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NATURE, ISSN 0028-0836, 09/2007, Volume 449, Issue 7160, pp. 361 - 361
The cytokine transforming growth factor-beta (TGF-beta) is an important negative regulator of adaptive immunity(1-3). TGF-beta is secreted by cells as an... 
HOMEOSTASIS | ACTIVATION | INFLAMMATION | TOLERANCE | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION FACTOR FOXP3 | DISEASE | REGULATORY T-CELLS | MECHANISMS | EXPRESSION | TGF-BETA-1
Journal Article
AMERICAN JOURNAL OF PATHOLOGY, ISSN 0002-9440, 08/2010, Volume 177, Issue 2, pp. 632 - 643
We recently showed in a tetracycline-controlled transgenic mouse model that overexpression of transforming growth factor (TGF)-beta 1 in renal tubules induces... 
APOPTOSIS | LOCALIZATION | GROWTH-FACTOR-BETA | TGF-BETA | RAT-KIDNEY | INTERSTITIAL FIBROSIS | PATHOLOGY | EXPRESSION | TRANSGENIC MICE | TGF-BETA-1 | TRANSDIFFERENTIATION
Journal Article
ENDOCRINOLOGY, ISSN 0013-7227, 05/2013, Volume 154, Issue 5, pp. 1768 - 1779
TGF-beta plays an important role in the progression of prostate cancer. It exhibits both tumor suppressor and tumor-promoting activities. Correlations between... 
COLON-CANCER | CYCLOOXYGENASE-2 | CARCINOMA CELLS | GROWTH | INVOLVEMENT | ENDOCRINOLOGY & METABOLISM | RECEPTOR | INDUCTION | EXPRESSION | PROSTAGLANDIN E-2 | TGF-BETA-1
Journal Article
CLINICAL CANCER RESEARCH, ISSN 1078-0432, 08/2015, Volume 21, Issue 16, pp. 3678 - 3684
Background: The TGF-beta signaling pathway is crucial in the progression and metastasis of malignancies. We investigated whether the serum TGF-beta 1 level was... 
BIOMARKERS | GROWTH-FACTOR-BETA | THERAPY | ONCOLOGY | MESENCHYMAL TRANSITION | CANCER | TGF-BETA-1
Journal Article
IMMUNITY, ISSN 1074-7613, 05/2015, Volume 42, Issue 5, pp. 903 - 915
Regulatory T (Treg) cells play a pivotal role in suppressing self-harmful T cell responses, but how Treg cells mediate suppression to maintain immune... 
INTESTINAL INFLAMMATION | GROWTH-FACTOR-BETA | TOLERANCE | TRANSCRIPTION FACTOR FOXP3 | IN-VIVO | IMMUNE PATHOLOGY | DIFFERENTIATION | IMMUNOLOGY | EXPRESSION | BOWEL-DISEASE | TGF-BETA-1
Journal Article
Nature Reviews Immunology, ISSN 1474-1733, 08/2010, Volume 10, Issue 8, pp. 554 - 567
Transforming growth factor-beta (TGF beta) is an immunosuppressive cytokine produced by tumour cells and immune cells that can polarize many components of the... 
GROWTH-FACTOR-BETA | MEMBRANE-BOUND TGF-BETA-1 | MYELOID DENDRITIC CELLS | NK CELLS | REGULATORY T-CELLS | FACTOR-KAPPA-B | ANTITUMOR IMMUNITY | SUPPRESSOR-CELLS | IMMUNOLOGY | LARGE ESTABLISHED MELANOMA | I KINASE INHIBITOR
Journal Article
SCIENCE TRANSLATIONAL MEDICINE, ISSN 1946-6234, 05/2015, Volume 7, Issue 288
Integrins are transmembrane heterodimeric receptors that contribute to diverse biological functions and play critical roles in many human diseases. Studies... 
MEDICINE, RESEARCH & EXPERIMENTAL | GROWTH-FACTOR-BETA | TGF-BETA | CONTRACTION | CELL-DEVELOPMENT | ACTIVATES LATENT TGF-BETA-1 | CRYSTAL-STRUCTURE | INFLAMMATION | FIBRONECTIN | RECEPTOR | MICE | CELL BIOLOGY
Journal Article
Cancer Research, ISSN 0008-5472, 2019, Volume 79, Issue 6, pp. 1178 - 1190
Activated regulatory T (Treg) cells express the surface receptor glycoprotein-A repetitions predominant (GARP), which binds and activates latent TGF beta. How... 
TGF-BETA | COLITIS | ONCOLOGY | INFLAMMATION | SURFACE EXPRESSION | INDUCTION | CD103 | TGF-BETA-1
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 04/2019, Volume 202, Issue 8, pp. 2473 - 2481
Helminthic infections modulate host immunity and may protect their hosts from developing immunological diseases like inflammatory bowel disease. Induction of... 
RESPONSES | INFLAMMATION | LEADS | MICE | DIFFERENTIATION | IMMUNOLOGY | GATA-3 | CUTTING EDGE | TGF-BETA-1
Journal Article
SCIENCE TRANSLATIONAL MEDICINE, ISSN 1946-6234, 05/2014, Volume 6, Issue 238
Rapid advancements in the field of stem cell biology have led to many current efforts to exploit stem cells as therapeutic agents in regenerative medicine.... 
MEDICINE, RESEARCH & EXPERIMENTAL | MATRIX | GROWTH-FACTOR-BETA | IN-VITRO | PULP COMPLEX | ACTIVATION | LEVEL LASER IRRADIATION | BONE-MARROW | AMELOBLASTS | PROTEINS | TGF-BETA-1 | CELL BIOLOGY
Journal Article
BLOOD, ISSN 0006-4971, 11/2008, Volume 112, Issue 9, pp. 3533 - 3534
Although platelets are a rich source of latent TGF-beta it has not been determined how platelet-derived latent TGF-beta is activated in vivo. In this issue of... 
HEMATOLOGY | TGF-BETA-1
Journal Article
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, ISSN 0022-3565, 08/2018, Volume 366, Issue 2, pp. 341 - 348
Radiation-induced lung injury (RILI) is the main complication of radiotherapy for thoracic malignancies. Since naringenin, a potent immune-modulator, has been... 
FIBROSIS | IRRADIATION | INFLAMMASOME | PNEUMONITIS | PHARMACOLOGY & PHARMACY | MECHANISMS | RADIOTHERAPY | CANCER | EXPRESSION | CHEMOTHERAPY | TGF-BETA-1
Journal Article
Nature Reviews Immunology, ISSN 1474-1733, 06/2007, Volume 7, Issue 6, pp. 443 - 453
In the immune system, transforming growth factor-beta (TGF beta) affects multiple cell lineages by either promoting or opposing their differentiation, survival... 
HELPER TYPE-1 | GROWTH-FACTOR-BETA | REGULATORY CELLS | IMMUNE-RESPONSES | TRANSCRIPTION FACTOR FOXP3 | DOWN-REGULATION | RECEPTOR | DIFFERENTIATION | IMMUNOLOGY | CUTTING EDGE | TGF-BETA-1
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 12/2011, Volume 187, Issue 11, pp. 6094 - 6107
Severe asthma is associated with airway remodeling, characterized by structural changes including increased smooth muscle mass and matrix deposition in the... 
FIBROSIS | GROWTH-FACTOR-BETA | INCREASED EXPRESSION | INFLAMMATION | MEDIATED ACTIVATION | MAST-CELLS | LATENT TGF-BETA-1 | RECEPTOR | MICE | IMMUNOLOGY | FIBROBLASTS
Journal Article
Current Opinion in Cell Biology, ISSN 0955-0674, 2009, Volume 21, Issue 5, pp. 616 - 622
The extracellular matrix plays a key role in organ formation and tissue homeostasis. Recent studies have revealed that fibrillin assemblies (microfibrils)... 
Internal Medicine | MATRIX | ACTIVATES LATENT TGF-BETA-1 | MARFAN-SYNDROME | MOUSE MODEL | FIBRILLIN-1 | BINDING PROTEIN-1 | LUNG DEVELOPMENT | CELL-ADHESION | HEPARAN-SULFATE PROTEOGLYCANS | THORACIC AORTIC-ANEURYSM | CELL BIOLOGY
Journal Article
Clinical cancer research : an official journal of the American Association for Cancer Research, ISSN 1078-0432, 04/2019, Volume 25, Issue 14, pp. 4343 - 4350
Radiation pneumonitis is an important adverse event in patients with non-small cell lung cancer (NSCLC) receiving thoracic radiotherapy. However, the risk of... 
THERAPY | ONCOLOGY | PLASMA PROTEOMIC ANALYSIS | RISK | TOXICITY | SINGLE-NUCLEOTIDE POLYMORPHISM | TGF-BETA-1 GENE | RADIOTHERAPY | PARAMETERS | SUPEROXIDE-DISMUTASE | CONCURRENT CHEMORADIOTHERAPY
Journal Article
by Zhong, J and Guo, B and Xie, J and Deng, SW and Fu, N and Lin, SY and Li, G and Lin, YF and Cai, XX
BONE RESEARCH, ISSN 2095-4700, 02/2016, Volume 4
Adipose-derived stem cells (ASCs) and mesenchymal stem cells are promising for tissue repair because of their multilineage differentiation capacity. Our... 
CARTILAGE DEFECTS | IMPLANTATION | REGENERATION | BONE-MARROW | MATRIX FORMATION | OSTEOGENIC DIFFERENTIATION | CHONDROGENIC DIFFERENTIATION | STROMAL CELLS | SCAFFOLD | TGF-BETA-1 | CELL & TISSUE ENGINEERING
Journal Article
EUROPEAN RESPIRATORY JOURNAL, ISSN 0903-1936, 02/2014, Volume 43, Issue 2, pp. 464 - 473
Airway remodelling is a feature of asthma that contributes to loss of lung function. One of the central components of airway remodelling is subepithelial... 
CELLS | LUNG | GROWTH-FACTOR-BETA | TGF-BETA | RESPIRATORY SYSTEM | GENE-EXPRESSION | PHENOTYPE | BRONCHIAL FIBROBLASTS | IL-13 | SUBEPITHELIAL FIBROSIS | TGF-BETA-1
Journal Article
by Hinz, B
MATRIX BIOLOGY, ISSN 0945-053X, 09/2015, Volume 47, pp. 54 - 65
Journal Article
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