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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1422-0067, 01/2019, Volume 20, Issue 2
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 01/2019, Volume 20, Issue 2, p. 448
Theiler’s murine encephalomyelitis virus (TMEV), a naturally occurring, enteric pathogen of mice is a Cardiovirus of the Picornaviridae family. Low... 
Myocarditis | Animal model | Multiple sclerosis | Demyelination | Theiler’s murine encephalomyelitis virus | Epilepsy | Adaptive immune response | Innate immune response | Seizures | epilepsy | innate immune response | demyelination | multiple sclerosis | myocarditis | seizures | adaptive immune response | animal model
Journal Article
Brain Pathology, ISSN 1015-6305, 11/2015, Volume 25, Issue 6, pp. 712 - 723
Journal Article
Journal of Neuroimmunology, ISSN 0165-5728, 07/2017, Volume 308, pp. 30 - 42
Mouse models are great tools to study the mechanisms of disease development. Theiler's murine encephalomyelitis virus is used in two distinct viral infection... 
Mouse model | Immune response | Theiler's murine encephalomyelitis virus (TMEV) | Multiple sclerosis (MS) | Epilepsy | Seizures | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | TEMPORAL-LOBE EPILEPSY | EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS | METABOTROPIC GLUTAMATE RECEPTORS | IMMUNOLOGY | NEUROSCIENCES | CD8(+) T-CELLS | CHRONIC INTERLEUKIN-6 ALTERS | ACTIVITIES IN-VITRO | MYELIN BASIC-PROTEIN | CENTRAL-NERVOUS-SYSTEM | INDUCED DEMYELINATING DISEASE | Poliomyelitis - complications | Epilepsy - virology | T-Lymphocytes - virology | Antigens, CD - metabolism | Macrophages - virology | Mice, Mutant Strains | Epilepsy - immunology | B-Lymphocytes - virology | Microglia - pathology | Epilepsy - genetics | B-Lymphocytes - pathology | T-Lymphocytes - pathology | Theilovirus - pathogenicity | Disease Models, Animal | Adaptive Immunity | Macrophages - pathology | Mice, Inbred C57BL | Multiple Sclerosis - virology | Multiple Sclerosis - genetics | Disease Progression | Animals | Microglia - virology | Multiple Sclerosis - immunology | Multiple Sclerosis - pathology | Mice | Epilepsy - pathology | Virus diseases | Multiple sclerosis | Encephalomyelitis | Analysis | Health aspects | Medical research | Brain | Glutamate | T cells | Biological response modifiers | GABA | Medicine, Experimental | West Nile fever | Interferon | Seizures (Medicine) | Myelin proteins | Injuries
Journal Article
Brain Pathology, ISSN 1015-6305, 01/2016, Volume 26, Issue 1, pp. 102 - 119
Journal Article
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1422-0067, 02/2019, Volume 20, Issue 4
Background: Spinal cord (SC) lesions in Theiler's murine encephalomyelitis virus induced demyelinating disease (TMEV-IDD) resemble important features of brain... 
BRAIN ATROPHY | spinal cord atrophy | multiple sclerosis | BIOCHEMISTRY & MOLECULAR BIOLOGY | VIRAL MODELS | CLINICAL DISABILITY | CHEMISTRY, MULTIDISCIPLINARY | Theiler's murine encephalomyelitis virus | EXPERIMENTAL-MODELS | DEGENERATION | IMMUNE | reticulospinal tract | MOUSE MODEL | INFECTION | spinal cord | axonal loss | INSIGHTS
Journal Article
Acta Neuropathologica, ISSN 0001-6322, 07/2012, Volume 124, Issue 1, pp. 127 - 142
Matrix metalloproteinases (MMPs) are a family of extracellular proteases involved in the pathogenesis of demyelinating diseases like multiple sclerosis (MS).... 
MMP-12 | Knockout mice | Multiple sclerosis | Matrix metalloproteinases | Theiler's murine encephalomyelitis | Microarray analysis | VIRAL MODEL | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | WHITE-MATTER | SPINAL-CORD | PATHOLOGY | BLOOD-BRAIN-BARRIER | NEUROSCIENCES | CLINICAL NEUROLOGY | EXTRACELLULAR PROTEOLYSIS | MULTIPLE-SCLEROSIS | TISSUE INHIBITOR | CENTRAL-NERVOUS-SYSTEM | CEREBRAL-ISCHEMIA | Encephalomyelitis - virology | Blood-Brain Barrier - physiopathology | Brain Stem - ultrastructure | Matrix Metalloproteinase 12 - genetics | Demyelinating Diseases - metabolism | Glial Fibrillary Acidic Protein - metabolism | Matrix Metalloproteinase 12 - deficiency | Matrix Metalloproteinase 9 - metabolism | Time Factors | Brain Stem - pathology | Microarray Analysis | Encephalomyelitis - complications | Demyelinating Diseases - etiology | Nogo Proteins | Theilovirus - pathogenicity | Demyelinating Diseases - drug therapy | Disease Models, Animal | Tegmentum Mesencephali - pathology | Electron Microscope Tomography | Tegmentum Mesencephali - ultrastructure | Mice, Knockout | Animals | Mice | Myelin Proteins - metabolism | Matrix Metalloproteinase 3 - genetics | Lysosomal-Associated Membrane Protein 2 - metabolism | Matrix Metalloproteinase 3 - deficiency | Matrix Metalloproteinase 9 - administration & dosage | Index Medicus | Cerebellum | Leakage | Animal models | Stromelysin 1 | Demyelinating diseases | Encephalomyelitis | Transcription | Myelin | Proteinase | Inflammation | Leukocytes | Matrix metalloproteinase | Macrophages | Blood-brain barrier | Demyelination | Extravasation | Oligodendrocytes | Extracellular matrix
Journal Article
Brain Pathology, ISSN 1015-6305, 05/2018, Volume 28, Issue 3, pp. 349 - 368
Theiler's murine encephalomyelitis (TME) of susceptible mouse strains is a commonly used infectious animal model for multiple sclerosis. The study aim was to... 
virus elimination | resistant mice | regulatory T cell expansion | Theiler's murine encephalomyelitis virus | chronic demyelination | CD8 depletion | CD8 dep etion | EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS | EFFECTOR DIFFERENTIATION | NECROSIS-FACTOR-ALPHA | RESISTANT C57BL/6 MICE | PATHOLOGY | NEUROSCIENCES | CLINICAL NEUROLOGY | VIRUS-INDUCED DEMYELINATION | INDUCED ENCEPHALITIS | PICORNAVIRUS INFECTION | MULTIPLE-SCLEROSIS | IMMUNE-RESPONSES | CENTRAL-NERVOUS-SYSTEM | Demyelinating Diseases - virology | Mice, Inbred C57BL | Brain - virology | Cardiovirus Infections - immunology | T-Lymphocytes, Regulatory - immunology | Spinal Cord - immunology | Animals | Demyelinating Diseases - immunology | Female | Spinal Cord - virology | Theilovirus - immunology | CD8-Positive T-Lymphocytes - immunology | Brain - immunology | Disease Models, Animal | Antiviral agents | Multiple sclerosis | Encephalomyelitis | RNA | Amyloid beta-protein | Antibodies | T cells | Viral antibodies | Disease transmission | Interleukins | Analysis | Mice | Health aspects | Myelin proteins | Spinal cord | CD8 antigen | Interleukin | Chronic infection | Cytotoxicity | Viruses | Infections | Lymphocytes T | Macrophages | Immunity | Accumulation | Myelin basic protein | Demyelination | Lymphocytes | Alzheimer's disease | Cytokines | Myelin | Immunoregulation | Tumor necrosis factor-α | Gene expression | Amyloid precursor protein | Microglia | Axons | Depletion | Lymphocytes B | Hippocampus
Journal Article
by Attig and Spitzbarth and Kalkuhl and Deschl and Puff and Baumgärtner and Ulrich
International Journal of Molecular Sciences, ISSN 1422-0067, 06/2019, Volume 20, Issue 13, p. 3217
(1) Background: Canine distemper virus (CDV)-induced demyelinating leukoencephalitis (CDV-DL) in dogs and Theiler’s murine encephalomyelitis (TME) virus... 
canine distemper leukoencephalitis | superoxide dismutase | reactive oxygen species | E06 | 8-hydroxyguanosine | malondialdehyde | Theiler’s murine encephalomyelitis | catalase
Journal Article
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1422-0067, 04/2019, Volume 20, Issue 7
Theiler's murine encephalomyelitis (TME) represents a versatile animal model for studying the pathogenesis of demyelinating diseases such as multiple... 
CELLS | knockout mice | Theiler's murine encephalomyelitis | VIRUS-INFECTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | astrogliosis | MODEL | INDUCTION | CHEMISTRY, MULTIDISCIPLINARY | microglia phenotype | RESPONSES | PRIMARY ASTROCYTES | NECROSIS | EPITOPE | DEMYELINATION | matrix metalloproteinases | EXPRESSION | chemokine receptor 2
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 04/2019, Volume 20, Issue 7, p. 1702
Theiler’s murine encephalomyelitis (TME) represents a versatile animal model for studying the pathogenesis of demyelinating diseases such as multiple... 
Astrogliosis | Knockout mice | Microglia phenotype | Matrix metalloproteinases | M1 | M2 | Chemokine receptor 2 | Theiler’s murine encephalomyelitis | knockout mice | astrogliosis | matrix metalloproteinases | microglia phenotype | chemokine receptor 2
Journal Article
International Journal of Molecular Sciences, ISSN 1422-0067, 02/2019, Volume 20, Issue 4, p. 989
Background: Spinal cord (SC) lesions in Theiler’s murine encephalomyelitis virus induced demyelinating disease (TMEV-IDD) resemble important features of brain... 
spinal cord | reticulospinal tract | spinal cord atrophy | Theiler’s murine encephalomyelitis virus | axonal loss | multiple sclerosis
Journal Article
Journal Article
Molecular and Cellular Probes, ISSN 0890-8508, 10/2018, Volume 41, pp. 27 - 31
Journal Article