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Journal Article
Journal Article
Basic research in cardiology, ISSN 1435-1803, 2007, Volume 102, Issue 4, pp. 350 - 358
.... After we detected the presence of PAR1 mRNA and protein in the rat heart by RT-PCR and immunoblot analysis,we assessed the potential protective role of SCH 79797, a selective PAR1 antagonist, in two... 
protease-activated receptors | myocardial ischemic reperfusion injury | Medicine & Public Health | Cardiology | thrombin receptor antagonist | Myocardial ischemic reperfusion injury | Thrombin receptor antagonist | Protease-activated receptors | CARDIAC & CARDIOVASCULAR SYSTEMS | ATP CHANNELS | MECHANISM | SENSITIVE K+ CHANNELS | ISCHEMIA-REPERFUSION INJURY | INHIBITION | PROTEASE-ACTIVATED RECEPTOR-1 | CARDIOPROTECTION | THROMBIN RECEPTOR | EXPRESSION | TISSUE FACTOR | Receptor, PAR-1 - metabolism | Thrombin - antagonists & inhibitors | Male | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | RNA, Messenger - metabolism | Potassium Channels - metabolism | Myocardial Reperfusion Injury - pathology | Glyburide - pharmacology | Time Factors | Myocardium - metabolism | Myocardial Infarction - physiopathology | Proto-Oncogene Proteins c-akt - metabolism | Myocardial Reperfusion Injury - genetics | Potassium Channel Blockers - pharmacology | Disease Models, Animal | Ventricular Function, Left - drug effects | Enzyme Inhibitors - pharmacology | Rats | Cardiotonic Agents - pharmacology | Myocardial Infarction - metabolism | Rats, Sprague-Dawley | Myocardial Reperfusion Injury - physiopathology | Signal Transduction - drug effects | Myocardial Infarction - prevention & control | Nitric Oxide Synthase - metabolism | Oligopeptides - pharmacology | Quinazolines - pharmacology | Myocardial Reperfusion Injury - prevention & control | Myocardial Infarction - genetics | Nitric Oxide Synthase - antagonists & inhibitors | omega-N-Methylarginine - pharmacology | Phosphatidylinositol 3-Kinases - metabolism | Cardiotonic Agents - therapeutic use | Dose-Response Relationship, Drug | Myocardial Infarction - pathology | Pyrroles - therapeutic use | Receptor, PAR-1 - antagonists & inhibitors | Myocardium - pathology | Recombinant Proteins - pharmacology | Receptor, PAR-1 - genetics | Myocardial Reperfusion Injury - metabolism | Pyrroles - pharmacology | Animals | Androstadienes - pharmacology | Quinazolines - therapeutic use | Thrombin - metabolism | Nitric Oxide - metabolism | Research Design | Hirudins - pharmacology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Myocardial ischemia | Reperfusion injury
Journal Article
Journal Article
Journal Article
Value in Health Regional Issues, ISSN 2212-1099, 05/2015, Volume 6, pp. 22 - 32
Meta-analysis for the efficacy and safety data of thrombin-receptor antagonist (TRA) based on patients with acute coronary syndrome... 
coronary artery disease | meta-analysis | thrombin-receptor antagonist | acute coronary syndrome | randomized controlled trials | Acute coronary syndrome | Coronary artery disease | Thrombin-receptor antagonist | Meta-analysis | Randomized controlled trials
Journal Article
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1524-4636, 2009, Volume 29, Issue 4, pp. 449 - 457
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 11/2013, Volume 4, Issue 11, pp. 1054 - 1058
Octahydroindene was identified as a novel scaffold for protease activated receptor 1 (PAR1) antagonists... 
bleeding | Octahydroindene | PRP aggregation | antiplatelet | PAR1 antagonist | THROMBIN RECEPTOR ANTAGONIST | CHEMISTRY, MEDICINAL | ANALOGS | INHIBITION | ANTITHROMBOTIC AGENTS | FR171113 | (-)-HALICLONADIAMINE | VORAPAXAR | PROTEASE-ACTIVATED RECEPTOR-1
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 05/2014, Volume 5, Issue 5, pp. 561 - 565
We have synthesized several C7-spirocyclic analogues of vorapaxar and evaluated their in vitro activities against PAR-1 receptor. Some of these analogues... 
himbacine | PAR-1 antagonist | vorapaxar | thrombin receptor
Journal Article
Journal Article