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Journal Article
Experimental Parasitology, ISSN 0014-4894, 11/2007, Volume 117, Issue 3, pp. 304 - 317
Schistosome parasites have co-evolved an intricate relationship with their human and snail hosts as well as a novel interplay between the adult male and female... 
e2IFα | GPI | extracellular signal-regulated kinase | histone acetyltransferase | latency associated protein | short interfering RNA | SmInACT | transforming growth factor β-induced gene-human clone 3 | anti-Mullerian hormone | RT-PCR | Common-Smads | cDNA | CREB binding protein | TβRII | AMH | TGF-b type I receptor | beta-ig-h3 | receptor kinase | Schistosoma mansoni | TβRI | GCN5 | RNAi | Schistactivin receptor-like kinasesosoma mansoni | GS region | Co-Smads | alternating glycine and serine residues | GDFs | FK506-binding protein | growth/differentiation factors | MAPK | N-terminal extracellular domain | IL-7 | BMPs | activin type Ib receptor | receptor-regulated Smads | Smad | SIP | ERK | RNA interference | Smad anchor for receptor activation | transforming growth factor beta | I-Smads | complementary deoxyribonucleic acid | Interleukin-7 | ActRIb | EGFR | Host–parasite interactions | CBP | mitogen-activated protein kinase | Mad homology region | reverse transcriptase polymerase chain reaction | TGF-β | general control nonderepressible-5 protein | SARA | SmRK1-interacting protein | human | bone morphogenetic proteins | SmInhibin/activin-like molecule | eukaryotic translation initiation factor 2α subunit | epidermal growth factor receptor | ECD | inhibitory Smads | siRNA | gynecophoral canal protein | ALKs | Male–female interactions | FKBP | GCP | LTBP | R-Smads | activin receptor-like kinases | TGF-b type II receptor | HAT | LAP | glycosylphosphatidylinositol | latent TGF-β binding protein | Male-female interactions | Host-parasite interactions | ECD, N-terminal extracellular domain | HAT, historic acetyltransferase | CELL-MEMBRANE | RNAi, RNA interference | ALKs, activin receptor-like kinases | e2IF alpha, eukaryotic translation initiation factor 2 alpha subunit | RECEPTOR SERINE/THREONINE KINASE | TGF-beta | MAD-RELATED PROTEIN | SIP, SmRK1-interacting protein | TGF-beta, transforming growth factor beta | PARASITOLOGY | male-female interactions | IL-7, Interleukin-7 | SARA, Smad anchor for receptor activation | SMAD PROTEINS | CRYSTAL-STRUCTURE | AMH, anti-Mullerian hormone | CBP, CREB binding protein | FKBP, FK506-binding protein | RK, receptor kinase | EGFR, epidermal growth factor receptor | SmInACT, SmInhibin/activin-like molecule | cDNA, complementary deoxyribonucleic acid | MH, Mad homology region | GDFs, growth/differentiation factors | Sm, Schistosoma mansoni | GCP, gynecophoral canal protein | LTBP, latent TGF-beta binding protein | MAPK, mitogen-activated protein kinase | RT-PCR, reverse transcriptase polymerase chain reaction | h, human | beta-ig-h3, transforming growth factor beta-induced gene-human clone 3, Host-parasite interactions | siRNA, short interfering RNA | REPRODUCTIVE DEVELOPMENT | GS region, alternating glycine and serine residues | GCN5, general control nonderepressible-5 protein | DNA-BINDING | I-Smads, inhibitory Smads | ActRIb, activin type Ib receptor | BMPs, bone morphogenetic proteins | Co-Smads, Common-Smads | GPI, glycosylphosphatidylinositol | HISTONE ACETYLTRANSFERASE | T beta RII, TGF-b type II receptor | GROWTH-FACTOR-BETA | ERK, extracellular signal-regulated kinase | R-Smads, receptor-regulated Smads | HOST-PARASITE RELATIONSHIPS | LAP, latency associated protein | T beta RI, TGF-b type I receptor | Schistosoma mansoni - physiology | Protein-Serine-Threonine Kinases - physiology | Humans | Transforming Growth Factor beta - physiology | Reproduction - physiology | Skin - parasitology | Male | Smad Proteins - physiology | Animals | Schistosomiasis mansoni - parasitology | Snails - parasitology | Helminth Proteins - physiology | Sex Factors | Female | Ligands | Signal Transduction - physiology | Host-Parasite Interactions | Liver - parasitology | Schistosoma mansoni - growth & development | Life Cycle Stages - physiology
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2016, Volume 291, Issue 7, pp. 3395 - 3410
By non-covalent association after proteolytic cleavage, the pro-domains modulate the activities of the mature growth factor domains across the transforming... 
SUPPRESSES TUMOR-GROWTH | HEREDITARY HEMORRHAGIC TELANGIECTASIA | ANGIOGENESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PRODOMAIN | bone morphogenetic protein (BMP) | surface plasmon resonance (SPR) | BMP9 | protein complex | IDENTIFICATION | MESENCHYMAL STEM-CELLS | homeostasis | transforming growth factor (TGF-B) | KINASE 1 ALK1 | MUTATIONS | TGF-BETA-1 | Activin Receptors, Type II - metabolism | Growth Differentiation Factor 2 - metabolism | Human Umbilical Vein Endothelial Cells - metabolism | Protein Precursors - blood | Protein Precursors - chemistry | Humans | Growth Differentiation Factors - blood | Antigens, CD - genetics | Recombinant Fusion Proteins - metabolism | Antigens, CD - metabolism | Endoglin | Human Umbilical Vein Endothelial Cells - cytology | HEK293 Cells | Female | Growth Differentiation Factors - genetics | Receptors, Cell Surface - chemistry | Antigens, CD - chemistry | Protein Interaction Domains and Motifs | Dimerization | Growth Differentiation Factor 2 - blood | Peptide Fragments - genetics | Activin Receptors, Type II - chemistry | Recombinant Proteins - metabolism | Growth Differentiation Factor 2 - isolation & purification | Peptide Fragments - metabolism | Protein Precursors - genetics | Specific Pathogen-Free Organisms | Bone Morphogenetic Protein Receptors, Type II - genetics | Signal Transduction | Peptide Fragments - isolation & purification | Cells, Cultured | Models, Molecular | Receptors, Cell Surface - metabolism | Recombinant Proteins - chemistry | Recombinant Fusion Proteins - chemistry | Bone Morphogenetic Protein Receptors, Type II - metabolism | Protein Precursors - metabolism | Growth Differentiation Factors - metabolism | Animals | Peptide Fragments - agonists | Activin Receptors, Type II - genetics | Mice, Inbred BALB C | Bone Morphogenetic Protein Receptors, Type II - chemistry | Growth Differentiation Factors - chemistry | Receptors, Cell Surface - genetics | transforming growth factor β (TGF-B) | Cell Biology
Journal Article
Journal Article
2003, AD-a416 442.
Transforming Growth Factor-beta (TGF-beta) are polypeptides that are constitutively secreted and activated by many breast carcinomas. They contribute to the... 
mammary glands | phosphorus transferases | metastasis | proteins | angiogenesis | cells(biology) | breast cancer | peptides | enzymes | gene therapy | tgf-b(transforming growth factor-beta)
Government Document
Oncotarget, ISSN 1949-2553, 2015, Volume 6, Issue 32, pp. 33237 - 33252
The downregulation of transforming growth factor-beta (TGF-beta) type II receptor (T beta RII) expression and function plays a pivotal role in the loss of the... 
TGF-b type II receptor | MiR-20a | TGF-b | c-Myc | MiR-145 | miR-20a | IN-VIVO ALTERATIONS | DOWN-REGULATION | MICRORNAS | CELL BIOLOGY | CELL LUNG-CANCER | BREAST-CANCER | GROWTH-FACTOR-BETA | COLORECTAL-CANCER | miR-145 | DISEASE
Journal Article
Developmental Biology, ISSN 0012-1606, 11/2007, Volume 311, Issue 2, pp. 500 - 511
Vg1, a member of the TGF-β superfamily of ligands, has been implicated in the induction of mesoderm, formation of primitive streak, and left–right patterning... 
Nodal | Gastrulation | tgf-b superfamily | Mesoderm | Visceral endoderm | Furin | Smad | Growth and differentiation factors | XENOPUS DEVELOPMENT | growth and differentiation factors | NODAL SIGNALS | ANTERIOR-POSTERIOR AXIS | smad | DEVELOPMENTAL BIOLOGY | nodal | mesoderm | CELL FATE | EARLY MOUSE EMBRYO | MESODERM FORMATION | GENE-EXPRESSION | FACTOR-BETA SUPERFAMILY | furin | BONE-MORPHOGENETIC PROTEIN-4 | visceral endoderm | gastrulation | Xenopus | Activin Receptors, Type II - metabolism | Membrane Glycoproteins - metabolism | Xenopus Proteins - genetics | Humans | Mesoderm - cytology | Phylogeny | Neoplasm Proteins - metabolism | Morphogenesis | Intercellular Signaling Peptides and Proteins - metabolism | In Situ Hybridization | Xenopus Proteins - classification | Embryo, Mammalian - anatomy & histology | Body Patterning | Neoplasm Proteins - genetics | Growth Differentiation Factor 1 | Growth Differentiation Factor 3 | Transforming Growth Factor beta - classification | Cell Line | Protein Precursors - genetics | Epidermal Growth Factor - genetics | Intercellular Signaling Peptides and Proteins - genetics | Activin Receptors, Type I - metabolism | Epidermal Growth Factor - metabolism | Activin Receptors, Type I - genetics | Membrane Glycoproteins - genetics | Mice, Knockout | Protein Precursors - metabolism | Embryo, Mammalian - physiology | Intercellular Signaling Peptides and Proteins - classification | Animals | Transforming Growth Factor beta - genetics | Chickens | Activin Receptors, Type II - genetics | Mesoderm - physiology | Signal Transduction - physiology | Xenopus Proteins - metabolism | Mice | Transforming Growth Factor beta - metabolism | Nodal Protein | Transforming growth factors
Journal Article
Journal of Bone Oncology, ISSN 2212-1374, 06/2019, Volume 16, p. 100231
Over the past few decades, there has been growing interest in understanding the molecular mechanisms of cancer pathogenesis and progression, as it is still... 
Tissue | Regeneration | Sarcoma | Biology | Bone | Stromal | Cell | Orthopaedic | Mesenchymal | PROGENITOR CELLS | EWINGS-SARCOMA | INTERFERON-BETA | BREAST-CANCER | NEURAL STEM-CELLS | IN-VITRO | HEPATOCELLULAR-CARCINOMA | APOPTOSIS-INDUCING LIGAND | ONCOLOGY | GROWTH-FACTOR | ADIPOSE-TISSUE
Journal Article
Human Vaccines & Immunotherapeutics, ISSN 2164-5515, 11/2014, Volume 10, Issue 11, pp. 3270 - 3285
Research on innate immune signaling and regulation has recently focused on pathogen recognition receptors (PRRs) and their signaling pathways. Members of PRRs... 
IFI16, interferon, gamma-inducible protein 16 | IRF, interferon regulatory factor | CDNs, cyclic dinucleotides | AIM2, absent in melanoma 2 | LT, lethal toxin | MIB, mind bomb | ALRs, AIM2-like receptors | MDP, muramyl dipeptide | LUBAC, linear ubiquitin assembly complex | innate immunity | TRIF, TIR domain-containing adaptor inducing IFN-b | DDX41, DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 | IKK, IkB kinase | MyD88, myeloid differentiation factor 88 | TRAILR, tumor-necrosis factor-related apoptosis-inducing ligand receptor | AMPK, AMP activated protein kinase | LBP, LPS-binding protein | NEMO, NF-kB essential modulator | TRIMs, tripartite motif containing proteins | IKKi, inducible IkB kinase | PKC-d, protein kinase C delta | LRR, leucine-rich repeat | TAK1, TGF-b-activating kinase 1 | RIP, receptor-interacting protein | TBK1, TANK binding kinase 1 | TRIP, TRAF-interacting protein | TLRs, Toll-like receptors | LGP 2, laboratory of genetics and physiology 2 | PKR, dsRNA-dependent protein kinase | PRRs, pathogen recognition receptors | STING, stimulator of interferon gene | GBP5, guanylate-binding protein 5 | RLRs, RIG-I-like receptors | ULK1, autophagy related serine threonine UNC-51- like kinase | TIR, Toll IL-1 receptor | LPS, lipopolysaccharide | TRAF, TNFR-associated factor | Atg16L, autophagy related 16-like | cDC, conventional dendritic cell | MDA5, melanoma differentiation-associated protein 5 | DCs, dendritic cells | CARD, caspase recruitment domain | PRRs | KSHV, Kaposi's sarcoma-associated herpesvirus | RAUL, RTA-associated E3 ligase | CLRs, C-type lectin receptors | pDC, plasmacytoid dendritic cell | MAVS, mitochondrial antiviral signaling protein | inflammation | NAIPs, neuronal apoptosis inhibitory proteins | CYLD, the familial cylindromatosis tumor suppressor gene | SIGIRR, single Ig IL-1-related receptor | ROS, reactive oxygen species | RIG-I, retinoic acid-inducible gene 1 | TANK, TRAF family-member-associated NF-kB activator | ASC, apoptosis-associated speck-like protein containing a CARD | DAMPs, danger-associated molecular patterns | IFN, interferon | TRAM, TRIF-related adaptor molecule | TIRAP, TIR domain-containing adapter protein | iE-DAP, g-D-glutamyl-meso-diaminopimelic acid | PAMPs, pathogen-associated molecular patterns | cGAS, cyclic GMP-AMP synthase | cIAP, cellular inhibitor of apoptosis protein | GSK3β, Glycogen synthase kinase 3β | NOD, nucleotide-binding oligomerization domain | IRAK, interleukin-1 receptor-associated kinase | BMM, bone marrow-derived macrophage | type I interferon | RACK1, receptor for activated C kinase 1 | SARM, sterile a- and armadillo motif-containing protein | SOCS, suppressor of cytokine signaling | CMV, cytomegalovirus | cancer | NLRs, Nod- like receptors | Nrdp1, neuregulin receptor degradation protein 1 | HCC, hepatocellular carcinoma | ER, endoplasmic reticulum | Innate immunity | Inflammation | Type I interferon | Cancer | linear ubiquitin assembly complex | C-type lectin receptors | IKKi | TRIP | TRAF | apoptosis-associated speck-like protein containing a CARD | neuregulin receptor degradation protein 1 | RIG-I | TRAM | CARD | TRIF-related adaptor molecule | dendritic cells | TBK1 | cytomegalovirus | cyclic dinucleotides | DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 | cellular inhibitor of apoptosis protein | GSK3 | PAMPs | retinoic acid-inducible gene 1 | CDNs | hepatocellular carcinoma | TANK binding kinase 1 | RAUL | GBP5 | Toll IL-1 receptor | cDC | MIB | protein kinase C delta | iE-DAP | CMV | SARM | SIGIRR | IRAK | sterile a- and armadillo motif-containing protein | cyclic GMP-AMP synthase | TNFR-associated factor | autophagy related serine threonine UNC-51-like kinase | AMPK | ULK1 | lipopolysaccharide | TRIF | IRF | RLRs | Nrdp1 | receptor-interacting protein | LPS-binding protein | plasmacytoid dendritic cell | tripartite motif containing proteins | LPS | DAMPs | melanoma differentiation-associated protein 5 | ASC | TAK1 | KSHV | LGP 2 | neuronal apoptosis inhibitory proteins | TRIMs | danger-associated molecular patterns | cGAS | T-CELL DEVELOPMENT | RIG-I-like receptors | lethal toxin | BMM | muramyl dipeptide | interleukin-1 receptor-associated kinase | IKK | AMP activated protein kinase | absent in melanoma 2 | IkB kinase | CYLD | dsRNA-dependent protein kinase | MAVS | Kaposi's sarcoma-associated herpesvirus | TIR domain-containing adaptor inducing IFN-b | STING | TIR | AIM2-like receptors | laboratory of genetics and physiology 2 | DDX41 | IMMUNOLOGY | LRR | MyD88 | nucleotide-binding oligomerization domain | CLRs | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | myeloid differentiation factor 88 | MDP | RACK1 | LBP | TRAF-interacting protein | bone marrow-derived macrophage | NF-KAPPA-B | NOD-LIKE RECEPTOR | NOD | conventional dendritic cell | IFN-BETA PRODUCTION | HCC | TGF-b-activating kinase 1 | inducible IkB kinase | TUMOR-SUPPRESSOR CYLD | TIRAP | Atg16L | mind bomb | pathogen-associated molecular patterns | AIM2 | PKR | SINGLE-STRANDED RNA | TRAF family-member-associated NF-kB activator | ROS | interferon regulatory factor | g-D-glutamyl-meso-diaminopimelic acid | pathogen recognition receptors | NLRs | UBIQUITIN-DEPENDENT KINASE | NEMO | stimulator of interferon gene | RTA-associated E3 ligase | Nod- like receptors | CYTOSOLIC DNA SENSOR | the familial cylindromatosis tumor suppressor gene | tumor-necrosis factor-related apoptosis-inducing ligand receptor | TANK | MDA5 | IFN | mitochondrial antiviral signaling protein | ALRs | IFI16 | DCs | TRAILR | reactive oxygen species | Toll-like receptors | cIAP | TIR domain-containing adapter protein | PATTERN-RECOGNITION RECEPTORS | single Ig IL-1-related receptor | guanylate-binding protein 5 | suppressor of cytokine signaling | autophagy related 16-like | leucine-rich repeat | NF-kB essential modulator | Glycogen synthase kinase 3 | SOCS | interferon | LUBAC | caspase recruitment domain | pDC | NAIPs | receptor for activated C kinase 1 | PKC-d | RIP | gamma-inducible protein 16 | TLRs | endoplasmic reticulum | Immunity, Innate - immunology | Signal Transduction - immunology | Neoplasms - immunology | Humans | Inflammasomes - immunology | RNA Viruses - immunology | Toll-Like Receptors - immunology | Interferon Type I - immunology | DNA Viruses - immunology
Journal Article
Journal Article
Journal Article