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Journal Article
TRENDS IN CELL BIOLOGY, ISSN 0962-8924, 10/2019, Volume 29, Issue 10, pp. 777 - 790
T cells responding to persistent tumor or viral antigens progressively lose their functional properties, a feature known as exhaustion. This state is also... 
TRANSCRIPTION FACTORS | TIM-3 EXPRESSION | RESPONSES | CHAIN CYTOKINES IL-2 | RESISTANCE | ANTITUMOR IMMUNITY | DYSFUNCTION | CD8(+) T-CELLS | EXHAUSTION | PD-1 EXPRESSION | CELL BIOLOGY
Journal Article
General and Comparative Endocrinology, ISSN 0016-6480, 06/2019, Volume 277, pp. 30 - 37
Hepatitis A virus cellular receptor2 (Havcr2) also named T-cell immunoglobulin and mucin domain containing-3 (Tim-3) was initially described as a T helper... 
Medaka | Immune response | Havcr2 | Gene expression | Protein structure | PROTEIN | RECEPTOR | CD8(+) T-CELLS | PREDICTION | TIM-3 EXPRESSION | RESPONSES | AUTOIMMUNE | ROLES | ENDOCRINOLOGY & METABOLISM | DYSFUNCTION | TH1 | RNA | Genes | Liver | T cells | Mitogens
Journal Article
OncoImmunology, ISSN 2162-4011, 11/2018, Volume 7, Issue 11, p. e1502128
Tumor-infiltrating lymphocytes (TILs) are predominantly present in breast cancer patients with estrogen receptor negative tumors, among whom increasing levels... 
LAG-3 | PD-L1 | breast cancer | tumor-infiltrating lymphocytes | immunohistochemistry | TIM-3 | PD-1 | immune checkpoints | MULTICENTER | ATEZOLIZUMAB | IMMUNOLOGY | SINGLE-ARM | PROGNOSTIC VALUE | CHEMOTHERAPY | PEMBROLIZUMAB | ONCOLOGY | CISPLATIN-INELIGIBLE PATIENTS | T-CELL DYSFUNCTION | IPILIMUMAB
Journal Article
Oncotarget, ISSN 1949-2553, 09/2017, Volume 8, Issue 37, pp. 61425 - 61439
Exhausted T-cells in follicular lymphoma (FL) typically express PD-1, but expression of PD-1 is not limited to exhausted cells. Although expected to be... 
Follicular lymphoma | Immune checkpoint | T-cell exhaustion | LAG-3 | PD-1 | SURVIVAL | IMMUNITY | follicular lymphoma | PD-L1 EXPRESSION | CHRONIC VIRAL-INFECTION | CANCER | CELL BIOLOGY | CXC CHEMOKINE RECEPTOR-5 | immune checkpoint | NON-HODGKINS-LYMPHOMA | TIM-3 | CLASS-II | DISEASE PROGRESSION
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 09/2017, Volume 23, Issue 17, pp. 5024 - 5033
Purpose: Disruption of PD-L1/cytotoxic T-cell PD-1 signaling by immune checkpoint inhibitors improves survival in cancer patients. This study sought to... 
BIOMARKERS | ACTIVATION | THERAPY | ONCOLOGY | EXPANSION | NIVOLUMAB | TIM-3 | CD8-Positive T-Lymphocytes - pathology | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Gene Expression Regulation, Neoplastic | Male | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Antibodies, Monoclonal, Humanized - administration & dosage | Melanoma - genetics | Immunotherapy | Adult | Female | Antibodies, Monoclonal, Humanized - adverse effects | Kaplan-Meier Estimate | Drug Resistance, Neoplasm - immunology | Lymphocytes, Tumor-Infiltrating - drug effects | Melanoma - pathology | B7-H1 Antigen - genetics | B7-H1 Antigen - immunology | Drug Resistance, Neoplasm - genetics | B7-H1 Antigen - antagonists & inhibitors | Antibodies, Monoclonal - administration & dosage | Biopsy | Melanoma - immunology | Melanoma - drug therapy | Aged | Biomarkers, Tumor - genetics | Programmed Cell Death 1 Receptor - immunology | CD8-Positive T-Lymphocytes - immunology | Biomarkers, Tumor - immunology | Programmed Cell Death 1 Receptor - genetics | Lymphocytes, Tumor-Infiltrating - immunology | Cell survival | PD-1 protein | CD8 antigen | Medical treatment | Melanoma | Cytotoxicity | Lymphocytes T | Macrophages | Patients | Metastases | Signaling | Immune checkpoint | Lymphocytes | Experimental design | PD-L1 protein | Infiltration | Immune system | Cancer
Journal Article
Journal of Neuroimmunology, ISSN 0165-5728, 10/2018, Volume 323, pp. 105 - 108
Multiple sclerosis (MS), is an autoimmune disorder of central nervous system (CNS) characterized by inflammation and demyelination. Self-tolerance impairment... 
Multiple sclerosis | CTLA-4 | TIM-3 | PD-1 | GALECTIN-9 | MECHANISMS | IMMUNOLOGY | NEUROSCIENCES | MULTIPLE-SCLEROSIS | T-CELL-ACTIVATION | DISEASE | INFECTION | ASSOCIATION | PROMOTES
Journal Article
Cell Reports, ISSN 2211-1247, 01/2019, Volume 26, Issue 3, pp. 639 - 651.e2
The thymoproteasome subunit β5t is specifically expressed in cortical thymic epithelial cells (TECs) and generates unique peptides to support positive... 
thymic selection | proteasome | memory T cells | naïve T cells | autoimmunity | thymic epithelial cells | thymoproteasome | self peptide | autoimmune disease | naïve T cells | memory T cells | INTERFERON | MEMORY | CORTEX | ROLES | CLONAL DELETION | GENERATION | SUBUNITS | THYMOCYTES | TIM-3 | NAIVE | CELL BIOLOGY
Journal Article
International Immunopharmacology, ISSN 1567-5769, 04/2018, Volume 57, pp. 139 - 146
Follicular helper T (Tfh) cells are critical regulators of immune responses in several human malignancies. Their characteristics in ovarian cancer (OC)... 
IgG | Follicular helper T cell | Tim-3 | Ovarian cancer | IL-15 | PHARMACOLOGY & PHARMACY | IMMUNOLOGY | EXHAUSTION | IL-21
Journal Article