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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 05/2007, Volume 104, Issue 20, pp. 8520 - 8525
Activation of tetroclotoxin-resistant sodium channels contributes to action potential electrogenesis in neurons. Antisense oligonucleotide studies directed... 
ROOT GANGLION NEURONS | NA+ CURRENTS | MULTIDISCIPLINARY SCIENCES | sensory neurons | NERVE-INJURY | TETRODOTOXIN-RESISTANT | VISCERAL PAIN | allodynia | electrophysiology | SNS | SNS/PN3 | hyperalgesia | PRIMARY SENSORY NEURONS | EXPRESSION
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 01/2003, Volume 23, Issue 1, pp. 158 - 166
The underlying mechanisms of neuropathic pain are poorly understood, and existing treatments are mostly ineffective. We recently demonstrated that antisense... 
Nerve injury | Peripheral nerve | Nociceptor | Tetrodotoxin resistant | Voltage-gated Na | Dorsal root ganglion | voltage-gated Na | nociceptor | ARTICLE | tetrodotoxin resistant | peripheral nerve | nerve injury | dorsal root ganglion
Journal Article
Cardiovascular Research, ISSN 0008-6363, 11/2018, Volume 114, Issue 13, pp. 1691 - 1693
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 12/2008, Volume 28, Issue 52, pp. 14062 - 14073
Journal Article
Circulation research, ISSN 0009-7330, 2012, Volume 111, Issue 3, pp. 333 - 343
Rationale: The SCN10A gene encodes the neuronal sodium channel isoform Na(V)1.8. Several recent genome-wide association studies have linked SCN10A to PR... 
cardiac electrophysiology | COMMON VARIANTS | CARDIAC & CARDIOVASCULAR SYSTEMS | autonomic nervous system | RAT | GATED SODIUM-CHANNELS | DRG NEURONS | SINOATRIAL NODE | SENSORY NEURONS | TETRODOTOXIN-RESISTANT | SCN10A | PR INTERVAL | sodium channels | PERIPHERAL VASCULAR DISEASE | HEART-RATE | QRS DURATION | HEMATOLOGY
Journal Article
JOURNAL OF NEUROSCIENCE, ISSN 0270-6474, 12/2011, Volume 31, Issue 50, pp. 18381 - 18390
Changes in function of voltage-gated sodium channels in nociceptive primary sensory neurons participate in the development of peripheral hyperexcitability that... 
NEUROPATHIC PAIN | TETRODOTOXIN-RESISTANT | CURRENT-DENSITY | NOCICEPTIVE NEURONS | DRG NEURONS | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | SPINAL-CORD | RECEPTOR ACTIVATION | CENTRAL-NERVOUS-SYSTEM | DORSAL-ROOT GANGLION | NEUROSCIENCES
Journal Article
by Su, YY and Ye, MY and Li, L and Liu, C and Pan, J and Liu, WW and Jiang, YB and Jiang, XY and Zhang, X and Shu, YS and Bao, L
JOURNAL OF NEUROSCIENCE, ISSN 0270-6474, 11/2013, Volume 33, Issue 45, pp. 17884 - 17896
Na(v)1.8 is a tetrodotoxin-resistant voltage-gated sodium channel selectively expressed in primary sensory neurons. Peripheral inflammation and nerve injury... 
TETRODOTOXIN-RESISTANT | CURRENT-DENSITY | KINESIN | PAIN | ELECTROGENESIS | TRAFFICKING | MECHANISMS | UP-REGULATION | EXPRESSION | NEUROSCIENCES | SENSORY NEURONS
Journal Article
JOURNAL OF GENERAL PHYSIOLOGY, ISSN 0022-1295, 08/2018, Volume 150, Issue 8, pp. 1125 - 1144
Damage-sensing nociceptors in the skin provide an indispensable protective function thanks to their specialized ability to detect and transmit hot temperatures... 
TETRODOTOXIN-RESISTANT | PHYSIOLOGY | PERSISTENT NA+ CURRENT | ELECTROGENESIS | TEMPERATURE | RAT | MEMBRANE CURRENTS | NOCICEPTORS | PAIN SENSATION | SENSORY NEURONS | NOXIOUS HEAT
Journal Article
JOURNAL OF GENERAL PHYSIOLOGY, ISSN 0022-1295, 02/2013, Volume 141, Issue 2, pp. 193 - 202
Tetrodotoxin (TTX)-resistant voltage-gated Na (Na-V) channels have been implicated in nociception. In particular, Na(V)1.9 contributes to expression of... 
TETRODOTOXIN-RESISTANT | PHYSIOLOGY | EXCITABILITY | HUMAN-CELLS | DRG NEURONS | MOUSE | PRIMARY SENSORY NEURONS | GENE-TRANSFER | NAV1.9 | EXPRESSION | RESISTANT NA+ CURRENT
Journal Article
Neuroscience Letters, ISSN 0304-3940, 01/2004, Volume 355, Issue 1-2, pp. 45 - 48
In an attempt to understand mechanisms underlying peripheral sensitization of primary afferent fibers, we investigated the presence of the... 
Nociception | Pain | Primary afferent | Tetrodotoxin-resistant sodium channel
Journal Article
JOURNAL OF NEUROPHYSIOLOGY, ISSN 0022-3077, 04/2014, Volume 111, Issue 7, pp. 1429 - 1443
The link between sodium channel Na(v)1.7 and pain has been strengthened by identification of gain-of-function mutations in patients with inherited... 
pain | PHYSIOLOGY | RAT | ROOT GANGLION NEURONS | channelopathy | DRG NEURONS | Hodgkin-Huxley equations | CURRENTS | NEUROSCIENCES | SPINAL SENSORY NEURONS | TETRODOTOXIN-RESISTANT | sodium channel | dynamic-clamp | CLOSED-STATE INACTIVATION | SENSITIVE SODIUM-CHANNELS | INFLAMMATORY PAIN | RESISTANT NA+ CURRENT
Journal Article
JOURNAL OF NEUROPHYSIOLOGY, ISSN 0022-3077, 04/2015, Volume 113, Issue 7, pp. 2618 - 2634
Stretch-sensitive afferents comprise similar to 33% of the pelvic nerve innervation of mouse colorectum, which are activated by colorectal distension and... 
ACTION-POTENTIALS | PURKINJE NEURONS | GUINEA-PIG CORNEA | PHYSIOLOGY | ROOT GANGLION NEURONS | GATED SODIUM-CHANNELS | NEUROSCIENCES | SPINAL SENSORY NEURONS | TETRODOTOXIN-RESISTANT | visceral pain | VISCERAL HYPERSENSITIVITY | sodium channel | computational model | colon | single fiber | IRRITABLE-BOWEL-SYNDROME | NA+ CURRENT
Journal Article
JOURNAL OF PHYSIOLOGY-LONDON, ISSN 0022-3751, 02/2008, Volume 586, Issue 4, pp. 1077 - 1087
Persistent tetrodotoxin-resistant (TTX-r) sodium currents up-regulated by intracellular GTP have been invoked as the site of action of peripheral inflammatory... 
TETRODOTOXIN-RESISTANT | PROTEIN-KINASE-C | PHYSIOLOGY | SODIUM-CHANNEL NA(V)1.9 | RAT | ROOT GANGLION NEURONS | INFLAMMATORY PAIN | PRIMARY SENSORY NEURONS | EXPRESSION | NEUROSCIENCES | MODULATION | DELETION
Journal Article
JOURNAL OF NEUROSCIENCE, ISSN 0270-6474, 05/2017, Volume 37, Issue 20, pp. 5204 - 5214
Voltage-gated sodium (Na-V) channels are responsible for the initiation and conduction of action potentials within primary afferents. The nine NaV channel... 
nociceptor | GUINEA-PIG CORNEA | pain | DRG NEURONS | PRIMARY AFFERENT-FIBERS | UNMYELINATED AXONS | DORSAL-ROOT GANGLIA | nonhuman primate | NEUROSCIENCES | SENSORY NEURONS | TETRODOTOXIN-RESISTANT | sodium channels | ELECTRICAL-ACTIVITY | INFLAMMATORY PAIN | PAINFUL NEUROPATHY
Journal Article
07/2013
Purpose: To explore the mechanism of antagonistic interaction between cochinchinenin A and B in modulating tetrodotoxin-resistant (TTR-X) sodium currents.... 
Occupancy theory | Rate theory | Cochinchinenin | Antagonistic interaction | Tetrodotoxin-resistant sodium channel
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