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Journal Article
Molecular Cancer Research, ISSN 1541-7786, 12/2010, Volume 8, Issue 12, pp. 1633 - 1642
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 11/2017, Volume 18, Issue 11, p. 2494
The G protein-coupled receptor proteinase-activated receptor 2 (PAR2) has been implicated in various aspects of cellular physiology including inflammation,... 
Signaling | TGF-β | Pancreatic carcinoma | ALK5 | PAR2 | Serine proteinases | Adenocarcinoma | Proteinase-activated receptor 2 | Transforming growth factor | Serine | Proteinase | Crosstalk | Gene expression | Cell adhesion & migration | Metastases | Proteins | Tumorigenesis | Pancreas | Cell migration | Cancer | signaling | serine proteinases | pancreatic carcinoma
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 08/2017, Volume 118, Issue 8, pp. 2241 - 2249
ABSTRACT Idiopathic pulmonary fibrosis is a progressive and deadly disorder with very few therapeutic options. Palomid 529... 
TGF‐β | FIBRONECTIN DEPOSITION | PULMONARY FIBROSIS | MYOFIBROBLAST | mTOR | P529 | Smad | ACTIN CYTOSKELETON | mTORC2 | mTORC1 | TGF-β | TARGET | BINDING PARTNER | TORC1/TORC2 INHIBITOR | STRESS FIBER FORMATION | TGF-BETA | REDUCES TUMOR-GROWTH | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | TGF | PALOMID 529 | IDIOPATHIC PULMONARY-FIBROSIS | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Humans | Actins - metabolism | Cells, Cultured | Mechanistic Target of Rapamycin Complex 1 - antagonists & inhibitors | Survival of Motor Neuron 1 Protein - metabolism | Myofibroblasts - drug effects | Phosphoproteins - metabolism | Blotting, Western | Fibronectins - metabolism | Mechanistic Target of Rapamycin Complex 1 - metabolism | Myofibroblasts - cytology | Collagen - metabolism | Mechanistic Target of Rapamycin Complex 2 - metabolism | Transforming Growth Factor beta - pharmacology | Receptors, Transforming Growth Factor beta - metabolism | Cell Differentiation - drug effects | Phosphorylation - drug effects | Adaptor Proteins, Signal Transducing - metabolism | Benzopyrans - pharmacology | Mechanistic Target of Rapamycin Complex 2 - antagonists & inhibitors | Protein-Serine-Threonine Kinases - metabolism | Fibronectins | Collagen | Bone morphogenetic proteins | Respiratory tract diseases | Transforming growth factors | Muscle proteins | Genetic translation | Protein binding | TOR protein | Phosphorylation | Smad protein | Matrices (mathematics) | AKT protein | Activation | Biochemistry | Kinases | Matrix methods | Fibronectin | Proteins | Mathematical analysis | Actin | Smad2 protein | Transcription activation | Fibroblasts | Inhibition | Matrix protein | p70 S6 kinase | Deposition | Activation analysis | Binding | Stresses | Translocation | Lung diseases | Dose dependency | Translation initiation | Wounds | Rapamycin | Gene expression | Stress | Inhibitors | Fibrosis | Differentiation | actin cytoskeleton | myofibroblast | pulmonary fibrosis | fibronectin deposition
Journal Article
Gastroenterology, ISSN 0016-5085, 2015, Volume 149, Issue 3, pp. 765 - 776.e10
Background & Aims Little is known about the pathogenic mechanisms of chronic pancreatitis. We investigated the roles of complement component 5 (C5) in... 
Gastroenterology and Hepatology | Transcriptome Analysis | αSMA | Complement System | Pancreatic Stellate Cells | alpha SMA | CYTOKINES | LUNG INJURY | FIBROGENESIS | IDENTIFICATION | C5A | NECROSIS | INFLAMMATION | FACTOR-5 | MICE | INHIBITOR | GASTROENTEROLOGY & HEPATOLOGY | Complement C5 - genetics | Pancreatic Stellate Cells - drug effects | Pancreatitis, Chronic - chemically induced | Case-Control Studies | Ligation | Pancreatic Stellate Cells - immunology | Time Factors | Pancreatitis, Chronic - drug therapy | Pancreatic Stellate Cells - pathology | Disease Models, Animal | Pancreatitis, Chronic - immunology | Genetic Predisposition to Disease | Aniline Compounds - pharmacology | Complement C5 - metabolism | Mice, Inbred C57BL | Pancreatic Ducts - surgery | Complement C5 - deficiency | Pancreatitis, Chronic - genetics | Mice, Knockout | Pancreatitis, Chronic - pathology | Phenotype | Animals | Tetrahydronaphthalenes - pharmacology | Fibrosis | Polymorphism, Single Nucleotide | Receptor, Anaphylatoxin C5a - antagonists & inhibitors | Ceruletide | Pancreatitis, Chronic - metabolism | Pancreatic Stellate Cells - metabolism | Receptor, Anaphylatoxin C5a - metabolism | Models | Pancreatitis | αSMA, α smooth muscle actin | TGFβ, transforming growth factor β | Original Research | TNFα, tumor necrosis factor α | SNP, single-nucleotide polymorphism | MPO, myeloperoxidase | PSC, pancreatic stellate cell | C5, complement component 5 | IP, intraperitoneal | HSC, hepatic stellate cell | IL, interleukin
Journal Article
Cytokine and Growth Factor Reviews, ISSN 1359-6101, 12/2017, Volume 38, pp. 49 - 58
Fibrosis is a pathological condition that is characterized by the replacement of dead or damaged tissue with a nonfunctional, mechanically aberrant scar, and... 
TGF-β | FGF2 | Fibroblast | Myofibroblast | Fibrosis | SMOOTH MUSCLE ACTIN | STEM-CELLS | INTERSTITIAL COLLAGENASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SELF-RENEWAL | OSTEOGENIC DIFFERENTIATION | FACTOR RECEPTOR | CELL BIOLOGY | EPITHELIAL-MESENCHYMAL TRANSITION | TGF-beta | DERMAL FIBROBLASTS | REDUCES SCAR FORMATION | Gene expression | Growth factors | Collagen | Analysis | Genes | Stem cells
Journal Article
Journal Article
OncoImmunology, ISSN 2162-4011, 01/2015, Volume 4, Issue 1, p. 954829
Myeloid-derived suppressor cells (MDSCs) contribute to tumor-mediated immune escape and negatively correlate with overall survival of cancer patients.... 
NAC, N-acetyl cysteine | WA, withaferin A | 5-Fluorouracil | TGFβ, transforming growth factor β | TNFα, tumor necrosis factor α | HSCs, hematopoietic stem cells | VEGFR, vascular endothelial growth factor receptor | IL-6, interleukin 6 | MDSCs, myeloid-derived suppressor cells | HIF-1α, hypoxia inducible factor 1α | SCF, stem cell factor | ADAM17, metalloproteinase domain-containing protein 17 | mRCC, metastatic renal cell carcinoma | c-kit, Mast/stem cell growth factor receptor | PDE-5, phosphodiesterase type 5 | APCs, antigen presenting cells | IMCs, immature myeloid cells | all-trans retinoic acid | IL-13, interleukin 13 | sunitinib therapeutic vaccination | GITR, anti-glucocorticoid tumor necrosis factor receptor | MMPs, metalloproteinases (e.g., MMP9) | CD62L, L-selectin | STAT3, signal transducer and activator of transcription 3 | Tregs, regulatory T cells | CTLs, cytotoxic T lymphocytes | NSAID, nonsteroidal anti-inflammatory drugs | GM-CSF/CSF2, granulocyte monocyte colony stimulating factor | IFNγ, interferon γ | ODN, oligodeoxynucleotides | CDDO-Me, bardoxolone methyl | IL-10, interleukin 10 | TCR, T cell receptor | HLA, human leukocyte antigen | DCs, dendritic cells | GSH, glutathione | HPV-16, human papillomavirus 16 | PGE2, prostaglandin E2 | TAMs, tumor-associated macrophages | ICT, 3, 5, 7-trihydroxy-4′-emthoxy-8-(3-hydroxy-3-methylbutyl)-flavone | CXCL15, chemokine (C-X-C motif) ligand 15 | 5-FU, 5-fluorouracil | NADPH, nicotinamide adenine dinucleotide phosphate-oxidase NK cells, natural killer cells | NO, nitric oxide | COX2, cyclooxygenase 2 | ERK1/2, extracellular signal-regulated kinases | FoxP3, forkhead box P3 | bisphosphonates | ROS, reactive oxygen species | Flt3, Fms-like tyrosine kinase 3 | CCL2, chemokine (C-C motif) ligand 2 | Myd88, myeloid differentiation primary response protein 88 | HNSCC, head and neck squamous cell carcinoma | WRE, Withaferin somnifera | NOHA, N-hydroxy-L-Arginine | myeloid-derived suppressor cells | IL-4, interleukin 4 | immune suppressive mechanisms | iNOS2, inducible nitric oxid synthase 2 | IL-1β, interleukin 1 β | ARG1, arginase-1 | JAK2, Janus kinase 2 | gemcitabine | ATRA, all-trans retinoic acid | RNS, reactive nitrogen species | CXCL12, chemokine (C-X-C motif) ligand 12 | CARCINOMA PATIENTS | TRANS-RETINOIC ACID | IMMUNOLOGY | CD8(+) T-CELLS | CANCER-PATIENTS | TUMOR-BEARING MICE | ONCOLOGY | IN-VIVO | IMMUNOSUPPRESSIVE ACTIVITY | WITHANIA-SOMNIFERA | ANTITUMOR IMMUNITY | ESTABLISHED TUMORS
Journal Article
Frontiers in immunology, 2018, Volume 9, p. 3161
Parasite-derived lipids may play important roles in host-pathogen interactions and immune evasion mechanisms. Remarkable accumulation of eosinophils is a... 
eoxin | PGD2 | schistosoma | lipids | TGFβ | TLR | eosinophil | LPC
Journal Article
FEBS Letters, ISSN 0014-5793, 12/2015, Volume 589, Issue 24, pp. 3760 - 3772
Glial cell line-derived neurotrophic factor (GDNF) and its canonical receptor Ret can signal together or independently to fulfill many important functions in... 
Rearranged during transfection | Parkinson disease | Drug addiction | Mouse model | Dopaminergic system | Glia cell line-derived neurotrophic factor | MAOA/MAOB | orphan nuclear receptor and transcription factor | cytoplasmic SH2 domain containing protein tyrosine phosphatase | Ras | RRF | COMT | PTEN-induced putative kinase 1 | SH3 and multiple ankyrin repeat domains 3, proline-rich synapse-associated protein 2 (ProSAP2) | PI3K | sorting protein-related receptor with A-type repeats, a member of the mammal Vps10p domain receptor | subunits of the Ca2+-sensitive, voltage gated A-type K+ channel | SH2 domain containing transforming protein 1 | Nurr1 | proprotein convertases | protein kinase B, serine/threonine-specific protein kinase | calcium-calmodulin-dependent protein kinase II β isoform | FRS2 | phosphatase and tensin homolog | catecholamine | SHP-2 | growth factor receptor-bound protein 2, 7 and 10, adaptor proteins | fibroblast growth factor receptor substrate 2, adaptor protein | monoamine oxidases A and B | carbonyl cyanide m-chlorophenyl hydrazone | ERK | brain derived neurotrophic factor | deglycase, oxidative stress sensor and redox-sensitive chaperone and protease | VTA | tyrosines, which can be phosphorylated | cAMP | extracellular-signal-regulated kinases, classical MAPKs | CaMKIIβ | Kv4.3 and KChip3 | GRB2/7/10 | Ser/Thr | SNP | endoplasmatic reticulum | nerve growth factor | monoamine, neurotransmitter type including dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline) | TGF-β | Akt, PKB | phospholipase γ cleaves the phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2) into diacyl glycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) ppp3R1/ppp3CB, calcineurin subunits | PC5A, PC5B, and PC7 | EGR1 | proprotein convertase subtilisin/kexin type 6 | substantia nigra | phosphotyrosine-interaction domain | BDNF | adaptor protein of the PDZ-LIM family | γ-aminobutyric acid, inhibitory neurotransmitter in mammalian central nervous system | Tyr | FosB/ΔFosB | IRS1/2 | LIM | dopamine transporter | enhanced green fluorescent protein | GDNF | DAT | SOS | 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | retro-rubal field | transforming growth factor β is a secreted protein that controls proliferation and cellular differentiation | MPTP | GTPase | hypoxia-inducible factor-1alpha | GDNF family of ligands | Ret | GPI | Shank3 | NCAM | Enigma | JNK | (rearranged during transfection) canonical GDNF receptor, a receptor tyrosine kinase | PTEN | 6-OHDA | DJ-1 | (rapidly accelerated fibrosarcoma/rat fibrosarcoma) family of serine/threonine-protein kinase | SHC | NF-κB | (acronym combining the first letters of three proteins – post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), and zonula occludens-1 protein (zo-1) that have this common domain) protein interaction domain | phosphotyrosine-binding domains | insulin receptor substrate 1, adaptor protein, contains a PTB and PH domain | Rac1 | GFRα | nuclear factor ‘kappa-light-chain-enhancer’ of activated B-cells, transcription factor family with Rel homology domain (RHD) | catechol-O-methyltransferase | early growth response protein 1, Zif268 (zinc finger protein 225), NGFI-A (nerve growth factor-induced protein A), is a zinc finger transcription factor | serine and threonine, which can be phosphorylated | GDNF family receptor α | PKA | protein kinase A, a family of cAMP-dependent protein kinase | MAPK | NGF | SorLA | ventral tegmental area | son of sevenless, family of guanine nucleotide exchange factors that act on Ras | GABA | HIF-1a | Ras-related C3 botulinum toxin substrate 1 (Rho family), a small GTPase, like CDC42 | GAP1/2 | PTB | (Rat sarcoma) family of small membrane-associated GTPase | cycles between an active GTP-bound and an inactive GDP-bound state | glycogen synthase kinase 3β | Src | glia cell line-derived neurotrophic factor | PACE4, PCSK6 | pleckstrin homology domain | co-repressor for element-1-silencing transcription factor, a chromatin-modifying corepressor complex that acts with REST (repressor for element-1 silencing transcription factor) complex | c-Jun N-terminal kinases, members of the MAPK family of proteins | EGFP | cell division control protein 42 homolog, a plasma membrane-associated small GTPase of the Rho family | (acronym combining the first letters of three proteins – Lin11, Isl-1 and Mec-3 – that have this common domain) protein interaction domain of two contiguous zinc finger domains, separated by a two-amino acid residue hydrophobic linker | CCCP | (sarcoma protein) membrane-associated tyrosine kinase with different Src homology (SH) domains characteristic for all 9 members of the Src family kinases | DOK1/4/5/6 | (Ras homolog) family of small GTPases including Cdc42, Rac1, and RhoA | single-nucleotide polymorphism analysis | VPS10P | Rho | MEN2B | phosphatidylinositol-4,5-bisphosphate 3-kinase | 6-hydroxy-dopamine | mitogen-activated protein kinase, can phosphorylate serine, threonine, and tyrosine, e.g. p38MAPK | Cdc42 | docking proteins, have a PH and SH3 domain | GFLs | PDZ | vacuolar protein sorting 10 protein-domain receptors are type 1 transmembrane proteins | PLCγ | GTPase-activating proteins 1 and 2 | 3′,5′-cyclic adenosine monophosphate | neuronal cell adhesion molecule | TIEG | TGF-β-inducible early-response gene, a zinc finger transcription factor Vav2, adaptor protein and guanine nucleotide exchange factor for the Rho family of Ras-related GTPases | PINK1 | Raf | CoREST | multiple endocrine neoplasia 2 type B, mutation in the kinase domain of the Ret leading to constitutive active receptor | dopaminergic | glycosylphosphatidylinositol | FBJ murine osteosarcoma viral oncogene homolog B, a transcription factor with a truncated Δ form | gsk3β | ENTERIC NERVOUS-SYSTEM | BIOCHEMISTRY & MOLECULAR BIOLOGY | SUBSTANTIA-NIGRA | CELL BIOLOGY | MICE LACKING GDNF | C-RET | BIOPHYSICS | NEUROTROPHIC FACTOR PROMOTES | MULTIPLE ENDOCRINE NEOPLASIA | SURVIVAL IN-VIVO | RECEPTOR TYROSINE KINASE | CELL-LINE | EARLY-ONSET PARKINSONISM | Glial Cell Line-Derived Neurotrophic Factor - physiology | Parkinson Disease - pathology | Animals | Proto-Oncogene Proteins c-ret - physiology | Dopamine - physiology | Mesencephalon - metabolism | Humans | Dopaminergic Neurons - physiology | Parkinson Disease - metabolism | Synaptic Transmission | Mesencephalon - pathology | Physiological aspects | Neurons | Parkinson's disease
Journal Article