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tia1 (42) 42
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humans (25) 25
biochemistry & molecular biology (17) 17
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1. Full Text No supportive evidence for TIA1 gene mutations in a European cohort of ALS-FTD spectrum patients
by Baradaran-Heravi, Yalda and Dillen, Lubina and Nguyen, Hung Phuoc and Van Mossevelde, Sara and Baets, Jonathan and De Jonghe, Peter and Engelborghs, Sebastiaan and De Deyn, Peter P and Vandenbulcke, Mathieu and Vandenberghe, Rik and Van Damme, Philip and Cras, Patrick and Salmon, Eric and Synofzik, Matthis and Heutink, Peter and Wilke, Carlo and Simon-Sanchez, Javier and Rojas-Garcia, Ricard and Turon-Sans, Janina and Lleó, Alberto and Illán-Gala, Ignacio and Clarimón, Jordi and Borroni, Barbara and Padovani, Alessandro and Pastor, Pau and Diez-Fairen, Monica and Aguilar, Miquel and Gelpi, Ellen and Sanchez-Valle, Raquel and Borrego-Ecija, Sergi and Matej, Radoslav and Parobkova, Eva and Nacmias, Benedetta and Sorbi, Sandro and Bagnoli, Silvia and de Mendonça, Alexandre and Ferreira, Catarina and Fraidakis, Matthew J and Diehl-Schmid, Janine and Alexopoulos, Panagiotis and Almeida, Maria Rosário and Santana, Isabel and Van Broeckhoven, Christine and van der Zee, Julie and Goeman, Johan and Nuytten, Dirk and Sieben, Anne and De Bleecker, Jan L and Santens, Patrick and Versijpt, Jan and Michotte, Alex and Ivanoiu, Adrian and Deryck, Olivier and Bergmans, Bruno and Willems, Christiana and De Klippel, Nina and Peeters, Dirk and Archettim, Silvana and Bonomi, Elisa and Piaceri, Irene and Ferrari, Camilla and Simões do Couto, Frederico and Verdelho, Ana and Miltenberger-Miltényi, Gabriel and EU EOD Consortium and BELNEU Consortium
Neurobiology of Aging, ISSN 0197-4580, 09/2018, Volume 69, pp. 293.e9 - 293.e11
We evaluated the genetic contribution of the T cell–restricted intracellular antigen-1 gene ( ) in a European cohort of frontotemporal dementia (FTD) and... 
T cell–restricted intracellular antigen-1 gene (TIA1) | TAR DNA-Binding protein 43 (TDP-43) | Amyotrophic lateral sclerosis (ALS) | Frontotemporal dementia (FTD) | FRONTOTEMPORAL DEMENTIA | T cellerestricted intracellular antigen-1 gene (TIA1) | NEUROSCIENCES | GERIATRICS & GERONTOLOGY | Frontotemporal Dementia - genetics | European Continental Ancestry Group - genetics | Amyotrophic Lateral Sclerosis - genetics | Gene Frequency | Humans | Female | Male | T-Cell Intracellular Antigen-1 - genetics | Mutation, Missense | Cohort Studies | Genetic research | Genetic aspects | Florists | Index Medicus
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2. Full Text RNA granules associated with SAMD9-mediated poxvirus restriction are similar to antiviral granules in composition but do not require TIA1 for poxvirus restriction
by Meng, Xiangzhi and Xiang, Yan
Virology, ISSN 0042-6822, 03/2019, Volume 529, pp. 16 - 22
Stress granule (SG)-like antiviral granules (AVG) had been found in some vaccinia virus infection conditions and shown to repress translation. Similar RNA... 
Vaccinia virus | Host restriction factor | Stress granule | TIA1 | Host range gene | Poxvirus | PATHWAYS | VIRUS | PROTEIN | VIROLOGY | STRESS GRANULES | Index Medicus
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3. Full Text Mutation analysis of the TIA1 gene in Chinese patients with amyotrophic lateral sclerosis and frontotemporal dementia
by Yuan, Zhenhua and Jiao, Bin and Hou, Lihua and Xiao, Tingting and Liu, Xixi and Wang, Junling and Xu, Jun and Zhou, Lin and Yan, Xinxiang and Tang, Beisha and Shen, Lu
Neurobiology of Aging, ISSN 0197-4580, 04/2018, Volume 64, pp. 160.e9 - 160.e12
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons in the brain and spinal cord.... 
Frontotemporal dementia | Amyotrophic lateral sclerosis | TIA1 | CRITERIA | MAMMALIAN STRESS GRANULES | ALS | C9ORF72 | NEUROSCIENCES | GERIATRICS & GERONTOLOGY | REGULATOR | DISTAL MYOPATHY | MESSENGER-RNA | EXPANSION | FTD | HEXANUCLEOTIDE REPEAT | Index Medicus
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4. Full Text Genetic analysis of TIA1 gene in Chinese patients with amyotrophic lateral sclerosis
by Zhang, Kang and Zhang, Xue and Liu, Shuangwu and Liu, Mingsheng and Liu, Qing and Shen, Dongchao and Tai, Hongfei and Fu, Hanhui and Wang, Zhili and Shi, Jiayu and Ding, Qingyun and Li, Xiaoguang and Cui, Liying
Neurobiology of Aging, ISSN 0197-4580, 07/2018, Volume 67, pp. 201.e9 - 201.e10
Mutations in the low-complexity domain (LCD) of T cell–restricted intracellular antigen-1 ( ) was recently identified to be associated with amyotrophic lateral... 
Amyotrophic lateral sclerosis | TIA1 | Mutation | PHASE-SEPARATION | NEUROSCIENCES | GERIATRICS & GERONTOLOGY | Medical colleges | Neurosciences | Analysis | Genetic research | Liquid crystal displays | Genetic aspects | T cells | Index Medicus
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5. Full Text A Heterologous Cell Model for Studying the Role of T-Cell Intracellular Antigen 1 in Welander Distal Myopathy
by Carrascoso, Isabel and Carrascoso, Isabel and Sánchez-Jiménez, Carmen and Sánchez-Jiménez, Carmen and Silion, Elena and Silion, Elena and Alcalde, José and Alcalde, José and Izquierdo, José M and Izquierdo, José M
Molecular and cellular biology, ISSN 0270-7306, 01/2019, Volume 39, Issue 1
Welander distal myopathy (WDM) is a muscle dystrophy characterized by adult-onset distal muscle weakness, prevalently impacting the distal long extensors of... 
stress granules | TIA1 | autophagy | Welander distal myopathy | gene expression | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | FRAGMENTATION | CELL BIOLOGY | RNA-BINDING PROTEINS | PHASE-SEPARATION | ORGANIZATION | MESSENGER-RNAS | TIA-1 | REGULATOR | STRESS GRANULE FORMATION | EXPRESSION
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6. Full Text The p.S85C-mutation in MATR3 impairs stress granule formation in Matrin-3 myopathy
by Mensch, Alexander and Meinhardt, Beate and Bley, Nadine and Hüttelmaier, Stefan and Schneider, Ilka and Stoltenburg-Didinger, Gisela and Kraya, Torsten and Müller, Tobias and Zierz, Stephan
Experimental Neurology, ISSN 0014-4886, 08/2018, Volume 306, pp. 222 - 231
Matrin-3-related distal myopathy is characterized mainly by progressive distal weakness of the lower extremities. The mutation p.S85C in matrin-3 (MATR3) has... 
Distal myopathy | Matrin-3 myopathy | Cellular stress | TIA1 | VCPDM | G3BP1 | Stress granule | MATR3 | DOMINANT DISTAL MYOPATHY | OXIDATIVE STRESS | PROTEIN | PHENOTYPE | VOCAL CORD | PHARYNGEAL WEAKNESS | NEUROSCIENCES | HUMAN SKELETAL-MUSCLE | DAMAGE | FAMILY | MUTATION | Analysis | Arsenic compounds | Index Medicus
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7. Full Text miR-487a promotes progression of gastric cancer by targeting TIA1
by Yang, Xuefeng and Wang, Mingda and Lin, Bohao and Yao, Dongjie and Li, Sanhua and Li, Jin and Tang, Xianchun and Liu, Yun and Xie, Rui and Yu, Shouyang
Biochimie, ISSN 0300-9084, 11/2018, Volume 154, pp. 119 - 126
Gastric cancer (GC) is one of the most common malignancies as well as the third leading cause for cancer-related death. Molecular basis of GC are essential and... 
TIA1 | miR-487a | Proliferation | Apoptosis | MIGRATION | CELLS | RNA | MICRORNA BIOGENESIS | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | HEPATOCELLULAR-CARCINOMA | INVASION | LYMPHOCYTES | Development and progression | T cells | Health aspects | Stomach cancer | Cells | Cancer | Index Medicus
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8. Full Text Genetic Perturbation of TIA1 Reveals a Physiological Role in Fear Memory
by Rayman, Joseph B and Hijazi, Joud and Li, Xiang and Kedersha, Nancy and Anderson, Paul J and Kandel, Eric R
Cell Reports, ISSN 2211-1247, 03/2019, Volume 26, Issue 11, pp. 2970 - 2983.e4
TIA1 is a prion-related RNA-binding protein whose capacity to form various types of intracellular aggregates has been implicated in neurodegenerative disease.... 
stress | TIA1 | ventral hippocampus | fear memory | gene-environment interaction | contextual fear conditioning | avoidance behavior | glucocorticoids | sex differences | long-term potentiation | PHASE-SEPARATION | PROTEINS TIA-1 | TRANSLATIONAL SILENCER | ODOR DISCRIMINATION | VENTRAL HIPPOCAMPUS | DEFENSIVE BEHAVIOR | LONG-TERM POTENTIATION | SEX-DIFFERENCES | EXPRESSION | STRESS GRANULES | CELL BIOLOGY
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9. Full Text Identification of a novel MTOR activator and discovery of a competing endogenous RNA regulating autophagy in vascular endothelial cells
by Ge, Di and Han, Lei and Huang, ShuYa and Peng, Nan and Wang, PengChong and Jiang, Zheng and Zhao, Jing and Su, Le and Zhang, ShangLi and Zhang, Yun and Kung, HsiangFu and Zhao, BaoXiang and Miao, JunYing
Autophagy, ISSN 1554-8627, 06/2014, Volume 10, Issue 6, pp. 957 - 971
MTOR, a central regulator of autophagy, is involved in cancer and cardiovascular and neurological diseases. Modulating the MTOR signaling balance could be of... 
TIA1 | lncRNA | autophagy | MTOR activator | ATG13 | MIR4459 | LncRNA | Autophagy | MAMMALIAN TARGET | PROGENITOR CELLS | APOPTOSIS | PROTEIN | CELL BIOLOGY | TIA-1 | TRANSLATIONAL SILENCER | RAPAMYCIN MTOR | GENE-EXPRESSION | GROWTH-FACTOR | DIFFERENTIATION | Human Umbilical Vein Endothelial Cells | Autophagy-Related Proteins | Phosphorylation | TOR Serine-Threonine Kinases - metabolism | Tacrolimus Binding Proteins - chemistry | Transforming Growth Factor beta2 - metabolism | Humans | MicroRNAs - metabolism | Autophagy - physiology | Tacrolimus Binding Proteins - metabolism | Autophagy - drug effects | Poly(A)-Binding Proteins - metabolism | Autophagy - genetics | T-Cell Intracellular Antigen-1 | 3' Untranslated Regions | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | 4-Butyrolactone - pharmacology | Models, Molecular | RNA, Long Noncoding - genetics | Enzyme Activation - drug effects | Sirolimus - pharmacology | Signal Transduction - drug effects | Adaptor Proteins, Signal Transducing - genetics | MicroRNAs - genetics | 4-Butyrolactone - analogs & derivatives | Transforming Growth Factor beta2 - genetics | Adaptor Proteins, Signal Transducing - metabolism | RNA, Long Noncoding - metabolism | Index Medicus | Basic Research Paper
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10. Full Text TIA-1 Self-Multimerization, Phase Separation, and Recruitment into Stress Granules Are Dynamically Regulated by Zn2
by Rayman, Joseph B and Karl, Kevin A and Kandel, Eric R
Cell Reports, ISSN 2211-1247, 01/2018, Volume 22, Issue 1, pp. 59 - 71
Stress granules are non-membranous structures that transiently form in the cytoplasm during cellular stress, where they promote translational repression of... 
TIA-1 | TIA1 | phase separation | stress granules | zinc regulation | functional prion | cellular stress | PROTEIN | MESSENGER-RNA | PERSISTENCE | FUNCTIONAL PRION | ZINC | AGGREGATION | CELL BIOLOGY | Index Medicus
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11. Full Text miR-19a promotes colorectal cancer proliferation and migration by targeting TIA1
by Liu, Yanqing and Liu, Rui and Yang, Fei and Cheng, Rongjie and Chen, Xiaorui and Cui, Shufang and Gu, Yuanyuan and Sun, Wu and You, Chaoying and Liu, Zhijian and Sun, Feng and Wang, Yanbo and Fu, Zheng and Ye, Chao and Zhang, Chenyu and Li, Jing and Chen, Xi
Molecular Cancer, ISSN 1476-4598, 03/2017, Volume 16, Issue 1, pp. 53 - 53
Background: Colorectal cancer (CRC) is a major worldwide health problem due to its high prevalence and mortality rate. T-cell intracellular antigen 1 (TIA1) is... 
TIA1 | MicroRNA | Colorectal cancer | MiR-19a | METASTASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | C-MYC | MICRORNA TARGETS | MESENCHYMAL TRANSITION | miR-19a | RENAL-CELL CARCINOMA | MESSENGER-RNA | ONCOLOGY | SMRNA-SEQ DATABASE | microRNA | PROTEINS | EXPRESSION | BINDING | RNA-Binding Proteins - genetics | Meta-Analysis as Topic | Colorectal Neoplasms - genetics | Humans | Gene Expression Regulation, Neoplastic | Male | Gene Expression Profiling | Genes, myc | RNA, Messenger - metabolism | Cell Movement - genetics | Heterografts | RNA Interference | Poly(A)-Binding Proteins - metabolism | Apoptosis Regulatory Proteins - genetics | T-Cell Intracellular Antigen-1 | 3' Untranslated Regions | Binding Sites | Colorectal Neoplasms - metabolism | Disease Models, Animal | Cell Proliferation - genetics | RNA Processing, Post-Transcriptional | Poly(A)-Binding Proteins - genetics | RNA, Messenger - genetics | Animals | Cell Line, Tumor | Mice | MicroRNAs - genetics | Colorectal Neoplasms - pathology | Cell proliferation | Antigen receptors, T cell | Receptors | Physiological aspects | Development and progression | Genetic aspects | Research | Properties | T cells | Index Medicus
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12. Full Text TIA1 regulates the generation and response to toxic tau oligomers
by Jiang, Lulu and Ash, Peter E. A and Maziuk, Brandon F and Ballance, Heather I and Boudeau, Samantha and Abdullatif, Ali Al and Orlando, Marcello and Petrucelli, Leonard and Ikezu, Tsuneya and Wolozin, Benjamin
Acta Neuropathologica, ISSN 0001-6322, 02/2019, Volume 137, Issue 2, pp. 259 - 277
RNA binding proteins (RBPs) are strongly linked to the pathophysiology of motor neuron diseases. Recent studies show that RBPs, such as TIA1, also contribute... 
TIA1 | Neurodegeneration | Neuropathology | Tau fibrils | Tau oligomers | Tau propagation | Tauopathy | Stress granules | RNA binding proteins | STRAINS | LEWY BODY | ALPHA-SYNUCLEIN | PATHOLOGY | MODEL | NEUROSCIENCES | CLINICAL NEUROLOGY | FIBRILS | MICE | DIVERSITY | PROPAGATION | PROGRESSION | Oligomers | Medicine, Experimental | Medical research | Binding proteins | Protein binding | RNA-binding protein | Propagation | Neurodegenerative diseases | Tau protein | Fibrils | Ribonucleic acid--RNA | Seeding | Hippocampus | Original Paper
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13. Full Text Proteomic profile changes associated with diminished expression of T-cell intracellular antigens reveal a hormesis response
by Alcalde, José and Izquierdo, José M
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 09/2018, Volume 503, Issue 4, pp. 2569 - 2575
T-cell intracellular antigen (TIA) proteins function as regulators of cell homeostasis by controlling global gene expression in response to dynamic regulatory... 
TIAR | Proteome | TIA1 | Gene regulatory networks | Adaptive metabolism | TIA-Hormesis | HUR | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING PROTEIN TIAR | PROLIFERATION | TRANSLATION | IDENTIFICATION | CANCER | MESSENGER-RNAS | BIOPHYSICS | GENES | TUMOR-SUPPRESSOR | STRESS GRANULES | Proteins | Antigens | Analysis | Environmental law | Genes | Physiological aspects | T cells | Gene expression | Mass spectrometry | Index Medicus
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14. Full Text Welander Distal Myopathy Caused by an Ancient Founder Mutation in TIA1 Associated with Perturbed Splicing
by Klar, Joakim and Sobol, Maria and Melberg, Atle and Mäbert, Katrin and Ameur, Adam and Johansson, Anna C.V and Feuk, Lars and Entesarian, Miriam and Örlén, Hanna and Casar‐Borota, Olivera and Dahl, Niklas and Medicinska fakulteten and Science for Life Laboratory, SciLifeLab and Medicinska och farmaceutiska vetenskapsområdet and Institutionen för immunologi, genetik och patologi and Neurologi and Medicinsk genetik and Genomik and Molekylär och morfologisk patologi and Uppsala universitet and Institutionen för neurovetenskap
Human Mutation, ISSN 1059-7794, 04/2013, Volume 34, Issue 4, pp. 572 - 577
W elander distal myopathy ( WDM ) is an adult onset autosomal dominant disorder characterized by distal limb weakness, which progresses slowly from the fifth... 
elander distal myopathy | splicing | TIA | founder mutation | cellular stress | Cellular stress | TIA1 | Founder mutation | Welander distal myopathy | Splicing | POSITIONAL CLONING | GENETIC-LINKAGE | GENETICS & HEREDITY | CHROMOSOME 2P13 | INCLUSION-BODY MYOSITIS | G3BP | GRANULES | Haplotypes | Amino Acid Sequence | Gene Expression | Alternative Splicing | Exons | Poly(A)-Binding Proteins - genetics | Humans | Molecular Sequence Data | Muscle, Skeletal - metabolism | Exome | Founder Effect | Distal Myopathies - genetics | RNA Splicing | Sequence Alignment | Poly(A)-Binding Proteins - metabolism | Base Sequence | Survival of Motor Neuron 2 Protein - genetics | Distal Myopathies - metabolism | Muscle, Skeletal - pathology | Mutation | T-Cell Intracellular Antigen-1 | Microsatellite Repeats | Proteins | Muscles | Genetic aspects | RNA | T cells | Muscular dystrophy | Index Medicus | Clinical Medicine | Neurology | Neurologi | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap
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15. Full Text T-Cell intracellular antigens and Hu antigen R antagonistically modulate mitochondrial activity and dynamics by regulating optic atrophy 1 gene expression
by Carrascoso, Isabel and Alcalde, José and Sánchez-Jiménez, Carmen and González-Sánchez, Paloma and Izquierdo, José M
Molecular and Cellular Biology, ISSN 0270-7306, 09/2017, Volume 37, Issue 17
Mitochondria undergo frequent morphological changes to control their function. We show here that T-cell intracellular antigens (TIA1b/TIARb) and Hu antigen R... 
TIAR | TIA1 | HuR | OPA1 | Mitochondrial spatial dynamics | Mitophagy | Autophagy | Apoptosis | RECRUITMENT | autophagy | FUSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | mitochondrial spatial dynamics | apoptosis | CELL BIOLOGY | RNA-BINDING PROTEINS | MESSENGER-RNAS | TIA-1 | mitophagy | BIOGENESIS | METABOLISM | DISEASE | FISSION | Cell Proliferation | Mitochondrial Dynamics - genetics | Humans | Optic Atrophy, Autosomal Dominant - metabolism | RNA, Messenger - genetics | Cytoplasm - metabolism | Mitochondria - metabolism | Mitochondrial Proteins - genetics | Mitochondrial Membranes - metabolism | ELAV-Like Protein 1 - metabolism | GTP Phosphohydrolases - metabolism | Mitochondria - genetics | Mitochondrial Proteins - metabolism | Poly(A)-Binding Proteins - metabolism | Gene Expression - physiology | Optic Atrophy, Autosomal Dominant - genetics | T-Cell Intracellular Antigen-1 | Index Medicus
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