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Steroids, ISSN 0039-128X, 05/2015, Volume 97, pp. 2 - 7
The skin irritating principle from was isolated, named thapsigargin and the structure elucidated. By inhibiting the sarco/endoplasmic reticulum Ca ATPase... 
Thapsigargin | Prodrug | Sarco/endoplasmic reticulum (SERCA) | Targeting drugs | Prostate specific antigen (PSA) | Prostate specific membrane antigen (PSMA) | ANALOGS | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SARCOPLASMIC-RETICULUM | TRILOBOLIDE | CA2+-ATPASE | PROSTATE-CANCER CELLS | CALCIUM | ENDOCRINOLOGY & METABOLISM | BINDING-SITE | LIBERATING SESQUITERPENE LACTONES | THAPSIA-GARGANICA L | Apoptosis - drug effects | Humans | Soft Tissue Neoplasms - drug therapy | Male | Prodrugs - isolation & purification | Prodrugs - chemistry | Neovascularization, Pathologic - pathology | Enzyme Inhibitors - chemistry | Sarcoplasmic Reticulum Calcium-Transporting ATPases - antagonists & inhibitors | Apiaceae - chemistry | Molecular Structure | Prostatic Neoplasms - drug therapy | Thapsigargin - chemistry | Prostatic Neoplasms - pathology | Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism | Enzyme Inhibitors - pharmacology | Antineoplastic Agents, Phytogenic - chemistry | Enzyme Inhibitors - isolation & purification | Thapsigargin - isolation & purification | Animals | Neovascularization, Pathologic - drug therapy | Soft Tissue Neoplasms - pathology | Thapsigargin - pharmacology | Cell Proliferation - drug effects | Mice | Antineoplastic Agents, Phytogenic - pharmacology | Prodrugs - pharmacology | Antineoplastic Agents, Phytogenic - isolation & purification | Tumors | endoplasmic reticulum (SERCA) | Sarco
Journal Article
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 10/2017, Volume 139, Issue 42, pp. 15022 - 15032
Journal Article
RESEARCH NOTE - (Ca2+-Mg2+)ATPase in Schistosoma mansoni: Evidence for Heterogeneity and Resistance to Praziquantel, 12/1998
In mammals, Ca2+ pumps use the chemical energy derived from the hydrolysis of ATP to remove Ca2+ from the cytoplasm of a variety of cell types. The pumps of... 
ATPase - calcium -(Ca2+-Mg2+)ATPase - Schistosoma mansoni - thapsigargin - praziquantel
Journal
Journal of Biological Chemistry, ISSN 0021-9258, 03/2002, Volume 277, Issue 9, pp. 6898 - 6902
In a previous study we overexpressed the thapsigargin (tg)-insensitive Pmr1 Ca super(2+) pump of the Golgi apparatus of Caenorhabditis elegans in COS-1 cells... 
Thapsigargin
Journal Article
PLoS Pathogens, ISSN 1553-7366, 05/2012, Volume 8, Issue 5, p. e1002708
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2001, Volume 276, Issue 40, pp. 37266 - 37272
Preincubation of thapsigargin with sarcoplasmic reticulum vesicles in the presence of high Ca super(2+) or the addition of high Ca super(2+) to microsomal... 
thapsigargin
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 09/2012, Volume 104, Issue 17, pp. 1320 - 1334
Journal Article
Journal Article
Molecular Cell, ISSN 1097-2765, 06/2011, Volume 42, Issue 6, pp. 731 - 743
Journal Article
Biochemical Journal, ISSN 0264-6021, 07/2001, Volume 357, Issue 2, pp. 363 - 371
We investigated the role of mitochondria in the agonist-induced and/or caffeine-induced Ca super(2+) transients in rat aortic smooth muscle cells. We explored... 
thapsigargin
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2001, Volume 276, Issue 23, pp. 20186 - 20189
In nonexcitable cells, the predominant mechanism for regulated entry of Ca super(2+) is capacitative calcium entry, whereby depletion of intracellular Ca... 
thapsigargin
Journal Article
American Journal of Physiology: Cell Physiology, ISSN 0363-6143, 09/2001, Volume 281, Issue 3, pp. C876 - C885
We examined the effects of dissolved nitric oxide (NO) gas on cytoplasmic calcium levels ([Ca super(2+)] sub(i)) in C6 glioma cells under anoxic conditions.... 
thapsigargin
Journal Article
American Journal of Physiology: Heart and Circulatory Physiology, ISSN 0363-6135, 08/2001, Volume 281, Issue 2, pp. H745 - H754
Endothelial migration is one of the major events of pathological neovascularization. We compared the characteristics of Ca super(2+) mobilization in... 
thapsigargin
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 04/2001, Volume 308, Issue 2, pp. 231 - 240
Thapsigargin (TG) is a potent inhibitor of Ca super(2)-ATPase from sarcoplasmic and endoplasmic reticula. Previous enzymatic studies have concluded that Ca... 
thapsigargin
Journal Article