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Molecular Cancer Therapeutics, ISSN 1535-7163, 05/2017, Volume 16, Issue 5, pp. 819 - 830
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 09/2017, Volume 138, pp. 630 - 643
A series of novel 6-substituted pyrrolo[3,2-d]pyrimidine analogues (10a, 11a-13a, 15a, 17a, 18a, 27a and 28a) have been designed and synthesized as antifolate... 
Colony formation inhibition | Anti-proliferation | Dihydrofolate reductase | G2/M-phase increased | Thymidylate synthase | Structure–activity relationship | 6-substituted pyrrolo[3,2-d]pyrimidines | CHEMISTRY, MEDICINAL | PURINE NUCLEOTIDE BIOSYNTHESIS | DRUG-RESISTANCE | THYMIDYLATE | CELLULAR UPTAKE | RECEPTOR-ALPHA | GLYCINAMIDE RIBONUCLEOTIDE FORMYLTRANSFERASE | Structure activity relationship | THIENOYL REGIOISOMERS | COUPLED FOLATE TRANSPORTER | DIHYDROFOLATE-REDUCTASE | DUAL INHIBITORS | Folic Acid Antagonists - chemistry | Pyrimidines - chemical synthesis | Antineoplastic Agents - chemical synthesis | Humans | Structure-Activity Relationship | Enzyme Inhibitors - chemical synthesis | Pyrimidines - chemistry | Dose-Response Relationship, Drug | Enzyme Inhibitors - chemistry | Drug Design | Antineoplastic Agents - pharmacology | Molecular Structure | Cell Death - drug effects | Folic Acid Antagonists - chemical synthesis | Enzyme Inhibitors - pharmacology | Thymidylate Synthase - metabolism | Pyrimidines - pharmacology | Antineoplastic Agents - chemistry | Tetrahydrofolate Dehydrogenase - metabolism | Pyrroles - pharmacology | Pyrroles - chemical synthesis | Cell Line, Tumor | Folic Acid - metabolism | Pyrroles - chemistry | Cell Proliferation - drug effects | Thymidylate Synthase - antagonists & inhibitors | Folic Acid Antagonists - pharmacology | Drug Screening Assays, Antitumor | Antimitotic agents | Pyrimidines | Biomimetics | Cell death | Analysis | Antineoplastic agents
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2016, Volume 59, Issue 17, pp. 7856 - 7876
Journal Article
Journal Article
Journal Article
Molecular Pharmacology, ISSN 0026-895X, 10/2012, Volume 82, Issue 4, pp. 591 - 600
Journal Article
Cancer Biology & Therapy, ISSN 1538-4047, 12/2012, Volume 13, Issue 14, pp. 1355 - 1373
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2015, Volume 58, Issue 3, pp. 1479 - 1493
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 1/2018, Volume 81, Issue 1, pp. 1 - 15
This review considers the “promise” of exploiting the proton-coupled folate transporter (PCFT) for selective therapeutic targeting of cancer. PCFT was... 
Antifolate | Reduced folate carrier | Medicine & Public Health | Targeted therapy | Oncology | Cancer Research | Hypoxia | Proton-coupled folate transporter | Purine | Pharmacology/Toxicology | Folate | Glycinamide ribonucleotide formyltransferase | ANTIFOLATE INHIBITORS | NOVO PURINE BIOSYNTHESIS | THYMIDYLATE SYNTHASE | TRANSMEMBRANE DOMAIN | 6-SUBSTITUTED PYRROLO | CELLULAR UPTAKE | RECEPTOR-ALPHA | ONCOLOGY | PHARMACOLOGY & PHARMACY | THIENOYL ANTIFOLATE | PHASE-I | Lung Neoplasms - drug therapy | Folic Acid Antagonists - administration & dosage | Purine Nucleotides - biosynthesis | Humans | Lung Neoplasms - metabolism | Carcinoma, Non-Small-Cell Lung - metabolism | Proton-Coupled Folate Transporter - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Molecular Targeted Therapy | Reduced Folate Carrier Protein - metabolism | Mesothelioma - drug therapy | Pleural Neoplasms - drug therapy | Cell Hypoxia | Folic Acid Antagonists - therapeutic use | Pleural Neoplasms - metabolism | Mesothelioma - metabolism | Proton-Coupled Folate Transporter - metabolism | Carcinoma, Non-Small-Cell Lung - drug therapy | Acidosis | Alkaloids | Medical colleges | Pyrimidines | Analysis | Lung cancer, Non-small cell | Health aspects | Folic acid | Cancer | Lung cancer | Non-small cell lung carcinoma | Cytotoxicity | Mesothelioma | Biosynthesis | pH effects | Substrates | Anticancer properties | Diet | Intestine | Vitamin B | Antitumor activity | Transport | Intestinal absorption | Transporter | Tumors | hypoxia | proton-coupled folate transporter | targeted therapy | folate | purine | glycinamide ribonucleotide formyltransferase | reduced folate carrier
Journal Article
Journal Article