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by Jones, David T. W and Jäger, Natalie and Kool, Marcel and Zichner, Thomas and Hutter, Barbara and Sultan, Marc and Cho, Yoon-Jae and Pugh, Trevor J and Hovestadt, Volker and Stütz, Aian M and Rausch, Tobias and Warnatz, Hans-Jörg and Ryzhova, Marina and Bender, Sebastian and Sturm, Dominik and Pleier, Sabrina and Cin, Huriye and Pfaff, Elke and Sieber, Laura and Wittmann, Anea and Remke, Marc and Witt, Henik and Hutter, Sonja and Tzaridis, Theophilos and Weischenfeldt, Joachim and Raeder, Benjamin and Avci, Meryem and Amstislavskiy, Vyacheslav and Zapatka, Marc and Weber, Ursula D and Wang, Qi and Lasitschka, Bärbel and Bartholomae, Cynthia C and Schmidt, Manfred and von Kalle, Christof and Ast, Volker and Lawerenz, Chris and Eils, Jürgen and Kabbe, Rolf and Benes, Vladimir and van Sluis, Peter and Koster, Jan and Volckmann, Richard and Shih, David and Betts, Matthew J and Russell, Robert B and Coco, Simona and Tonini, Gian Paolo and Schüller, Ulrich and Hans, Volkmar and Graf, Norbert and Kim, Yoo-Jin and Monoranu, Camelia and Roggendorf, Wolfgang and Unterberg, Aneas and Herold-Mende, Christel and Milde, Till and Kulozik, Aneas E and von Deimling, Aneas and Witt, Olaf and Maass, Eberhard and Rössler, Jochen and Ebinger, Martin and Schuhmann, Martin U and Frühwald, Michael C and Hasselblatt, Martin and Jabado, Nada and Rutkowski, Stefan and von Bueren, Ané O and Williamson, Dan and Clifford, Steven C and McCabe, Martin G and Collins, V. Peter and Wolf, Stephan and Wiemann, Stefan and Lehrach, Hans and Brors, Benedikt and Scheurlen, Wolfram and Felsberg, Jörg and Reifenberger, Guido and Northcott, Paul A and Taylor, Michael D and Meyerson, Matthew and Pomeroy, Scott L and Yaspo, Marie-Laure and Korbel, Jan O and Korshunov, Aney and Eils, Roland and Pfister, Stefan M and Lichter, Peter
Nature, ISSN 0028-0836, 2012, Volume 488, Issue 7409, pp. 100 - 105
Medulloblastoma is an aggressively growing tumour, arising in the cerebellum or medulla/brain stem. It is the most common malignant brain tumour in children,... 
ACTIVATION | PATHWAY | LANDSCAPE | MULTIDISCIPLINARY SCIENCES | GENES | TETRAPLOID TUMOR-CELLS | TBR1 | MUTATIONS | SUBGROUPS | CANCER | Chromatin - metabolism | Cerebellar Neoplasms - diagnosis | Genomics | Humans | Hedgehog Proteins - metabolism | Wnt Proteins - metabolism | Histone Demethylases - genetics | Aging - genetics | Medulloblastoma - pathology | Cerebellar Neoplasms - pathology | Patched Receptors | Cerebellar Neoplasms - classification | Medulloblastoma - genetics | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Child | DNA Helicases - genetics | Amino Acid Sequence | Polyploidy | Signal Transduction | Chromosomes, Human - genetics | Medulloblastoma - diagnosis | Mutation Rate | Cerebellar Neoplasms - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mutation - genetics | T-Box Domain Proteins - genetics | Genome, Human - genetics | beta Catenin - genetics | DEAD-box RNA Helicases - genetics | Phosphoprotein Phosphatases - genetics | Sequence Analysis, RNA | Cell Transformation, Neoplastic | Oncogene Proteins, Fusion - genetics | High-Throughput Nucleotide Sequencing | Methylation | Medulloblastoma - classification | Patched-1 Receptor | Receptors, Cell Surface - genetics | Medulloblastoma | Physiological aspects | Development and progression | Genetic aspects | Research | Metastasis | Cancer | Index Medicus
Journal Article
Genes and Development, ISSN 0890-9369, 08/2004, Volume 18, Issue 15, pp. 1875 - 1885
Journal Article
BMB Reports, ISSN 1976-6696, 2017, Volume 50, Issue 7, pp. 379 - 383
Journal Article
Radiation Research, ISSN 0033-7587, 02/2018, Volume 189, Issue 2, pp. 146 - 155
Synchrotron microbeam radiation therapy is a promising preclinical radiotherapy modality that has been proposed as an alternative to conventional radiation... 
CANCER-CELLS | 9L GLIOSARCOMA | TETRAPLOID TUMOR-CELLS | CHILDREN | BEAM | BIOPHYSICS | CLINICAL-TRIALS | BIOLOGY | POLYPLOIDY | SENESCENCE | IONIZING-RADIATION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | BRAIN | Care and treatment | Usage | Gliomas | Radiotherapy | Comparative analysis | Health aspects | Methods | Synchrotron radiation | Index Medicus | Space life sciences
Journal Article
Journal Article
International Journal of Cancer, ISSN 0020-7136, 06/2010, Volume 126, Issue 12, pp. 2813 - 2825
The role of the mismatch repair (MMR) system in correcting base base mismatches is well established; its involvement in the response to DNA double strand... 
Irinotecan | Chemotherapy | Tetraploid G1 arrest | Mismatch repair | Colon carcinoma cells | colon carcinoma cells | CANCER-CELLS | irinotecan | DNA-DAMAGE | CYCLE ARREST | mismatch repair | DEATH | chemotherapy | UCN-01 | COLON-CARCINOMA CELLS | P53 | INHIBITION | ONCOLOGY | tetraploid G1 arrest | IONIZING-RADIATION | G CHECKPOINT ABROGATION | Neoplasms - metabolism | Protein Kinases - metabolism | MutL Protein Homolog 1 | Phosphorylation | Protein Kinases - genetics | Tumor Suppressor Protein p53 - antagonists & inhibitors | Apoptosis - drug effects | Cyclin-Dependent Kinase 4 - genetics | Humans | Protein Kinases - chemistry | G1 Phase - drug effects | RNA, Messenger - metabolism | Tumor Suppressor Protein p53 - genetics | Neoplasms - genetics | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Tumor Cells, Cultured | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Nuclear Proteins - genetics | Camptothecin - analogs & derivatives | DNA Damage - drug effects | Cyclin-Dependent Kinase 2 - metabolism | Tumor Stem Cell Assay | Cell Survival | RNA, Messenger - genetics | RNA, Small Interfering - pharmacology | Tumor Suppressor Protein p53 - metabolism | Cyclin-Dependent Kinase 2 - genetics | DNA Mismatch Repair - drug effects | Nuclear Proteins - metabolism | Cyclin-Dependent Kinase 4 - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Nuclear Proteins - antagonists & inhibitors | Ploidies | Adaptor Proteins, Signal Transducing - genetics | Cyclin-Dependent Kinase 2 - antagonists & inhibitors | Checkpoint Kinase 1 | Adaptor Proteins, Signal Transducing - metabolism | Antineoplastic Agents, Phytogenic - pharmacology | Neoplasms - pathology | Camptothecin - pharmacology | Index Medicus
Journal Article
Cell Structure and Function, ISSN 0386-7196, 2001, Volume 26, Issue 5, pp. 263 - 269
Journal Article
Leukemia Research, ISSN 0145-2126, 1987, Volume 11, Issue 11, pp. 1011 - 1017
Journal Article
Current Pharmaceutical Design, ISSN 1381-6128, 2010, Volume 16, Issue 6, pp. 734 - 740
Journal Article
International Journal of Hyperthermia, ISSN 0265-6736, 1987, Volume 3, Issue 3, pp. 235 - 244
Journal Article
ONCOTARGET, 01/2016, Volume 7, Issue 1, pp. 885 - 901
Several lines of evidence indicate that whole-genome duplication resulting in tetraploidy facilitates carcinogenesis by providing an intermediate and... 
AZ 3146 | PANCREATIC-CANCER | TETRAPLOID CELLS | CHROMOSOMAL INSTABILITY | CELL BIOLOGY | regulated cell death | BREAST-CANCER | KINASE INHIBITION | polyploidy | reversine | COPY-NUMBER ALTERATION | MITOTIC CHECKPOINT | PROMOTES TUMORIGENESIS | P53-DEFICIENT CANCER-CELLS | mitotic spindle | SPINDLE-ASSEMBLY CHECKPOINT
Journal Article
European Journal of Cancer (1965), ISSN 0014-2964, 1967, Volume 3, Issue 4, pp. 329 - 333
Diploid and tetraploid cell lines, both derived from the same Ehrlich ascites tumor, were mixed together in varying proportions. The resulting cell populations... 
Neoplasms, Experimental - pathology | Animals | Cell Division - radiation effects | Radiation Effects | Mice | Kinetics | Carcinoma, Ehrlich Tumor - pathology | Index Medicus
Journal Article
Seminars in Diagnostic Pathology, ISSN 0740-2570, 1994, Volume 11, Issue 2, pp. 118 - 125
Several genetic features have been identified that are characteristic of neuroblastomas. These include hyperdiploidy, deletion of 1p, amplification of N-myc,... 
molecular genetics | oncogenes | double-minute chromatin bodies | prognostic factors | deletion of chromosome 1p | Neuroblastoma | cytogenetics | nerve growth factor receptor | suppressor genes | near-diploid | ploidy | amplification | restriction fragment length polymorphism | genetics | homogeneously staining region | nerve growth factor | near-triploid | N-myc | loss of heterozygosity | tumor cell DNA content | near- tetraploid | polymerase chain reaction | ONCOGENES | PROGNOSTIC FACTORS | HOMOGENEOUSLY STAINING REGION | NEAR-TETRAPLOID | NEAR-TRIPLOID | SUPPRESSOR GENES | NERVE GROWTH FACTOR RECEPTOR | NEUROBLASTOMA | NEAR-DIPLOID | PATHOLOGY | CYTOGENETICS | TUMOR CELL DNA CONTENT | NERVE GROWTH FACTOR | RESTRICTION FRAGMENT LENGTH POLYMORPHISM | LOSS OF HETEROZYGOSITY | AMPLIFICATION | POLYMERASE CHAIN REACTION | GENETICS | MOLECULAR GENETICS | N-MYC | DELETION OF CHROMOSOME 1P | MEDICAL LABORATORY TECHNOLOGY | PLOIDY | DOUBLE-MINUTE CHROMATIN BODIES | Receptor, trkA | Oncogenes - genetics | Receptors, Nerve Growth Factor - biosynthesis | Humans | Neuroblastoma - genetics | Receptor Protein-Tyrosine Kinases - biosynthesis | Gene Expression Regulation, Neoplastic | Genes, Tumor Suppressor - genetics | Infant | Gene Amplification - genetics | Proto-Oncogene Proteins - biosynthesis | Peripheral Nervous System Neoplasms - genetics
Journal Article