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Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 06/2018, Volume 62, Issue 6, pp. e00051 - e00118
In Toxoplasma gondii, calcium-dependent protein kinase 1 (CDPK1) is an essential protein kinase required for invasion of host cells. We have developed several... 
Inhibitor | Cellular thermal shift assay | Toxoplasma gondii | Bumped kinase inhibitor | Protein kinase | TARGET | CELLS | PARASITES | ACTIVATION | CDPK1 | C. PARVUM | MICROBIOLOGY | bumped kinase inhibitor | protein kinase | POTENT | T. GONDII | inhibitor | SELECTIVE INHIBITORS | PHARMACOLOGY & PHARMACY | INFECTION | cellular thermal shift assay
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2018, Volume 1729, pp. 281 - 290
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 9472 - 16
Assessment of the interactions between a drug and its protein target in a physiologically relevant cellular environment constitutes a major challenge in the... 
POTENT | PROTEIN | PERMEABILITY | SMALL-MOLECULE INHIBITORS | STABILIZATION | MULTIDISCIPLINARY SCIENCES | DRUG TARGET ENGAGEMENT | BINDING | DEHYDROGENASE | DISCOVERY | LIVING CELLS | High-throughput screening | Phenotypes | Drug discovery | Thermal stability
Journal Article
Current protocols in protein science, 02/2015, Volume 79, pp. 28.9.1 - 28.9.14
Purification of recombinant proteins for biochemical assays and structural studies is time-consuming and presents inherent difficulties that depend on the... 
thermal denaturation | TSA | ThermoFluor | ligand screening | buffer optimization | differential scanning fluorimetry | Temperature | Proteins - metabolism | Ligands | Biological Assay - methods | Proteins - analysis | Fluorometry | Protein Stability | Proteins - chemistry
Journal Article
Journal Article
Journal Article
Journal of Pharmaceutical and Biomedical Analysis, ISSN 0731-7085, 12/2019, p. 113065
Journal Article