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Journal Article
Biochemical Journal, ISSN 0264-6021, 07/2004, Volume 381, Issue 2, pp. 437 - 446
Early events play a decisive role in virus multiplication. We have shown previously that activation of MAPK/ERK1/2 (mitogen-activated protein... 
Extracellular-signal-regulated kinase 1/2 (ERK1/2) | Signal transduction | MAPK/ERK kinase (MEK) | egr-1 | Vaccinia virus (VV) | VV growth factor (VGF) | MYXOMA VIRUS | SURVIVAL PATHWAY | signal transduction | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | vaccinia virus (VV) | CELL-LINES | extracellular-signal-regulated kinase 1/2 | HIPPOCAMPAL-NEURONS | MESSENGER-RNAS | ERK1/2 | GENE | INFECTED CELLS | IN-VIVO | GROWTH-FACTOR | MAP Kinase Signaling System - physiology | Phosphorylation | Vero Cells - virology | Ribosomal Protein S6 Kinases - metabolism | Protein-Tyrosine Kinases - metabolism | Actins - metabolism | Protein Biosynthesis - physiology | Cercopithecus aethiops | Gene Expression Regulation, Viral - genetics | Genes, Immediate-Early - genetics | Extracellular Signal-Regulated MAP Kinases - metabolism | DNA-Binding Proteins - metabolism | Early Growth Response Protein 1 | Vaccinia virus - enzymology | Proto-Oncogene Proteins - metabolism | Cell Line | ets-Domain Protein Elk-1 | Peptides - physiology | Immediate-Early Proteins - biosynthesis | 3T3 Cells - virology | Transcription Factors - biosynthesis | Transcription Factors - metabolism | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Mitogen-Activated Protein Kinases - physiology | DNA Replication - genetics | Mice | Mice, Inbred BALB C | DNA, Viral - genetics | DNA-Binding Proteins - biosynthesis | Enzyme Activation - physiology | Virus Replication - physiology | 3T3 Cells - enzymology | Mitogen-Activated Protein Kinase 1 - metabolism | MEK, MAPK | VGF, VV growth factor | CHX, cycloheximide | BAD, Bcl-2 | extracellular-signal-regulated kinase 1 | 2 (ERK1 | ERK kinase | ERK kinase (MEK) | IMV, intracellular mature virus | ERK1 | RSK, ribosomal S6 kinase | GEN, genistein | VV, vaccinia virus | hpi, hour post-infection | WR, wild-type VV | PTX, pertussis toxin | TK, thymidine kinase | MAPK | Ara C, cytosine arabinoside | 2, extracellular-signal-regulated kinase 1 | VGF−, mutant VV | MOI, multiplicity of infection | Bcl-XL-antagonist, causing cell death | FBS, foetal bovine serum | egr-1, early growth response gene-1 | MAPK, mitogen-activated protein kinase | PKA, protein kinase A
Journal Article
The Biochemical journal, ISSN 0264-6021, 07/2014, Volume 461, Issue 2, pp. 233 - 245
NUAK1 (NUAK family SnF1-like kinase-1) and NUAK2 protein kinases are activated by the LKB1 tumour suppressor and have been implicated in regulating multiple... 
Protein Kinases - metabolism | Cell Cycle - genetics | Protein Kinases - genetics | Cell Proliferation | SKP Cullin F-Box Protein Ligases - genetics | Humans | Molecular Sequence Data | Repressor Proteins - antagonists & inhibitors | Cell Cycle Proteins - antagonists & inhibitors | Myosin-Light-Chain Phosphatase - metabolism | HEK293 Cells | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Repressor Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Proto-Oncogene Proteins - antagonists & inhibitors | Signal Transduction | Myosin-Light-Chain Phosphatase - genetics | Cell Cycle Proteins - metabolism | Gene Expression Regulation | Protein-Serine-Threonine Kinases - genetics | Ubiquitin-Protein Ligases - metabolism | Repressor Proteins - genetics | Proto-Oncogene Proteins - genetics | SKP Cullin F-Box Protein Ligases - metabolism | Sequence Alignment | Animals | Cell Line, Tumor | Protein Binding | Protein Kinase Inhibitors - pharmacology | Ubiquitin-Protein Ligases - genetics | Polo kinase (PLK) ubiquitylation | WT, wild-type | HEK, human embryonic kidney | AMPK, AMP-activated protein kinase | HRP, horseradish peroxidase | PP1, protein phosphatase 1 | AMP-activated protein kinase (AMPK) | PEI, polyethylenimine | CDK, cyclin-dependent kinase | Wee1, WEE1 G2 checkpoint kinase | GST, glutathione transferase | DTB, double thymidine block | IKK, inhibitor of nuclear factor κB kinase | LKB1, liver kinase B1 | NEM, N-ethylmaleimide | cell cycle | PI, propidium iodide | PLK1, Polo kinase 1 | SKP1, S-phase kinase-associated protein 1 | Emi1, early mitotic inhibitor 1 | mitosis | HA, haemagglutinin | NUAK, NUAK family SnF1-like kinase | degron | CK1, casein kinase 1 | XIC, extracted ion chromatogram analysis | DMEM, Dulbecco’s modified Eagle’s medium | AMPK-related kinase 5 (ARK5) | MEF, mouse embryonic fibroblast | SCFβTrCP, Skp, Cullin and F-boxβTrCP | Cul1, cullin 1
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 11/2010, Volume 80, Issue 10, pp. 1528 - 1536
Journal Article
STEM CELLS, ISSN 1066-5099, 12/2006, Volume 24, Issue 12, pp. 2637 - 2648
This study investigated the effect of ATP and its related signal cascades on the proliferation of mouse ESCs. ATP increased the level of... 
Mitogen‐activated protein kinases | Protein kinase C | Phosphatidylinositol 3‐kinase/Akt | Embryonic stem cells | ATP | Phosphatidylinositol 3-kinase/Akt | Mitogen-activated protein kinases | EXTRACELLULAR ATP | embryonic stem cells | MUSCLE | NUCLEOTIDE RECEPTOR | SELF-RENEWAL | phosphatidylinositol 3-kinase/Akt | MONOCYTIC CELLS | CELL & TISSUE ENGINEERING | CELL BIOLOGY | IN-VITRO | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | mitogen-activated protein kinases | P2X RECEPTORS | CHICK-EMBRYO | HEMATOLOGY | ES CELLS | EXPRESSION | protein kinase C | Embryonic Stem Cells - cytology | Enzyme Inhibitors - pharmacology | Purinergic P2 Receptor Antagonists | Adenosine Triphosphate - agonists | Phosphatidylinositol 3-Kinases - metabolism | Protein Kinase C - antagonists & inhibitors | Type C Phospholipases - antagonists & inhibitors | Adenosine Triphosphate - pharmacology | Animals | Embryonic Stem Cells - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Calcium Signaling - drug effects | Protein Kinase C - metabolism | Adenosine Monophosphate - pharmacology | Cell Proliferation - drug effects | Mice | Bromodeoxyuridine - metabolism | Phosphorylation - drug effects | Cell Cycle - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Cyclic AMP - metabolism | Thymidine - metabolism
Journal Article
Bone, ISSN 8756-3282, 2003, Volume 32, Issue 3, pp. 241 - 251
This study sought to assess the role of several signaling pathways in the fluid flow shear stress-induced proliferation and differentiation of normal human... 
Shear stress | Proliferation | Signal transduction (human) | Differentiation | Osteoblasts | differentiation | ACTIVATED PROTEIN-KINASE | proliferation | NITRIC-OXIDE SYNTHASE | OSTEOSARCOMA CELLS | MAP-KINASES | ALKALINE-PHOSPHATASE ACTIVITY | IN-VITRO | shear stress | MESSENGER-RNA | MECHANICAL STRAIN | BONE-FORMATION | ENDOCRINOLOGY & METABOLISM | signal transduction (human) | osteoblasts | GROWTH-FACTOR | Phosphorylation | Nitriles - pharmacology | Humans | Alkaline Phosphatase - metabolism | Nitric Oxide Synthase - antagonists & inhibitors | Stress, Mechanical | Tritium | MAP Kinase Kinase 1 | Mitogen-Activated Protein Kinase Kinases - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Flavonoids - pharmacology | Osteoblasts - cytology | Cell Differentiation - physiology | Protein-Serine-Threonine Kinases - metabolism | Pertussis Toxin - pharmacology | Thymidine - pharmacokinetics | NG-Nitroarginine Methyl Ester - pharmacology | Butadienes - pharmacology | Osteoblasts - physiology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Prostaglandins - biosynthesis | Cell Division - drug effects | Indomethacin - pharmacology | Cyclooxygenase Inhibitors - pharmacology | Cell Division - physiology | Integrin beta1 - metabolism | Signal Transduction - drug effects | Cell Differentiation - drug effects | Signal Transduction - physiology | Nitric Oxide Synthase - metabolism | Mitogen-Activated Protein Kinase 3 | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinases - metabolism
Journal Article