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Neuroscience, ISSN 0306-4522, 11/2006, Volume 142, Issue 4, pp. 941 - 952
A recent epidemiological study suggested that higher caffeine intake over decades reduces the risk of Alzheimer's disease (AD). The present study sought to... 
adenosine | learning | memory | transgenic mice | BACE | PS1 | COFFEE | PERFORMANCE | RISK | NEUROSCIENCES | OLIGOMERS | DISEASE | A-BETA | CONSUMPTION | TG2576 MOUSE MODEL | Memory Disorders - physiopathology | Purinergic P1 Receptor Antagonists | Presenilin-1 - drug effects | Amyloid beta-Peptides - drug effects | Memory, Short-Term - physiology | Brain - metabolism | Dose-Response Relationship, Drug | Cognition Disorders - prevention & control | Neuroprotective Agents - pharmacology | Alzheimer Disease - prevention & control | Amyloid beta-Peptides - metabolism | Caffeine - pharmacology | Disease Models, Animal | Alzheimer Disease - physiopathology | Cognition Disorders - physiopathology | Peptide Fragments - metabolism | Amyloid beta-Peptides - biosynthesis | Brain - physiopathology | Mice, Inbred C57BL | Alzheimer Disease - drug therapy | Memory, Short-Term - drug effects | Mice, Transgenic | Treatment Outcome | Cognition Disorders - drug therapy | Brain - drug effects | Neuropsychological Tests | Amyloid Precursor Protein Secretases - metabolism | Memory Disorders - prevention & control | Animals | Memory Disorders - drug therapy | Amyloid Precursor Protein Secretases - drug effects | Presenilin-1 - metabolism | Peptide Fragments - drug effects | Adenosine - metabolism | Cell Line, Tumor | Mice | Receptors, Purinergic P1 - metabolism | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 04/2012, Volume 122, Issue 4, pp. 1377 - 1392
Journal Article
Biomaterials, ISSN 0142-9612, 2014, Volume 44, pp. 155 - 172
Abstract Diagnosis of Alzheimer's disease (AD) can be performed with the assistance of amyloid imaging. The current method relies on positron emission... 
Advanced Basic Science | Dentistry | Curcumin | Iron oxide nanoparticles | Tg2576 mice | MRI | Alzheimer's disease | Amyloid plaques | IRON-OXIDE NANOPARTICLES | PEGYLATED POLYCYANOACRYLATE NANOPARTICLES | MATERIALS SCIENCE, BIOMATERIALS | CLINICAL-TRIAL | CONTRAST AGENTS | ENGINEERING, BIOMEDICAL | AQUEOUS DISPERSIONS | EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS | IN-VIVO MRI | BLOOD-BRAIN-BARRIER | CELLULAR UPTAKE | TRANSGENIC MICE | Immunohistochemistry | Photoelectron Spectroscopy | Alzheimer Disease - complications | Magnetite Nanoparticles - ultrastructure | Spectrometry, Mass, Secondary Ion | Curcumin - chemistry | Humans | Thermogravimetry | Mice, Transgenic | Polyethylene Glycols - chemistry | Spectroscopy, Fourier Transform Infrared | Alzheimer Disease - diagnosis | Particle Size | Plaque, Amyloid - complications | Magnetic Resonance Imaging | Animals | Adsorption | X-Ray Diffraction | Cell Membrane Permeability - drug effects | Dogs | Madin Darby Canine Kidney Cells | Cell Line, Tumor | Plaque, Amyloid - diagnosis | Disease Models, Animal | Atomic force microscopy | PET imaging | X-ray spectroscopy | Electron microscopy | Biopolymers | Polyols | Nanoparticles | Iron compounds | Magnetic resonance imaging | Ferric oxide | Pharmacy | Genetic engineering | Precipitation (Meteorology) | Mass spectrometry | Index Medicus | Brain | X-rays | Positron emission | Tomography | Mice | Diagnosis
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2013, Volume 8, Issue 2, pp. e55774 - e55774
Amyloid precursor protein (APP) proteolysis is required for production of amyloid-beta (A beta) peptides that comprise beta-amyloid plaques in brains of... 
OXIDATIVE STRESS | ASPARTYL PROTEASE | MEMORY DEFICITS | MULTIDISCIPLINARY SCIENCES | IN-VIVO | A-BETA | COGNITIVE IMPAIRMENT | AMYLOID PRECURSOR PROTEIN | GAMMA-SECRETASE | TG2576 MOUSE MODEL | CEREBRAL AMYLOIDOSIS | Inflammation - pathology | Neurons - pathology | Coumaric Acids - administration & dosage | Coumaric Acids - chemistry | Oxidative Stress | Male | Alzheimer Disease - pathology | Brain - metabolism | Inflammation - metabolism | Amyloid beta-Protein Precursor - metabolism | Behavior, Animal - drug effects | Female | Neurons - metabolism | Disease Models, Animal | Mice, Transgenic | Brain - drug effects | Amyloid Precursor Protein Secretases - metabolism | Amyloid beta-Protein Precursor - genetics | Animals | Alzheimer Disease - metabolism | Brain - pathology | Cerebral Amyloid Angiopathy | Mice | Alzheimer Disease - genetics | Coumaric Acids - pharmacology | Amyloidogenesis | Brain | Oxidative stress | Neurosciences | Peptides | Disease | Laboratories | Hyperactivity | Impairment | Spatial discrimination | Clinical trials | Kinases | Defects | Proteins | Antioxidants | Oligomers | Transgenic animals | Proteolysis | Rodents | Aging | Behavior | Transgenes | Pharmaceutical industry | Alzheimer's disease | Plaques | Age | Neurodegenerative diseases | Oral administration | Transgenic mice | Inflammation | Pattern recognition | Object recognition | Variance analysis | Amyloid precursor protein | Ferulic acid | Medicine | Pathology | Hypotheses | Acids | Presenilin 1 | Phenols | β-Amyloid | Amyloidosis | Human behavior | Secretase | Spatial memory | Index Medicus
Journal Article
The Journal of Comparative Neurology, ISSN 0021-9967, 01/2007, Volume 500, Issue 2, pp. 311 - 321
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2006, Volume 281, Issue 51, pp. 39413 - 39423
Increasing evidence points to soluble assemblies of aggregating proteins as a major mediator of neuronal and synaptic dysfunction. In Alzheimer disease ( AD),... 
IMMUNIZATION | IMMUNOTHERAPY | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | NEURODEGENERATION | PATHOLOGY | DEFICITS | MEMORY LOSS | PEPTIDE | TG2576 MOUSE MODEL
Journal Article