics | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Mice | DNA-Binding Proteins - genetics | Myeloproliferative Disorders - genetics | Index Medicus | Abridged Index Medicus
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