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American Journal of Clinical Oncology: Cancer Clinical Trials, ISSN 0277-3732, 02/2009, Volume 32, Issue 1, pp. 38 - 43
Journal Article
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, ISSN 1070-4280, 01/2017, Volume 53, Issue 1, pp. 103 - 108
Ethyl 4'-amino-5',8'-dimethyl-1' H-spiro[cyclopentane-1,2'-naphthalene]-3'-carboxylate reacted with allyl isothiocyanate to give... 
1843U89 | THYMIDYLATE SYNTHASE | CHEMISTRY, ORGANIC
Journal Article
EUROPEAN RESPIRATORY JOURNAL, ISSN 0903-1936, 03/2014, Volume 43, Issue 3, pp. 872 - 883
Numerous studies have been published on single aspects of pulmonary adenocarcinoma (ADC). To comprehensively link clinically relevant ADC characteristics, we... 
INDEPENDENT PREDICTOR | RESPIRATORY SYSTEM | SURGICALLY RESECTED ADENOCARCINOMA | THYMIDYLATE SYNTHASE | PROTEIN EXPRESSION | CLASSIFICATION | INTERNATIONAL ASSOCIATION | MUTATIONS | DNA-REPAIR | CANCER | ERCC1 EXPRESSION
Journal Article
Bioorganic Chemistry, ISSN 0045-2068, 10/2019, Volume 91, pp. 103159 - 103159
Cancer is a perplexing and challenging problem for researchers. In this study, a series of 6-aryl-5-cyano-pyrimidine derivatives were designed, synthesized and... 
Docking | Anticancer | Thymidylate synthase | Pyrimidine | Apoptosis | Index Medicus
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 04/2019, Volume 62, Issue 8, pp. 3989 - 4012
2-Amino-benzo[d]thiazole was identified as a new scaffold for the development of improved pteridine reductase-1 (PTR1) inhibitors and anti-trypanosomatidic... 
BINDING MODES | CHEMISTRY, MEDICINAL | ASSAY | THYMIDYLATE SYNTHASE | DIHYDROFOLATE-REDUCTASE | VALIDATION | RESISTANCE | IDENTIFICATION | DERIVATIVES | LEISHMANIA | SOLUBILITY
Journal Article
The Oncologist, ISSN 1083-7159, 04/2019, Volume 24, Issue 4, pp. 459 - e131
经验获取 • 在晚期非小细胞肺癌老年患者中同时使用 S‐1 和紫杉醇进行治疗显示出良好的疗效。 • 在晚期非小细胞肺癌老年患者中同时使用 S‐1 和紫杉醇进行治疗显示出可耐受的毒性。 摘要 背景。 虽然晚期非小细胞肺癌 (NSCLC)... 
MONOTHERAPY | VINORELBINE | ONCOLOGY | THYMIDYLATE SYNTHASE | FLUOROPYRIMIDINE | GENE-EXPRESSION | DIHYDROPYRIMIDINE-DEHYDROGENASE | CHEMOTHERAPY | GEMCITABINE | PHOSPHORYLASE | Clinical Trial Results
Journal Article
Cancer, ISSN 0008-543X, 2/2018, Volume 124, Issue 4, pp. 688 - 697
Colorectal cancer patients were assigned treatment based on thymidylate synthase protein (TS) expression (low versus high) in tumor tissue to a combination... 
Irinotecan | Oxaliplatin | 5-Fluorouracil | Predictive factors | Colorectal cancer | Thymidylate synthase | Prognostic factors | Bevacizumab
Journal Article
Molecular Therapy - Nucleic Acids, ISSN 2162-2531, 09/2017, Volume 8, pp. 356 - 369
One major reason for the failure of advanced colorectal cancer (CRC) treatment is the occurrence of chemoresistance to fluoropyrimidine (FU)-based... 
HOTAIR | 5-fluorouracil | NF-κB | thymidylate synthase | colorectal cancer | miR-218
Journal Article
PLOS ONE, ISSN 1932-6203, 09/2016, Volume 11, Issue 9
In colorectal cancer chemotherapy, the current standard of care includes combination therapy with 5-fluorouracil (5-FU) and leucovorin (LV). However, the... 
REDUCTASE GENE POLYMORPHISMS | 5-FLUOROURACIL | ORAL LEUCOVORIN | THYMIDYLATE SYNTHASE | PREDICTORS | MULTIDISCIPLINARY SCIENCES | MECHANISMS | FLUOROURACIL | CLINICAL-RESPONSE
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 07/2008, Volume 26, Issue 21, pp. 3543 - 3551
Journal Article
MOLECULAR CANCER THERAPEUTICS, ISSN 1535-7163, 04/2015, Volume 14, Issue 4, pp. 1004 - 1013
Trifluridine (FTD) is a key component of the novel oral antitumor drug TAS-102, which consists of FTD and a thymidine phosphorylase inhibitor. Like... 
CANCER-CELLS | TAS-102 | REPAIR | SOLID TUMORS | ONCOLOGY | THYMIDYLATE SYNTHASE | COLORECTAL-CANCER | BASE EXCISION | ANTITUMOR-ACTIVITY | 5-FLUOROURACIL CYTOTOXICITY | P53
Journal Article
Biochemistry, ISSN 0006-2960, 05/2018, Volume 57, Issue 19, pp. 2786 - 2795
In Escherichia coli thymidylate synthase (EcTS), rate-determining hydride transfer from the cofactor 5,10-methylene-5,6,7,8-tetrahydrofolate to the... 
SYSTEM | MUTANTS | LIGAND-BINDING | COLI THYMIDYLATE SYNTHASE | MECHANISM | SUBSTRATE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DYNAMICS | INTERMEDIATE | STATE | Index Medicus
Journal Article
New England Journal of Medicine, ISSN 0028-4793, 04/2004, Volume 350, Issue 15, pp. 1535 - 1548
Journal Article
Journal Article
Indian Journal of Heterocyclic Chemistry, ISSN 0971-1627, 2014, Volume 24, Issue 1, pp. 35 - 40
A series of some novel dihydrofolate reductase inhibitors (DHFR) of 2,3-disubstituted quinazolinone derivatives were synthesized by condensing benzoxazone... 
CHEMISTRY, ORGANIC | THYMIDYLATE SYNTHASE | AGENTS
Journal Article
Annals of Oncology, ISSN 0923-7534, 2017, Volume 28, Issue 11, pp. 2725 - 2732
Thymidylate synthase (TS) has a predictive role in pemetrexed treatment of mesothelioma; however, additional chemoresistance mechanisms are poorly understood.... 
Malignant pleural mesothelioma | PCFT | Methylation | Expression | Pemetrexed | Outcome | malignant pleural mesothelioma | pemetrexed | CARBOPLATIN | expression | SOLID TUMORS | HUMAN LEUKEMIA-CELLS | PHASE-II | MECHANISMS | THYMIDYLATE SYNTHASE EXPRESSION | CHEMOTHERAPY | LUNG-CANCER | ONCOLOGY | methylation | MUTATIONS | outcome | Index Medicus | Original
Journal Article
IMMUNITY, ISSN 1074-7613, 06/2007, Volume 26, Issue 6, pp. 759 - 772
The alpha beta and gamma delta T lineages are thought to arise from a common precursor; however, the regulation of separation and development of these lineages... 
LINEAGE COMMITMENT | ALLELIC EXCLUSION | CHAIN GENE REARRANGEMENT | THYMIDYLATE SYNTHASE | DNA-DAMAGE | IN-VIVO | PRE-TCR | RECEPTOR | ENDOPLASMIC-RETICULUM | IMMUNOLOGY | P53
Journal Article
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