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thioredoxin-interacting protein (534) 534
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oxidative stress (257) 257
apoptosis (159) 159
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proteins (95) 95
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endoplasmic-reticulum stress (75) 75
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cells (60) 60
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metabolism (59) 59
inflammasomes - metabolism (58) 58
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endoplasmic reticulum stress (55) 55
thioredoxins - genetics (55) 55
up-regulated protein-1 (55) 55
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immunology (53) 53
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endoplasmic reticulum (48) 48
thioredoxin interacting protein (48) 48
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insulin (45) 45
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antioxidants (43) 43
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type 2 diabetes (43) 43
homeostasis (42) 42
hyperglycemia (42) 42
inflammasome (42) 42
insulin resistance (42) 42
mice, inbred c57bl (41) 41
mitochondria (41) 41
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stress (40) 40
apoptosis - drug effects (39) 39
health aspects (39) 39
cell line, tumor (38) 38
dextrose (38) 38
glucose - metabolism (38) 38
kinases (38) 38
unfolded protein response (37) 37
cytokines (36) 36
diabetes mellitus, type 2 - metabolism (36) 36
genetic aspects (36) 36
medicine, research & experimental (36) 36
nlr family, pyrin domain-containing 3 protein (34) 34
obesity (34) 34
oxidative stress - drug effects (34) 34
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neurosciences (32) 32
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oxidation-reduction (31) 31
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disease models, animal (30) 30
inhibition (30) 30
protein binding (30) 30
rats, sprague-dawley (30) 30
carbohydrate response element (29) 29
gene expression regulation (29) 29
liver (29) 29
phosphorylation (29) 29
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Immunity, ISSN 1074-7613, 09/2015, Volume 43, Issue 3, pp. 451 - 462
Endoplasmic reticulum (ER) stress is observed in many human diseases, often associated with inflammation. ER stress can trigger inflammation through... 
LISTERIA-MONOCYTOGENES | CYTOCHROME-C | MESSENGER-RNA | BRUCELLA-ABORTUS | INDUCED APOPTOSIS | ER STRESS | THIOREDOXIN-INTERACTING PROTEIN | SECRETION | IMMUNOLOGY | TRANSCRIPTION FACTOR | CELL-DEATH | Caspase 2 - genetics | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | Brucella abortus - physiology | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | BH3 Interacting Domain Death Agonist Protein - genetics | Caspase 2 - metabolism | Mitochondria - immunology | Endoplasmic Reticulum Stress - genetics | Endoplasmic Reticulum Stress - immunology | Caspase 2 - immunology | Host-Pathogen Interactions - immunology | DNA-Binding Proteins - metabolism | Mitochondria - genetics | Brucella abortus - immunology | Interleukin-1beta - metabolism | Reactive Oxygen Species - immunology | HEK293 Cells | Transcription Factors - immunology | BH3 Interacting Domain Death Agonist Protein - metabolism | Carrier Proteins - immunology | Macrophages - immunology | Macrophages - microbiology | Protein-Serine-Threonine Kinases - metabolism | RNA Interference - immunology | DNA-Binding Proteins - immunology | Endoribonucleases - metabolism | Mice, Inbred C57BL | Cells, Cultured | Interleukin-1beta - immunology | Mitochondria - metabolism | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Regulatory Factor X Transcription Factors | Blotting, Western | Mice, Knockout | Transcription Factors - metabolism | Carrier Proteins - genetics | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Inflammasomes - immunology | BH3 Interacting Domain Death Agonist Protein - immunology | Protein-Serine-Threonine Kinases - immunology | Endoribonucleases - immunology | Medical colleges | Stress (Physiology) | Mitochondrial DNA | Analysis | Cytochrome | Bacterial infections | Dehydrogenases | Infections | Inflammation | Proteins | Studies | Mitochondria | Rodents | Ligands | Endoplasmic reticulum | Deoxyribonucleic acid--DNA | Apoptosis | Index Medicus
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 03/2014, Volume 383, Issue 1-2, pp. 126 - 136
Glucocorticoid excess is associated with glucose intolerance and diabetes. In addition to inducing insulin resistance, glucocorticoids impair β-cell function... 
Protein phosphatase 5 | Glucocorticoids | Pancreatic islet | p38 MAPK | JNK | Apoptosis | P38 MAPK | INDUCED APOPTOSIS | N-TERMINAL KINASE | INHALED CORTICOSTEROIDS | THIOREDOXIN-INTERACTING PROTEIN | ENDOPLASMIC-RETICULUM STRESS | RECEPTOR PHOSPHORYLATION | INDUCED INSULIN-RESISTANCE | CELL BIOLOGY | GLUCOSE-METABOLISM | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | SECRETING CELLS | Phosphorylation | Apoptosis - drug effects | Phosphoprotein Phosphatases - metabolism | Caspase 3 - metabolism | JNK Mitogen-Activated Protein Kinases - metabolism | Insulin-Secreting Cells - metabolism | Dexamethasone - pharmacology | Caspase 3 - genetics | Insulin-Secreting Cells - cytology | Stress, Physiological - drug effects | p38 Mitogen-Activated Protein Kinases - metabolism | DNA Fragmentation - drug effects | JNK Mitogen-Activated Protein Kinases - genetics | Nuclear Proteins - genetics | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Signal Transduction | Mice, Inbred C57BL | Gene Expression Regulation | p38 Mitogen-Activated Protein Kinases - genetics | Nuclear Proteins - metabolism | Mice, Knockout | Animals | Phosphoprotein Phosphatases - genetics | Insulin-Secreting Cells - drug effects | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Glucocorticoids - pharmacology | Mice | Protein Kinase Inhibitors - pharmacology | Index Medicus | Proteins | Dexamethasone | Inhibitors | Activation | Kinases
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 09/2017, Volume 110, pp. 291 - 299
Mounting evidence demonstrated deficient cystathionine-γ-lyase (CSE)/H S implicated the development of cardiovascular disease. The present study aimed to... 
Hydrogen sulfide | TXNIP | Endothelial function | MAPK | CELLS | OXIDATIVE STRESS | ANGIOGENESIS | NITRIC-OXIDE SYNTHASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CYSTATHIONINE-GAMMA-LYASE | ATHEROSCLEROSIS | THIOREDOXIN-INTERACTING PROTEIN | INFLAMMATION | ENDOCRINOLOGY & METABOLISM | CARDIOVASCULAR-DISEASE | HYPERTENSION | Human Umbilical Vein Endothelial Cells | Hydrogen Sulfide - metabolism | Glycine - analogs & derivatives | RNA, Small Interfering - genetics | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Endothelium, Vascular - drug effects | Aorta - metabolism | MAP Kinase Kinase 4 - metabolism | Thioredoxins - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Alkynes - pharmacology | MAP Kinase Kinase 4 - antagonists & inhibitors | Thioredoxins - metabolism | Thioredoxins - antagonists & inhibitors | p38 Mitogen-Activated Protein Kinases - metabolism | Cystathionine gamma-Lyase - genetics | Nitric Oxide Synthase Type III - metabolism | Cystathionine gamma-Lyase - deficiency | Sulfides - pharmacology | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Aorta - drug effects | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Carrier Proteins - antagonists & inhibitors | Gene Expression Regulation | p38 Mitogen-Activated Protein Kinases - genetics | Nitric Oxide Synthase Type III - genetics | Mice, Knockout | Aorta - pathology | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Glycine - pharmacology | Mitogen-Activated Protein Kinase 3 - metabolism | Endothelium, Vascular - metabolism | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | MAP Kinase Kinase 4 - genetics | Endothelium, Vascular - pathology | Mice | Protein Kinase Inhibitors - pharmacology | Mitogen-Activated Protein Kinase 1 - metabolism | RNA, Small Interfering - metabolism | Medical research | Nitric oxide | Medicine, Experimental | Acetylcholine | Thioredoxin | Protein kinases | Endothelium | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2015, Volume 10, Issue 6, pp. e0130635 - e0130635
Perturbation of endoplasmic reticulum (ER) homeostasis triggers the ER stress response (also known as Unfolded Protein Response), a hallmark of many... 
TARGET | METABOLIC DISEASE | APOPTOSIS | ACTIVATION | UNFOLDED PROTEIN RESPONSE | ER-STRESS | MULTIDISCIPLINARY SCIENCES | IRE1-ALPHA | THIOREDOXIN-INTERACTING PROTEIN | CELL-DEATH | BETA | Adaptor Proteins, Signal Transducing - chemistry | Up-Regulation | Inflammasomes - metabolism | eIF-2 Kinase - metabolism | Humans | Endoplasmic Reticulum - metabolism | X-Box Binding Protein 1 | DNA-Binding Proteins - metabolism | RNA Splicing | Apoptosis Regulatory Proteins - genetics | Real-Time Polymerase Chain Reaction | Protein-Serine-Threonine Kinases - metabolism | Promoter Regions, Genetic | Endoribonucleases - metabolism | Signal Transduction | Jurkat Cells | Apoptosis Regulatory Proteins - chemistry | HCT116 Cells | Transcription Factors - genetics | DNA-Binding Proteins - genetics | CRISPR-Cas Systems - genetics | Regulatory Factor X Transcription Factors | Apoptosis Regulatory Proteins - metabolism | Transcription Factors - metabolism | Activating Transcription Factor 4 - metabolism | Mutagenesis | Endoplasmic Reticulum Stress | Adaptor Proteins, Signal Transducing - genetics | K562 Cells | Protein Binding | Activating Transcription Factor 4 - chemistry | HeLa Cells | Adaptor Proteins, Signal Transducing - metabolism | Genomes | Inflammation | Gene expression | Analysis | Genomics | Cells | Stresses | CRISPR | Chromatin | Immune response | Immunoprecipitation | Splicing | Activating transcription factor 4 | Homeostasis | Kinases | Stress | Proteins | Protein folding | Rodents | Cell lines | Endoplasmic reticulum | Viral infections | Apoptosis | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 01/2011, Volume 469, Issue 7329, pp. 221 - 225
Journal Article
EMBO Molecular Medicine, ISSN 1757-4676, 06/2014, Volume 6, Issue 6, pp. 732 - 743
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2014, Volume 9, Issue 8, pp. e104771 - e104771
Background: Nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome is associated with metabolic disorder and cell death, which... 
HEART | PATHOGENESIS | OXIDATIVE STRESS | METALLOTHIONEIN | INFLAMMASOME ACTIVATION | MULTIDISCIPLINARY SCIENCES | HIGH GLUCOSE | THIOREDOXIN-INTERACTING PROTEIN | PYROPTOSIS | NF-KAPPA-B | CELL-DEATH | RNA, Small Interfering - genetics | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Streptozocin | Diabetes Mellitus, Experimental - genetics | Caspase 1 - metabolism | NF-kappa B - metabolism | Interleukin-1beta - genetics | Diabetes Mellitus, Experimental - therapy | Interleukin-1beta - metabolism | Diet, High-Fat | Apoptosis Regulatory Proteins - genetics | Diabetes Mellitus, Experimental - complications | Diabetes Mellitus, Type 2 | Diabetic Cardiomyopathies - therapy | Cell Line | Signal Transduction | Carrier Proteins - antagonists & inhibitors | Gene Expression Regulation | Gene Silencing | Rats | Diabetic Cardiomyopathies - complications | Rats, Sprague-Dawley | Inflammasomes - genetics | Apoptosis Regulatory Proteins - metabolism | Diabetic Cardiomyopathies - genetics | Carrier Proteins - genetics | Myocytes, Cardiac - pathology | Animals | Carrier Proteins - metabolism | NF-kappa B - genetics | Caspase 1 - genetics | CARD Signaling Adaptor Proteins | Diabetes Mellitus, Experimental - pathology | Myocytes, Cardiac - metabolism | Diabetic Cardiomyopathies - pathology | Apoptosis | RNA, Small Interfering - metabolism | Type 2 diabetes | Oligomers | Cardiomyopathy | Genes | Genetic engineering | Glucose | Thioredoxin | Heart diseases | Dextrose | Protein binding | Heart | Therapy | Oxidative stress | Reactive oxygen species | Phosphorylation | Laboratories | Pathogenesis | Interleukin | Activation | Kinases | High fat diet | Caspase-1 | Proteins | Signal transduction | Hyperglycemia | Histopathology | Ultrastructure | Education | Gangrene | Inhibition | Diabetes mellitus (non-insulin dependent) | NF-κB protein | Oligomerization | Echocardiography | Nutrient deficiency | Diabetes mellitus | Mortality | Caspase | Cardiomyocytes | siRNA | Pharmacology | IL-1β | Studies | Gene silencing | Cell death | Speck | Fibrosis | Low fat diet | In vivo methods and tests | Diabetes | Index Medicus
Journal Article
by Gu, CM and Liu, SM and Wang, HY and Dou, HC
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, ISSN 1107-3756, 06/2019, Volume 43, Issue 6, pp. 2440 - 2450
Inflammatory response serves an important role in diabetic nephropathy (DN); however, the mechanism of inflammatory response results in renal damage is not yet... 
MEDICINE, RESEARCH & EXPERIMENTAL | thioredoxin interacting protein | APOPTOSIS | CELLS | OXIDATIVE STRESS | inflammatory | INJURY | NLRP3 INFLAMMASOME | KAPPA-B | MAPK | NOD-like receptor protein 3 | PATHWAY | oxidative | TXNIP | CASPASE-1 ACTIVATION | diabetic nephropathy | Antioxidants | Proteins | Cell culture | Oxidative stress | Kidneys | Pathogenesis | Genes | Glucose | Diabetes | Kinases | Laboratory animals
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 08/2011, Volume 31, Issue 8, pp. 1890 - 1897
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 2016, Volume 25, Issue 20, pp. 4556 - 4565
Lipid traits (total, low-density and high-density lipoprotein cholesterol, and triglycerides) are risk factors for cardiovascular disease. DNA methylation is... 
DENSITY-LIPOPROTEIN CHOLESTEROL | THIOREDOXIN INTERACTING PROTEIN | GENE PROMOTER | RISK-FACTORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | FAMILIAL COMBINED HYPERLIPIDEMIA | BODY-MASS INDEX | ASSOCIATION | CORONARY-ARTERY-DISEASE | LOWERING DRUGS | BLOOD | Carnitine O-Palmitoyltransferase - genetics | Cholesterol - blood | Epigenesis, Genetic | Humans | Amino Acid Transport System y+ - genetics | Male | Genetic Loci | ATP Binding Cassette Transporter, Subfamily G, Member 1 - metabolism | Cardiovascular Diseases - enzymology | Cardiovascular Diseases - genetics | Cholesterol - chemistry | ras GTPase-Activating Proteins - genetics | DNA Methylation | Amino Acid Transport System y+ - metabolism | ATP Binding Cassette Transporter, Subfamily G, Member 1 - genetics | Carnitine O-Palmitoyltransferase - metabolism | Female | Lipid Metabolism - genetics | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | Sterol Regulatory Element Binding Protein 1 - metabolism | Genetic Predisposition to Disease | Phosphoric Monoester Hydrolases - genetics | ras GTPase-Activating Proteins - metabolism | Cardiovascular Diseases - metabolism | Genetic Association Studies | Ubiquitin-Protein Ligases - metabolism | Cholesterol - metabolism | Sequence Analysis, DNA | Triglycerides - metabolism | Carrier Proteins - genetics | Carrier Proteins - metabolism | Sterol Regulatory Element Binding Protein 1 - genetics | Triglycerides - blood | CpG Islands | Triglycerides - genetics | Phosphoric Monoester Hydrolases - metabolism | Ubiquitin-Protein Ligases - genetics | Index Medicus
Journal Article