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1. Full Text CD4 +CD3 − Accessory Cells Costimulate Primed CD4 T Cells through OX40 and CD30 at Sites Where T Cells Collaborate with B Cells
by Kim, Mi-Yeon and Gaspal, Fabrina M.C and Wiggett, Helen E and McConnell, Fiona M and Gulbranson-Judge, Adam and Raykundalia, Chandra and Walker, Lucy S.K and Goodall, Margaret D and Lane, Peter J.L
Immunity, ISSN 1074-7613, 2003, Volume 18, Issue 5, pp. 643 - 654
In this report we identify an accessory cell that interacts with primed and memory T cells at sites where they collaborate with B cells. These cells are... 
GERMINAL CENTER FORMATION | DENDRITIC CELLS | AFFINITY MATURATION | LYMPH-NODES | IN-VIVO | CHEMOKINE RECEPTOR | POPULATIONS | MICE | LIGAND | IMMUNOLOGY | EXPRESSION | Spleen - immunology | Coculture Techniques | Tumor Necrosis Factors | Ki-1 Antigen - immunology | Spleen - cytology | Th2 Cells - immunology | Th1 Cells - immunology | Antigen-Presenting Cells - immunology | CD4-Positive T-Lymphocytes - immunology | Microscopy, Confocal | Signal Transduction - immunology | Animals | B-Lymphocytes - immunology | Lymphocyte Cooperation | Mice | Membrane Glycoproteins - immunology | Antigens | Flow cytometry | Cytokines | Lymphocytes | Rodents | Ligands | T cell receptors | Immune system
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2. Full Text Human interleukin 17-producing cells originate from a CD161 +CD4+ T cell precursor
by Cosmi, Lorenzo and De Palma, Raffaele and Santarlasci, Veronica and Maggi, Laura and Capone, Manuela and Frosali, Francesca and Rodolico, Gabriella and Querci, Valentina and Abbate, Gianfranco and Angeli, Roberta and Berrino, Liberato and Fambrini, Massimiliano and Caproni, Marzia and Tonelli, Francesco and Lazzeri, Elena and Parronchi, Paola and Liotta, Francesco and Maggi, Enrico and Romagnani, Sergio and Annunziato, Francesco
Journal of Experimental Medicine, ISSN 0022-1007, 08/2008, Volume 205, Issue 8, pp. 1903 - 1916
We demonstrate that CD161 is a highly up-regulated gene in human interleukin (IL) 17 T helper cell (Th17) clones and that all IL-17-producing cells are... 
HELPER TYPE-1 | MEDICINE, RESEARCH & EXPERIMENTAL | NKT CELLS | DISTINCT | RECEPTOR | HUMAN NKR-P1A | DIFFERENTIATION | IMMUNOLOGY | UP-REGULATION | EXPRESSION | TH17 CELLS | LYMPHOCYTES | T-Lymphocyte Subsets - immunology | Crohn Disease - genetics | Inflammation - pathology | Up-Regulation | T-Lymphocyte Subsets - cytology | Humans | Th2 Cells - immunology | Lectins, C-Type - genetics | RNA, Messenger - metabolism | Th1 Cells - immunology | Case-Control Studies | Receptors, Retinoic Acid - genetics | CD4-Positive T-Lymphocytes - immunology | Lectins, C-Type - metabolism | Hematopoietic Stem Cells - immunology | Psoriasis - genetics | Receptors, Thyroid Hormone - genetics | Antigens, Surface - metabolism | Adult | Cell Differentiation | Infant, Newborn | Nuclear Receptor Subfamily 1, Group F, Member 3 | Psoriasis - immunology | Fetal Blood - immunology | CD4-Positive T-Lymphocytes - cytology | RNA, Messenger - genetics | Antigens, Surface - genetics | Thymus Gland - cytology | Th2 Cells - cytology | Inflammation - immunology | Fetal Blood - cytology | Interleukin-17 - biosynthesis | Crohn Disease - immunology | Receptors, Interleukin - genetics | Hematopoietic Stem Cells - cytology | Inflammation - genetics | Thymus Gland - immunology | Th1 Cells - cytology | NK Cell Lectin-Like Receptor Subfamily B
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3. Full Text Preformed CD40L is stored in Th1, Th2, Th17, and T follicular helper cells as well as CD4 +8 - thymocytes and invariant NKT cells but not in Treg cells
by Koguchi, Yoshinobu and Buenafe, Abigail C and Thauland, Timothy J and Gardell, Jennifer L and Bivins-Smith, Elizabeth R and Jacoby, David B and Slifka, Mark K and Parker, David C
PLoS ONE, ISSN 1932-6203, 02/2012, Volume 7, Issue 2, p. e31296
CD40L is essential for the development of adaptive immune responses. It is generally thought that CD40L expression in CD4(+) T cells is regulated... 
POSTTRANSCRIPTIONAL REGULATION | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | DENDRITIC CELLS | THYMIC EPITHELIAL-CELLS | IMMUNE-RESPONSES | MULTIDISCIPLINARY SCIENCES | IN-VIVO | EFFECTOR FUNCTION | CD40-CD40 LIGAND | SECRETORY LYSOSOMES | TRANSGENIC MICE | CD8-Positive T-Lymphocytes - cytology | Inflammation - pathology | T-Lymphocytes, Regulatory - metabolism | Natural Killer T-Cells - drug effects | Thymocytes - metabolism | Protein Transport - drug effects | Th2 Cells - drug effects | Side-Population Cells - drug effects | T-Lymphocytes, Helper-Inducer - drug effects | Th1 Cells - metabolism | Interleukin-4 - pharmacology | Th17 Cells - drug effects | CD40 Ligand - metabolism | Th17 Cells - metabolism | Natural Killer T-Cells - metabolism | Side-Population Cells - metabolism | T-Lymphocytes, Helper-Inducer - cytology | T-Lymphocytes, Regulatory - cytology | CD8-Positive T-Lymphocytes - metabolism | Th17 Cells - cytology | Th1 Cells - drug effects | Intracellular Space - drug effects | T-Lymphocytes, Helper-Inducer - metabolism | Mice, Inbred C57BL | Natural Killer T-Cells - cytology | Th2 Cells - cytology | Inflammation - immunology | Down-Regulation - drug effects | Side-Population Cells - cytology | Th2 Cells - metabolism | T-Lymphocytes, Regulatory - drug effects | Animals | Lymphocyte Activation - drug effects | CD8-Positive T-Lymphocytes - drug effects | Intracellular Space - metabolism | Staining and Labeling | Antigens - immunology | Thymocytes - cytology | Thymocytes - drug effects | Mice | Th1 Cells - cytology | Transcription | Helper cells | Central nervous system | Science | Effector cells | Critical care | Cytotoxicity | Viruses | Lipids | Activation | Lymphocytes T | CD40L protein | Invariants | Respiratory tract | Hepatitis | Cell activation | Immunology | Lymphocytes | Rodents | Natural killer cells | Encephalitis | Antigens | Antigen presentation | Immunological memory | Lymphatic system | Memory cells | Immunoglobulins | Immune response | Cytokines | Dendritic cells | T cell receptors | Experimental allergic encephalomyelitis | Asthma | CD4 antigen | Computer memory | Thymocytes | Lymphocytes B | Antigen-presenting cells | Influenza | Apoptosis
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4. Full Text Human Langerhans Cells Are More Efficient Than CD14−CD1c+ Dermal Dendritic Cells at Priming Naive CD4+ T Cells
by Furio, Laetitia and Briotet, Isabelle and Journeaux, Alexandra and Billard, Hermine and Péguet-Navarro, Josette
Journal of Investigative Dermatology, ISSN 0022-202X, 05/2010, Volume 130, Issue 5, pp. 1345 - 1354
Few data are available regarding the role of human skin dendritic cells (DCs) in driving T-cell responses. In this study we analyzed the relative capacity of... 
PATHWAYS | RESPONSES | IMMUNITY | ACTIVATION | MACROPHAGES | B7 FAMILY | SUBSETS | POPULATIONS | ANTIGEN-PRESENTING CELLS | DIFFERENTIATION | DERMATOLOGY | Cell Communication - immunology | B7-H1 Antigen | Humans | Glycoproteins - metabolism | Immunophenotyping | Th2 Cells - cytology | Th2 Cells - immunology | Th1 Cells - immunology | Antigens, CD - metabolism | Lipopolysaccharide Receptors - metabolism | Cell Movement - immunology | Cell Differentiation - immunology | Lymphocyte Activation - immunology | CD40 Ligand - pharmacology | Cell Division - immunology | Down-Regulation - immunology | Lymphocyte Activation - drug effects | Antigens, CD1 - metabolism | Isoantigens - immunology | Langerhans Cells - immunology | Th1 Cells - cytology | Langerhans Cells - metabolism | Interferon-gamma - pharmacology | Langerhans Cells - cytology
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5. Full Text Type‐1 polarized dendritic cells loaded with apoptotic prostate cancer cells are potent inducers of CD8+ T cells against prostate cancer cells and defined prostate cancer‐specific epitopes
by Wieckowski, Eva and Chatta, Gurkamal S and Mailliard, Robbie M and Gooding, William and Palucka, Karolina and Banchereau, Jacques and Kalinski, Pawel
The Prostate, ISSN 0270-4137, 02/2011, Volume 71, Issue 2, pp. 125 - 133
BACKGROUND In order to develop improved vaccines for patients with recurrent prostate cancer (PCa), we tested the feasibility of using type‐1 polarized... 
IL‐12 | prostate cancer | dendritic cells | vaccines | CTLs | IL-12 | Immunotherapy, Adoptive - methods | Dendritic Cells - immunology | Humans | Male | Th1 Cells - immunology | Prostate-Specific Antigen - analysis | Prostatic Neoplasms - immunology | Prostatic Neoplasms - therapy | Cancer Vaccines - immunology | Cancer Vaccines - therapeutic use | Flow Cytometry | Interleukin-12 - immunology | Alkaline Phosphatase - analysis | Cell Line, Tumor | Prostatic Neoplasms - blood | Epitopes, T-Lymphocyte - immunology | CD8-Positive T-Lymphocytes - immunology | Interleukin-12 - biosynthesis
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6. Full Text Mesenchymal stem cells generate a CD4+CD25+Foxp3 + regulatory T cell population during the differentiation process of Th1 and Th17 cells
by Luz-Crawford, Patricia and Kurte, Monica and Bravo-Alegría, Javiera and Contreras, Rafael and Nova-Lamperti, Estefania and Tejedor, Gautier and Noël, Danièle and Jorgensen, Christian and Figueroa, Fernando and Djouad, Farida and Carrión, Flavio
Stem Cell Research and Therapy, ISSN 1757-6512, 2013, Volume 4, Issue 3, pp. 65 - 65
Introduction: Mesenchymal stem cells (MSCs) are adult, multipotent, stem cells with immunomodulatory properties. The mechanisms involved in the capacity of... 
CD4 | Immunosuppression | CD25 | Foxp3 | T cells | Th1 | Th17 | Mesenchymal stem cells | MEDICINE, RESEARCH & EXPERIMENTAL | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | SYSTEMIC-LUPUS-ERYTHEMATOSUS | DENDRITIC CELLS | INDUCE | LYMPHOCYTE | SUBSETS | PROLIFERATION | CELL BIOLOGY | CD4(+)CD25(+)Foxp3(+) T cells | CD4(+) | PROSTAGLANDIN E-2 | INHIBIT | T-Lymphocytes, Regulatory - metabolism | Cell Proliferation | Coculture Techniques | Th1 Cells - immunology | T-Lymphocytes, Regulatory - immunology | Mesenchymal Stromal Cells - cytology | Forkhead Transcription Factors - metabolism | T-Lymphocytes, Regulatory - cytology | Interleukin-10 - metabolism | Female | Th17 Cells - cytology | Cell Differentiation | Bone Marrow Cells - cytology | Lymphocyte Activation | Mice, Inbred C57BL | Cells, Cultured | Mesenchymal Stromal Cells - metabolism | Encephalomyelitis, Autoimmune, Experimental - therapy | Animals | Interleukin-2 Receptor alpha Subunit - metabolism | Th17 Cells - immunology | Mice | Th1 Cells - cytology | Mesenchymal Stem Cell Transplantation | CD4 Antigens - metabolism | Flow cytometry | Usage | Research | Cell differentiation | Stem cells | Cell proliferation | Antigens | Stem cell research | Life Sciences | Cellular Biology | Genetics
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7. Full Text Interleukin-12 Converts Foxp3+ Regulatory T Cells to Interferon–γ-Producing Foxp3+ T Cells That Inhibit Colitis
by Feng, Ting and Cao, Anthony T and Weaver, Casey T and Elson, Charles O and Cong, Yingzi
Gastroenterology, ISSN 0016-5085, 2011, Volume 140, Issue 7, pp. 2031 - 2043
Background & Aims Regulatory T (Treg) cells are plastic, but the in vivo mechanisms by which they are converted into foxhead box p3 (Foxp3+ ) interferon... 
Gastroenterology and Hepatology | Immune Regulation | IBD | Inflammation | Inflammatory Bowel Disease | Treg | HOMEOSTASIS | TGF-BETA | RESPONSES | RETINOIC ACID | DISEASE | GENERATION | GASTROENTEROLOGY & HEPATOLOGY | LINEAGE | PLASTICITY | Spleen - immunology | Colitis - genetics | Genes, T-Cell Receptor delta | Colitis - pathology | Interferon-gamma - metabolism | Genes, T-Cell Receptor beta | Th1 Cells - immunology | Genes, RAG-1 | Intestines - immunology | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | Flow Cytometry | Forkhead Transcription Factors - metabolism | Intestinal Mucosa - immunology | Flagellin - genetics | Cell Differentiation | Interferon-gamma - genetics | Colitis - immunology | Disease Models, Animal | Intestines - pathology | Mice, Inbred C57BL | Cells, Cultured | Mice, Transgenic | Interleukin-12 - metabolism | Cell Separation - methods | Forkhead Transcription Factors - genetics | Mice, Knockout | Interleukin-17 - metabolism | Animals | CD4-Positive T-Lymphocytes - transplantation | Th17 Cells - immunology | Mice | Colitis - prevention & control | Transforming Growth Factor beta - metabolism
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8. Full Text Human CD141 + (BDCA-3) + dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens
by Jongbloed, Sarah L and Kassianos, Andrew J and McDonald, Kylie J and Clark, Georgina J and Ju, Xinsheng and Angel, Catherine E and Chen, Chun-Jen J and Dunbar, P. Rod and Wadley, Robert B and Jeet, Varinder and Vulink, Annelie J. E and Hart, Derek N. J and Radford, Kristen J
Journal of Experimental Medicine, ISSN 0022-1007, 06/2010, Volume 207, Issue 6, pp. 1247 - 1260
The characterization of human dendritic cell (DC) subsets is essential for the design of new vaccines. We report the first detailed functional analysis of the... 
TOLL-LIKE RECEPTOR-3 | MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNE-RESPONSE | CD8(+) | PHYSIOLOGICAL STIMULI | C-TYPE LECTIN | IFN-GAMMA | IN-VIVO | CD8-ALPHA(+) | IMMUNOLOGY | T-CELLS | BLOOD | Myeloid Cells - cytology | Phosphoproteins - immunology | CD8-Positive T-Lymphocytes - cytology | Dendritic Cells - immunology | Humans | Th1 Cells - immunology | Necrosis - pathology | Lymphoid Tissue - immunology | Necrosis - immunology | CD4-Positive T-Lymphocytes - immunology | Cross-Priming - drug effects | Thrombomodulin - metabolism | Myeloid Cells - immunology | Antigens, Surface - metabolism | Dendritic Cells - drug effects | Myeloid Cells - drug effects | Lymphoid Tissue - drug effects | Interleukin-12 - biosynthesis | Antigens, CD1 - immunology | Cell Line | Th1 Cells - drug effects | Poly I-C - pharmacology | CD4-Positive T-Lymphocytes - cytology | Interferon-beta - biosynthesis | Toll-Like Receptor 3 - metabolism | Lymphoid Tissue - cytology | Cross-Priming - immunology | Recombinant Proteins - immunology | CD8-Positive T-Lymphocytes - drug effects | Antigens - immunology | Dendritic Cells - cytology | Th1 Cells - cytology | Viral Matrix Proteins - immunology | CD8-Positive T-Lymphocytes - immunology | CD4-Positive T-Lymphocytes - drug effects
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9. Full Text Peritoneal cavity regulatory B cells (B10 cells) modulate IFN-γ+CD4+ T cell numbers during colitis development in mice
by Maseda, Damian and Candando, Kathleen M and Smith, Susan H and Kalampokis, Ioannis and Weaver, Casey T and Plevy, Scott E and Poe, Jonathan C and Tedder, Thomas F
Journal of Immunology, ISSN 0022-1767, 09/2013, Volume 191, Issue 5, pp. 2780 - 2795
The spleen regulatory B cell subset with the functional capacity to express IL-10 (B10 cells) modulates both immune responses and autoimmune disease severity.... 
INFLAMMATORY-BOWEL-DISEASE | AUTOIMMUNITY | IMMUNE-RESPONSES | ULCERATIVE-COLITIS | TH1 CELLS | B-1B CELLS | INTERLEUKIN-10 | IMMUNOLOGY | EXPRESSION | LYMPHOCYTE DEPLETION | IL-10 | Enzyme-Linked Immunosorbent Assay | Mice, Inbred C57BL | Male | Adoptive Transfer | B-Lymphocytes, Regulatory - immunology | Lymphocyte Subsets - immunology | Mice, Knockout | CD4-Positive T-Lymphocytes - immunology | Animals | Peritoneal Cavity - cytology | Interferon-gamma - immunology | Fluorescent Antibody Technique | Interleukin-10 - biosynthesis | Mice | Colitis - immunology | Interleukin-10 - immunology | Disease Models, Animal
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10. Full Text Control of T Helper 2 Responses by Transcription Factor IRF4-Dependent Dendritic Cells
by Gao, Yan and Nish, Simone A and Jiang, Ruoyi and Hou, Lin and Licona-Limón, Paula and Weinstein, Jason S and Zhao, Hongyu and Medzhitov, Ruslan
Immunity, ISSN 1074-7613, 10/2013, Volume 39, Issue 4, pp. 722 - 732
CD4 T cell differentiation is regulated by specialized antigen-presenting cells. Dendritic cells (DCs) produce cytokines that promote naive CD4 T cell... 
DUST MITE ALLERGEN | IN-VIVO | LYMPH-NODES | CONTACT HYPERSENSITIVITY | TYPE-2 IMMUNITY | DIFFERENTIATION | SPECIFICATION | IMMUNOLOGY | EXPRESSION | T-CELLS | INTERFERON REGULATORY FACTOR-4 | Th1 Cells - pathology | Ovalbumin - immunology | Coculture Techniques | Dendritic Cells - immunology | Dendritic Cells - pathology | Th2 Cells - immunology | Nippostrongylus - immunology | Th1 Cells - immunology | T-Lymphocytes, Regulatory - pathology | T-Lymphocytes, Regulatory - immunology | Th2 Cells - parasitology | Allergens - immunology | Strongylida Infections - parasitology | Bone Marrow Cells - immunology | Strongylida Infections - immunology | Cell Differentiation | T-Lymphocytes, Regulatory - parasitology | Th2 Cells - pathology | Dendritic Cells - parasitology | Signal Transduction | Bone Marrow Cells - cytology | Gene Expression Regulation | Interferon Regulatory Factors - genetics | Mice, Transgenic | Strongylida Infections - pathology | Bone Marrow Cells - parasitology | Interferon Regulatory Factors - immunology | Animals | Th1 Cells - parasitology | Mice | Immunity, Cellular | Allergens | Dendritic cells | Proteases | Developmental biology | Biological response modifiers | T cells | Public health | Flow cytometry | Transcription factors | Cytokines | Lymphocytes | Rodents | T cell receptors | Infections | Genomes | Gene expression | Deoxyribonucleic acid--DNA | Immune system
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11. Full Text Human Blood CXCR5+CD4+ T Cells Are Counterparts of T Follicular Cells and Contain Specific Subsets that Differentially Support Antibody Secretion
by Morita, Rimpei and Schmitt, Nathalie and Bentebibel, Salah-Eddine and Ranganathan, Rajaram and Bourdery, Laure and Zurawski, Gerard and Foucat, Emile and Dullaers, Melissa and Oh, SangKon and Sabzghabaei, Natalie and Lavecchio, Elizabeth M and Punaro, Marilynn and Pascual, Virginia and Banchereau, Jacques and Ueno, Hideki
Immunity, ISSN 1074-7613, 01/2011, Volume 34, Issue 1, pp. 108 - 121
Although a fraction of human blood memory CD4 T cells expresses chemokine (C-X-C motif) receptor 5 (CXCR5), their relationship to T follicular helper (Tfh)... 
CHEMOKINE RECEPTOR EXPRESSION | B-CELLS | RESPONSES | SYSTEMIC-LUPUS-ERYTHEMATOSUS | DENDRITIC CELLS | HUMAN TH17 CELLS | GENE-EXPRESSION | HELPER MEMORY CELLS | IMMUNOLOGY | IL-21 | CUTTING EDGE | Th1 Cells - pathology | Humans | Th1-Th2 Balance | Child, Preschool | Male | Th2 Cells - immunology | Th1 Cells - immunology | Th1 Cells - metabolism | Dermatomyositis - immunology | Th17 Cells - metabolism | Adult | Female | B-Lymphocytes - pathology | Child | B-Lymphocytes - metabolism | Th2 Cells - pathology | Th17 Cells - pathology | Paracrine Communication | Th2 Cells - metabolism | Disease Progression | B-Lymphocytes - immunology | Adolescent | Antibody Formation | Th17 Cells - immunology | Immunologic Memory | Receptors, CXCR5 - biosynthesis | CD4 Antigens - biosynthesis | Interleukins - secretion | Studies | Ligands | Cytokines | Autoimmune diseases | Rodents | Immune system
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