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PloS one, ISSN 1932-6203, 12/2016, Volume 11, Issue 12, p. e0168363
Transforming growth factor-beta (TGF-beta) is a multi-functional cytokine implicated in the control of cell growth and differentiation. TGF-beta signals... 
BREAST-CANCER | FIBROSIS | EPITHELIAL-CELL PROLIFERATION | GROWTH-FACTOR-BETA | MULTIDISCIPLINARY SCIENCES | NA+/K+-ATPASE | SMOOTH-MUSCLE-CELLS | PULMONARY MYOFIBROBLAST DIFFERENTIATION | FIBROBLASTS | CARDIAC-GLYCOSIDES | DIGITALIS | Phosphorylation | Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors | Signal Transduction | Down-Regulation | Humans | Cells, Cultured | Lung - cytology | Sodium-Potassium-Exchanging ATPase - metabolism | Receptors, Transforming Growth Factor beta - antagonists & inhibitors | Receptors, Transforming Growth Factor beta - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Fibroblasts - cytology | Lung - metabolism | Transforming Growth Factor beta - metabolism | Protein-Serine-Threonine Kinases - metabolism | Fibroblasts - metabolism | Vimentin | Transcription factors | Smad protein | Mesenchyme | Laboratories | Epithelial cells | Transforming growth factor-b | Genes | Lung cancer | Ouabain | Transforming growth factor-a | Critical care | Smooth muscle | Lipids | Biology | Metastasis | Kinases | Cancer therapies | Fibronectin | Receptors | Cell growth | Actin | Rodents | Smad2 protein | Fibroblasts | Inhibition | Alveoli | Growth factors | Muscles | Breast cancer | Biophysics | Gene expression | Na+/K+-exchanging ATPase | Membrane proteins | Medicine | Signaling | Sodium | Potassium | Binding sites | Apoptosis
Journal Article
Aging cell, ISSN 1474-9726, 2004, Volume 3, Issue 6, pp. 379 - 389
Summary Osteoblasts and adipocytes originate from a common progenitor, which arises from bone marrow mesenchymal stroma/stem cells (mMSC). Aging causes a... 
marrow stem cells | PPAR‐γ | aging | osteoblast | TGF‐β/BMP | adipocyte | Aging | Osteoblast | Adipocyte | TGF-β/BMP | Marrow stem cells | PPAR-γ | BMP | TGF-β
Journal Article
The Journal of cell biology, ISSN 1540-8140, 2004, Volume 165, Issue 5, pp. 723 - 734
Transforming growth factor-βs (TGF-β) are secreted as inactive complexes containing the TGF-β, the TGF-β propeptide, also called the latency-associated protein... 
Polymerase chain reaction | Cell growth | Complementary DNA | Carrier proteins | Cell lines | Amino acids | Mathematical functions | CHO cells | Cells | Integrins | Latent TGF-β | TGF-β | Integrin | LTBP | LTBP; TGF-β; integrin; αvβ6; latent TGF-β
Journal Article
Nature genetics, ISSN 1546-1718, 2014, Volume 46, Issue 5, pp. 457 - 461
Journal Article
Chest, ISSN 0012-3692, 2018, Volume 153, Issue 4, pp. 851 - 862
The expression and localization of transforming growth factor-β (TGF-β) pathway proteins in different compartments of the lower airways of patients with stable... 
airway inflammation | TGF-β | SMAD | autoimmunity | BAMBI | CTGF | DOWN-REGULATION | BINDING-PROTEINS | PATHOGENESIS | TGF-beta | OBSTRUCTIVE PULMONARY-DISEASE | GROWTH-FACTOR-BETA | RESPIRATORY SYSTEM | TRANSFORMING GROWTH-FACTOR-BETA-1 | EMPHYSEMA | GENE-EXPRESSION | ASTHMA | CIGARETTE-SMOKE | CRITICAL CARE MEDICINE | Biomarkers - metabolism | Immunohistochemistry | Humans | Middle Aged | Transforming Growth Factor beta1 - metabolism | Male | Transforming Growth Factor beta3 - metabolism | Case-Control Studies | Bronchi - metabolism | Female | Signal Transduction - physiology | Aged | Lung - metabolism | Membrane Proteins - metabolism | Macrophages, Alveolar - metabolism | Pulmonary Disease, Chronic Obstructive - metabolism | Respiratory Mucosa - metabolism | Smad Proteins - metabolism | Lung diseases, Obstructive | Control | Usage | Smokers | Diagnosis | Transforming growth factors | Health aspects | Smoking | PI3K, phosphoinositide 3-kinase | CCN2, connective tissue growth factor | ECM, extracellular matrix | TGIF, 5′-TG-3′-interacting factor | BAMBI, bone morphogenetic proteins and activin membrane-bound inhibitor | TGFBI, transforming growth factor-β-induced protein | TRAP-1, transforming growth factor-β receptor-associated binding protein | TGF-βR, TGF-β receptor | SMAD, small mother against decapentaplegic | TGF, transforming growth factor | LLC, large latent complex | LTBP, latent transforming growth factor-β binding protein | BMP, bone morphogenetic protein | LAP, latency-associated peptide | MAPK, mitogen-activated protein kinase
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 04/2016, Volume 117, Issue 4, pp. 860 - 871
ABSTRACT Regular consumption of moderate amounts of ethanol has important health benefits on atherosclerotic cardiovascular disease (ASCVD). Overindulgence can... 
CANONICAL TGF‐β SIGNALING | TGF‐β RECEPTORS | TGF‐β ENHANCER | NON‐LIPID RAFT MICRODOMAINS | TGF-β RECEPTORS | NON-LIPID RAFT MICRODOMAINS | CANONICAL TGF-β SIGNALING | TGF-β ENHANCER | TGF-beta ENHANCER | DI-LEUCINE FAMILY | TGF-beta RECEPTORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALCOHOL-CONSUMPTION | CONSTITUTIVE ENDOCYTOSIS | CELL BIOLOGY | SIGNAL-TRANSDUCTION | GROWTH-FACTOR-BETA | CANONICAL TGF-beta SIGNALING | LIPID RAFTS | MEDIATED ENDOCYTOSIS | DEPENDENT ENDOCYTOSIS | ASSOCIATION | PLASMA-CONCENTRATION | Cytoplasmic Vesicles - drug effects | Cell Fractionation | Phosphorylation | Receptors, Transforming Growth Factor beta - genetics | Epithelial Cells - metabolism | Luciferases - metabolism | Membrane Microdomains - metabolism | Epithelial Cells - drug effects | Caveolae - drug effects | Cytoplasmic Vesicles - chemistry | Lung - cytology | Luciferases - genetics | Dose-Response Relationship, Drug | Protein Isoforms - metabolism | Smad2 Protein - genetics | Cytoplasmic Vesicles - metabolism | Lung - metabolism | Epithelial Cells - cytology | Mink | Genes, Reporter | Signal Transduction | Caveolae - metabolism | Gene Expression Regulation | Smad2 Protein - metabolism | Caveolin 1 - genetics | Membrane Microdomains - chemistry | Caveolae - chemistry | Caveolin 1 - metabolism | Ethanol - pharmacology | Animals | Transforming Growth Factor beta - genetics | Receptors, Transforming Growth Factor beta - metabolism | Membrane Microdomains - drug effects | Lung - drug effects | Transforming Growth Factor beta - metabolism | Cell Line, Transformed | Protein Isoforms - genetics
Journal Article
Biochemical journal, ISSN 0264-6021, 08/2012, Volume 445, Issue 3, pp. 403 - 411
N-linked 21ycosylation is a critical determinant of protein structure and function, regulating processes such as protein folding, stability and localization,... 
Type II transforming growth factor β receptor (TβRII) | N-linked glycosylation | Cell surface transport | Transforming growth factor β sensitivity (TGF-β sensitivity) | Transforming growth factor β signalling (TGF-β signalling) | transforming growth factor beta signalling (TGF-beta signalling) | OLIGOSACCHARIDES | MEMBRANE | STABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHENOTYPE | MECHANISMS | type II transforming growth factor beta receptor (T beta RII) | transforming growth factor beta sensitivity (TGF-beta sensitivity) | CELL-SURFACE TRANSPORT | BIOSYNTHESIS | TUMOR-SUPPRESSOR | cell surface transport | PROTEINS | EXPRESSION | Receptors, Transforming Growth Factor beta - genetics | Receptors, Transforming Growth Factor beta - chemistry | Humans | Molecular Sequence Data | Glycosylation - drug effects | HEK293 Cells | Conserved Sequence | Cell Membrane - metabolism | Protein-Serine-Threonine Kinases - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | Cell Line | Alkaloids - pharmacology | Mutagenesis, Site-Directed | Protein-Serine-Threonine Kinases - genetics | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Hep G2 Cells | Sequence Homology, Amino Acid | Receptors, Transforming Growth Factor beta - metabolism | Signal Transduction - drug effects | Tunicamycin - pharmacology | Protein-Serine-Threonine Kinases - chemistry | HeLa Cells | Transforming Growth Factor beta - metabolism | Amino Acid Substitution | Asparagine - chemistry | transforming growth factor β sensitivity (TGF-β sensitivity) | KIF, kifunensine | dNG, deficient N-linked glycosylation | TβRII, type II TGF-β receptor | WT, wild-type | Tun, tunicamycin | FBS, fetal bovine serum | TGF-β, transforming growth factor β | Endo H, endoglycosidase H | HEK, human embryonic kidney | DAPI, 4′,6-diamidino-2-phenylindole | type II transforming growth factor β receptor (TβRII) | PNGase F, peptide N-glycosidase F | PEI, polyethyleneimine | GlcNAc, N-acetylglucosamine | transforming growth factor β signalling (TGF-β signalling) | TβRI, type I TGF-β receptor | ER, endoplasmic reticulum | PDI, protein disulfide-isomerase | RT, room temperature
Journal Article
The journal of histochemistry and cytochemistry, ISSN 1551-5044, 2016, Volume 64, Issue 3, pp. 157 - 167
Transforming growth factor-beta1 (TGF-β1), a key member in the TGF-β superfamily, plays a critical role in the development of hepatic fibrosis. Its expression... 
TGF-β/SMAD | miRNAs | hepatic fibrosis | Epithelial-myofibroblast transition | Liver Cirrhosis - pathology | Signal Transduction | Smad Proteins - metabolism | Transforming Growth Factor beta - metabolism | Humans | Liver Cirrhosis - metabolism | TGF-β | Review | SMAD
Journal Article
Translational research : the journal of laboratory and clinical medicine, ISSN 1931-5244, 2015, Volume 165, Issue 4, pp. 512 - 530
Renal fibrosis is the hallmark of virtually all progressive kidney diseases and strongly correlates with the deterioration of kidney function. The... 
Internal Medicine | activating transcription factor 2 | inhibitor of kappa B | activator protein-1 | unilateral ureteral obstruction | AP-1 | CTGF | ANG II | TGF-β-inducible gene | TβRII | angiotensin-converting enzyme | bone morphogenetic protein receptor | Monocyte chemoattractant protein-1 | idiopathic pulmonary fibrosis | PPARγ | ARB | plasminogen activator inhibitor-1 | TAK1-binding protein 1 | receptor-regulated Smads | angiotensin II receptor blocker | MAPK kinase kinase kinase | stz | CCL2-CCR2 | uterine sensitization-associated gene-1 | ESRD | chronic kidney disease | TSP 1 | nuclear factor kappa B | acute tubular necrosis | mitogen-activated protein kinase | Peroxisome proliferator-activated receptor γ | TrKA | A Study of Cardiovascular Events in Diabetes | TAK1 | USAG-1 | ASCEND | transforming growth factor β1 | von Willebrand factor | βig-h3 | FSGS | MKKK | heparan sulfate proteoglycan | CCR1 | ACE | HSPG | BMP | MKK | bone morphogenetic protein | ECM | endothelin | thrombospondin type 1 | tyrosine receptor kinase A | ETA | focal segmental glomerular sclerosis | ATN | phosphodiesterase | TAB1 | ATF 2 | extracellular matrix | Kielin/chordin-like protein | JNK | RAAS | small interfering RNA | LRP | lipoprotein receptor-related protein | NF-κB | renin-angiotensin-aldosterone system | BMPR | PAI-1 | LC3 | TGF-β type I receptor | c-Jun N-terminal kinase | TβRI | IGF-1 | end-stage renal disease | MAPK | EMT | UUO | epithelial-to-mesenchymal transition | connective tissue growth factor | streptozotocin | Nox | ROS | mitogen-activated protein kinase kinase | insulin-like growth factor 1 | nicotinamide adenine dinucleotide phosphate oxidase | MCP-1 | tumor necrosis factor α | estimated glomerular filtration rate | vWF | CC motif chemokine ligand 2-CC receptor type 2 | TGF-β type II receptor | IκB | microtubule-associated protein 1 light chain 3 | PDE | TGF-β-activated kinase 1 | reactive oxygen species | CC receptor type 1 | Angiotensin II | CKD | endothelin A receptor | eGFR | VEGF | siRNA | TNF-α | R-Smads | vascular endothelial growth factor | KCP | TGF-β1 | IPF | MEDICINE, RESEARCH & EXPERIMENTAL | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | ANGIOTENSIN-ALDOSTERONE SYSTEM | DIABETIC-NEPHROPATHY | MATRIX GENE-EXPRESSION | RENAL FIBROSIS | MEDICINE, GENERAL & INTERNAL | TISSUE GROWTH-FACTOR | TRANSFORMING GROWTH-FACTOR-BETA-1 | BONE MORPHOGENETIC PROTEIN-7 | TGF-BETA ANTIBODY | MEDICAL LABORATORY TECHNOLOGY | IDIOPATHIC PULMONARY-FIBROSIS | Fibrosis - drug therapy | Signal Transduction | Humans | Transforming Growth Factor beta1 - metabolism | Drug Design | Transforming Growth Factor beta1 - genetics | Fibrosis - pathology | Renal Insufficiency, Chronic - drug therapy | Renal Insufficiency, Chronic - pathology | Oxidases | Phosphates | Niacinamide | Medical colleges | Development and progression | Transforming growth factors | Homeopathy | Materia medica and therapeutics | Purines | Chronic kidney failure | Nitric oxide | Therapeutics | Angiotensin | Bone morphogenetic proteins | Health aspects | bone morphogenic protein-7 | autophagy | transforming growth factor-β | NADPH oxidase | tumor necrosis factor-α | Kidney fibrosis | endothelin-1 | C-C motif chemokine | chemokine receptor
Journal Article